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The map label for this gene is pdxA

Identifier: 157368970

GI number: 157368970

Start: 801885

End: 802877

Strand: Reverse

Name: pdxA

Synonym: Spro_0725

Alternate gene names: 157368970

Gene position: 802877-801885 (Counterclockwise)

Preceding gene: 157368971

Following gene: 157368969

Centisome position: 14.73

GC content: 58.81

Gene sequence:

>993_bases
ATGCACAACAATAATCGCATCGTAATCACCCCCGGCGAGCCTGCCGGGGTTGGGCCGGATTTGGTGGCAGCGCTGGCGCA
ACAGGATTGGCCTGTTGAACTGGTGGTGTGCGCGGATCCGGCCTTGTTGCTTGAACGCGCCCGGCAGTTAGACCTGCCGC
TGCAACTGCGCACCTATCAGCCACAGCAACCTGCTCAGCCACAGCGCGCGGGTACCTTGACGGTGTTGCCGGTCGCTACC
GCTCATCCGGTAGTAGCGGGTGAGTTGAACGTAGGTAACAGTGCCTACGTGGTAGAAACCTTGGCGCGTGCCTGCGACGG
TTGTCTGAACGGTGAATTCGCCGCGCTGATCACCGGCCCGGTGAACAAGGGCGTCATCAACGACGCCGGCGTGCCGTTCA
TTGGCCATACCGAATTCTTTGCCGATCGCAGCGGTTGCGATCGCGTGGTGATGATGTTGGCGACCGAAGAGCTGCGCGTG
GCGCTGGCGACCACCCACCTGCCCTTACTGGCGGTGCCTGGCGCTATCACCCGGCAAAGCCTGCATGAAGTCATCCGCAT
TCTCGACCACGACCTGAAAACCAAATTTGGCCTCGCCCAACCGCAGATCTACGTCTGTGGCTTGAACCCGCATGCCGGGG
AAGGCGGCCATATGGGACGTGAAGAGATAGATACCATCATCCCGGCGCTCGACGAGCTGCGTGCTGAAGGTATCACTCTG
ATCGGCCCACTGCCGGCAGACACCCTGTTCCAGCCCAAGTATCTGCAACATGCCGATGCGGTGCTGGCGATGTATCACGA
TCAGGGTCTGCCGGTGCTAAAATACCAAGGGTTCGGCCGGGCGGTAAATATTACCCTCGGTTTGCCTTTTATCCGTACCT
CGGTCGACCACGGTACCGCTTTGGAACTGGCCGGCACCGGCACCGCCGATGCAGGCAGTTTTAAAACGGCCTTGAATCTC
GCCATTAAAATGATAATTAATTGTAATGAATAA

Upstream 100 bases:

>100_bases
CGCGCTTACCGCATGCTGTTCAACCGCAAGTTTGCTGAAGAAGCGCAGACCTGGATGCAGGAACAACGTGCTCAGGCTTA
CGTGAAGATCCTTGACGGTA

Downstream 100 bases:

>100_bases
TAAAGTCCACCAAGGGCACTTTGCCCGCAAACGCTTTGGACAGAACTTTTTAACCGATCAGTTTGTCATCGACAGCATTG
TCTCCGCCATTCACCCGATG

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MHNNNRIVITPGEPAGVGPDLVAALAQQDWPVELVVCADPALLLERARQLDLPLQLRTYQPQQPAQPQRAGTLTVLPVAT
AHPVVAGELNVGNSAYVVETLARACDGCLNGEFAALITGPVNKGVINDAGVPFIGHTEFFADRSGCDRVVMMLATEELRV
ALATTHLPLLAVPGAITRQSLHEVIRILDHDLKTKFGLAQPQIYVCGLNPHAGEGGHMGREEIDTIIPALDELRAEGITL
IGPLPADTLFQPKYLQHADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTALELAGTGTADAGSFKTALNL
AIKMIINCNE

Sequences:

>Translated_330_residues
MHNNNRIVITPGEPAGVGPDLVAALAQQDWPVELVVCADPALLLERARQLDLPLQLRTYQPQQPAQPQRAGTLTVLPVAT
AHPVVAGELNVGNSAYVVETLARACDGCLNGEFAALITGPVNKGVINDAGVPFIGHTEFFADRSGCDRVVMMLATEELRV
ALATTHLPLLAVPGAITRQSLHEVIRILDHDLKTKFGLAQPQIYVCGLNPHAGEGGHMGREEIDTIIPALDELRAEGITL
IGPLPADTLFQPKYLQHADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTALELAGTGTADAGSFKTALNL
AIKMIINCNE
>Mature_330_residues
MHNNNRIVITPGEPAGVGPDLVAALAQQDWPVELVVCADPALLLERARQLDLPLQLRTYQPQQPAQPQRAGTLTVLPVAT
AHPVVAGELNVGNSAYVVETLARACDGCLNGEFAALITGPVNKGVINDAGVPFIGHTEFFADRSGCDRVVMMLATEELRV
ALATTHLPLLAVPGAITRQSLHEVIRILDHDLKTKFGLAQPQIYVCGLNPHAGEGGHMGREEIDTIIPALDELRAEGITL
IGPLPADTLFQPKYLQHADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTALELAGTGTADAGSFKTALNL
AIKMIINCNE

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=327, Percent_Identity=77.9816513761468, Blast_Score=511, Evalue=1e-146,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_SERP5 (A8G9P1)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001476959.1
- ProteinModelPortal:   A8G9P1
- SMR:   A8G9P1
- STRING:   A8G9P1
- GeneID:   5605069
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0725
- eggNOG:   COG1995
- HOGENOM:   HBG451136
- OMA:   NPANAAY
- ProtClustDB:   PRK00232
- BioCyc:   SPRO399741:SPRO_0725-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 35205; Mature: 35205

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: BINDING 136-136 BINDING 137-137 BINDING 274-274 BINDING 283-283 BINDING 292-292

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNNNRIVITPGEPAGVGPDLVAALAQQDWPVELVVCADPALLLERARQLDLPLQLRTYQ
CCCCCEEEEECCCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCEEEECCC
PQQPAQPQRAGTLTVLPVATAHPVVAGELNVGNSAYVVETLARACDGCLNGEFAALITGP
CCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECC
VNKGVINDAGVPFIGHTEFFADRSGCDRVVMMLATEELRVALATTHLPLLAVPGAITRQS
CCCCCCCCCCCCEEECHHHHCCCCCHHHEEHHHHHHHHEEEEEECCCCCEECCCHHHHHH
LHEVIRILDHDLKTKFGLAQPQIYVCGLNPHAGEGGHMGREEIDTIIPALDELRAEGITL
HHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEE
IGPLPADTLFQPKYLQHADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTA
EECCCCCCCCCCHHHHHHHHEEEEEECCCCCEEEECCCCCEEEEEECCCHHEECCCCCCE
LELAGTGTADAGSFKTALNLAIKMIINCNE
EEEECCCCCCCCHHHHHHHHHEEEEEECCC
>Mature Secondary Structure
MHNNNRIVITPGEPAGVGPDLVAALAQQDWPVELVVCADPALLLERARQLDLPLQLRTYQ
CCCCCEEEEECCCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCEEEECCC
PQQPAQPQRAGTLTVLPVATAHPVVAGELNVGNSAYVVETLARACDGCLNGEFAALITGP
CCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECC
VNKGVINDAGVPFIGHTEFFADRSGCDRVVMMLATEELRVALATTHLPLLAVPGAITRQS
CCCCCCCCCCCCEEECHHHHCCCCCHHHEEHHHHHHHHEEEEEECCCCCEECCCHHHHHH
LHEVIRILDHDLKTKFGLAQPQIYVCGLNPHAGEGGHMGREEIDTIIPALDELRAEGITL
HHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEE
IGPLPADTLFQPKYLQHADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTA
EECCCCCCCCCCHHHHHHHHEEEEEECCCCCEEEECCCCCEEEEEECCCHHEECCCCCCE
LELAGTGTADAGSFKTALNLAIKMIINCNE
EEEECCCCCCCCHHHHHHHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA