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The map label for this gene is prlC [H]

Identifier: 157372933

GI number: 157372933

Start: 5195187

End: 5197229

Strand: Reverse

Name: prlC [H]

Synonym: Spro_4701

Alternate gene names: 157372933

Gene position: 5197229-5195187 (Counterclockwise)

Preceding gene: 157372934

Following gene: 157372932

Centisome position: 95.38

GC content: 59.13

Gene sequence:

>2043_bases
ATGACAAATCCGTTGCTGACCCCGTTTTCCCTGCCACCGTTTTCCGCCATTCGCCCAGAAGATATCGTGCCTGCGGTGCA
ATCCGCATTGGCCGATTGCCGCGCTGCGGTAGAGCGCGTTGTCGCGCAGCCGGGGCCATTCACCTGGGATAACCTGTGTC
AGCCGCTGGCGGAGTCTGACGATCGCCTGTCGCGCATCTGGTCGCCGGTGGGGCATTTGAACTCGGTAAAAAACAGCCCG
GAACTGCGTGCCGCCTATGAGCAGGCGTTGCCGTTGCTGTCTGAGTACGGCACCTGGGTTGGGCAACACGAAGGTTTGTA
TCAGGCGTACCGCAGCCTGAAAGAAGGCGAAGCCTTCAATCAACTGACCGCACCACAGCGCAAGTCGGTAGAAAATGCGC
TGCGTGATTTTGAGCTGTCGGGCATCGGCCTGTCGCCGGAAAAACAGCGTCGCTATGGTGAAATCGTCGCGCGTCTGTCC
GAGCTGGGTTCTACCTACAGCAACAACGTGCTCGACGCCACCATGGGTTGGAGCAAGCTGATTACCAATGAAACCGAGCT
GAGCGGCCTGCCGGAAAGCGCGTTGGCCCAGGCTCAGGCGATGGCGCAGGCCAAAGAGCAGGACGGCTGGCTGCTGACGC
TGGATATGCCGAGCTATCTGCCGGTACTGACCTACGGCGACAACCGCGCACTGCGTGAAGAGATGTATCGCGCCTTCGCT
ACCCGCGCTTCCGATCAGGGGCCGAATGCCGGTAAGTGGGACAACAGCGAAGTGATGGCGGAAACGCTGGCGCTGCGCCA
TGAACTGGCCCAACTGCTGGGCTTTGACAGCTACGCCGACAAATCGCTGGCGACCAAAATGGCGGAAAACCCGGAGCAGG
TGCTCGGTTTCCTCAGCGATCTGGCCAAACGCGCCCGTCCACAGGCCGAGCAGGAATTGGCGCAGCTGCGCGCCTTCGCC
AAACAGCATTACGGCGTAGATGAACTGGAAGCCTGGGACATTACCTATTACGGCGAAAAACAGAAACAACACCTGTTCTC
GATCAGCGACGAGCAACTGCGCCCGTACTTCCCGGAACAGCGGGTGGTGGAAGGTCTGTTCGAAGTGGTCAAACGCATTT
ACGGCATCACTGCCAAAGAGCGCAAGGATGTGGATACCTGGCATCCAGAGGTGCGCTTCTTTGATCTGTTCGACGCCAAC
GGCGAGCTGCGCGGCAGCTTCTACCTTGACCTGTATGCGCGTGAAAACAAACGCGGCGGGGCGTGGATGGACGACTGCGT
CGGCAGCCTGCGCAAGGCCAACGGCGAACTACAAAAACCGGTCGCCTATCTGACCTGTAACTTTAACCGTCCGCTGGGCG
ACAAGCCGGCGCTGTTCACCCATAACGAAGTGACCACCTTGTTCCACGAGTTCGGCCACGGTCTGCACCATATGCTGACC
CAGATCGACACCGCCGGCGTTTCCGGCATCAGCGGTGTGCCATGGGATGCGGTCGAACTGCCAAGCCAGTTTATGGAAAA
CTGGTGCTGGGAGCCGGAAGCGCTGGCGTTTATCTCCGGCCACTATCAGAGCGGTGAACCGCTGCCGAAAGAGATGCTCG
ACAAGCTGCTGGCCGCCAAAAATTACCAGGCGGCGCTGTTTATTCTGCGTCAGTTGGAGTTCGGCCTGTTCGACTTCCGC
ATGCACGCCGAATACAACCCTTCAAGCGGCGCGCAGATCCTGCCAACCTTGGCGGAAGTGAAGAAAATGGTGGCGGTGGT
ACCTTCACCAAGCTGGGGCCGTTTCCCACATGCTTTCAGCCATATCTTCGCTGGCGGCTACGCGGCGGGCTACTACAGCT
ACCTGTGGGCGGAAGTGCTGTCGGCCGATGCCTATTCGCGCTTTGAGGAAGAGGGGATTTTCAACGCCGAAACCGGTAAA
TCCTTCCTCGACAACATCCTGTCGCGCGGCGGTTCGGAAGAGCCGATGGAACTGTTCAAACGCTTCCGTGGCCGTGAGCC
GCAGCTGGATGCTATGCTGCGCCATTACGGCATTAAAGGATAA

Upstream 100 bases:

>100_bases
GATCATTGATTTTCCTGCCGCTTGGCTCCATGTTAGATATTCATACGCATTTTAAGGCCTGCCCGCTGCGGCGGGCCCCA
ACGCTAATCAGGACTGCCCT

Downstream 100 bases:

>100_bases
CCCCACCGGTGAGCGTGTGTTTATTGTGTGAAGAAGGCGCCGACCCCGGCGCCTTGTCTATTCTGGCGCAGCGCTGGCAG
TTAACTTCGGACGACGAGGC

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MTNPLLTPFSLPPFSAIRPEDIVPAVQSALADCRAAVERVVAQPGPFTWDNLCQPLAESDDRLSRIWSPVGHLNSVKNSP
ELRAAYEQALPLLSEYGTWVGQHEGLYQAYRSLKEGEAFNQLTAPQRKSVENALRDFELSGIGLSPEKQRRYGEIVARLS
ELGSTYSNNVLDATMGWSKLITNETELSGLPESALAQAQAMAQAKEQDGWLLTLDMPSYLPVLTYGDNRALREEMYRAFA
TRASDQGPNAGKWDNSEVMAETLALRHELAQLLGFDSYADKSLATKMAENPEQVLGFLSDLAKRARPQAEQELAQLRAFA
KQHYGVDELEAWDITYYGEKQKQHLFSISDEQLRPYFPEQRVVEGLFEVVKRIYGITAKERKDVDTWHPEVRFFDLFDAN
GELRGSFYLDLYARENKRGGAWMDDCVGSLRKANGELQKPVAYLTCNFNRPLGDKPALFTHNEVTTLFHEFGHGLHHMLT
QIDTAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYQSGEPLPKEMLDKLLAAKNYQAALFILRQLEFGLFDFR
MHAEYNPSSGAQILPTLAEVKKMVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWAEVLSADAYSRFEEEGIFNAETGK
SFLDNILSRGGSEEPMELFKRFRGREPQLDAMLRHYGIKG

Sequences:

>Translated_680_residues
MTNPLLTPFSLPPFSAIRPEDIVPAVQSALADCRAAVERVVAQPGPFTWDNLCQPLAESDDRLSRIWSPVGHLNSVKNSP
ELRAAYEQALPLLSEYGTWVGQHEGLYQAYRSLKEGEAFNQLTAPQRKSVENALRDFELSGIGLSPEKQRRYGEIVARLS
ELGSTYSNNVLDATMGWSKLITNETELSGLPESALAQAQAMAQAKEQDGWLLTLDMPSYLPVLTYGDNRALREEMYRAFA
TRASDQGPNAGKWDNSEVMAETLALRHELAQLLGFDSYADKSLATKMAENPEQVLGFLSDLAKRARPQAEQELAQLRAFA
KQHYGVDELEAWDITYYGEKQKQHLFSISDEQLRPYFPEQRVVEGLFEVVKRIYGITAKERKDVDTWHPEVRFFDLFDAN
GELRGSFYLDLYARENKRGGAWMDDCVGSLRKANGELQKPVAYLTCNFNRPLGDKPALFTHNEVTTLFHEFGHGLHHMLT
QIDTAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYQSGEPLPKEMLDKLLAAKNYQAALFILRQLEFGLFDFR
MHAEYNPSSGAQILPTLAEVKKMVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWAEVLSADAYSRFEEEGIFNAETGK
SFLDNILSRGGSEEPMELFKRFRGREPQLDAMLRHYGIKG
>Mature_679_residues
TNPLLTPFSLPPFSAIRPEDIVPAVQSALADCRAAVERVVAQPGPFTWDNLCQPLAESDDRLSRIWSPVGHLNSVKNSPE
LRAAYEQALPLLSEYGTWVGQHEGLYQAYRSLKEGEAFNQLTAPQRKSVENALRDFELSGIGLSPEKQRRYGEIVARLSE
LGSTYSNNVLDATMGWSKLITNETELSGLPESALAQAQAMAQAKEQDGWLLTLDMPSYLPVLTYGDNRALREEMYRAFAT
RASDQGPNAGKWDNSEVMAETLALRHELAQLLGFDSYADKSLATKMAENPEQVLGFLSDLAKRARPQAEQELAQLRAFAK
QHYGVDELEAWDITYYGEKQKQHLFSISDEQLRPYFPEQRVVEGLFEVVKRIYGITAKERKDVDTWHPEVRFFDLFDANG
ELRGSFYLDLYARENKRGGAWMDDCVGSLRKANGELQKPVAYLTCNFNRPLGDKPALFTHNEVTTLFHEFGHGLHHMLTQ
IDTAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYQSGEPLPKEMLDKLLAAKNYQAALFILRQLEFGLFDFRM
HAEYNPSSGAQILPTLAEVKKMVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWAEVLSADAYSRFEEEGIFNAETGKS
FLDNILSRGGSEEPMELFKRFRGREPQLDAMLRHYGIKG

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=613, Percent_Identity=32.952691680261, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI14149738, Length=642, Percent_Identity=30.5295950155763, Blast_Score=288, Evalue=1e-77,
Organism=Homo sapiens, GI156105687, Length=672, Percent_Identity=27.2321428571429, Blast_Score=204, Evalue=2e-52,
Organism=Escherichia coli, GI1789913, Length=680, Percent_Identity=81.9117647058823, Blast_Score=1165, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=691, Percent_Identity=31.4037626628075, Blast_Score=304, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI71999758, Length=576, Percent_Identity=26.9097222222222, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI32565901, Length=619, Percent_Identity=23.4248788368336, Blast_Score=115, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6319793, Length=690, Percent_Identity=28.8405797101449, Blast_Score=303, Evalue=7e-83,
Organism=Saccharomyces cerevisiae, GI6322715, Length=641, Percent_Identity=24.6489859594384, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21356111, Length=581, Percent_Identity=30.1204819277108, Blast_Score=259, Evalue=5e-69,
Organism=Drosophila melanogaster, GI20129717, Length=540, Percent_Identity=26.6666666666667, Blast_Score=179, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76520; Mature: 76389

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLLTPFSLPPFSAIRPEDIVPAVQSALADCRAAVERVVAQPGPFTWDNLCQPLAESD
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCH
DRLSRIWSPVGHLNSVKNSPELRAAYEQALPLLSEYGTWVGQHEGLYQAYRSLKEGEAFN
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHH
QLTAPQRKSVENALRDFELSGIGLSPEKQRRYGEIVARLSELGSTYSNNVLDATMGWSKL
HHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCHHHHCCHHHH
ITNETELSGLPESALAQAQAMAQAKEQDGWLLTLDMPSYLPVLTYGDNRALREEMYRAFA
HCCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSEVMAETLALRHELAQLLGFDSYADKSLATKMAENPEQVLGFLSD
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQAEQELAQLRAFAKQHYGVDELEAWDITYYGEKQKQHLFSISDEQLRPYFPEQ
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCHHHCCCCCCHH
RVVEGLFEVVKRIYGITAKERKDVDTWHPEVRFFDLFDANGELRGSFYLDLYARENKRGG
HHHHHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEEEECCCCCCCEEEEEEEEECCCCCCC
AWMDDCVGSLRKANGELQKPVAYLTCNFNRPLGDKPALFTHNEVTTLFHEFGHGLHHMLT
CCHHHHHHHHHHCCCCHHCCEEEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHH
QIDTAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYQSGEPLPKEMLDKLLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHC
NYQAALFILRQLEFGLFDFRMHAEYNPSSGAQILPTLAEVKKMVAVVPSPSWGRFPHAFS
CHHHHHHHHHHHHHCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWAEVLSADAYSRFEEEGIFNAETGKSFLDNILSRGGSEEPMELFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLRHYGIKG
HHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TNPLLTPFSLPPFSAIRPEDIVPAVQSALADCRAAVERVVAQPGPFTWDNLCQPLAESD
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCH
DRLSRIWSPVGHLNSVKNSPELRAAYEQALPLLSEYGTWVGQHEGLYQAYRSLKEGEAFN
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHH
QLTAPQRKSVENALRDFELSGIGLSPEKQRRYGEIVARLSELGSTYSNNVLDATMGWSKL
HHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCHHHHCCHHHH
ITNETELSGLPESALAQAQAMAQAKEQDGWLLTLDMPSYLPVLTYGDNRALREEMYRAFA
HCCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSEVMAETLALRHELAQLLGFDSYADKSLATKMAENPEQVLGFLSD
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQAEQELAQLRAFAKQHYGVDELEAWDITYYGEKQKQHLFSISDEQLRPYFPEQ
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCHHHCCCCCCHH
RVVEGLFEVVKRIYGITAKERKDVDTWHPEVRFFDLFDANGELRGSFYLDLYARENKRGG
HHHHHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEEEECCCCCCCEEEEEEEEECCCCCCC
AWMDDCVGSLRKANGELQKPVAYLTCNFNRPLGDKPALFTHNEVTTLFHEFGHGLHHMLT
CCHHHHHHHHHHCCCCHHCCEEEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHH
QIDTAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYQSGEPLPKEMLDKLLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHC
NYQAALFILRQLEFGLFDFRMHAEYNPSSGAQILPTLAEVKKMVAVVPSPSWGRFPHAFS
CHHHHHHHHHHHHHCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWAEVLSADAYSRFEEEGIFNAETGKSFLDNILSRGGSEEPMELFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLRHYGIKG
HHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]