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The map label for this gene is dxr

Identifier: 157372021

GI number: 157372021

Start: 4186075

End: 4187271

Strand: Reverse

Name: dxr

Synonym: Spro_3786

Alternate gene names: 157372021

Gene position: 4187271-4186075 (Counterclockwise)

Preceding gene: 157372022

Following gene: 157372020

Centisome position: 76.85

GC content: 58.65

Gene sequence:

>1197_bases
ATGAAGCAACTGACTATTCTTGGTTCCACCGGCTCAGTGGGGACCAGTACCCTGGCCGTGGTCAGGGAAAATCCCGACCG
TTTTGCGATTAAAGCGCTGGTTGCCGGCCGCAATGTCGCGGTCATGGCGCAACAGTGCATCGAATTTCGCCCGGCGTATG
CCGCGATGGCGGACGAAGGCGCTGCGCGTGAACTGCGTATTCTGCTGGCGGAAAACGGTATTGCCACCGAGGTGATGGCG
GGCGAGCAGGCGGCCTGTGAGTTGGCGGCATTGGACGACGTCGACCAGGTCACGGCAGCCATTGTGGGCGCAGCCGGCCT
ACTGCCAACGCTGGCGGCAATTCGTGCCGGCAAGCAGGTGCTGCTGGCGAACAAAGAGTCGCTGGTCACCTGCGGGCGTC
TGTTTATGGACGCGGTGCAACAGAGCAAGACGCAGTTACTGCCGCTCGACAGCGAACATAACGCCATTTTTCAGAGTTTG
CCTGAGAGCATTCAGCGTCAGTTGGGATACTCTTCATTAGAGAGTCATGGTGTGTCGCGCATCGTGCTTACCGGTTCTGG
CGGCCCGTTCCGCACTACGCCGCTGGAGCAGTTCACCGCGATGACGCCGGATCAGGCCTGTGCCCATCCCAATTGGTCGA
TGGGGCGCAAGATCTCGGTGGACTCCGCCACCATGATGAACAAAGGACTGGAATATATTGAGGCCCGCTGGCTGTTTAAC
GCCTCGGCCGAGCAAATGGAAGTGATTCTGCATCCGCAGTCGGTGATCCACTCGATGGTTCGTTACACCGATGGCAGCGT
ACTGGCCCAGTTGGGCACGCCGGATATGCGTACGCCGATCGCCCATGCGATGGCTTATCCTCAGCGCGTTAATTCTGGTG
TGGAAGCGCTGGATTTCTGCCGCATCGGCTCGCTGACCTTTGCCGAGCCTGAACGGGAACGCTATCCCTGCCTGTATCTG
GCCATTGAGGCCTTTGATGCCGGTCAGGCGGCGACTACCGCGCTGAACGCGGCTAACGAAGTGGCCGTGGCGGCTTTCCT
GCAGGAGCAGATTCGCTTTACCGATATTGCGGCAGTGAACCAAAAAGTAGTCGAACGGCTGTCACTGCAGGAACCGTCCT
GCATTGATGCGGTCTTAGAAATAGATCGCCAGGCGCGTGAGGTTGCGGTTGGATTGGTTAAATCACTGCATAACTGA

Upstream 100 bases:

>100_bases
GATCCCGTTTCATCGTACTGATTGATCATGGACAAGTGGTGGCCAAGGTTACACACTGGAGCACCTCCGATCTCATCAGA
CAGTTATTCAGAGTGAGCTC

Downstream 100 bases:

>100_bases
TACCGGCAATTATCCTATTTTGTTCGCAAATTACGCGTGCCGCAGTGGGGCCGTTTGTTCAGGCCTTGCTGAGGTGGTAT
AGTCTGCGCCACCTTTCAGC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MKQLTILGSTGSVGTSTLAVVRENPDRFAIKALVAGRNVAVMAQQCIEFRPAYAAMADEGAARELRILLAENGIATEVMA
GEQAACELAALDDVDQVTAAIVGAAGLLPTLAAIRAGKQVLLANKESLVTCGRLFMDAVQQSKTQLLPLDSEHNAIFQSL
PESIQRQLGYSSLESHGVSRIVLTGSGGPFRTTPLEQFTAMTPDQACAHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
ASAEQMEVILHPQSVIHSMVRYTDGSVLAQLGTPDMRTPIAHAMAYPQRVNSGVEALDFCRIGSLTFAEPERERYPCLYL
AIEAFDAGQAATTALNAANEVAVAAFLQEQIRFTDIAAVNQKVVERLSLQEPSCIDAVLEIDRQAREVAVGLVKSLHN

Sequences:

>Translated_398_residues
MKQLTILGSTGSVGTSTLAVVRENPDRFAIKALVAGRNVAVMAQQCIEFRPAYAAMADEGAARELRILLAENGIATEVMA
GEQAACELAALDDVDQVTAAIVGAAGLLPTLAAIRAGKQVLLANKESLVTCGRLFMDAVQQSKTQLLPLDSEHNAIFQSL
PESIQRQLGYSSLESHGVSRIVLTGSGGPFRTTPLEQFTAMTPDQACAHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
ASAEQMEVILHPQSVIHSMVRYTDGSVLAQLGTPDMRTPIAHAMAYPQRVNSGVEALDFCRIGSLTFAEPERERYPCLYL
AIEAFDAGQAATTALNAANEVAVAAFLQEQIRFTDIAAVNQKVVERLSLQEPSCIDAVLEIDRQAREVAVGLVKSLHN
>Mature_398_residues
MKQLTILGSTGSVGTSTLAVVRENPDRFAIKALVAGRNVAVMAQQCIEFRPAYAAMADEGAARELRILLAENGIATEVMA
GEQAACELAALDDVDQVTAAIVGAAGLLPTLAAIRAGKQVLLANKESLVTCGRLFMDAVQQSKTQLLPLDSEHNAIFQSL
PESIQRQLGYSSLESHGVSRIVLTGSGGPFRTTPLEQFTAMTPDQACAHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
ASAEQMEVILHPQSVIHSMVRYTDGSVLAQLGTPDMRTPIAHAMAYPQRVNSGVEALDFCRIGSLTFAEPERERYPCLYL
AIEAFDAGQAATTALNAANEVAVAAFLQEQIRFTDIAAVNQKVVERLSLQEPSCIDAVLEIDRQAREVAVGLVKSLHN

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=389, Percent_Identity=73.5218508997429, Blast_Score=592, Evalue=1e-170,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_SERP5 (A8GIE2)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480010.1
- ProteinModelPortal:   A8GIE2
- SMR:   A8GIE2
- STRING:   A8GIE2
- GeneID:   5607297
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_3786
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   SPRO399741:SPRO_3786-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42871; Mature: 42871

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: BINDING 125-125 BINDING 152-152 BINDING 186-186 BINDING 209-209 BINDING 231-231

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLTILGSTGSVGTSTLAVVRENPDRFAIKALVAGRNVAVMAQQCIEFRPAYAAMADEG
CCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCC
AARELRILLAENGIATEVMAGEQAACELAALDDVDQVTAAIVGAAGLLPTLAAIRAGKQV
CHHHEEEEEECCCCCHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLANKESLVTCGRLFMDAVQQSKTQLLPLDSEHNAIFQSLPESIQRQLGYSSLESHGVSR
EEECCHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCEE
IVLTGSGGPFRTTPLEQFTAMTPDQACAHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
EEEECCCCCCCCCCHHHHHCCCCCHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCC
ASAEQMEVILHPQSVIHSMVRYTDGSVLAQLGTPDMRTPIAHAMAYPQRVNSGVEALDFC
CCHHHHEEEECCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
RIGSLTFAEPERERYPCLYLAIEAFDAGQAATTALNAANEVAVAAFLQEQIRFTDIAAVN
HCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKVVERLSLQEPSCIDAVLEIDRQAREVAVGLVKSLHN
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQLTILGSTGSVGTSTLAVVRENPDRFAIKALVAGRNVAVMAQQCIEFRPAYAAMADEG
CCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCC
AARELRILLAENGIATEVMAGEQAACELAALDDVDQVTAAIVGAAGLLPTLAAIRAGKQV
CHHHEEEEEECCCCCHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLANKESLVTCGRLFMDAVQQSKTQLLPLDSEHNAIFQSLPESIQRQLGYSSLESHGVSR
EEECCHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCEE
IVLTGSGGPFRTTPLEQFTAMTPDQACAHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
EEEECCCCCCCCCCHHHHHCCCCCHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCC
ASAEQMEVILHPQSVIHSMVRYTDGSVLAQLGTPDMRTPIAHAMAYPQRVNSGVEALDFC
CCHHHHEEEECCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
RIGSLTFAEPERERYPCLYLAIEAFDAGQAATTALNAANEVAVAAFLQEQIRFTDIAAVN
HCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKVVERLSLQEPSCIDAVLEIDRQAREVAVGLVKSLHN
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA