Click here to switch to the map view.

The map label for this gene is nadC [H]

Identifier: 157369024

GI number: 157369024

Start: 868346

End: 869236

Strand: Reverse

Name: nadC [H]

Synonym: Spro_0779

Alternate gene names: 157369024

Gene position: 869236-868346 (Counterclockwise)

Preceding gene: 157369026

Following gene: 157369023

Centisome position: 15.95

GC content: 58.81

Gene sequence:

>891_bases
ATGCCGACACGCCGCTACAGTGCCGACAGTCGCCGCACCGAGCTTCTTGAACGAATTGAAAGCGATATCCCCTATGCCGT
TGCCCAGGCGCTGCGTGAAGACCTGGGTGGTGAAGTCGATGCCGAACGCGATATTACCGCGCAATTATTACCGGCTGACA
CCCAGGCCGAAGCCACCATTATTACCCGCGAGCCCGGCATCTTTTGTGGTAAGCGTTGGCTGAATGAAGTCTTCATTCAA
CTGGGTAACCAGGTGAAAGTGGAATGGCAGGTGGCGGACGGCGACAGCCTGGTCCCAGACCAGCCGCTCTGCAAACTGAC
CGGCCCTGCTCGGGTATTGTTGACCGGTGAGCGCACCGCACTGAATTTTGTCCAGACGCTTTCCGGCGTAGCGACCGAAG
TCAGCCGCTACGTGGCGCTGTTGCAGGGCACGCAAACCCGCCTGCTGGACACCCGCAAAACTCTGCCAGGGCTGCGCACC
GCGCTGAAATATGCCGTGCTGTGCGGCGGCGGCAGTAACCATCGCCTGGGGCTTTCCGATGCCTTCCTGATCAAGGAAAA
CCACATCATTGCCTCCGGTTCGATTAAAAAGGCGGTCGAGAAAGCCTTCTGGCTGCATGCCGACGTACCTGTAGAGGTGG
AGGTCGAATCGCTGGACGAACTGCAGCAGGCGCTGGATGCCGGTGCCGACATCGTCATGCTGGATAATTTCAGCGTCGAG
ATGATGCGTGCCGCCGTGGCGCAAACTCAGGGGCGTGCCCAACTGGAAGTTTCAGGCAACGTGACCAGTGAAACCCTGCG
CACCTTCGCCGAAACCGGCGTGGACTACATCTCTGTTGGCGCCCTGACCAAACACGTGACTGCGCTCGATCTGTCGATGC
GCTTTAAATAA

Upstream 100 bases:

>100_bases
ACCAGATTAGCGGTGCAACCACCGCGCTGCGGTGGTACTTATCATGGCAACAGAGTAGCATGTTCCCCCTACGATATTAC
CGTCCATTTCGGAGTTTTCT

Downstream 100 bases:

>100_bases
ACTCCGTCATCCCTGCCTCCCTGTCCATCGGGGAGGTATTTTCTCGTCAGAATTGCGAAGCTCGCCCCATCTTTTTTCTT
TCCTCTGCAATGCGGATAAA

Product: quinolinate phosphoribosyltransferase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MPTRRYSADSRRTELLERIESDIPYAVAQALREDLGGEVDAERDITAQLLPADTQAEATIITREPGIFCGKRWLNEVFIQ
LGNQVKVEWQVADGDSLVPDQPLCKLTGPARVLLTGERTALNFVQTLSGVATEVSRYVALLQGTQTRLLDTRKTLPGLRT
ALKYAVLCGGGSNHRLGLSDAFLIKENHIIASGSIKKAVEKAFWLHADVPVEVEVESLDELQQALDAGADIVMLDNFSVE
MMRAAVAQTQGRAQLEVSGNVTSETLRTFAETGVDYISVGALTKHVTALDLSMRFK

Sequences:

>Translated_296_residues
MPTRRYSADSRRTELLERIESDIPYAVAQALREDLGGEVDAERDITAQLLPADTQAEATIITREPGIFCGKRWLNEVFIQ
LGNQVKVEWQVADGDSLVPDQPLCKLTGPARVLLTGERTALNFVQTLSGVATEVSRYVALLQGTQTRLLDTRKTLPGLRT
ALKYAVLCGGGSNHRLGLSDAFLIKENHIIASGSIKKAVEKAFWLHADVPVEVEVESLDELQQALDAGADIVMLDNFSVE
MMRAAVAQTQGRAQLEVSGNVTSETLRTFAETGVDYISVGALTKHVTALDLSMRFK
>Mature_295_residues
PTRRYSADSRRTELLERIESDIPYAVAQALREDLGGEVDAERDITAQLLPADTQAEATIITREPGIFCGKRWLNEVFIQL
GNQVKVEWQVADGDSLVPDQPLCKLTGPARVLLTGERTALNFVQTLSGVATEVSRYVALLQGTQTRLLDTRKTLPGLRTA
LKYAVLCGGGSNHRLGLSDAFLIKENHIIASGSIKKAVEKAFWLHADVPVEVEVESLDELQQALDAGADIVMLDNFSVEM
MRAAVAQTQGRAQLEVSGNVTSETLRTFAETGVDYISVGALTKHVTALDLSMRFK

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=275, Percent_Identity=36.7272727272727, Blast_Score=150, Evalue=9e-37,
Organism=Escherichia coli, GI1786299, Length=297, Percent_Identity=73.7373737373737, Blast_Score=428, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321162, Length=254, Percent_Identity=34.251968503937, Blast_Score=144, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32367; Mature: 32236

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTRRYSADSRRTELLERIESDIPYAVAQALREDLGGEVDAERDITAQLLPADTQAEATI
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCEEE
ITREPGIFCGKRWLNEVFIQLGNQVKVEWQVADGDSLVPDQPLCKLTGPARVLLTGERTA
EECCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCEEECCCEEEEEECCHHH
LNFVQTLSGVATEVSRYVALLQGTQTRLLDTRKTLPGLRTALKYAVLCGGGSNHRLGLSD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHEEECCCCCCCCCCCC
AFLIKENHIIASGSIKKAVEKAFWLHADVPVEVEVESLDELQQALDAGADIVMLDNFSVE
EEEEECCCEEECCHHHHHHHHHHHEECCCCEEEEHHHHHHHHHHHHCCCCEEEECCCCHH
MMRAAVAQTQGRAQLEVSGNVTSETLRTFAETGVDYISVGALTKHVTALDLSMRFK
HHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEEEHHHHHHHHEEEEEEEECC
>Mature Secondary Structure 
PTRRYSADSRRTELLERIESDIPYAVAQALREDLGGEVDAERDITAQLLPADTQAEATI
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCEEE
ITREPGIFCGKRWLNEVFIQLGNQVKVEWQVADGDSLVPDQPLCKLTGPARVLLTGERTA
EECCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCEEECCCEEEEEECCHHH
LNFVQTLSGVATEVSRYVALLQGTQTRLLDTRKTLPGLRTALKYAVLCGGGSNHRLGLSD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHEEECCCCCCCCCCCC
AFLIKENHIIASGSIKKAVEKAFWLHADVPVEVEVESLDELQQALDAGADIVMLDNFSVE
EEEEECCCEEECCHHHHHHHHHHHEECCCCEEEEHHHHHHHHHHHHCCCCEEEECCCCHH
MMRAAVAQTQGRAQLEVSGNVTSETLRTFAETGVDYISVGALTKHVTALDLSMRFK
HHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEEEHHHHHHHHEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8419294; 11677609; 9016724 [H]