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The map label for this gene is yeiG [H]

Identifier: 157369799

GI number: 157369799

Start: 1695390

End: 1696232

Strand: Reverse

Name: yeiG [H]

Synonym: Spro_1556

Alternate gene names: 157369799

Gene position: 1696232-1695390 (Counterclockwise)

Preceding gene: 157369800

Following gene: 157369790

Centisome position: 31.13

GC content: 58.84

Gene sequence:

>843_bases
ATGACCTTGTCATTAGAACTTCTCGAAGAGCACCGTATGTTCGGCGGCTGGCAACAGCGTTATCGCCATGCGGCGCAGAG
CCTGAATTGCAACATGACTTTCAGCATCTATCTGCCGCCCCCGCGCGATGATAACCCGCCGCCAGTGCTGTACTGGCTGT
CGGGGCTGACCTGCAATGATGAAAACTTCACGCTGAAGGCCGGCGCGCAGCGTGTCGCCGCCGAGCTGGGGTTGGTGCTG
GTGATGGCCGATACCAGCCCGCGTGGCGACGATGTGCCCAATGATGAAGGCTACGATTTGGGCCAGGGTGCCGGTTTTTA
TTTGAACGCCACCCAGGCGCCGTGGGACAAGCACTTTCGCATGTATGATTACATCAGTGACGAGCTGCCGGCGCTGATTA
ATCAGCATTTCAGCGTCAGCGATCGCCAGTCGATCTTCGGTCACTCAATGGGTGGCCACGGCGCACTGGTAATGGCGTTT
CGCAATCCGCAGCGTTTCCGTTCAGTGTCGGCCTTTGCGCCCATCGTTAACCCCTGTCAGGTTCCATGGGGACGTAAAGC
CTTTGCCACCTATTTGGGCAATGATGAAAGCCAGTGGCTGCAGTATGACAGTTGCCACCTGCTGGCCAACGGCGCGGAAA
AAATGCCGGTGCTGGTGGATCAGGGTGACGACGATCAGTTCCTGGCGGATCAACTGCAACCGGCGAAGCTGGCCGAACTG
GCGCGCCAGCGCGACTGGCCGCTAACCCTGCGCATCCAGCCGGGCTACGACCACAGCTACTTCACCATCGCCAGCTTTAT
CGAAGACCACCTGCGCTTCCACGCCGAACATCTGTTCCGCTGA

Upstream 100 bases:

>100_bases
TGGGGCTGGAGCAGATTAACGAAGCGTTCGATTTGATGCACGAAGGCAAATCCATCCGTTCCGTTATTCACTTCGACAAA
AAATAAGCCAGGAGGCAGAG

Downstream 100 bases:

>100_bases
TCGATAAATCCGGGCGGTTACCCCGCCCGGATTTAATCAGATACCGTCGAGAAGAAAATCTATTGCGGCTTTAACCTCGG
TCCGGTATTGGGTAGCATCG

Product: S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MTLSLELLEEHRMFGGWQQRYRHAAQSLNCNMTFSIYLPPPRDDNPPPVLYWLSGLTCNDENFTLKAGAQRVAAELGLVL
VMADTSPRGDDVPNDEGYDLGQGAGFYLNATQAPWDKHFRMYDYISDELPALINQHFSVSDRQSIFGHSMGGHGALVMAF
RNPQRFRSVSAFAPIVNPCQVPWGRKAFATYLGNDESQWLQYDSCHLLANGAEKMPVLVDQGDDDQFLADQLQPAKLAEL
ARQRDWPLTLRIQPGYDHSYFTIASFIEDHLRFHAEHLFR

Sequences:

>Translated_280_residues
MTLSLELLEEHRMFGGWQQRYRHAAQSLNCNMTFSIYLPPPRDDNPPPVLYWLSGLTCNDENFTLKAGAQRVAAELGLVL
VMADTSPRGDDVPNDEGYDLGQGAGFYLNATQAPWDKHFRMYDYISDELPALINQHFSVSDRQSIFGHSMGGHGALVMAF
RNPQRFRSVSAFAPIVNPCQVPWGRKAFATYLGNDESQWLQYDSCHLLANGAEKMPVLVDQGDDDQFLADQLQPAKLAEL
ARQRDWPLTLRIQPGYDHSYFTIASFIEDHLRFHAEHLFR
>Mature_279_residues
TLSLELLEEHRMFGGWQQRYRHAAQSLNCNMTFSIYLPPPRDDNPPPVLYWLSGLTCNDENFTLKAGAQRVAAELGLVLV
MADTSPRGDDVPNDEGYDLGQGAGFYLNATQAPWDKHFRMYDYISDELPALINQHFSVSDRQSIFGHSMGGHGALVMAFR
NPQRFRSVSAFAPIVNPCQVPWGRKAFATYLGNDESQWLQYDSCHLLANGAEKMPVLVDQGDDDQFLADQLQPAKLAELA
RQRDWPLTLRIQPGYDHSYFTIASFIEDHLRFHAEHLFR

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=280, Percent_Identity=50, Blast_Score=305, Evalue=2e-83,
Organism=Escherichia coli, GI1788477, Length=278, Percent_Identity=73.0215827338129, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1786551, Length=274, Percent_Identity=52.9197080291971, Blast_Score=322, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI17510185, Length=281, Percent_Identity=47.3309608540925, Blast_Score=252, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6322393, Length=299, Percent_Identity=42.4749163879599, Blast_Score=228, Evalue=6e-61,
Organism=Drosophila melanogaster, GI45551932, Length=283, Percent_Identity=46.9964664310954, Blast_Score=261, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24648347, Length=283, Percent_Identity=46.9964664310954, Blast_Score=261, Evalue=5e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31824; Mature: 31693

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSLELLEEHRMFGGWQQRYRHAAQSLNCNMTFSIYLPPPRDDNPPPVLYWLSGLTCND
CEEEHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEECCEEECC
ENFTLKAGAQRVAAELGLVLVMADTSPRGDDVPNDEGYDLGQGAGFYLNATQAPWDKHFR
CCEEEEHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHCC
MYDYISDELPALINQHFSVSDRQSIFGHSMGGHGALVMAFRNPQRFRSVSAFAPIVNPCQ
HHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCC
VPWGRKAFATYLGNDESQWLQYDSCHLLANGAEKMPVLVDQGDDDQFLADQLQPAKLAEL
CCCCHHHHHHHHCCCHHHHEEECCEEEEECCCCCCCEEEECCCCCHHHHHHCCHHHHHHH
ARQRDWPLTLRIQPGYDHSYFTIASFIEDHLRFHAEHLFR
HHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLSLELLEEHRMFGGWQQRYRHAAQSLNCNMTFSIYLPPPRDDNPPPVLYWLSGLTCND
EEEHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEECCEEECC
ENFTLKAGAQRVAAELGLVLVMADTSPRGDDVPNDEGYDLGQGAGFYLNATQAPWDKHFR
CCEEEEHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHCC
MYDYISDELPALINQHFSVSDRQSIFGHSMGGHGALVMAFRNPQRFRSVSAFAPIVNPCQ
HHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCC
VPWGRKAFATYLGNDESQWLQYDSCHLLANGAEKMPVLVDQGDDDQFLADQLQPAKLAEL
CCCCHHHHHHHHCCCHHHHEEECCEEEEECCCCCCCEEEECCCCCHHHHHHCCHHHHHHH
ARQRDWPLTLRIQPGYDHSYFTIASFIEDHLRFHAEHLFR
HHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA