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The map label for this gene is uppS [H]

Identifier: 157372020

GI number: 157372020

Start: 4185038

End: 4185796

Strand: Reverse

Name: uppS [H]

Synonym: Spro_3785

Alternate gene names: 157372020

Gene position: 4185796-4185038 (Counterclockwise)

Preceding gene: 157372021

Following gene: 157372019

Centisome position: 76.82

GC content: 52.44

Gene sequence:

>759_bases
ATGTCGTCCGCAAATCAACAAGAGGCTAATCTGTCCACTCTGGGGCCACGACATGTCGCCATTATTATGGACGGCAACGG
GCGCTGGGCTAAACGTCAGGGTAAGTTACGTGTCTTCGGTCATAAAGCAGGGGTGAAATCGGTGCGTCGCGCGGTCAGTT
TTGCCGCCAACAACCATTTAGATGCGCTCACGCTTTATGCCTTCAGCAGCGAGAACTGGAATCGTCCAGTGCAGGAAGTT
TCCGCTTTGATGGAGCTTTTCGTCCGCGCCTTGGACAGTGAAGTAAAAAGCCTGCATAAACATAACGTCAGACTGCGAGT
GATCGGTGATATCAGCCGTTTCAGCACGCGCTTGCAGGAGCGGATCCGTCGCTCCGAGCAACTGACAGAAAATAACGATG
GCCTGACGCTCAACATTGCTGCCAACTATGGCGGCCGTTGGGATATTATTCAGGGAGTAAGGGAACTGGCTGAGCAGGTG
AAGGACGGTTCACTGCGTCCGGATCAAATCAGCGAAGAGTTACTGGGTGAGCGGATCTGCATGAACGATCTGTCGCCGGT
GGATTTGGTGATCCGTACCGGTGGCGAACATCGCATCAGTAACTTCTTGCTGTGGCAAATTGCTTATGCCGAACTTTACT
TTACTGATGTACTCTGGCCTGATTTTGATGAACTTGTCTTTGAAGGTGCGCTGAATGCATTTGCACAACGCGAGCGTCGC
TTCGGGGGAACAACACCTATCGGCGCCAATGCGTCCTAG

Upstream 100 bases:

>100_bases
AGTCTGAAAAGCCGTGTCGGGCACACGGCTTTTTTTGCGCGTAAGGGCCTGATGTTCCGGAAGGGCAGTTGTATTTCTAT
TGAGGAAATAAGTACGAGTT

Downstream 100 bases:

>100_bases
GGGGAACTTTTGCTGAAGTATCGCCTCATAACTGCTCTGATCTTAATTCCGATTGTTATCGCGGCGCTGTTTTTGCTGCC
GCCGGTGGGCTTTGCCCTGG

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSSANQQEANLSTLGPRHVAIIMDGNGRWAKRQGKLRVFGHKAGVKSVRRAVSFAANNHLDALTLYAFSSENWNRPVQEV
SALMELFVRALDSEVKSLHKHNVRLRVIGDISRFSTRLQERIRRSEQLTENNDGLTLNIAANYGGRWDIIQGVRELAEQV
KDGSLRPDQISEELLGERICMNDLSPVDLVIRTGGEHRISNFLLWQIAYAELYFTDVLWPDFDELVFEGALNAFAQRERR
FGGTTPIGANAS

Sequences:

>Translated_252_residues
MSSANQQEANLSTLGPRHVAIIMDGNGRWAKRQGKLRVFGHKAGVKSVRRAVSFAANNHLDALTLYAFSSENWNRPVQEV
SALMELFVRALDSEVKSLHKHNVRLRVIGDISRFSTRLQERIRRSEQLTENNDGLTLNIAANYGGRWDIIQGVRELAEQV
KDGSLRPDQISEELLGERICMNDLSPVDLVIRTGGEHRISNFLLWQIAYAELYFTDVLWPDFDELVFEGALNAFAQRERR
FGGTTPIGANAS
>Mature_251_residues
SSANQQEANLSTLGPRHVAIIMDGNGRWAKRQGKLRVFGHKAGVKSVRRAVSFAANNHLDALTLYAFSSENWNRPVQEVS
ALMELFVRALDSEVKSLHKHNVRLRVIGDISRFSTRLQERIRRSEQLTENNDGLTLNIAANYGGRWDIIQGVRELAEQVK
DGSLRPDQISEELLGERICMNDLSPVDLVIRTGGEHRISNFLLWQIAYAELYFTDVLWPDFDELVFEGALNAFAQRERRF
GGTTPIGANAS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=220, Percent_Identity=40, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI45580742, Length=220, Percent_Identity=40, Blast_Score=149, Evalue=2e-36,
Organism=Escherichia coli, GI1786371, Length=246, Percent_Identity=78.8617886178862, Blast_Score=409, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71993029, Length=216, Percent_Identity=38.8888888888889, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319474, Length=216, Percent_Identity=36.1111111111111, Blast_Score=125, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=215, Percent_Identity=33.4883720930233, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI18857969, Length=230, Percent_Identity=37.3913043478261, Blast_Score=137, Evalue=9e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28405; Mature: 28274

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSANQQEANLSTLGPRHVAIIMDGNGRWAKRQGKLRVFGHKAGVKSVRRAVSFAANNHL
CCCCCCCCCCHHHCCCCEEEEEECCCCCEECCCCCEEEEECHHHHHHHHHHHHHHHCCCC
DALTLYAFSSENWNRPVQEVSALMELFVRALDSEVKSLHKHNVRLRVIGDISRFSTRLQE
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHH
RIRRSEQLTENNDGLTLNIAANYGGRWDIIQGVRELAEQVKDGSLRPDQISEELLGERIC
HHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
MNDLSPVDLVIRTGGEHRISNFLLWQIAYAELYFTDVLWPDFDELVFEGALNAFAQRERR
HCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
FGGTTPIGANAS
CCCCCCCCCCCC
>Mature Secondary Structure 
SSANQQEANLSTLGPRHVAIIMDGNGRWAKRQGKLRVFGHKAGVKSVRRAVSFAANNHL
CCCCCCCCCHHHCCCCEEEEEECCCCCEECCCCCEEEEECHHHHHHHHHHHHHHHCCCC
DALTLYAFSSENWNRPVQEVSALMELFVRALDSEVKSLHKHNVRLRVIGDISRFSTRLQE
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHH
RIRRSEQLTENNDGLTLNIAANYGGRWDIIQGVRELAEQVKDGSLRPDQISEELLGERIC
HHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
MNDLSPVDLVIRTGGEHRISNFLLWQIAYAELYFTDVLWPDFDELVFEGALNAFAQRERR
HCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
FGGTTPIGANAS
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA