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The map label for this gene is frr

Identifier: 157372022

GI number: 157372022

Start: 4187429

End: 4187986

Strand: Reverse

Name: frr

Synonym: Spro_3787

Alternate gene names: 157372022

Gene position: 4187986-4187429 (Counterclockwise)

Preceding gene: 157372023

Following gene: 157372021

Centisome position: 76.86

GC content: 48.57

Gene sequence:

>558_bases
GTGATTAATGAAATCAGAAAAGATGCTGATTCACGCATGGAAAAAAGCGTAGAAGCATTCAAAAACCAAATCAGTAAAAT
CCGTACCGGCCGCGCTTCTCCGAGCATCCTGGACGGCATCATGGTTGAATATTACGGCGCATCTACGCCGCTGCGTCAGC
TGGCTAGCGTGACGGTAGAAGATTCTCGTACGCTGAAAATTAACGTATTTGACCGCTCTATCAGTGCCGCTGTTGAAAAG
GCAATCATGAGCTCCGATCTGGGTCTGAACCCATCTTCAGCCGGTAGCGACATCCGTGTTCCACTTCCTGCATTGACCGA
AGAGCGCCGTAAAGATCTGATCAAGATCGTGCGTAATGAAGCTGAGCAGGGCCGTGTAGCGGTTCGTAACGTGCGCCGTG
ATGCCAACGACAAGGTTAAAGCACTGCTGAAAGACAAAGAAATCAGCGAAGATGAAGATCGTCGTTCACAGGACGACGTT
CAGAAACTGACCGATGCTTACATCAAACTTCTGGATGCCGCTTTGGCGGATAAAGAAAAAGAGCTGATGGAATTCTAA

Upstream 100 bases:

>100_bases
GAGCGGGTAACGCCAGGCGTAGCGCGCTTTCCTTGAGTAAAATTCACGGGCTATACTGTGGTATGGCCTGCCAAGTATCC
AGCTTTCAAGGGTTCGCAAC

Downstream 100 bases:

>100_bases
TCAGCATCGCGCAGAAAAAAAGCGTCGCCTGGGCGGCGCTTTGTTTTTTGTGGCGCAGATCCCGTTTCATCGTACTGATT
GATCATGGACAAGTGGTGGC

Product: ribosome recycling factor

Products: NA

Alternate protein names: RRF; Ribosome-releasing factor

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MINEIRKDADSRMEKSVEAFKNQISKIRTGRASPSILDGIMVEYYGASTPLRQLASVTVEDSRTLKINVFDRSISAAVEK
AIMSSDLGLNPSSAGSDIRVPLPALTEERRKDLIKIVRNEAEQGRVAVRNVRRDANDKVKALLKDKEISEDEDRRSQDDV
QKLTDAYIKLLDAALADKEKELMEF

Sequences:

>Translated_185_residues
MINEIRKDADSRMEKSVEAFKNQISKIRTGRASPSILDGIMVEYYGASTPLRQLASVTVEDSRTLKINVFDRSISAAVEK
AIMSSDLGLNPSSAGSDIRVPLPALTEERRKDLIKIVRNEAEQGRVAVRNVRRDANDKVKALLKDKEISEDEDRRSQDDV
QKLTDAYIKLLDAALADKEKELMEF
>Mature_185_residues
MINEIRKDADSRMEKSVEAFKNQISKIRTGRASPSILDGIMVEYYGASTPLRQLASVTVEDSRTLKINVFDRSISAAVEK
AIMSSDLGLNPSSAGSDIRVPLPALTEERRKDLIKIVRNEAEQGRVAVRNVRRDANDKVKALLKDKEISEDEDRRSQDDV
QKLTDAYIKLLDAALADKEKELMEF

Specific function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another

COG id: COG0233

COG function: function code J; Ribosome recycling factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RRF family

Homologues:

Organism=Homo sapiens, GI20270317, Length=179, Percent_Identity=31.2849162011173, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI291042689, Length=150, Percent_Identity=32, Blast_Score=70, Evalue=8e-13,
Organism=Escherichia coli, GI1786368, Length=185, Percent_Identity=85.945945945946, Blast_Score=316, Evalue=5e-88,
Organism=Drosophila melanogaster, GI24661488, Length=176, Percent_Identity=30.1136363636364, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): RRF_SERP5 (A8GIE3)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480011.1
- ProteinModelPortal:   A8GIE3
- SMR:   A8GIE3
- STRING:   A8GIE3
- GeneID:   5607206
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_3787
- eggNOG:   COG0233
- HOGENOM:   HBG533975
- OMA:   YYGAETP
- ProtClustDB:   PRK00083
- BioCyc:   SPRO399741:SPRO_3787-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00040
- InterPro:   IPR002661
- InterPro:   IPR015998
- PANTHER:   PTHR20982
- PANTHER:   PTHR20982:SF3
- TIGRFAMs:   TIGR00496

Pfam domain/function: PF01765 RRF; SSF55194 Ribosome_recyc_fac

EC number: NA

Molecular weight: Translated: 20766; Mature: 20766

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINEIRKDADSRMEKSVEAFKNQISKIRTGRASPSILDGIMVEYYGASTPLRQLASVTVE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCC
DSRTLKINVFDRSISAAVEKAIMSSDLGLNPSSAGSDIRVPLPALTEERRKDLIKIVRNE
CCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHH
AEQGRVAVRNVRRDANDKVKALLKDKEISEDEDRRSQDDVQKLTDAYIKLLDAALADKEK
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
ELMEF
HHHCC
>Mature Secondary Structure
MINEIRKDADSRMEKSVEAFKNQISKIRTGRASPSILDGIMVEYYGASTPLRQLASVTVE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCC
DSRTLKINVFDRSISAAVEKAIMSSDLGLNPSSAGSDIRVPLPALTEERRKDLIKIVRNE
CCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHH
AEQGRVAVRNVRRDANDKVKALLKDKEISEDEDRRSQDDVQKLTDAYIKLLDAALADKEK
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
ELMEF
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA