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The map label for this gene is hdaH [H]

Identifier: 157368861

GI number: 157368861

Start: 681963

End: 683075

Strand: Reverse

Name: hdaH [H]

Synonym: Spro_0616

Alternate gene names: 157368861

Gene position: 683075-681963 (Counterclockwise)

Preceding gene: 157368862

Following gene: 157368860

Centisome position: 12.54

GC content: 61.37

Gene sequence:

>1113_bases
GTGAAAAGAAAAACCGGTTTCTTGTTTGATGAACGCTGCTTCTGGCATAGCACCGGCCTGCACGCCACTACGCTACCGGT
CGGCGGCTGGGTGCAACCGCCTTCGGGGGCCGGCCATGCCGAGTCGCCGGAGACCAAACGGCGGATGAAGAACCTGATGG
ATGTGTCCGGCCTGTCGCACCAGCTCTCACTGCTGAGCGCCGAGCTGGCGACCGATGAAGACCTGCTGCGCATTCACCCC
GCCAACTATCTGCAACGTTTCAAACAGTTAAGCGACAACGGCGGCGGCATGCTGGGAGAGGAAGCTCCGCTGGGGCCGGG
CAGTTATGAAATCGCCAAACTGTCCGCCGGGCTGGCCTGCGCCGCCGTCGAGGCGGTACTGCAGGGAGAGCTGGAAAACG
CCTATGCACTGTCGCGCCCACCCGGCCACCACTGCCTGCCGGACCAGTCGATGGGCTTTTGCTTTTTGGCCAATATTCCG
ATCGCCATCGAACGTGCCAAGGCCAAATACGGCCTGGGCAAAGTCGCGGTGCTCGACTGGGACGTGCATCACGGCAATGG
TACCCAGCATATCTACTGGCAGCGGGATGACGTGTTGACGCTGTCGCTGCATCAGGACGGCTGCTTCCCCGCCGGGTACT
CCGGTGAACAAGACCGTGGTGCCGGTGCGGGCGAAGGCTATAACGTCAATATTCCGCTGTTGGCCGGGGCCGGTGACGAC
GGCTATCTGTACGCCATGCGCCAAATCGTCATCCCGGCGCTGAAGCAATTCCAACCGGAACTGATCATTGTCGCCTGCGG
CTACGATGCCAACGCGCTCGATCCGCTGGCGCGCATGCAGTTGCACAGTGACAGTTTCCGCAGCATGACGGCTTTGGTGC
AGGACGCCGCCGATCGTCTGTGCAACGGCAAACTGGTGATGGTACACGAAGGGGGTTACGCCGAATCCTACGTGCCGTTC
TGTGGCCTGGCGGTGATGGAACAGCTCAGCGGCATCCGCACCGAAGTGCAGGATCCGCTGCTGGCCTTTATCCAGCAACA
GCAGCCGCGCGACGCCTTTAATCAGTTCCAGCGTCAGGCTATCGACCGGCTGGCGCAGCAGTTCAAACTGTAA

Upstream 100 bases:

>100_bases
GCACTGCTGGCCGGGGCGCTGGGCTGCTCGCTGCTGTCGTTGCTGTTGATTTTGTTGGCTTCACCGCGCGATCGCCGCGC
CGTTTAACAGGAGTAATAAG

Downstream 100 bases:

>100_bases
TTTCTCTTCGGGGCACAGCACGTTGTGCCCCTTGGCAATTCTGGCTTTGCCGCTACGCTGAATATGACCCTACCGTTGAG
AACAATAATATGTCTGAACA

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: HDAC-like amidohydrolase; HDAH [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MKRKTGFLFDERCFWHSTGLHATTLPVGGWVQPPSGAGHAESPETKRRMKNLMDVSGLSHQLSLLSAELATDEDLLRIHP
ANYLQRFKQLSDNGGGMLGEEAPLGPGSYEIAKLSAGLACAAVEAVLQGELENAYALSRPPGHHCLPDQSMGFCFLANIP
IAIERAKAKYGLGKVAVLDWDVHHGNGTQHIYWQRDDVLTLSLHQDGCFPAGYSGEQDRGAGAGEGYNVNIPLLAGAGDD
GYLYAMRQIVIPALKQFQPELIIVACGYDANALDPLARMQLHSDSFRSMTALVQDAADRLCNGKLVMVHEGGYAESYVPF
CGLAVMEQLSGIRTEVQDPLLAFIQQQQPRDAFNQFQRQAIDRLAQQFKL

Sequences:

>Translated_370_residues
MKRKTGFLFDERCFWHSTGLHATTLPVGGWVQPPSGAGHAESPETKRRMKNLMDVSGLSHQLSLLSAELATDEDLLRIHP
ANYLQRFKQLSDNGGGMLGEEAPLGPGSYEIAKLSAGLACAAVEAVLQGELENAYALSRPPGHHCLPDQSMGFCFLANIP
IAIERAKAKYGLGKVAVLDWDVHHGNGTQHIYWQRDDVLTLSLHQDGCFPAGYSGEQDRGAGAGEGYNVNIPLLAGAGDD
GYLYAMRQIVIPALKQFQPELIIVACGYDANALDPLARMQLHSDSFRSMTALVQDAADRLCNGKLVMVHEGGYAESYVPF
CGLAVMEQLSGIRTEVQDPLLAFIQQQQPRDAFNQFQRQAIDRLAQQFKL
>Mature_370_residues
MKRKTGFLFDERCFWHSTGLHATTLPVGGWVQPPSGAGHAESPETKRRMKNLMDVSGLSHQLSLLSAELATDEDLLRIHP
ANYLQRFKQLSDNGGGMLGEEAPLGPGSYEIAKLSAGLACAAVEAVLQGELENAYALSRPPGHHCLPDQSMGFCFLANIP
IAIERAKAKYGLGKVAVLDWDVHHGNGTQHIYWQRDDVLTLSLHQDGCFPAGYSGEQDRGAGAGEGYNVNIPLLAGAGDD
GYLYAMRQIVIPALKQFQPELIIVACGYDANALDPLARMQLHSDSFRSMTALVQDAADRLCNGKLVMVHEGGYAESYVPF
CGLAVMEQLSGIRTEVQDPLLAFIQQQQPRDAFNQFQRQAIDRLAQQFKL

Specific function: Exhibits significant levels of protein deacetylase activity comparable to those of eukaryotic HDACs in assays both with fluorogenic peptidic substrates and acetate-radiolabeled histones. Accepts proteins with epsilon-acetylated lysine residues and tritiat

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=290, Percent_Identity=34.4827586206897, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI20070354, Length=284, Percent_Identity=34.1549295774648, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI148539870, Length=250, Percent_Identity=35.6, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI169234807, Length=250, Percent_Identity=35.6, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI153085395, Length=246, Percent_Identity=34.1463414634146, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI17158039, Length=246, Percent_Identity=34.1463414634146, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI30795204, Length=246, Percent_Identity=34.1463414634146, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI30795202, Length=246, Percent_Identity=34.1463414634146, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI62750349, Length=250, Percent_Identity=34, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI62750347, Length=250, Percent_Identity=34, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI13128860, Length=353, Percent_Identity=26.0623229461756, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI226529806, Length=284, Percent_Identity=31.3380281690141, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI293336691, Length=256, Percent_Identity=29.296875, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI8923769, Length=252, Percent_Identity=26.1904761904762, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI13128862, Length=356, Percent_Identity=26.4044943820225, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI262073092, Length=224, Percent_Identity=27.2321428571429, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI262073088, Length=182, Percent_Identity=29.1208791208791, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI217272877, Length=278, Percent_Identity=24.8201438848921, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI209862883, Length=297, Percent_Identity=22.8956228956229, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17540334, Length=310, Percent_Identity=32.9032258064516, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI193206283, Length=310, Percent_Identity=32.9032258064516, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17540332, Length=310, Percent_Identity=32.9032258064516, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI193209491, Length=323, Percent_Identity=31.5789473684211, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17508561, Length=319, Percent_Identity=29.7805642633229, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17561978, Length=300, Percent_Identity=30.3333333333333, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25154020, Length=315, Percent_Identity=24.7619047619048, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI25154022, Length=315, Percent_Identity=24.4444444444444, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17537347, Length=239, Percent_Identity=30.1255230125523, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17534739, Length=245, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324307, Length=363, Percent_Identity=30.5785123966942, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6323999, Length=256, Percent_Identity=27.34375, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321244, Length=259, Percent_Identity=26.2548262548263, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325141, Length=239, Percent_Identity=27.1966527196653, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6325325, Length=201, Percent_Identity=27.8606965174129, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281360899, Length=326, Percent_Identity=34.6625766871166, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24642146, Length=326, Percent_Identity=34.6625766871166, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24642142, Length=326, Percent_Identity=34.6625766871166, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24642144, Length=326, Percent_Identity=34.6625766871166, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI281360799, Length=212, Percent_Identity=38.6792452830189, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI281360801, Length=212, Percent_Identity=38.6792452830189, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24641720, Length=212, Percent_Identity=38.6792452830189, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24657891, Length=296, Percent_Identity=30.0675675675676, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24644244, Length=301, Percent_Identity=25.5813953488372, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 40435; Mature: 40435

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKTGFLFDERCFWHSTGLHATTLPVGGWVQPPSGAGHAESPETKRRMKNLMDVSGLSH
CCCCCCCEEECCCEEECCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHH
QLSLLSAELATDEDLLRIHPANYLQRFKQLSDNGGGMLGEEAPLGPGSYEIAKLSAGLAC
HHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCHHH
AAVEAVLQGELENAYALSRPPGHHCLPDQSMGFCFLANIPIAIERAKAKYGLGKVAVLDW
HHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCEEEEECCCEEEEHHHHHCCCCEEEEEEE
DVHHGNGTQHIYWQRDDVLTLSLHQDGCFPAGYSGEQDRGAGAGEGYNVNIPLLAGAGDD
EEECCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCC
GYLYAMRQIVIPALKQFQPELIIVACGYDANALDPLARMQLHSDSFRSMTALVQDAADRL
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHCHHHHHHHCCHHHHHHHHHHHHHHHHH
CNGKLVMVHEGGYAESYVPFCGLAVMEQLSGIRTEVQDPLLAFIQQQQPRDAFNQFQRQA
HCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IDRLAQQFKL
HHHHHHHHCC
>Mature Secondary Structure
MKRKTGFLFDERCFWHSTGLHATTLPVGGWVQPPSGAGHAESPETKRRMKNLMDVSGLSH
CCCCCCCEEECCCEEECCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHH
QLSLLSAELATDEDLLRIHPANYLQRFKQLSDNGGGMLGEEAPLGPGSYEIAKLSAGLAC
HHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCHHH
AAVEAVLQGELENAYALSRPPGHHCLPDQSMGFCFLANIPIAIERAKAKYGLGKVAVLDW
HHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCEEEEECCCEEEEHHHHHCCCCEEEEEEE
DVHHGNGTQHIYWQRDDVLTLSLHQDGCFPAGYSGEQDRGAGAGEGYNVNIPLLAGAGDD
EEECCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCC
GYLYAMRQIVIPALKQFQPELIIVACGYDANALDPLARMQLHSDSFRSMTALVQDAADRL
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHCHHHHHHHCCHHHHHHHHHHHHHHHHH
CNGKLVMVHEGGYAESYVPFCGLAVMEQLSGIRTEVQDPLLAFIQQQQPRDAFNQFQRQA
HCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IDRLAQQFKL
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA