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The map label for this gene is pepP [H]

Identifier: 157372153

GI number: 157372153

Start: 4342840

End: 4344153

Strand: Reverse

Name: pepP [H]

Synonym: Spro_3919

Alternate gene names: 157372153

Gene position: 4344153-4342840 (Counterclockwise)

Preceding gene: 157372154

Following gene: 157372152

Centisome position: 79.73

GC content: 57.76

Gene sequence:

>1314_bases
ATGACTCAGCAGGAATTCAACAGCCGCCGTCAGGCGCTGTTGGCTAAAATGGCTCCGGCCAGCGCGGCGATTATTTTCTC
TGCGCCGGAAGCGACGCGCAGTGCCGATACTGAATATCCTTACCGTCAGAACAGCGATTTCTGGTACCTGACCGGTTTTA
ACGAGCCGGAAGCGGTGCTGATTCTGGTGAAAAGTGACGAGACGCATAACCACAGCGTGCTGTTCAACCGGGTGCGCGAT
CTGGCGGCGGAAACCTGGTTTGGCCGCCGTCTGGGCCAGGATGCCGCTCCGGCGAAGCTGAGTGTGGACCGCGCTCTGCC
GTTCAATGAAATCAACGATCAATTGCCTCTGTTGCTTAATGGCCTGGACGTGGTTTACCACGCACAGGGCCAGTACGCCT
ATGCCGATAAAATTGTGTTCGACGCGCTGGACAAGCTACGTAAAGGCTTCCGTCAGAACCTTCAGGCACCGGCGACTCTG
ACCGACTGGCGTCCGTGGCTGCACGAAATGCGCCTGTTCAAGTCGTCCGAAGAGATGGTTATCATGCGCCGCGCAGGTGA
AATTAGTGCGCTGGCCCATACCCGCGCGATGGAGAAATGCCGTCCGGGGATGTTCGAATATCAGCTCGAGGCGGAAATTC
ATCATGAGTTTACCCACCTGGGCGCCCGCTCCCCGTCCTACAACACCATCGTCGGTGGTGGAGACAACGCCTGCATCCTG
CATTACACCGAGAACGAAAGCGAATTGCGCGATGGCGATCTGGTGTTGATCGACGCAGGCTGTGAGTTTAAAGGCTATGC
CGGTGACATCACCCGTACCTTCCCGGTCAACGGCAAATTCAGCCGACCGCAGCGCGCGGTGTATGACATCGTGCTGGCGT
CACTGACGCGGGCGCTGGAGATGTTCAAACCGGGCATCAGCATCCGTGTGGTGAATGATGAGGTGGTGCGCATTATGATT
ACCGGGATGGTAGAGCTGGGGATCCTGAAAGGCGAAGTAGAGCAGTTAATTGCCGAGCAGGCCCACCGTCCGTTCTATAT
GCATGGCCTTGGCCACTGGTTGGGGCTGGATGTACATGATGTCGGCCATTACGGCACGCCGGATCGCGACCGTACGCTGG
AGCCGGGTATGGTGCTGACGGTTGAACCGGGGCTGTATATTGCGCCGGATGCCGACGTGCCGGAAGAATATCGCGGCATG
GGCATTCGTATTGAAGACGACATCCTGATCACCGCGACCGGTATTGAGAACCTGACTGCCGGCGTAGTGAAAGACGCTGA
CGCCATCGAAGCACTGATGGCGGCGGCAAGGTAA

Upstream 100 bases:

>100_bases
GCCGACGGCACCGGAAAATGCCAAACCGACCTTGCACTAAATACCCGCTATCACGTCCTTAAGGCCGTGAGCACAGGCAG
ATTGATTTCAGGAGAAGGTG

Downstream 100 bases:

>100_bases
TAGCATGAGTGTAATCATCGTTGGCGGCGGTATGGCGGGCGCGACTTTGGCGTTGGCCATTTCATCGCTTACTCAGGGAC
GATTGGCGGTTGATCTGGTC

Product: proline aminopeptidase P II

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MTQQEFNSRRQALLAKMAPASAAIIFSAPEATRSADTEYPYRQNSDFWYLTGFNEPEAVLILVKSDETHNHSVLFNRVRD
LAAETWFGRRLGQDAAPAKLSVDRALPFNEINDQLPLLLNGLDVVYHAQGQYAYADKIVFDALDKLRKGFRQNLQAPATL
TDWRPWLHEMRLFKSSEEMVIMRRAGEISALAHTRAMEKCRPGMFEYQLEAEIHHEFTHLGARSPSYNTIVGGGDNACIL
HYTENESELRDGDLVLIDAGCEFKGYAGDITRTFPVNGKFSRPQRAVYDIVLASLTRALEMFKPGISIRVVNDEVVRIMI
TGMVELGILKGEVEQLIAEQAHRPFYMHGLGHWLGLDVHDVGHYGTPDRDRTLEPGMVLTVEPGLYIAPDADVPEEYRGM
GIRIEDDILITATGIENLTAGVVKDADAIEALMAAAR

Sequences:

>Translated_437_residues
MTQQEFNSRRQALLAKMAPASAAIIFSAPEATRSADTEYPYRQNSDFWYLTGFNEPEAVLILVKSDETHNHSVLFNRVRD
LAAETWFGRRLGQDAAPAKLSVDRALPFNEINDQLPLLLNGLDVVYHAQGQYAYADKIVFDALDKLRKGFRQNLQAPATL
TDWRPWLHEMRLFKSSEEMVIMRRAGEISALAHTRAMEKCRPGMFEYQLEAEIHHEFTHLGARSPSYNTIVGGGDNACIL
HYTENESELRDGDLVLIDAGCEFKGYAGDITRTFPVNGKFSRPQRAVYDIVLASLTRALEMFKPGISIRVVNDEVVRIMI
TGMVELGILKGEVEQLIAEQAHRPFYMHGLGHWLGLDVHDVGHYGTPDRDRTLEPGMVLTVEPGLYIAPDADVPEEYRGM
GIRIEDDILITATGIENLTAGVVKDADAIEALMAAAR
>Mature_436_residues
TQQEFNSRRQALLAKMAPASAAIIFSAPEATRSADTEYPYRQNSDFWYLTGFNEPEAVLILVKSDETHNHSVLFNRVRDL
AAETWFGRRLGQDAAPAKLSVDRALPFNEINDQLPLLLNGLDVVYHAQGQYAYADKIVFDALDKLRKGFRQNLQAPATLT
DWRPWLHEMRLFKSSEEMVIMRRAGEISALAHTRAMEKCRPGMFEYQLEAEIHHEFTHLGARSPSYNTIVGGGDNACILH
YTENESELRDGDLVLIDAGCEFKGYAGDITRTFPVNGKFSRPQRAVYDIVLASLTRALEMFKPGISIRVVNDEVVRIMIT
GMVELGILKGEVEQLIAEQAHRPFYMHGLGHWLGLDVHDVGHYGTPDRDRTLEPGMVLTVEPGLYIAPDADVPEEYRGMG
IRIEDDILITATGIENLTAGVVKDADAIEALMAAAR

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=457, Percent_Identity=32.8227571115974, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI149589008, Length=476, Percent_Identity=31.9327731092437, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI260593665, Length=310, Percent_Identity=37.0967741935484, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI260593663, Length=475, Percent_Identity=29.2631578947368, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1789275, Length=437, Percent_Identity=76.4302059496568, Blast_Score=710, Evalue=0.0,
Organism=Escherichia coli, GI1788728, Length=255, Percent_Identity=29.8039215686275, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1790282, Length=300, Percent_Identity=30.6666666666667, Blast_Score=108, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17508215, Length=465, Percent_Identity=30.9677419354839, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71989583, Length=382, Percent_Identity=30.1047120418848, Blast_Score=140, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320922, Length=441, Percent_Identity=32.4263038548753, Blast_Score=212, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6321118, Length=478, Percent_Identity=31.1715481171548, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6323273, Length=321, Percent_Identity=20.8722741433022, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19920384, Length=417, Percent_Identity=36.4508393285372, Blast_Score=234, Evalue=8e-62,
Organism=Drosophila melanogaster, GI21357079, Length=452, Percent_Identity=33.6283185840708, Blast_Score=206, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 48933; Mature: 48802

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQEFNSRRQALLAKMAPASAAIIFSAPEATRSADTEYPYRQNSDFWYLTGFNEPEAVL
CCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEE
ILVKSDETHNHSVLFNRVRDLAAETWFGRRLGQDAAPAKLSVDRALPFNEINDQLPLLLN
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHCCCCCCCEEC
GLDVVYHAQGQYAYADKIVFDALDKLRKGFRQNLQAPATLTDWRPWLHEMRLFKSSEEMV
CCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEE
IMRRAGEISALAHTRAMEKCRPGMFEYQLEAEIHHEFTHLGARSPSYNTIVGGGDNACIL
EEECCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCCCCEEEECCCCEEEE
HYTENESELRDGDLVLIDAGCEFKGYAGDITRTFPVNGKFSRPQRAVYDIVLASLTRALE
EEECCCCCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
MFKPGISIRVVNDEVVRIMITGMVELGILKGEVEQLIAEQAHRPFYMHGLGHWLGLDVHD
HHCCCCEEEEECHHEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHCCCHHH
VGHYGTPDRDRTLEPGMVLTVEPGLYIAPDADVPEEYRGMGIRIEDDILITATGIENLTA
CCCCCCCCCCCCCCCCEEEEECCCEEECCCCCCCHHHCCCCEEEECCEEEEECCCCHHHH
GVVKDADAIEALMAAAR
HHHCCHHHHHHHHHHCC
>Mature Secondary Structure 
TQQEFNSRRQALLAKMAPASAAIIFSAPEATRSADTEYPYRQNSDFWYLTGFNEPEAVL
CHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEE
ILVKSDETHNHSVLFNRVRDLAAETWFGRRLGQDAAPAKLSVDRALPFNEINDQLPLLLN
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHCCCCCCCEEC
GLDVVYHAQGQYAYADKIVFDALDKLRKGFRQNLQAPATLTDWRPWLHEMRLFKSSEEMV
CCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEE
IMRRAGEISALAHTRAMEKCRPGMFEYQLEAEIHHEFTHLGARSPSYNTIVGGGDNACIL
EEECCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCCCCEEEECCCCEEEE
HYTENESELRDGDLVLIDAGCEFKGYAGDITRTFPVNGKFSRPQRAVYDIVLASLTRALE
EEECCCCCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
MFKPGISIRVVNDEVVRIMITGMVELGILKGEVEQLIAEQAHRPFYMHGLGHWLGLDVHD
HHCCCCEEEEECHHEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHCCCHHH
VGHYGTPDRDRTLEPGMVLTVEPGLYIAPDADVPEEYRGMGIRIEDDILITATGIENLTA
CCCCCCCCCCCCCCCCEEEEECCCEEECCCCCCCHHHCCCCEEEECCEEEEECCCCHHHH
GVVKDADAIEALMAAAR
HHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]