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The map label for this gene is moeA [H]

Identifier: 157369790

GI number: 157369790

Start: 1685628

End: 1686866

Strand: Reverse

Name: moeA [H]

Synonym: Spro_1547

Alternate gene names: 157369790

Gene position: 1686866-1685628 (Counterclockwise)

Preceding gene: 157369799

Following gene: 157369789

Centisome position: 30.96

GC content: 60.77

Gene sequence:

>1239_bases
ATGGATCATTGCCATACTTCCGATCTCATTTCCCTGGAGCAGGCGCTGGAGAAGATGCTCAGCCAGCTCTCCCCCCTGCA
GCAGACCGAATCCATTGCCCTGACCACCGCCGCAGGCCGCATTACCGCCGCACCGGTCATTTCGCCGATTGACGTGCCGC
CGTTCGCCAATTCGGCTATGGACGGTTACGCCGTGCGCCTGGCCGATTTGCAAGCCAATGCGCCGTTGCCGGTGGCGGGC
AAAGCCTTTGCCGGTGCGCCATTTGATGGCAACTGGCCGGCCAATACCTGCATACGCATTATGACCGGCGCCCCTGTCCC
GGTCGGTGCCGAAGCGGTGATCATGCAGGAACAGGCCGAGCTGAGTGATGCAGGCGTGCGCTTTACGGCCGAAGTACAAG
CCGGGCAAAATATTCGTCTGGCCGGGGAAGATATTCGCCAGGGCGCAGGCGTGTTAGCCGCAGGCATCAGGCTGGGTGCC
GCGCAATTGCCTCTGCTGGCCTCGCTCGGCGTTGCCGAAGTCCAGGTGATGCGCAAACTGAAAGTCGCGGTGTTCTCTAC
CGGCGACGAATTACAACCGGTCGGCCAGCCGTTGCAGGCCGGGCAAATCTACGATACCAATCGCTTTGCGGTGCGCCTGA
TGCTGGAACAGCTGGGCTGCGAGGTGATCGATCTGGGCATTATCCGCGACAATCAAGAAGCGCTGCGCGCCGCTTTCGAG
CAGGCGGACAGCCAGGCCGACGTGGTGATCAGCAGCGGTGGCGTTTCGGTCGGTGAAGCCGACTACACCAAGCAGATGCT
GGATGAACTGGGCGAAGTCAGCTTCTGGAAGCTGGCGATCAAACCGGGTAAGCCTTTTGCCTTCGGCAAGCTGAAACACG
CCTGGTTCTGTGGCCTGCCGGGCAACCCGGTTTCTGCCGCCCTGACCTTCTACCAACTGGTGCAACCGCTGCTGGCAAAA
CTGGCCGGCCACAGCGACTGGCAGTTGCCACCGCGTCTGCAAGCACGCGCATTGACGCCGTTGAAGAAAGCACCGGGCCG
TCTCGATTTCCAGCGCGGCGTCTTTAGCAGTAACGCCCAGGGCGAGTTGGAAGTCAGCAGCACCGGCCATCAAGGCTCGC
ACATCTTCAGTTCGTTCAGTCAGGGTAACTGTTTTATCGTACTGGAGCGCGATCGCGGTTCCGTAGCGGTGGGTGAAAAG
GTGGAAATTGAGCCTTTCAACGCCCTGCTGAGGAGCTAA

Upstream 100 bases:

>100_bases
GTGCATCACTGCCTCCTGTTGTTTACATCAGCATAGCATCCTTCATAATACCCCCACATTGCCGCTATTTATCGCGCACC
CTGATTACGGAGTTCCCCCG

Downstream 100 bases:

>100_bases
GCATGCTGCCGGAATTAACCGATGCCGAAACATTGCGCTATAACCGCCAGATTATCCTGCGTGGTTTCGACTTCGACGGT
CAGGAAAAGCTGAAAGCCGC

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MDHCHTSDLISLEQALEKMLSQLSPLQQTESIALTTAAGRITAAPVISPIDVPPFANSAMDGYAVRLADLQANAPLPVAG
KAFAGAPFDGNWPANTCIRIMTGAPVPVGAEAVIMQEQAELSDAGVRFTAEVQAGQNIRLAGEDIRQGAGVLAAGIRLGA
AQLPLLASLGVAEVQVMRKLKVAVFSTGDELQPVGQPLQAGQIYDTNRFAVRLMLEQLGCEVIDLGIIRDNQEALRAAFE
QADSQADVVISSGGVSVGEADYTKQMLDELGEVSFWKLAIKPGKPFAFGKLKHAWFCGLPGNPVSAALTFYQLVQPLLAK
LAGHSDWQLPPRLQARALTPLKKAPGRLDFQRGVFSSNAQGELEVSSTGHQGSHIFSSFSQGNCFIVLERDRGSVAVGEK
VEIEPFNALLRS

Sequences:

>Translated_412_residues
MDHCHTSDLISLEQALEKMLSQLSPLQQTESIALTTAAGRITAAPVISPIDVPPFANSAMDGYAVRLADLQANAPLPVAG
KAFAGAPFDGNWPANTCIRIMTGAPVPVGAEAVIMQEQAELSDAGVRFTAEVQAGQNIRLAGEDIRQGAGVLAAGIRLGA
AQLPLLASLGVAEVQVMRKLKVAVFSTGDELQPVGQPLQAGQIYDTNRFAVRLMLEQLGCEVIDLGIIRDNQEALRAAFE
QADSQADVVISSGGVSVGEADYTKQMLDELGEVSFWKLAIKPGKPFAFGKLKHAWFCGLPGNPVSAALTFYQLVQPLLAK
LAGHSDWQLPPRLQARALTPLKKAPGRLDFQRGVFSSNAQGELEVSSTGHQGSHIFSSFSQGNCFIVLERDRGSVAVGEK
VEIEPFNALLRS
>Mature_412_residues
MDHCHTSDLISLEQALEKMLSQLSPLQQTESIALTTAAGRITAAPVISPIDVPPFANSAMDGYAVRLADLQANAPLPVAG
KAFAGAPFDGNWPANTCIRIMTGAPVPVGAEAVIMQEQAELSDAGVRFTAEVQAGQNIRLAGEDIRQGAGVLAAGIRLGA
AQLPLLASLGVAEVQVMRKLKVAVFSTGDELQPVGQPLQAGQIYDTNRFAVRLMLEQLGCEVIDLGIIRDNQEALRAAFE
QADSQADVVISSGGVSVGEADYTKQMLDELGEVSFWKLAIKPGKPFAFGKLKHAWFCGLPGNPVSAALTFYQLVQPLLAK
LAGHSDWQLPPRLQARALTPLKKAPGRLDFQRGVFSSNAQGELEVSSTGHQGSHIFSSFSQGNCFIVLERDRGSVAVGEK
VEIEPFNALLRS

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=400, Percent_Identity=37, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI66932975, Length=400, Percent_Identity=37, Blast_Score=209, Evalue=3e-54,
Organism=Escherichia coli, GI1787049, Length=405, Percent_Identity=71.8518518518519, Blast_Score=578, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI25147659, Length=312, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17562606, Length=342, Percent_Identity=24.5614035087719, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17136978, Length=398, Percent_Identity=29.1457286432161, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24638841, Length=398, Percent_Identity=29.1457286432161, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43818; Mature: 43818

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHCHTSDLISLEQALEKMLSQLSPLQQTESIALTTAAGRITAAPVISPIDVPPFANSAM
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCEEEEECCCCEEECCCCCCCCCCCCCCCCC
DGYAVRLADLQANAPLPVAGKAFAGAPFDGNWPANTCIRIMTGAPVPVGAEAVIMQEQAE
CCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEHHHHH
LSDAGVRFTAEVQAGQNIRLAGEDIRQGAGVLAAGIRLGAAQLPLLASLGVAEVQVMRKL
HCCCCEEEEEEECCCCEEEECCHHHHCCCCHHHHHHHHCHHHCCHHHHCCHHHHHHHHHH
KVAVFSTGDELQPVGQPLQAGQIYDTNRFAVRLMLEQLGCEVIDLGIIRDNQEALRAAFE
HHEEECCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHCCEEEEEEEEECCHHHHHHHHH
QADSQADVVISSGGVSVGEADYTKQMLDELGEVSFWKLAIKPGKPFAFGKLKHAWFCGLP
HCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEECCC
GNPVSAALTFYQLVQPLLAKLAGHSDWQLPPRLQARALTPLKKAPGRLDFQRGVFSSNAQ
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHCCCCCCHHHCCCCCCCC
GELEVSSTGHQGSHIFSSFSQGNCFIVLERDRGSVAVGEKVEIEPFNALLRS
CEEEEECCCCCCHHHHHHCCCCCEEEEEECCCCCEEECCEEEECHHHHHHCC
>Mature Secondary Structure
MDHCHTSDLISLEQALEKMLSQLSPLQQTESIALTTAAGRITAAPVISPIDVPPFANSAM
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCEEEEECCCCEEECCCCCCCCCCCCCCCCC
DGYAVRLADLQANAPLPVAGKAFAGAPFDGNWPANTCIRIMTGAPVPVGAEAVIMQEQAE
CCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEHHHHH
LSDAGVRFTAEVQAGQNIRLAGEDIRQGAGVLAAGIRLGAAQLPLLASLGVAEVQVMRKL
HCCCCEEEEEEECCCCEEEECCHHHHCCCCHHHHHHHHCHHHCCHHHHCCHHHHHHHHHH
KVAVFSTGDELQPVGQPLQAGQIYDTNRFAVRLMLEQLGCEVIDLGIIRDNQEALRAAFE
HHEEECCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHCCEEEEEEEEECCHHHHHHHHH
QADSQADVVISSGGVSVGEADYTKQMLDELGEVSFWKLAIKPGKPFAFGKLKHAWFCGLP
HCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEECCC
GNPVSAALTFYQLVQPLLAKLAGHSDWQLPPRLQARALTPLKKAPGRLDFQRGVFSSNAQ
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHCCCCCCHHHCCCCCCCC
GELEVSSTGHQGSHIFSSFSQGNCFIVLERDRGSVAVGEKVEIEPFNALLRS
CEEEEECCCCCCHHHHHHCCCCCEEEEEECCCCCEEECCEEEECHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]