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The map label for this gene is ytpA [H]

Identifier: 157368860

GI number: 157368860

Start: 681067

End: 681873

Strand: Reverse

Name: ytpA [H]

Synonym: Spro_0615

Alternate gene names: 157368860

Gene position: 681873-681067 (Counterclockwise)

Preceding gene: 157368861

Following gene: 157368856

Centisome position: 12.51

GC content: 57.62

Gene sequence:

>807_bases
ATGTCTGAACAAAAAATAAGCTTTATCAAAGGCAGCCAGGGCGATATCGCCGTGCATGACTGGGGCCATGATCAGCCGCG
CTTTCTGGCGCTATTGGTACACGGGTACGGCGAACATCTTGGCCGCTATCAGTACGTGGCGCGCACGTTAGAGGCGCAGG
GCGCACGGGTATTCGGCCCCGACCACCTTGGCCATGGGTTGTCGCAGGGCGAACGCGTATTGATTGAGGATTATGATGCT
GTAGTCGACGACGTTCACCGCGTAGTTGAGCATTTTAAGGCTTTGCACCCTGATCTGCCGCTGGTGGTCATCGGCCATTC
CATGGGCGGCATGATTGCCACCCGTTACGTTCAACGTTATGGCGATAACCTGCGTGCGCTGGTGCTGTCCGGCCCGTTGA
TCGGCGAAAGAACCCAGATCTCCGATCTGCTTGAATTGCCGAAGATCCCCGACGAGCCGCTCGATACCGCCACCCTGTCG
CGCGATCCGGCGGTCGGCATTGCCTATCAGGCCGATCCGCTGGTATGGCATGGGCCATTCAAACGCCCCACGTTGCACGC
CATGCAGCAGATGCTGGCCAAAATCAACGCTGGAGCGGGCTTCGGCACACTGCCCACGCTGTGGATACACGGCGATGACG
ACCGGCTGGTGCTAATGGCGCAATCGCAAACCGCCATCAACCTGCTGAAGGGCAACGATTTTGAAGTCATGATCAACCCG
GGCGGGCGGCATGAAAGCTTTAACGAGACTAACAAGGATCAGATATTAAGGCGGATCGGCGATTTTATTGAGCGGGTGCT
GGGGTAG

Upstream 100 bases:

>100_bases
TCAAACTGTAATTTCTCTTCGGGGCACAGCACGTTGTGCCCCTTGGCAATTCTGGCTTTGCCGCTACGCTGAATATGACC
CTACCGTTGAGAACAATAAT

Downstream 100 bases:

>100_bases
CGGATCCCCTCTCCAACGAAGAGGGGAAAGTTCGAGATTAGCCTTCGACAATCGCCAGATAGTGTTTCACAAAGCGATCG
GAGGTGATCTCCCAGCGCAC

Product: alpha/beta hydrolase fold domain-containing protein

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MSEQKISFIKGSQGDIAVHDWGHDQPRFLALLVHGYGEHLGRYQYVARTLEAQGARVFGPDHLGHGLSQGERVLIEDYDA
VVDDVHRVVEHFKALHPDLPLVVIGHSMGGMIATRYVQRYGDNLRALVLSGPLIGERTQISDLLELPKIPDEPLDTATLS
RDPAVGIAYQADPLVWHGPFKRPTLHAMQQMLAKINAGAGFGTLPTLWIHGDDDRLVLMAQSQTAINLLKGNDFEVMINP
GGRHESFNETNKDQILRRIGDFIERVLG

Sequences:

>Translated_268_residues
MSEQKISFIKGSQGDIAVHDWGHDQPRFLALLVHGYGEHLGRYQYVARTLEAQGARVFGPDHLGHGLSQGERVLIEDYDA
VVDDVHRVVEHFKALHPDLPLVVIGHSMGGMIATRYVQRYGDNLRALVLSGPLIGERTQISDLLELPKIPDEPLDTATLS
RDPAVGIAYQADPLVWHGPFKRPTLHAMQQMLAKINAGAGFGTLPTLWIHGDDDRLVLMAQSQTAINLLKGNDFEVMINP
GGRHESFNETNKDQILRRIGDFIERVLG
>Mature_267_residues
SEQKISFIKGSQGDIAVHDWGHDQPRFLALLVHGYGEHLGRYQYVARTLEAQGARVFGPDHLGHGLSQGERVLIEDYDAV
VDDVHRVVEHFKALHPDLPLVVIGHSMGGMIATRYVQRYGDNLRALVLSGPLIGERTQISDLLELPKIPDEPLDTATLSR
DPAVGIAYQADPLVWHGPFKRPTLHAMQQMLAKINAGAGFGTLPTLWIHGDDDRLVLMAQSQTAINLLKGNDFEVMINPG
GRHESFNETNKDQILRRIGDFIERVLG

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI51242953, Length=229, Percent_Identity=30.1310043668122, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI6005786, Length=229, Percent_Identity=30.1310043668122, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 29755; Mature: 29624

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQKISFIKGSQGDIAVHDWGHDQPRFLALLVHGYGEHLGRYQYVARTLEAQGARVFGP
CCCCCCEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
DHLGHGLSQGERVLIEDYDAVVDDVHRVVEHFKALHPDLPLVVIGHSMGGMIATRYVQRY
HHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHH
GDNLRALVLSGPLIGERTQISDLLELPKIPDEPLDTATLSRDPAVGIAYQADPLVWHGPF
CCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCHHCCCCCCEEEEEECCCEEEECCC
KRPTLHAMQQMLAKINAGAGFGTLPTLWIHGDDDRLVLMAQSQTAINLLKGNDFEVMINP
CCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEECCCCEEEEEECCCEEEEECC
GGRHESFNETNKDQILRRIGDFIERVLG
CCCCCCCCCCCHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SEQKISFIKGSQGDIAVHDWGHDQPRFLALLVHGYGEHLGRYQYVARTLEAQGARVFGP
CCCCCEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
DHLGHGLSQGERVLIEDYDAVVDDVHRVVEHFKALHPDLPLVVIGHSMGGMIATRYVQRY
HHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHH
GDNLRALVLSGPLIGERTQISDLLELPKIPDEPLDTATLSRDPAVGIAYQADPLVWHGPF
CCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCHHCCCCCCEEEEEECCCEEEECCC
KRPTLHAMQQMLAKINAGAGFGTLPTLWIHGDDDRLVLMAQSQTAINLLKGNDFEVMINP
CCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEECCCCEEEEEECCCEEEEECC
GGRHESFNETNKDQILRRIGDFIERVLG
CCCCCCCCCCCHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]