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The map label for this gene is nirC [H]

Identifier: 157372829

GI number: 157372829

Start: 5072211

End: 5073011

Strand: Direct

Name: nirC [H]

Synonym: Spro_4597

Alternate gene names: 157372829

Gene position: 5072211-5073011 (Clockwise)

Preceding gene: 157372828

Following gene: 157372830

Centisome position: 93.09

GC content: 59.3

Gene sequence:

>801_bases
ATGTTCACCGATACCATCAACAAATGTGCCGCCAACGCGGCGCGCATCGTCAGGCTGGCAAAGCACAGCCCGCTGGGCTT
TTGGATCAGCTCGGCAATGGCCGGGGCCTACGTCGGCCTCGGCATCATATTGATCTTCACCCTCGGCAACCTGGTCGATC
CGTCACTTCGTCCACTGGTGATGGGTGCCACCTTCGGCATCGCGCTGACGCTGGTGATCATTGCCGGGTCGGAGTTGTTC
ACCGGTCATACCATGTTCCTGACGCTGGGCGTCAAAGCCGGCACCATTACGCAGGGCCAGATGTGGGCCGTATTGCCGCA
AACCTGGCTGGGTAACCTGTTGGGTTCGGTACTGGTAGCGCTGATGTACTATTACGGCGGCGGCAGCCTGTTGCCGGTGG
ACACCAGTCTGGTACACAGCGTGGCACTGGCGAAAACCACTGCACCGGCAGAAGTGCTGTTCTTCAAGGGCGTGCTGTGT
AACTGGCTGGTTTGCCTGGCGATTTGGATGGCCATTCGCGTTGAGGGTGCCGCCAAATTCATTGCCATCTGGTGGTGTCT
GCTGGCCTTTATCGCTTCCGGTTATGAACACTCGGTCGCTAACATGACGCTGTTCGCCCTGTCCTGGTTCGGTAATCACA
GCGAAGCCTATACCCTGAGCGGGATCGGCCATAACCTGCTGTGGGTGACGCTGGGCAATATCCTGTCCGGTGCCGTGTTG
ATGGGGCTGGGTTATTGGTACGCCACGCCGCGCGCCGAACGGCCACAGGCTGAGAAAACCGTAGCACGCCAGACCGCATA
A

Upstream 100 bases:

>100_bases
AAGATGACAGTCGCTGCGTCGCGCATTTCACCAGCCGGGTTGTGGACGGCATGGTACAGGTCGCGGCCTGATATTTTTAT
TTAACCTCAGGGGAAGCAGC

Downstream 100 bases:

>100_bases
TATTCCGGGGCGCCTTGCGCCCCACTGCTGATTGCCCCGAGGATTGCCGATGGATTACCTGCCGATTTTCTGCCAACTGC
AACACAAAGCCTGCCTGCTG

Product: nitrite transporter NirC

Products: Proton [Cytoplasm]; nitrite [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MFTDTINKCAANAARIVRLAKHSPLGFWISSAMAGAYVGLGIILIFTLGNLVDPSLRPLVMGATFGIALTLVIIAGSELF
TGHTMFLTLGVKAGTITQGQMWAVLPQTWLGNLLGSVLVALMYYYGGGSLLPVDTSLVHSVALAKTTAPAEVLFFKGVLC
NWLVCLAIWMAIRVEGAAKFIAIWWCLLAFIASGYEHSVANMTLFALSWFGNHSEAYTLSGIGHNLLWVTLGNILSGAVL
MGLGYWYATPRAERPQAEKTVARQTA

Sequences:

>Translated_266_residues
MFTDTINKCAANAARIVRLAKHSPLGFWISSAMAGAYVGLGIILIFTLGNLVDPSLRPLVMGATFGIALTLVIIAGSELF
TGHTMFLTLGVKAGTITQGQMWAVLPQTWLGNLLGSVLVALMYYYGGGSLLPVDTSLVHSVALAKTTAPAEVLFFKGVLC
NWLVCLAIWMAIRVEGAAKFIAIWWCLLAFIASGYEHSVANMTLFALSWFGNHSEAYTLSGIGHNLLWVTLGNILSGAVL
MGLGYWYATPRAERPQAEKTVARQTA
>Mature_266_residues
MFTDTINKCAANAARIVRLAKHSPLGFWISSAMAGAYVGLGIILIFTLGNLVDPSLRPLVMGATFGIALTLVIIAGSELF
TGHTMFLTLGVKAGTITQGQMWAVLPQTWLGNLLGSVLVALMYYYGGGSLLPVDTSLVHSVALAKTTAPAEVLFFKGVLC
NWLVCLAIWMAIRVEGAAKFIAIWWCLLAFIASGYEHSVANMTLFALSWFGNHSEAYTLSGIGHNLLWVTLGNILSGAVL
MGLGYWYATPRAERPQAEKTVARQTA

Specific function: May act as a nitrite transporter [H]

COG id: COG2116

COG function: function code P; Formate/nitrite family of transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FNT transporter (TC 2.A.44) family [H]

Homologues:

Organism=Escherichia coli, GI87082249, Length=266, Percent_Identity=86.0902255639098, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI1787132, Length=273, Percent_Identity=30.4029304029304, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788837, Length=275, Percent_Identity=28.7272727272727, Blast_Score=65, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321779, Length=160, Percent_Identity=29.375, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000292 [H]

Pfam domain/function: PF01226 Form_Nir_trans [H]

EC number: NA

Molecular weight: Translated: 28544; Mature: 28544

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS01005 FORMATE_NITRITE_TP_1 ; PS01006 FORMATE_NITRITE_TP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTDTINKCAANAARIVRLAKHSPLGFWISSAMAGAYVGLGIILIFTLGNLVDPSLRPLV
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
MGATFGIALTLVIIAGSELFTGHTMFLTLGVKAGTITQGQMWAVLPQTWLGNLLGSVLVA
HHHHHHHHHHHHHHCCCCHHCCCEEEEEEECCCCCCCCCCEEEECHHHHHHHHHHHHHHH
LMYYYGGGSLLPVDTSLVHSVALAKTTAPAEVLFFKGVLCNWLVCLAIWMAIRVEGAAKF
HHHHHCCCCEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAIWWCLLAFIASGYEHSVANMTLFALSWFGNHSEAYTLSGIGHNLLWVTLGNILSGAVL
HHHHHHHHHHHHCCCCHHHHHHHHEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
MGLGYWYATPRAERPQAEKTVARQTA
HHHHHHHCCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MFTDTINKCAANAARIVRLAKHSPLGFWISSAMAGAYVGLGIILIFTLGNLVDPSLRPLV
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
MGATFGIALTLVIIAGSELFTGHTMFLTLGVKAGTITQGQMWAVLPQTWLGNLLGSVLVA
HHHHHHHHHHHHHHCCCCHHCCCEEEEEEECCCCCCCCCCEEEECHHHHHHHHHHHHHHH
LMYYYGGGSLLPVDTSLVHSVALAKTTAPAEVLFFKGVLCNWLVCLAIWMAIRVEGAAKF
HHHHHCCCCEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAIWWCLLAFIASGYEHSVANMTLFALSWFGNHSEAYTLSGIGHNLLWVTLGNILSGAVL
HHHHHHHHHHHHCCCCHHHHHHHHEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
MGLGYWYATPRAERPQAEKTVARQTA
HHHHHHHCCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; nitrite [Periplasm] [C]

Specific reaction: Proton [Periplasm] + nitrite [Periplasm] = Proton [Cytoplasm] + nitrite [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1987123; 11677609 [H]