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The map label for this gene is ubiH [H]

Identifier: 157372152

GI number: 157372152

Start: 4341657

End: 4342835

Strand: Reverse

Name: ubiH [H]

Synonym: Spro_3918

Alternate gene names: 157372152

Gene position: 4342835-4341657 (Counterclockwise)

Preceding gene: 157372153

Following gene: 157372151

Centisome position: 79.7

GC content: 63.78

Gene sequence:

>1179_bases
ATGAGTGTAATCATCGTTGGCGGCGGTATGGCGGGCGCGACTTTGGCGTTGGCCATTTCATCGCTTACTCAGGGACGATT
GGCGGTTGATCTGGTCGAAGCGACCCGACCGGACGACCGCAGCCATCCGGGATTTGACGCCCGCGCCATTGCCCTGGCGC
AGGGCACCTGTCAGCAGTTGACGCGCATCGGCGTTTGGCCGGCGCTGCGTGACTGCGCGACGGCCATCACCCAGGTGCAC
GTTAGCGATCGTGGCCATGCCGGGTTCGTTAATTTGCACGCGCAGGATTATCAGGTTGACGCGTTGGGGCAGGTGATTGA
GCTGCACGACGCAGGGCAACGGCTGTTTGCTCTGCTGGCCAAGGCCCCCGGCGTTACGCTGCACTGTCCGGCCCGGGTGG
TCGATGTAGTGCGCACCGCGGAGCAGGCCGAAGTGCTGCTGGATAACGGTCAGCGCATCAGCGGGAAACTGCTGGTGGCG
GCAGACGGCTCGCGTTCGGCGCTGGCACAGGCCTGTAATGTGCAGTGGCAGCAAAGCGACTATCCGCAGTTTGCTACCAT
CGCCAATGTCACCACCGCCGAGCATCCGCAGGGGCGCGCTTTTGAACGCTTCACCCGGTACGGGCCGCTGGCATTATTGC
CGATGTCTCAGGGACGCAGCTCACTGGTGTGGTGCCATGCGCGTGAAGATCGCGAGCAGGTTGACGGCTGGGACGACGAA
CGTTTTATCAGTGAGTTGCAGCAGGCATTTGGCTGGCGTCTGGGGCGCATCCTTCGCGCCGGGAAACGTCACAGCTATCC
GCTCAGCCTATTGACCGCCAATCAGCATGTCAGCCATCGCCTGGCACTGGTGGGCAATGCCGCGCAAACGCTGCACCCGA
TCGCCGGGCAGGGGTTCAATCTCGGCCTGCGTGACGTGATGTCGCTGGCGGAAACCCTGGCCGAGGCGCAGCAGGCCGGA
GAAGATCCCGGTGGCTATGCGCTGTTGGGGCGTTACCAACAACGGCGGCAGCAAGATCAGCAGGCGACCATCGGCGTGAC
CGACGGCCTGATCCGGCTGTTCGCCAATCGCTACGGCCCGCTGGTGGTCGGTCGCAATCTGGGCCTGATGGCGATGGCCC
GGTTACCGGCGGTGCGAGACGCCTTTGCCAAGCGCACTTTGGGCTGGGTCGATCGCTAA

Upstream 100 bases:

>100_bases
GACATCCTGATCACCGCGACCGGTATTGAGAACCTGACTGCCGGCGTAGTGAAAGACGCTGACGCCATCGAAGCACTGAT
GGCGGCGGCAAGGTAATAGC

Downstream 100 bases:

>100_bases
GCGGTGTATGAGCAGGGGCGTAGCGTGCTGCGCCCAAAACGCTGGGCAATGGCACAGCGAGTCATTTAAGGAAATTAAGC
AGCATGCAATCATTTGACGT

Product: 2-octaprenyl-6-methoxyphenyl hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSVIIVGGGMAGATLALAISSLTQGRLAVDLVEATRPDDRSHPGFDARAIALAQGTCQQLTRIGVWPALRDCATAITQVH
VSDRGHAGFVNLHAQDYQVDALGQVIELHDAGQRLFALLAKAPGVTLHCPARVVDVVRTAEQAEVLLDNGQRISGKLLVA
ADGSRSALAQACNVQWQQSDYPQFATIANVTTAEHPQGRAFERFTRYGPLALLPMSQGRSSLVWCHAREDREQVDGWDDE
RFISELQQAFGWRLGRILRAGKRHSYPLSLLTANQHVSHRLALVGNAAQTLHPIAGQGFNLGLRDVMSLAETLAEAQQAG
EDPGGYALLGRYQQRRQQDQQATIGVTDGLIRLFANRYGPLVVGRNLGLMAMARLPAVRDAFAKRTLGWVDR

Sequences:

>Translated_392_residues
MSVIIVGGGMAGATLALAISSLTQGRLAVDLVEATRPDDRSHPGFDARAIALAQGTCQQLTRIGVWPALRDCATAITQVH
VSDRGHAGFVNLHAQDYQVDALGQVIELHDAGQRLFALLAKAPGVTLHCPARVVDVVRTAEQAEVLLDNGQRISGKLLVA
ADGSRSALAQACNVQWQQSDYPQFATIANVTTAEHPQGRAFERFTRYGPLALLPMSQGRSSLVWCHAREDREQVDGWDDE
RFISELQQAFGWRLGRILRAGKRHSYPLSLLTANQHVSHRLALVGNAAQTLHPIAGQGFNLGLRDVMSLAETLAEAQQAG
EDPGGYALLGRYQQRRQQDQQATIGVTDGLIRLFANRYGPLVVGRNLGLMAMARLPAVRDAFAKRTLGWVDR
>Mature_391_residues
SVIIVGGGMAGATLALAISSLTQGRLAVDLVEATRPDDRSHPGFDARAIALAQGTCQQLTRIGVWPALRDCATAITQVHV
SDRGHAGFVNLHAQDYQVDALGQVIELHDAGQRLFALLAKAPGVTLHCPARVVDVVRTAEQAEVLLDNGQRISGKLLVAA
DGSRSALAQACNVQWQQSDYPQFATIANVTTAEHPQGRAFERFTRYGPLALLPMSQGRSSLVWCHAREDREQVDGWDDER
FISELQQAFGWRLGRILRAGKRHSYPLSLLTANQHVSHRLALVGNAAQTLHPIAGQGFNLGLRDVMSLAETLAEAQQAGE
DPGGYALLGRYQQRRQQDQQATIGVTDGLIRLFANRYGPLVVGRNLGLMAMARLPAVRDAFAKRTLGWVDR

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=364, Percent_Identity=29.6703296703297, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI32967307, Length=382, Percent_Identity=29.3193717277487, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1789274, Length=392, Percent_Identity=68.8775510204082, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1786883, Length=392, Percent_Identity=32.9081632653061, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1789273, Length=396, Percent_Identity=30.3030303030303, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25146631, Length=424, Percent_Identity=27.3584905660377, Blast_Score=140, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6321694, Length=453, Percent_Identity=24.9448123620309, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI19920760, Length=383, Percent_Identity=26.3707571801567, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 42581; Mature: 42450

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVIIVGGGMAGATLALAISSLTQGRLAVDLVEATRPDDRSHPGFDARAIALAQGTCQQL
CEEEEEECCCHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCCCCCCCHHEEEHHHHHHHHH
TRIGVWPALRDCATAITQVHVSDRGHAGFVNLHAQDYQVDALGQVIELHDAGQRLFALLA
HHHCCCHHHHHHHHHHHHEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
KAPGVTLHCPARVVDVVRTAEQAEVLLDNGQRISGKLLVAADGSRSALAQACNVQWQQSD
HCCCCEEECHHHHHHHHHHHHHHHHHHCCCCEECCEEEEEECCCHHHHHHHHCCCCCCCC
YPQFATIANVTTAEHPQGRAFERFTRYGPLALLPMSQGRSSLVWCHAREDREQVDGWDDE
CCCHHHHCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCHHHCCCCCHH
RFISELQQAFGWRLGRILRAGKRHSYPLSLLTANQHVSHRLALVGNAAQTLHPIAGQGFN
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHCCCHHHHHCCCCCCCCC
LGLRDVMSLAETLAEAQQAGEDPGGYALLGRYQQRRQQDQQATIGVTDGLIRLFANRYGP
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
LVVGRNLGLMAMARLPAVRDAFAKRTLGWVDR
EEEECCCCHHHHHHCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SVIIVGGGMAGATLALAISSLTQGRLAVDLVEATRPDDRSHPGFDARAIALAQGTCQQL
EEEEEECCCHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCCCCCCCHHEEEHHHHHHHHH
TRIGVWPALRDCATAITQVHVSDRGHAGFVNLHAQDYQVDALGQVIELHDAGQRLFALLA
HHHCCCHHHHHHHHHHHHEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
KAPGVTLHCPARVVDVVRTAEQAEVLLDNGQRISGKLLVAADGSRSALAQACNVQWQQSD
HCCCCEEECHHHHHHHHHHHHHHHHHHCCCCEECCEEEEEECCCHHHHHHHHCCCCCCCC
YPQFATIANVTTAEHPQGRAFERFTRYGPLALLPMSQGRSSLVWCHAREDREQVDGWDDE
CCCHHHHCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCHHHCCCCCHH
RFISELQQAFGWRLGRILRAGKRHSYPLSLLTANQHVSHRLALVGNAAQTLHPIAGQGFN
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHCCCHHHHHCCCCCCCCC
LGLRDVMSLAETLAEAQQAGEDPGGYALLGRYQQRRQQDQQATIGVTDGLIRLFANRYGP
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
LVVGRNLGLMAMARLPAVRDAFAKRTLGWVDR
EEEECCCCHHHHHHCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]