| Definition | Serratia proteamaculans 568 chromosome, complete genome. |
|---|---|
| Accession | NC_009832 |
| Length | 5,448,853 |
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The map label for this gene is metL [H]
Identifier: 157373017
GI number: 157373017
Start: 5302752
End: 5305187
Strand: Reverse
Name: metL [H]
Synonym: Spro_4785
Alternate gene names: 157373017
Gene position: 5305187-5302752 (Counterclockwise)
Preceding gene: 157373018
Following gene: 157373016
Centisome position: 97.36
GC content: 60.3
Gene sequence:
>2436_bases ATGAATGCAATTGCGGTAGCAGGGCCGGTGAGCGGGCGTCAACTACACAAGTTTGGCGGCAGCAGCCTGGCAGACGTGAA GTGTTATCTGCGGGTGGCCGGGATCATGGCCGAATACAGCCAACCGGGTGACATGATGGTGGTGTCGGCTGCCGGCAGCA CCACCAACCAACTGATTAGCTGGCTGAAGCTCAGTCAAAGCGATCGTCTTTCTGCACATCAGGTTCAGCAGACGCTGCGT CGCTATCACAGCGAATTGATTGGCGGTCTGCTCCCACCGGAAACTGCCGAGCCGTTGATCGCCGAGTTTATTCAGGATCT GGAGCGTCTGGCGGTGTTGCTGGACGAAAAGCTCGACGACGCCGTATACGCCGAGGTCGTTGGGCACGGTGAGATTTGGT CGGCGCGGCTGATGGCGGCGGTACTGAACAAGCTGGATATGCAGGCCGCCTGGCTGGATGCGCGTGACTTCCTGCGCGCG GAGCGTGCCGCTCAACCCCAGGTTGACGAAGGCCGCTCTTATCCATTGCTGCAACAGTTGCTGGCTCAGCACCCGGGCAA ACGCCTGGTGGTGACCGGCTTTATTTCACGCAACGACGCCGGTGAAACCGTGTTGTTGGGGCGTAACGGCAGTGACTATT CCGCAACCCAGGTCGGCGCGTTGGCCGGTGCGGAGCGCGTGACCATTTGGAGCGACGTGGCCGGGGTTTACAGCGCCGAT CCGCGCAAGGTAAAAGATGCCTGCCTGCTGCCACTGTTGCGGTTGGATGAAGCCAGTGAACTGGCTCGCCTGGCGGCACC GGTGCTGCATACTCGTACCCTGCAGCCGGTGTCCGGCAGTGATATCGATCTGCAACTGCGCTGTAGCTATCAGCCGGAAC AAGGCTCAACGCGTATCGAACGTGTGCTGGCTTCCGGCACGGGCGCGAAGATTGTCACCAGCCATGACGACGTGTGTTTG ATTGAACTGAACGTTGCCAGCCAGCATGACTTCACACTGGCGCAGAAAGAGCTGGATTTGGTACTCAAGCGCGCGCAAAT CAAACCGCTGGCGATCGGCATTCATCCTGATCGTAATCTGGTTCAACTGTGCTACACCTCGGAAGTGGTCAATAGCGTGC TGCGTACCTTGCAGGAAGCGGCATTACCGGGTGAACTGCGGCTGCGTGAAGGCCTGGCGCTGGTGGCGCTGGTGGGCGCG GGCGTTTGCAAGAATCCGCTGCACAGCCACCGTTTCTATCAACAGTTGAAAGACCAGCCGGTAGAATTTATCTGGCAGGC CGAAGACGGCATCAGCCTGGTGGCGGTACTGCGTCAGGGGCCGACCGCGTTGCTGATCCAGGGCCTGCATCAGACCCTGT TCCGCGCCGAAAAAAGCATTGGCCTGGTGCTGTTCGGTAAAGGCAACATCGGCGCACGCTGGCTGGAGCTGTTTGCCCGC GAGCAGAAAAATATTTCCGCACGCAGCGGCTTTGAGTTCAGCCTGGCGGGCGTGGTGGACAGCCGCCGCAGCCTGCTCAA TTACGATGGGCTGGATGCCAGCCGCGCCCTGGCGTTCTTTGAGGACGAAGCACAGGAGCTGGACGAAGAGTCACTGTTCC TGTGGATGCGTGCGCATCCGTTCGACGATCTGGTGGTGCTTGACGTGACCGCCAGTGAGGAGCTGGCCGAACAATATCTG GATTTCGCCAGCTATGGCTTCCATGTGATCAGCGCCAACAAGCTGGCGGGCGCGTCTTGCAGCGATAATTATCGCCAAAT TCGTGATGCTTTCGCCAAAACCGGCCGCCACTGGCTGTATAACGCTACCGTCGGTGCCGGCCTGCCGGTCAACCATACGG TGCGAGATCTGCGTGACAGCGGCGACAGCATTCTGGCGATCAGCGGTATCTTCTCCGGTACGCTTTCCTGGCTGTTCCTG CAGTTCGACGGCACGGTGCCGTTCACCGAGTTGGTGGATCAGGCCTGGCAGCAGGGGCTGACCGAACCGGATCCGCGGGT CGATCTCTCCGGCCAGGACGTGATGCGCAAGCTGGTGATCCTGGCGCGTGAAGCGGGCTACGATATTGAGCCGAATCAGG TACGAGTCGAATCGCTGGTGCCTGCGGGGGCCGAACAGGGCTCCGTCGATCAGTTCTTCGAAAACGGCGATGCGTTGAAC CAGCAGATGCTGCAACGTTTTGAGGCCGCCAGTGAAATGGGGCTGGTGCTGCGCCACGTGGCGCGTTTCGATGCCAATGG TAAGGCGCGTGTCGGCGTGGAAGCGGTACGGCCTGAACATCCGCTGGCATCGTTGCTGCCGTGCGATAACGTGTTCGCTA TCGAAAGCCGCTGGTACCGCGACAACCCACTGGTGATCCGCGGGCCGGGTGCCGGGCGTGACGTCACTGCCGGTGCGATC CAGTCAGACCTTAACCGTTTGGCGCAGCTGCTTTAA
Upstream 100 bases:
>100_bases TTTCCGAGAGCCTGCTGCGTATCTCCGTGGGTATTGAAGACAGTGAAGATTTGATTGCCGATCTGGAACGAGCCTTCCAG GCGGCGGCAACGAGGTAAGC
Downstream 100 bases:
>100_bases TTTTCTTGTGGGCGCGGATCAACCGCGCCCCTCGTTTTTCCTGCCATAATTATTCTTATTCTGAACGTGAAATTCTTTCT CTTAACGGGTGAGGATTAAT
Product: bifunctional aspartate kinase II/homoserine dehydrogenase II
Products: NA
Alternate protein names: Aspartokinase II/homoserine dehydrogenase II; AKII-HDII; Aspartokinase; Homoserine dehydrogenase [H]
Number of amino acids: Translated: 811; Mature: 811
Protein sequence:
>811_residues MNAIAVAGPVSGRQLHKFGGSSLADVKCYLRVAGIMAEYSQPGDMMVVSAAGSTTNQLISWLKLSQSDRLSAHQVQQTLR RYHSELIGGLLPPETAEPLIAEFIQDLERLAVLLDEKLDDAVYAEVVGHGEIWSARLMAAVLNKLDMQAAWLDARDFLRA ERAAQPQVDEGRSYPLLQQLLAQHPGKRLVVTGFISRNDAGETVLLGRNGSDYSATQVGALAGAERVTIWSDVAGVYSAD PRKVKDACLLPLLRLDEASELARLAAPVLHTRTLQPVSGSDIDLQLRCSYQPEQGSTRIERVLASGTGAKIVTSHDDVCL IELNVASQHDFTLAQKELDLVLKRAQIKPLAIGIHPDRNLVQLCYTSEVVNSVLRTLQEAALPGELRLREGLALVALVGA GVCKNPLHSHRFYQQLKDQPVEFIWQAEDGISLVAVLRQGPTALLIQGLHQTLFRAEKSIGLVLFGKGNIGARWLELFAR EQKNISARSGFEFSLAGVVDSRRSLLNYDGLDASRALAFFEDEAQELDEESLFLWMRAHPFDDLVVLDVTASEELAEQYL DFASYGFHVISANKLAGASCSDNYRQIRDAFAKTGRHWLYNATVGAGLPVNHTVRDLRDSGDSILAISGIFSGTLSWLFL QFDGTVPFTELVDQAWQQGLTEPDPRVDLSGQDVMRKLVILAREAGYDIEPNQVRVESLVPAGAEQGSVDQFFENGDALN QQMLQRFEAASEMGLVLRHVARFDANGKARVGVEAVRPEHPLASLLPCDNVFAIESRWYRDNPLVIRGPGAGRDVTAGAI QSDLNRLAQLL
Sequences:
>Translated_811_residues MNAIAVAGPVSGRQLHKFGGSSLADVKCYLRVAGIMAEYSQPGDMMVVSAAGSTTNQLISWLKLSQSDRLSAHQVQQTLR RYHSELIGGLLPPETAEPLIAEFIQDLERLAVLLDEKLDDAVYAEVVGHGEIWSARLMAAVLNKLDMQAAWLDARDFLRA ERAAQPQVDEGRSYPLLQQLLAQHPGKRLVVTGFISRNDAGETVLLGRNGSDYSATQVGALAGAERVTIWSDVAGVYSAD PRKVKDACLLPLLRLDEASELARLAAPVLHTRTLQPVSGSDIDLQLRCSYQPEQGSTRIERVLASGTGAKIVTSHDDVCL IELNVASQHDFTLAQKELDLVLKRAQIKPLAIGIHPDRNLVQLCYTSEVVNSVLRTLQEAALPGELRLREGLALVALVGA GVCKNPLHSHRFYQQLKDQPVEFIWQAEDGISLVAVLRQGPTALLIQGLHQTLFRAEKSIGLVLFGKGNIGARWLELFAR EQKNISARSGFEFSLAGVVDSRRSLLNYDGLDASRALAFFEDEAQELDEESLFLWMRAHPFDDLVVLDVTASEELAEQYL DFASYGFHVISANKLAGASCSDNYRQIRDAFAKTGRHWLYNATVGAGLPVNHTVRDLRDSGDSILAISGIFSGTLSWLFL QFDGTVPFTELVDQAWQQGLTEPDPRVDLSGQDVMRKLVILAREAGYDIEPNQVRVESLVPAGAEQGSVDQFFENGDALN QQMLQRFEAASEMGLVLRHVARFDANGKARVGVEAVRPEHPLASLLPCDNVFAIESRWYRDNPLVIRGPGAGRDVTAGAI QSDLNRLAQLL >Mature_811_residues MNAIAVAGPVSGRQLHKFGGSSLADVKCYLRVAGIMAEYSQPGDMMVVSAAGSTTNQLISWLKLSQSDRLSAHQVQQTLR RYHSELIGGLLPPETAEPLIAEFIQDLERLAVLLDEKLDDAVYAEVVGHGEIWSARLMAAVLNKLDMQAAWLDARDFLRA ERAAQPQVDEGRSYPLLQQLLAQHPGKRLVVTGFISRNDAGETVLLGRNGSDYSATQVGALAGAERVTIWSDVAGVYSAD PRKVKDACLLPLLRLDEASELARLAAPVLHTRTLQPVSGSDIDLQLRCSYQPEQGSTRIERVLASGTGAKIVTSHDDVCL IELNVASQHDFTLAQKELDLVLKRAQIKPLAIGIHPDRNLVQLCYTSEVVNSVLRTLQEAALPGELRLREGLALVALVGA GVCKNPLHSHRFYQQLKDQPVEFIWQAEDGISLVAVLRQGPTALLIQGLHQTLFRAEKSIGLVLFGKGNIGARWLELFAR EQKNISARSGFEFSLAGVVDSRRSLLNYDGLDASRALAFFEDEAQELDEESLFLWMRAHPFDDLVVLDVTASEELAEQYL DFASYGFHVISANKLAGASCSDNYRQIRDAFAKTGRHWLYNATVGAGLPVNHTVRDLRDSGDSILAISGIFSGTLSWLFL QFDGTVPFTELVDQAWQQGLTEPDPRVDLSGQDVMRKLVILAREAGYDIEPNQVRVESLVPAGAEQGSVDQFFENGDALN QQMLQRFEAASEMGLVLRHVARFDANGKARVGVEAVRPEHPLASLLPCDNVFAIESRWYRDNPLVIRGPGAGRDVTAGAI QSDLNRLAQLL
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0527
COG function: function code E; Aspartokinases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the homoserine dehydrogenase family [H]
Homologues:
Organism=Escherichia coli, GI1790376, Length=811, Percent_Identity=83.9704069050555, Blast_Score=1400, Evalue=0.0, Organism=Escherichia coli, GI1786183, Length=816, Percent_Identity=31.0049019607843, Blast_Score=334, Evalue=1e-92, Organism=Escherichia coli, GI1790455, Length=462, Percent_Identity=27.7056277056277, Blast_Score=123, Evalue=4e-29, Organism=Saccharomyces cerevisiae, GI6322599, Length=369, Percent_Identity=32.7913279132791, Blast_Score=157, Evalue=5e-39, Organism=Saccharomyces cerevisiae, GI6320893, Length=505, Percent_Identity=22.7722772277228, Blast_Score=80, Evalue=1e-15,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001048 - InterPro: IPR005106 - InterPro: IPR001341 - InterPro: IPR018042 - InterPro: IPR011147 - InterPro: IPR001342 - InterPro: IPR019811 - InterPro: IPR016040 [H]
Pfam domain/function: PF00696 AA_kinase; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]
EC number: =2.7.2.4; =1.1.1.3 [H]
Molecular weight: Translated: 88942; Mature: 88942
Theoretical pI: Translated: 5.10; Mature: 5.10
Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00324 ASPARTOKINASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.0 %Cys (Translated Protein) 1.2 %Met (Translated Protein) 2.2 %Cys+Met (Translated Protein) 1.0 %Cys (Mature Protein) 1.2 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNAIAVAGPVSGRQLHKFGGSSLADVKCYLRVAGIMAEYSQPGDMMVVSAAGSTTNQLIS CCCEEEECCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHH WLKLSQSDRLSAHQVQQTLRRYHSELIGGLLPPETAEPLIAEFIQDLERLAVLLDEKLDD HHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCH AVYAEVVGHGEIWSARLMAAVLNKLDMQAAWLDARDFLRAERAAQPQVDEGRSYPLLQQL HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH LAQHPGKRLVVTGFISRNDAGETVLLGRNGSDYSATQVGALAGAERVTIWSDVAGVYSAD HHHCCCCEEEEEEEEECCCCCCEEEEECCCCCCCHHHHHHHCCCCEEEEHHHHCHHCCCC PRKVKDACLLPLLRLDEASELARLAAPVLHTRTLQPVSGSDIDLQLRCSYQPEQGSTRIE CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCHHHHH RVLASGTGAKIVTSHDDVCLIELNVASQHDFTLAQKELDLVLKRAQIKPLAIGIHPDRNL HHHHCCCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCH VQLCYTSEVVNSVLRTLQEAALPGELRLREGLALVALVGAGVCKNPLHSHRFYQQLKDQP HHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHCCHHCCCHHHHHHHHHHHCCC VEFIWQAEDGISLVAVLRQGPTALLIQGLHQTLFRAEKSIGLVLFGKGNIGARWLELFAR EEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHH EQKNISARSGFEFSLAGVVDSRRSLLNYDGLDASRALAFFEDEAQELDEESLFLWMRAHP HHCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCC FDDLVVLDVTASEELAEQYLDFASYGFHVISANKLAGASCSDNYRQIRDAFAKTGRHWLY CCCEEEEEECCCHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEE NATVGAGLPVNHTVRDLRDSGDSILAISGIFSGTLSWLFLQFDGTVPFTELVDQAWQQGL EECCCCCCCCHHHHHHHHCCCCCEEEEHHHHHHCEEEEEEEECCCCCHHHHHHHHHHCCC TEPDPRVDLSGQDVMRKLVILAREAGYDIEPNQVRVESLVPAGAEQGSVDQFFENGDALN CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEHHHHCCCCCCCCCHHHHHCCCHHHH QQMLQRFEAASEMGLVLRHVARFDANGKARVGVEAVRPEHPLASLLPCDNVFAIESRWYR HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCEECCCCCCHHHHCCCCCEEEECCCEEC DNPLVIRGPGAGRDVTAGAIQSDLNRLAQLL CCCEEEECCCCCCCCHHHHHHHHHHHHHHHC >Mature Secondary Structure MNAIAVAGPVSGRQLHKFGGSSLADVKCYLRVAGIMAEYSQPGDMMVVSAAGSTTNQLIS CCCEEEECCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHH WLKLSQSDRLSAHQVQQTLRRYHSELIGGLLPPETAEPLIAEFIQDLERLAVLLDEKLDD HHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCH AVYAEVVGHGEIWSARLMAAVLNKLDMQAAWLDARDFLRAERAAQPQVDEGRSYPLLQQL HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH LAQHPGKRLVVTGFISRNDAGETVLLGRNGSDYSATQVGALAGAERVTIWSDVAGVYSAD HHHCCCCEEEEEEEEECCCCCCEEEEECCCCCCCHHHHHHHCCCCEEEEHHHHCHHCCCC PRKVKDACLLPLLRLDEASELARLAAPVLHTRTLQPVSGSDIDLQLRCSYQPEQGSTRIE CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCHHHHH RVLASGTGAKIVTSHDDVCLIELNVASQHDFTLAQKELDLVLKRAQIKPLAIGIHPDRNL HHHHCCCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCH VQLCYTSEVVNSVLRTLQEAALPGELRLREGLALVALVGAGVCKNPLHSHRFYQQLKDQP HHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHCCHHCCCHHHHHHHHHHHCCC VEFIWQAEDGISLVAVLRQGPTALLIQGLHQTLFRAEKSIGLVLFGKGNIGARWLELFAR EEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHH EQKNISARSGFEFSLAGVVDSRRSLLNYDGLDASRALAFFEDEAQELDEESLFLWMRAHP HHCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCC FDDLVVLDVTASEELAEQYLDFASYGFHVISANKLAGASCSDNYRQIRDAFAKTGRHWLY CCCEEEEEECCCHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEE NATVGAGLPVNHTVRDLRDSGDSILAISGIFSGTLSWLFLQFDGTVPFTELVDQAWQQGL EECCCCCCCCHHHHHHHHCCCCCEEEEHHHHHHCEEEEEEEECCCCCHHHHHHHHHHCCC TEPDPRVDLSGQDVMRKLVILAREAGYDIEPNQVRVESLVPAGAEQGSVDQFFENGDALN CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEHHHHCCCCCCCCCHHHHHCCCHHHH QQMLQRFEAASEMGLVLRHVARFDANGKARVGVEAVRPEHPLASLLPCDNVFAIESRWYR HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCEECCCCCCHHHHCCCCCEEEECCCEEC DNPLVIRGPGAGRDVTAGAIQSDLNRLAQLL CCCEEEECCCCCCCCHHHHHHHHHHHHHHHC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 6298218; 8346018; 9278503 [H]