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The map label for this gene is lpxA

Identifier: 157372013

GI number: 157372013

Start: 4177262

End: 4178050

Strand: Reverse

Name: lpxA

Synonym: Spro_3778

Alternate gene names: 157372013

Gene position: 4178050-4177262 (Counterclockwise)

Preceding gene: 157372014

Following gene: 157372012

Centisome position: 76.68

GC content: 53.36

Gene sequence:

>789_bases
GTGATCGACAAAACCGCCTTTATCCATCCTAGCGCGATTATTGAAGAAGGCGCCGTTATCGGCGCTGGTGCGCACATCGG
TCCCTTCTGCTACGTCGGCTCCCAGGTGGAAATCGGCGAAGGCACGGTACTGAAGTCCCACATTGTGGTGAATGGCTTGA
CCAAAATCGGCCGCGATAATCAGATCTATCAGTTCGCCTCTATTGGCGAAGTGAATCAGGATCTGAAATACGCGGGTGAA
CCGACGCGTGTCGAGATTGGCGATCGCAACCGCATCCGCGAAAGCGTCACCATTCATCGCGGTACGGCGCAGGGCACCGG
TTTGACCAAAGTAGGTAATGACAACCTGCTGATGGTTAACGTGCATGTCGCGCACGACTGCGTGGTGGGTAACTCCTGTA
TCCTGGCAAACAACGCCACGCTGGCTGGCCATGTGGAAATTGACGATCATGCCATTATCGGTGGTATGACGGCTATTCAT
CAGTTCTGCATTATCGGGACTCACGTGATGGTTGGCGGTTGTTCCGGCGTTGCCCAGGACGTGCCACCTTTTGTCATTGC
GCAGGGTAACCACGCCACGCCATTCGGTGTTAACGCCGTTGGCCTGAAGCGTCGTGGTTTTGATAAAGATGAAATGCAGG
CTATCCGTAACGCCTACAAAATTCTTTATCGCAGCGAGAAAACGCTGGATGAAGCGAAAACAGAAATCGAAGCCCTGGCG
AAAGAACAGCCAGTGGTGCAGCAGTTCCTTGATTTCTTTGGTCGTTCCACCCGCGGTATTATTCGCTGA

Upstream 100 bases:

>100_bases
TCGTCGTGGTTTGACGCGCTTTAAAGGCGTGGCGACCGTCGACGGCAAAATTGTCTGCGAAGCAACCATGATGTGTGCGC
GCAGCCGGGAGGCCTAATCC

Downstream 100 bases:

>100_bases
CCTATGCAAAATCGCCCATTGACCATCGGATTGGTCGCCGGAGAAACTTCCGGTGATATTCTTGGCGCCGGTTTAATTCG
CGCGCTCAAGGCGCAGATCC

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MIDKTAFIHPSAIIEEGAVIGAGAHIGPFCYVGSQVEIGEGTVLKSHIVVNGLTKIGRDNQIYQFASIGEVNQDLKYAGE
PTRVEIGDRNRIRESVTIHRGTAQGTGLTKVGNDNLLMVNVHVAHDCVVGNSCILANNATLAGHVEIDDHAIIGGMTAIH
QFCIIGTHVMVGGCSGVAQDVPPFVIAQGNHATPFGVNAVGLKRRGFDKDEMQAIRNAYKILYRSEKTLDEAKTEIEALA
KEQPVVQQFLDFFGRSTRGIIR

Sequences:

>Translated_262_residues
MIDKTAFIHPSAIIEEGAVIGAGAHIGPFCYVGSQVEIGEGTVLKSHIVVNGLTKIGRDNQIYQFASIGEVNQDLKYAGE
PTRVEIGDRNRIRESVTIHRGTAQGTGLTKVGNDNLLMVNVHVAHDCVVGNSCILANNATLAGHVEIDDHAIIGGMTAIH
QFCIIGTHVMVGGCSGVAQDVPPFVIAQGNHATPFGVNAVGLKRRGFDKDEMQAIRNAYKILYRSEKTLDEAKTEIEALA
KEQPVVQQFLDFFGRSTRGIIR
>Mature_262_residues
MIDKTAFIHPSAIIEEGAVIGAGAHIGPFCYVGSQVEIGEGTVLKSHIVVNGLTKIGRDNQIYQFASIGEVNQDLKYAGE
PTRVEIGDRNRIRESVTIHRGTAQGTGLTKVGNDNLLMVNVHVAHDCVVGNSCILANNATLAGHVEIDDHAIIGGMTAIH
QFCIIGTHVMVGGCSGVAQDVPPFVIAQGNHATPFGVNAVGLKRRGFDKDEMQAIRNAYKILYRSEKTLDEAKTEIEALA
KEQPVVQQFLDFFGRSTRGIIR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=262, Percent_Identity=80.9160305343512, Blast_Score=445, Evalue=1e-126,
Organism=Escherichia coli, GI1786376, Length=209, Percent_Identity=29.1866028708134, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_SERP5 (A8GID4)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480002.1
- ProteinModelPortal:   A8GID4
- SMR:   A8GID4
- STRING:   A8GID4
- GeneID:   5607345
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_3778
- eggNOG:   COG1043
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- ProtClustDB:   PRK05289
- BioCyc:   SPRO399741:SPRO_3778-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 28212; Mature: 28212

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDKTAFIHPSAIIEEGAVIGAGAHIGPFCYVGSQVEIGEGTVLKSHIVVNGLTKIGRDN
CCCCCEEECCHHHHHCCCEEECCCCCCCEEEECCEEEECCCEEEEHHHEEHHHHHCCCCC
QIYQFASIGEVNQDLKYAGEPTRVEIGDRNRIRESVTIHRGTAQGTGLTKVGNDNLLMVN
CEEEEECCCCCCHHHHHCCCCCEEEECCCHHHHHEEEEECCCCCCCCCEEECCCCEEEEE
VHVAHDCVVGNSCILANNATLAGHVEIDDHAIIGGMTAIHQFCIIGTHVMVGGCSGVAQD
EEEEEEEEECCCEEEECCCEEEEEEEECCCEEEHHHHHHHHHHHHHCEEEEECCCCCHHC
VPPFVIAQGNHATPFGVNAVGLKRRGFDKDEMQAIRNAYKILYRSEKTLDEAKTEIEALA
CCCEEEECCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
KEQPVVQQFLDFFGRSTRGIIR
CCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIDKTAFIHPSAIIEEGAVIGAGAHIGPFCYVGSQVEIGEGTVLKSHIVVNGLTKIGRDN
CCCCCEEECCHHHHHCCCEEECCCCCCCEEEECCEEEECCCEEEEHHHEEHHHHHCCCCC
QIYQFASIGEVNQDLKYAGEPTRVEIGDRNRIRESVTIHRGTAQGTGLTKVGNDNLLMVN
CEEEEECCCCCCHHHHHCCCCCEEEECCCHHHHHEEEEECCCCCCCCCEEECCCCEEEEE
VHVAHDCVVGNSCILANNATLAGHVEIDDHAIIGGMTAIHQFCIIGTHVMVGGCSGVAQD
EEEEEEEEECCCEEEECCCEEEEEEEECCCEEEHHHHHHHHHHHHHCEEEEECCCCCHHC
VPPFVIAQGNHATPFGVNAVGLKRRGFDKDEMQAIRNAYKILYRSEKTLDEAKTEIEALA
CCCEEEECCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
KEQPVVQQFLDFFGRSTRGIIR
CCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA