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The map label for this gene is lpxB

Identifier: 157372012

GI number: 157372012

Start: 4176110

End: 4177258

Strand: Reverse

Name: lpxB

Synonym: Spro_3777

Alternate gene names: 157372012

Gene position: 4177258-4176110 (Counterclockwise)

Preceding gene: 157372013

Following gene: 157372011

Centisome position: 76.66

GC content: 58.75

Gene sequence:

>1149_bases
ATGCAAAATCGCCCATTGACCATCGGATTGGTCGCCGGAGAAACTTCCGGTGATATTCTTGGCGCCGGTTTAATTCGCGC
GCTCAAGGCGCAGATCCCCGACGCGCGTTTTGTTGGCGTCGCCGGCCCGCTGATGCAGGCCGAAGGCTGCGAAACCTGGT
ACGAAATGGAAGAGCTGGCGGTAATGGGCGTGGTCGAGGTGCTTGAGCGCCTGCCACGCCTGTTAAAGATCCGCAAGGAT
CTTACCCGCCGGTTCAGCGATCTCGCGCCTGACGTGTTTGTGGGTATCGACGCGCCGGACTTCAATATCACCCTGGAAGG
TCGTCTGAAACAGCGCGGCATCCGCACCATTCATTATGTCAGCCCCTCCGTCTGGGCCTGGCGTCAAAAGCGCGTTTTCA
AAATAGGCAAAGCCACCGATCTGGTGTTGGCGTTTCTCCCTTTCGAAAAAGCGTTTTACGATCGTTTCAACGTTCCCTGT
CGGTTTATCGGTCATACCATGGCCGACGCCATGCCGCTGCAACCGGACAAACTGGCTGCGCGCGCTAAACTGGGCATTGC
CGCTGATGCGCGTTGTCTGGCCCTGCTGCCGGGCAGCCGCGGCGCGGAAGTCGAGATGCTGAGCGCTGATTTCCTGAAGA
CGGCCCAGTTGCTGCGTACCCGCTATCCGGAGCTGGAACTGGTGGTGCCGTTGGTTAACGCCAAGCGACGCGAGCAGTTC
GAACGCATCAAGGCGGAAGTGGCACCTGAGTTAAGGGTCCATTTGCTCAATGGCCAGGGCCGTGAGGCGATGATCGCCAG
CGACGCAGCTTTACTGGCCTCAGGGACGGCGGCACTGGAGTGCATGCTGGCCAAATGCCCGATGGTGGTGGGTTACCGCA
TGAAGCCCTTTACCTTCTGGATAGCGCAGAGGTTGGTGAAGACTCCCTATGTCTCACTGCCCAACCTGTTGGCCGGTCGT
GAGATCGTCACCGAACTGTTGCAGCACGACTGCGTGCCGGACAAGTTGGCGGCATCGGTCATGCCGTTGCTGGAAGACAG
TCCGCAAACCGACGAACTGAAACAGACTTTCCTTACCCTGCACCAAAGCATCCGTTGTGGTGCCGATGAACAGGCCGCTC
AGGCTGTGTTGGAGCTGGCAAAAGCATGA

Upstream 100 bases:

>100_bases
AGCGAAAACAGAAATCGAAGCCCTGGCGAAAGAACAGCCAGTGGTGCAGCAGTTCCTTGATTTCTTTGGTCGTTCCACCC
GCGGTATTATTCGCTGACCT

Downstream 100 bases:

>100_bases
TTGAACCCTTCATTTATCCTGTCGCCACGCTGATTGCCGGCGTGGACGAAGTCGGCCGTGGCCCTTTGGTCGGGGCGGTA
GTGACCGCCGCAGTGATCCT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MQNRPLTIGLVAGETSGDILGAGLIRALKAQIPDARFVGVAGPLMQAEGCETWYEMEELAVMGVVEVLERLPRLLKIRKD
LTRRFSDLAPDVFVGIDAPDFNITLEGRLKQRGIRTIHYVSPSVWAWRQKRVFKIGKATDLVLAFLPFEKAFYDRFNVPC
RFIGHTMADAMPLQPDKLAARAKLGIAADARCLALLPGSRGAEVEMLSADFLKTAQLLRTRYPELELVVPLVNAKRREQF
ERIKAEVAPELRVHLLNGQGREAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWIAQRLVKTPYVSLPNLLAGR
EIVTELLQHDCVPDKLAASVMPLLEDSPQTDELKQTFLTLHQSIRCGADEQAAQAVLELAKA

Sequences:

>Translated_382_residues
MQNRPLTIGLVAGETSGDILGAGLIRALKAQIPDARFVGVAGPLMQAEGCETWYEMEELAVMGVVEVLERLPRLLKIRKD
LTRRFSDLAPDVFVGIDAPDFNITLEGRLKQRGIRTIHYVSPSVWAWRQKRVFKIGKATDLVLAFLPFEKAFYDRFNVPC
RFIGHTMADAMPLQPDKLAARAKLGIAADARCLALLPGSRGAEVEMLSADFLKTAQLLRTRYPELELVVPLVNAKRREQF
ERIKAEVAPELRVHLLNGQGREAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWIAQRLVKTPYVSLPNLLAGR
EIVTELLQHDCVPDKLAASVMPLLEDSPQTDELKQTFLTLHQSIRCGADEQAAQAVLELAKA
>Mature_382_residues
MQNRPLTIGLVAGETSGDILGAGLIRALKAQIPDARFVGVAGPLMQAEGCETWYEMEELAVMGVVEVLERLPRLLKIRKD
LTRRFSDLAPDVFVGIDAPDFNITLEGRLKQRGIRTIHYVSPSVWAWRQKRVFKIGKATDLVLAFLPFEKAFYDRFNVPC
RFIGHTMADAMPLQPDKLAARAKLGIAADARCLALLPGSRGAEVEMLSADFLKTAQLLRTRYPELELVVPLVNAKRREQF
ERIKAEVAPELRVHLLNGQGREAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWIAQRLVKTPYVSLPNLLAGR
EIVTELLQHDCVPDKLAASVMPLLEDSPQTDELKQTFLTLHQSIRCGADEQAAQAVLELAKA

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=380, Percent_Identity=81.8421052631579, Blast_Score=626, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_SERP5 (A8GID3)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480001.1
- ProteinModelPortal:   A8GID3
- STRING:   A8GID3
- GeneID:   5607353
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_3777
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- ProtClustDB:   PRK00025
- BioCyc:   SPRO399741:SPRO_3777-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 42312; Mature: 42312

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNRPLTIGLVAGETSGDILGAGLIRALKAQIPDARFVGVAGPLMQAEGCETWYEMEELA
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHCCCCCHHHHHHHHHH
VMGVVEVLERLPRLLKIRKDLTRRFSDLAPDVFVGIDAPDFNITLEGRLKQRGIRTIHYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCHHHCCCCEEEEC
SPSVWAWRQKRVFKIGKATDLVLAFLPFEKAFYDRFNVPCRFIGHTMADAMPLQPDKLAA
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHH
RAKLGIAADARCLALLPGSRGAEVEMLSADFLKTAQLLRTRYPELELVVPLVNAKRREQF
HHHCCCCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHCCCCEEEEEEHHCCHHHHHH
ERIKAEVAPELRVHLLNGQGREAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFW
HHHHHHHCCCEEEEEECCCCCEEEEECCHHHHHCCHHHHHHHHHHCCHHHCCCCCHHHHH
IAQRLVKTPYVSLPNLLAGREIVTELLQHDCVPDKLAASVMPLLEDSPQTDELKQTFLTL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
HQSIRCGADEQAAQAVLELAKA
HHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MQNRPLTIGLVAGETSGDILGAGLIRALKAQIPDARFVGVAGPLMQAEGCETWYEMEELA
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHCCCCCHHHHHHHHHH
VMGVVEVLERLPRLLKIRKDLTRRFSDLAPDVFVGIDAPDFNITLEGRLKQRGIRTIHYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCHHHCCCCEEEEC
SPSVWAWRQKRVFKIGKATDLVLAFLPFEKAFYDRFNVPCRFIGHTMADAMPLQPDKLAA
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHH
RAKLGIAADARCLALLPGSRGAEVEMLSADFLKTAQLLRTRYPELELVVPLVNAKRREQF
HHHCCCCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHCCCCEEEEEEHHCCHHHHHH
ERIKAEVAPELRVHLLNGQGREAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFW
HHHHHHHCCCEEEEEECCCCCEEEEECCHHHHHCCHHHHHHHHHHCCHHHCCCCCHHHHH
IAQRLVKTPYVSLPNLLAGREIVTELLQHDCVPDKLAASVMPLLEDSPQTDELKQTFLTL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
HQSIRCGADEQAAQAVLELAKA
HHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA