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The map label for this gene is uvrB [H]

Identifier: 157825404

GI number: 157825404

Start: 275759

End: 277744

Strand: Reverse

Name: uvrB [H]

Synonym: A1C_01490

Alternate gene names: 157825404

Gene position: 277744-275759 (Counterclockwise)

Preceding gene: 157825407

Following gene: 157825402

Centisome position: 22.56

GC content: 37.76

Gene sequence:

>1986_bases
ATGAATCATTTTTCTCTTATCTCAGAATATAAACCGGCAGGCGATCAACCAAAAGCAATAGATGAAATTATAGCAGGATT
AAATAGTAAAAAACGCTCACAAATGTTGCTTGGTATTACGGGGTCAGGCAAAACATTTACTATGGCAAATATTATAGAGA
GAACTAATCGCCCTACTCTTATAATGGCACATAATAAAACTTTAGCTGCTCAAATTTATTCAGAAATGAAGTCGATTTTT
CCAAAGAACGCCGTTGAATATTTTGTCTCATATTATGATTACTACCAACCCGAAGCTTATATAGCACGCACCGATACTTT
TATCGAAAAAGATTCATCAATTAATGAACACATTGATTTAATGCGTCATTCTGCTACAAGATCGTTATTAGAGCGTCGTG
ATGTTATAGTAGTTGCTTCCGTTTCCTGTATTTACGGACTTGGCTCTCCTGATCTATATTACCAAATGACCGTTAATCTA
GAACCTGGTAAAAGCTACCCTCGTGATAAACTACTAAATGATTTGATAAATCTACAATATAAACGTAACGATATGGGGTT
TGAGCGTGGCTGCTTTAGGGTTAAAGGCGACAACATTGATATTTTCCCCTCACATTATAGTGATAAAGCTTGGCGTTTAT
CGTTTTTCAGTAATGAACTCGAATATATCCACGAATTTGACCCACTAACAGGTGAAAAACTTGCTAAGCTTGATAAAGCT
ATAGTCTTTGGTCATTCACACTTTGTGATGCCACAAGATACGGTCAATAATGCCATATCAGGTATTGAGGAAGAATTACA
AAAACGCTTAGAGTTCTTAAAGTCGCAAAATAAACTGCTTGAAACTCAAAGGCTAAATCAACGTACTCAATATGATCTTG
AAATGTTAACGGAAACAGGCAGCTGTAAAGGCGTTGAAAATTATTCAAGATTCTTTACCGGTCGTAATGCCGGTGAGCCA
CCACCGACATTATTCGAATACTTGCCGAAAGATGCGTTATTATTTGTTGATGAAAGCCACGTATCCGTACCACAAATTAA
AGCGATGTATAACAGCGATCGAGCAAGGAAAGAAGTATTGGTAGAGCATGGGTTTCGTCTGCCTTCTGCTCTTGATAACA
GACCTTTAAAATTTGAAGAATGGGAAAAATTTAGACCGCAAACCGTTTTTGTATCGGCAACCCCGGGACCGTTCGAGTTA
GAAGAAACCGGAGGCACTGTAGTAGAGCTGATTATCAGACCTACGGGACTGCTTGATCCTGAATGTATTATAAAGCCGGC
CACCAAACAGGTTGAGGATTTAATTAGCGAAATTCAAGCCACTGTCGCTAAAGGCTTACGTGTCTTAGTCACCACCTTAA
CTAAAAAAATGGCTGAAGATTTAACCGCCTATTTGCAGGAACTAAAATATAAAACTTCCTACTTGCATTCTAACGTGCAT
ACTCTAGAACGCATCGAGATTTTACAAGATTTAAGACAAGGTACTATCGATATTTTAGTCGGTATTAATCTATTAAGAGA
GGGGCTTGATATCCCTGAATGCGGCTTAGTTGCTATACTTGATGCAGATAAAGAGGGATTTTTACGGTCGGAAGTATCGT
TAATACAAACGATCGGAAGAGCTGCAAGAAATAGTGAGGGCAGAGTCATACTTTATGCCGATAAAATGACTAAATCGATC
GATAAAGCTCTTAGTGAAACGTTGCGTAGAAGACAAATTCAGCAGGAATATAATGAAAAACACGGCATAATTCCAAAGAC
TATCAACCGTGCTATTCACGCTTTAGCAACACTTGAAAGAGTCGATAGTAAGTGTGATACAAAACAAGCTCATACTTTAT
TTGATAACACTGCTAAGTTAAAAGCTAATATCAACAAACTAAACAAAGAAATGCTTAAAGCCGCAAGTAATCTTGAATTT
GAACAAGCCGCAAAACTTCGAGATCAGCTAAAAACTCTAGAAGCGGCAGCACGTGAGTTAAGCTAA

Upstream 100 bases:

>100_bases
AATAATTGTGTGTAATATAGCTTTATTCATAATGTTATATTTTTTTGTTAGGTTTTAATATATTATCTTAAACTATAGTT
TTTTAAGCAAGTAAAAATGT

Downstream 100 bases:

>100_bases
AACCGATTGTCATCCCGTGGCTTGACCACGGGATCCAGTAAAAAATATAAATATAACAATTTCTTAAAACTAAAAGCTCG
ATTTATTTCGCTTTTTTCTG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 661; Mature: 661

Protein sequence:

>661_residues
MNHFSLISEYKPAGDQPKAIDEIIAGLNSKKRSQMLLGITGSGKTFTMANIIERTNRPTLIMAHNKTLAAQIYSEMKSIF
PKNAVEYFVSYYDYYQPEAYIARTDTFIEKDSSINEHIDLMRHSATRSLLERRDVIVVASVSCIYGLGSPDLYYQMTVNL
EPGKSYPRDKLLNDLINLQYKRNDMGFERGCFRVKGDNIDIFPSHYSDKAWRLSFFSNELEYIHEFDPLTGEKLAKLDKA
IVFGHSHFVMPQDTVNNAISGIEEELQKRLEFLKSQNKLLETQRLNQRTQYDLEMLTETGSCKGVENYSRFFTGRNAGEP
PPTLFEYLPKDALLFVDESHVSVPQIKAMYNSDRARKEVLVEHGFRLPSALDNRPLKFEEWEKFRPQTVFVSATPGPFEL
EETGGTVVELIIRPTGLLDPECIIKPATKQVEDLISEIQATVAKGLRVLVTTLTKKMAEDLTAYLQELKYKTSYLHSNVH
TLERIEILQDLRQGTIDILVGINLLREGLDIPECGLVAILDADKEGFLRSEVSLIQTIGRAARNSEGRVILYADKMTKSI
DKALSETLRRRQIQQEYNEKHGIIPKTINRAIHALATLERVDSKCDTKQAHTLFDNTAKLKANINKLNKEMLKAASNLEF
EQAAKLRDQLKTLEAAARELS

Sequences:

>Translated_661_residues
MNHFSLISEYKPAGDQPKAIDEIIAGLNSKKRSQMLLGITGSGKTFTMANIIERTNRPTLIMAHNKTLAAQIYSEMKSIF
PKNAVEYFVSYYDYYQPEAYIARTDTFIEKDSSINEHIDLMRHSATRSLLERRDVIVVASVSCIYGLGSPDLYYQMTVNL
EPGKSYPRDKLLNDLINLQYKRNDMGFERGCFRVKGDNIDIFPSHYSDKAWRLSFFSNELEYIHEFDPLTGEKLAKLDKA
IVFGHSHFVMPQDTVNNAISGIEEELQKRLEFLKSQNKLLETQRLNQRTQYDLEMLTETGSCKGVENYSRFFTGRNAGEP
PPTLFEYLPKDALLFVDESHVSVPQIKAMYNSDRARKEVLVEHGFRLPSALDNRPLKFEEWEKFRPQTVFVSATPGPFEL
EETGGTVVELIIRPTGLLDPECIIKPATKQVEDLISEIQATVAKGLRVLVTTLTKKMAEDLTAYLQELKYKTSYLHSNVH
TLERIEILQDLRQGTIDILVGINLLREGLDIPECGLVAILDADKEGFLRSEVSLIQTIGRAARNSEGRVILYADKMTKSI
DKALSETLRRRQIQQEYNEKHGIIPKTINRAIHALATLERVDSKCDTKQAHTLFDNTAKLKANINKLNKEMLKAASNLEF
EQAAKLRDQLKTLEAAARELS
>Mature_661_residues
MNHFSLISEYKPAGDQPKAIDEIIAGLNSKKRSQMLLGITGSGKTFTMANIIERTNRPTLIMAHNKTLAAQIYSEMKSIF
PKNAVEYFVSYYDYYQPEAYIARTDTFIEKDSSINEHIDLMRHSATRSLLERRDVIVVASVSCIYGLGSPDLYYQMTVNL
EPGKSYPRDKLLNDLINLQYKRNDMGFERGCFRVKGDNIDIFPSHYSDKAWRLSFFSNELEYIHEFDPLTGEKLAKLDKA
IVFGHSHFVMPQDTVNNAISGIEEELQKRLEFLKSQNKLLETQRLNQRTQYDLEMLTETGSCKGVENYSRFFTGRNAGEP
PPTLFEYLPKDALLFVDESHVSVPQIKAMYNSDRARKEVLVEHGFRLPSALDNRPLKFEEWEKFRPQTVFVSATPGPFEL
EETGGTVVELIIRPTGLLDPECIIKPATKQVEDLISEIQATVAKGLRVLVTTLTKKMAEDLTAYLQELKYKTSYLHSNVH
TLERIEILQDLRQGTIDILVGINLLREGLDIPECGLVAILDADKEGFLRSEVSLIQTIGRAARNSEGRVILYADKMTKSI
DKALSETLRRRQIQQEYNEKHGIIPKTINRAIHALATLERVDSKCDTKQAHTLFDNTAKLKANINKLNKEMLKAASNLEF
EQAAKLRDQLKTLEAAARELS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=661, Percent_Identity=57.4886535552194, Blast_Score=760, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75234; Mature: 75234

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHFSLISEYKPAGDQPKAIDEIIAGLNSKKRSQMLLGITGSGKTFTMANIIERTNRPTL
CCCHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCEEHHHHHHHHCCCCEE
IMAHNKTLAAQIYSEMKSIFPKNAVEYFVSYYDYYQPEAYIARTDTFIEKDSSINEHIDL
EEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCHHHHHHH
MRHSATRSLLERRDVIVVASVSCIYGLGSPDLYYQMTVNLEPGKSYPRDKLLNDLINLQY
HHHHHHHHHHHHCCEEEEEEHHHHHCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCEE
KRNDMGFERGCFRVKGDNIDIFPSHYSDKAWRLSFFSNELEYIHEFDPLTGEKLAKLDKA
CCCCCCHHCCEEEEECCCEEECCCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHH
IVFGHSHFVMPQDTVNNAISGIEEELQKRLEFLKSQNKLLETQRLNQRTQYDLEMLTETG
HEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SCKGVENYSRFFTGRNAGEPPPTLFEYLPKDALLFVDESHVSVPQIKAMYNSDRARKEVL
CCCCHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHCCHHHHHHHH
VEHGFRLPSALDNRPLKFEEWEKFRPQTVFVSATPGPFELEETGGTVVELIIRPTGLLDP
HHCCCCCCHHHCCCCCCCHHHHHCCCCEEEEECCCCCCEECCCCCEEEEEEECCCCCCCC
ECIIKPATKQVEDLISEIQATVAKGLRVLVTTLTKKMAEDLTAYLQELKYKTSYLHSNVH
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLERIEILQDLRQGTIDILVGINLLREGLDIPECGLVAILDADKEGFLRSEVSLIQTIGR
HHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHH
AARNSEGRVILYADKMTKSIDKALSETLRRRQIQQEYNEKHGIIPKTINRAIHALATLER
HHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VDSKCDTKQAHTLFDNTAKLKANINKLNKEMLKAASNLEFEQAAKLRDQLKTLEAAAREL
HHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
S
C
>Mature Secondary Structure
MNHFSLISEYKPAGDQPKAIDEIIAGLNSKKRSQMLLGITGSGKTFTMANIIERTNRPTL
CCCHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCEEHHHHHHHHCCCCEE
IMAHNKTLAAQIYSEMKSIFPKNAVEYFVSYYDYYQPEAYIARTDTFIEKDSSINEHIDL
EEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCHHHHHHH
MRHSATRSLLERRDVIVVASVSCIYGLGSPDLYYQMTVNLEPGKSYPRDKLLNDLINLQY
HHHHHHHHHHHHCCEEEEEEHHHHHCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCEE
KRNDMGFERGCFRVKGDNIDIFPSHYSDKAWRLSFFSNELEYIHEFDPLTGEKLAKLDKA
CCCCCCHHCCEEEEECCCEEECCCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHH
IVFGHSHFVMPQDTVNNAISGIEEELQKRLEFLKSQNKLLETQRLNQRTQYDLEMLTETG
HEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SCKGVENYSRFFTGRNAGEPPPTLFEYLPKDALLFVDESHVSVPQIKAMYNSDRARKEVL
CCCCHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHCCHHHHHHHH
VEHGFRLPSALDNRPLKFEEWEKFRPQTVFVSATPGPFELEETGGTVVELIIRPTGLLDP
HHCCCCCCHHHCCCCCCCHHHHHCCCCEEEEECCCCCCEECCCCCEEEEEEECCCCCCCC
ECIIKPATKQVEDLISEIQATVAKGLRVLVTTLTKKMAEDLTAYLQELKYKTSYLHSNVH
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLERIEILQDLRQGTIDILVGINLLREGLDIPECGLVAILDADKEGFLRSEVSLIQTIGR
HHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHH
AARNSEGRVILYADKMTKSIDKALSETLRRRQIQQEYNEKHGIIPKTINRAIHALATLER
HHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VDSKCDTKQAHTLFDNTAKLKANINKLNKEMLKAASNLEFEQAAKLRDQLKTLEAAAREL
HHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA