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The map label for this gene is rnr [H]

Identifier: 157368685

GI number: 157368685

Start: 489571

End: 492057

Strand: Direct

Name: rnr [H]

Synonym: Spro_0438

Alternate gene names: 157368685

Gene position: 489571-492057 (Clockwise)

Preceding gene: 157368684

Following gene: 157368686

Centisome position: 8.98

GC content: 57.14

Gene sequence:

>2487_bases
ATGTCACAAGATCCATTCCTGGAACGAGAAGCAGAAAAATATGAATCCCCAATCCCGAGCCGTGAATTCATTCTGGCCCA
TCTGGCGAAAAGAGAAACGCCGGCCAGCCGCGAAGAGCTGGCCAAAGAGCTGAATTTAACCGGTGAAGAGCCGTTAGAAG
CGTTGCGTCGCCGTTTGCGTGCGATGGAACGTGACGGTCAGTTAATATTTACCCGCCGTCAGTGCTATGCGCTGCCGGAA
CGTCTCGATCTGCTGCGCGGTACCGTTATCGGCCACCGTGATGGCTTTGGTTTCCTGCGTATTGAAGGCAGCAAAGACGA
CCTGTATCTGTCAGCTGAGCAGATGAAAATGGCAATCCACGGTGATGTGGTGCTGGCACAGGCAATGGCTGCAGATCGCA
AGGGCCGCCGTGAAGCGCGTATCGTCCGTGTGCTGGTGCCGAAAACCAGCCAAATCGTCGGTCGCTTCTTTATGGATGCC
GGTACCGGCTTTGTGGTGCCGGATGATAGCCGCCTGAGCTTTGATATCCTGATCCCGGCCGAAGCAGCCAGTGGCGCACG
CATGGGCTTTATGGTGGTGGTTGAGCTGACCCAACGTCCGACCAGCCGCACCAAGGCGGTGGGCAAGATCGTTGAGATCC
TCGGCGATAAAATGGGCACCAGCATGGCGGTGGATATCGCTCTGCGCACCCATGAGATCCCGCATGTTTGGCCGCCACAG
GTGGAAAAACAGGTCGCCGATCTCAGTGAACAGGTACCTGAAGCCGCCAAGAAAGGCCGTGTCGATCTGCGTCAGTTACC
TTTGGTGACCATTGACGGCGAAGACGCACGCGATTTCGATGACGCGGTTTACTGCGAGAAAAAACGTGGCGGCGGTTGGC
GCCTGTGGGTAGCCATTGCCGACGTCAGCTACTACGTGCGTCCGCGCACCGCGCTGGATGATGAAGCGCGCAACCGTGCT
ACCTCGGTGTACTTCCCATCGGAAGTCATCCCGATGCTGCCGGAAGTGCTGTCCAACGGCCTGTGTTCGCTTAACCCGCA
GGTTGACCGCCTGTGTATGGTGTGCGAGATGACCATCTCCGCCCAGGGGCGCCTGTCGACGGCCAAATTCTATGAAGCGG
TAATGAGCTCTCATGCCCGTTTAACCTACAACAAAGTCTGGCACATCTTGCAGGGCGATCAGGAGCTGCGTGAGCATTAT
CACCCGCTGGTTAAGCACCTGGAAGAACTGCACACAATGTACAAGGTGTTGGATCAGGCGCGCGCCGAACGTGGCGGTAT
TGCTTTCGAAACCGAAGAAGCCAAGTTTATCTTCAACGCCGAACGTCGTATTGAACGTGTTGAGCCAACGGTGCGTAACG
ACGCCCACAAACTGATCGAAGAGTGCATGATCATGGCGAACGTTGCCGCGGCGCGCTTCGTTGAGAAGAATAACGAGCCG
GCGCTGTTCCGCGTACATGACCGTCCAAGCGACGATCACATTACCGCCTTGCGCAGCGTGCTGGGCGAACTGGGTCTGAC
GCTGGGCGGCGGGAACAAGCCGCAGCCGAAGGACTACGCCACCTTGATGGATGAAGTGTCCGAACGTCCTGACCATGAAA
TGCTGCAAACCATGCTGCTGCGTTCCATGAAGCAGGCGGTCTACGATCCGGAAAACCGGGGCCACTTTGGTCTGGCGCTG
GCTTCTTATGGCCACTTCACCTCGCCGATCCGTCGTTATCCGGATCTGGCGATGCACCGCGCAATCAAATACCAGCTGGC
TAAAGAGCACGGCGAGCCGAAAGAGCGCTGGACGCCGACCGGTGGCTGGCACAGCGAGTTTGAAGAAATGCTGCAGCTGG
GCGAGCACTGTTCGATGGCCGAGCGCCGCGCTGATGAAGCGACGCGTAACGTTGCCGACTGGCTGAAATGCGACTTTATG
CAGGATCACGTTGGCGAAGTGTTCAGCGGTATTATTGCCAGCGTGACCGGCTTTGGTTTCTTCGTCCGTCTGAACGATCT
GTTTATCGACGGTCTGGTGCACGTATCATCGCTGGATAATGACTATTATCGCTACGATAATATCGGCCAGCGTCTGATTG
GCGAATCCTCCGGCGTGGTTTATCGCCTGGGCGATACGGTAGAGATCCGCGTTGAAGCGGTGCATATGGACGAGCGTAAA
ATTGACTTCGCTTTGGTCTCCAGCACTCGCAAGCCGCGTGGTGAAGGCAAAACCGAACGCGATCGCGCCAAAAATGGTGG
CCAACGCACCCTGCGTGGCGGGGCTGGCGCAGGCCGCACTTCCGCTCCGCGTAAACGTCGCGGCGGCAAACCGCCCGCCA
ATTTTGAGCCTGACAGCGCCTTCCGTAAAGACGAAGCCAAACCCGCTGACAAGGTGAAGAAAGACAAAAAGGCGAAAGCC
AAGAAAGTGTCCGACAAAACCCGGAAAATAGCGTCGGCGACCAAGGCCAAACGCGCCGGCAAGAAGAAAGGTGCTGAGCA
GGCTTAA

Upstream 100 bases:

>100_bases
AAGACAATCCATCGCTCTACAAGCTATTGCTTGTCGAATAAAGCGTCGCTGAGAAGACAAGGCTCAGCGGCACCCTGCTG
ATGACAACGGAGGAACCGCA

Downstream 100 bases:

>100_bases
GCTGCCACACGTCATTATCACCGGCTGGCATACGCCAGCCGCACAGTTAAAAGAGCATCATGAGCGAAATTATTTACGGT
ATTCATGCCGTCAAGGCCCT

Product: exoribonuclease R

Products: NA

Alternate protein names: RNase R; Protein vacB [H]

Number of amino acids: Translated: 828; Mature: 827

Protein sequence:

>828_residues
MSQDPFLEREAEKYESPIPSREFILAHLAKRETPASREELAKELNLTGEEPLEALRRRLRAMERDGQLIFTRRQCYALPE
RLDLLRGTVIGHRDGFGFLRIEGSKDDLYLSAEQMKMAIHGDVVLAQAMAADRKGRREARIVRVLVPKTSQIVGRFFMDA
GTGFVVPDDSRLSFDILIPAEAASGARMGFMVVVELTQRPTSRTKAVGKIVEILGDKMGTSMAVDIALRTHEIPHVWPPQ
VEKQVADLSEQVPEAAKKGRVDLRQLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIADVSYYVRPRTALDDEARNRA
TSVYFPSEVIPMLPEVLSNGLCSLNPQVDRLCMVCEMTISAQGRLSTAKFYEAVMSSHARLTYNKVWHILQGDQELREHY
HPLVKHLEELHTMYKVLDQARAERGGIAFETEEAKFIFNAERRIERVEPTVRNDAHKLIEECMIMANVAAARFVEKNNEP
ALFRVHDRPSDDHITALRSVLGELGLTLGGGNKPQPKDYATLMDEVSERPDHEMLQTMLLRSMKQAVYDPENRGHFGLAL
ASYGHFTSPIRRYPDLAMHRAIKYQLAKEHGEPKERWTPTGGWHSEFEEMLQLGEHCSMAERRADEATRNVADWLKCDFM
QDHVGEVFSGIIASVTGFGFFVRLNDLFIDGLVHVSSLDNDYYRYDNIGQRLIGESSGVVYRLGDTVEIRVEAVHMDERK
IDFALVSSTRKPRGEGKTERDRAKNGGQRTLRGGAGAGRTSAPRKRRGGKPPANFEPDSAFRKDEAKPADKVKKDKKAKA
KKVSDKTRKIASATKAKRAGKKKGAEQA

Sequences:

>Translated_828_residues
MSQDPFLEREAEKYESPIPSREFILAHLAKRETPASREELAKELNLTGEEPLEALRRRLRAMERDGQLIFTRRQCYALPE
RLDLLRGTVIGHRDGFGFLRIEGSKDDLYLSAEQMKMAIHGDVVLAQAMAADRKGRREARIVRVLVPKTSQIVGRFFMDA
GTGFVVPDDSRLSFDILIPAEAASGARMGFMVVVELTQRPTSRTKAVGKIVEILGDKMGTSMAVDIALRTHEIPHVWPPQ
VEKQVADLSEQVPEAAKKGRVDLRQLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIADVSYYVRPRTALDDEARNRA
TSVYFPSEVIPMLPEVLSNGLCSLNPQVDRLCMVCEMTISAQGRLSTAKFYEAVMSSHARLTYNKVWHILQGDQELREHY
HPLVKHLEELHTMYKVLDQARAERGGIAFETEEAKFIFNAERRIERVEPTVRNDAHKLIEECMIMANVAAARFVEKNNEP
ALFRVHDRPSDDHITALRSVLGELGLTLGGGNKPQPKDYATLMDEVSERPDHEMLQTMLLRSMKQAVYDPENRGHFGLAL
ASYGHFTSPIRRYPDLAMHRAIKYQLAKEHGEPKERWTPTGGWHSEFEEMLQLGEHCSMAERRADEATRNVADWLKCDFM
QDHVGEVFSGIIASVTGFGFFVRLNDLFIDGLVHVSSLDNDYYRYDNIGQRLIGESSGVVYRLGDTVEIRVEAVHMDERK
IDFALVSSTRKPRGEGKTERDRAKNGGQRTLRGGAGAGRTSAPRKRRGGKPPANFEPDSAFRKDEAKPADKVKKDKKAKA
KKVSDKTRKIASATKAKRAGKKKGAEQA
>Mature_827_residues
SQDPFLEREAEKYESPIPSREFILAHLAKRETPASREELAKELNLTGEEPLEALRRRLRAMERDGQLIFTRRQCYALPER
LDLLRGTVIGHRDGFGFLRIEGSKDDLYLSAEQMKMAIHGDVVLAQAMAADRKGRREARIVRVLVPKTSQIVGRFFMDAG
TGFVVPDDSRLSFDILIPAEAASGARMGFMVVVELTQRPTSRTKAVGKIVEILGDKMGTSMAVDIALRTHEIPHVWPPQV
EKQVADLSEQVPEAAKKGRVDLRQLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIADVSYYVRPRTALDDEARNRAT
SVYFPSEVIPMLPEVLSNGLCSLNPQVDRLCMVCEMTISAQGRLSTAKFYEAVMSSHARLTYNKVWHILQGDQELREHYH
PLVKHLEELHTMYKVLDQARAERGGIAFETEEAKFIFNAERRIERVEPTVRNDAHKLIEECMIMANVAAARFVEKNNEPA
LFRVHDRPSDDHITALRSVLGELGLTLGGGNKPQPKDYATLMDEVSERPDHEMLQTMLLRSMKQAVYDPENRGHFGLALA
SYGHFTSPIRRYPDLAMHRAIKYQLAKEHGEPKERWTPTGGWHSEFEEMLQLGEHCSMAERRADEATRNVADWLKCDFMQ
DHVGEVFSGIIASVTGFGFFVRLNDLFIDGLVHVSSLDNDYYRYDNIGQRLIGESSGVVYRLGDTVEIRVEAVHMDERKI
DFALVSSTRKPRGEGKTERDRAKNGGQRTLRGGAGAGRTSAPRKRRGGKPPANFEPDSAFRKDEAKPADKVKKDKKAKAK
KVSDKTRKIASATKAKRAGKKKGAEQA

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs. Required for the expression of virulence genes in enteroinvasive strains of E.coli [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=566, Percent_Identity=27.5618374558304, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI190014625, Length=566, Percent_Identity=27.5618374558304, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI134288890, Length=409, Percent_Identity=30.3178484107579, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI219521928, Length=741, Percent_Identity=24.8313090418354, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI19115966, Length=741, Percent_Identity=24.8313090418354, Blast_Score=142, Evalue=2e-33,
Organism=Escherichia coli, GI87082383, Length=782, Percent_Identity=78.5166240409207, Blast_Score=1268, Evalue=0.0,
Organism=Escherichia coli, GI1787542, Length=652, Percent_Identity=26.840490797546, Blast_Score=171, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI212645896, Length=414, Percent_Identity=30.4347826086957, Blast_Score=172, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17553506, Length=528, Percent_Identity=26.5151515151515, Blast_Score=157, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324552, Length=515, Percent_Identity=27.378640776699, Blast_Score=148, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6323943, Length=366, Percent_Identity=24.8633879781421, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24649634, Length=474, Percent_Identity=27.6371308016878, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI19922976, Length=379, Percent_Identity=29.287598944591, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24654597, Length=379, Percent_Identity=29.287598944591, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24654592, Length=379, Percent_Identity=29.287598944591, Blast_Score=140, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 93332; Mature: 93200

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQDPFLEREAEKYESPIPSREFILAHLAKRETPASREELAKELNLTGEEPLEALRRRLR
CCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
AMERDGQLIFTRRQCYALPERLDLLRGTVIGHRDGFGFLRIEGSKDDLYLSAEQMKMAIH
HHHCCCCEEEEHHHHHHCHHHHHHHHHHHEECCCCCEEEEEECCCCCEEEEHHHHHHHHH
GDVVLAQAMAADRKGRREARIVRVLVPKTSQIVGRFFMDAGTGFVVPDDSRLSFDILIPA
HHHHHHHHHHHHHCCCCHHEEEEEECCCHHHHHHHHHHHCCCCEEECCCCCEEEEEEEEC
EAASGARMGFMVVVELTQRPTSRTKAVGKIVEILGDKMGTSMAVDIALRTHEIPHVWPPQ
CCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHH
VEKQVADLSEQVPEAAKKGRVDLRQLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIA
HHHHHHHHHHHHHHHHHCCCCCHHHCCEEEECCCCCCCCCHHHEEECCCCCCEEEEEEEE
DVSYYVRPRTALDDEARNRATSVYFPSEVIPMLPEVLSNGLCSLNPQVDRLCMVCEMTIS
CCEEEECCCCCCCHHHHCCEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC
AQGRLSTAKFYEAVMSSHARLTYNKVWHILQGDQELREHYHPLVKHLEELHTMYKVLDQA
CCCCCHHHHHHHHHHHCCCCEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAERGGIAFETEEAKFIFNAERRIERVEPTVRNDAHKLIEECMIMANVAAARFVEKNNEP
HHHHCCCEEECCCCEEEECHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ALFRVHDRPSDDHITALRSVLGELGLTLGGGNKPQPKDYATLMDEVSERPDHEMLQTMLL
CEEEECCCCCCHHHHHHHHHHHHHCEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
RSMKQAVYDPENRGHFGLALASYGHFTSPIRRYPDLAMHRAIKYQLAKEHGEPKERWTPT
HHHHHHHCCCCCCCCEEEEEHHCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHCCCC
GGWHSEFEEMLQLGEHCSMAERRADEATRNVADWLKCDFMQDHVGEVFSGIIASVTGFGF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEE
FVRLNDLFIDGLVHVSSLDNDYYRYDNIGQRLIGESSGVVYRLGDTVEIRVEAVHMDERK
EEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCEEEEEEEEEECCCHH
IDFALVSSTRKPRGEGKTERDRAKNGGQRTLRGGAGAGRTSAPRKRRGGKPPANFEPDSA
HHHHHHHCCCCCCCCCCCHHHHHCCCCCCEECCCCCCCCCCCCHHHCCCCCCCCCCCCCH
FRKDEAKPADKVKKDKKAKAKKVSDKTRKIASATKAKRAGKKKGAEQA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SQDPFLEREAEKYESPIPSREFILAHLAKRETPASREELAKELNLTGEEPLEALRRRLR
CCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
AMERDGQLIFTRRQCYALPERLDLLRGTVIGHRDGFGFLRIEGSKDDLYLSAEQMKMAIH
HHHCCCCEEEEHHHHHHCHHHHHHHHHHHEECCCCCEEEEEECCCCCEEEEHHHHHHHHH
GDVVLAQAMAADRKGRREARIVRVLVPKTSQIVGRFFMDAGTGFVVPDDSRLSFDILIPA
HHHHHHHHHHHHHCCCCHHEEEEEECCCHHHHHHHHHHHCCCCEEECCCCCEEEEEEEEC
EAASGARMGFMVVVELTQRPTSRTKAVGKIVEILGDKMGTSMAVDIALRTHEIPHVWPPQ
CCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHH
VEKQVADLSEQVPEAAKKGRVDLRQLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIA
HHHHHHHHHHHHHHHHHCCCCCHHHCCEEEECCCCCCCCCHHHEEECCCCCCEEEEEEEE
DVSYYVRPRTALDDEARNRATSVYFPSEVIPMLPEVLSNGLCSLNPQVDRLCMVCEMTIS
CCEEEECCCCCCCHHHHCCEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC
AQGRLSTAKFYEAVMSSHARLTYNKVWHILQGDQELREHYHPLVKHLEELHTMYKVLDQA
CCCCCHHHHHHHHHHHCCCCEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAERGGIAFETEEAKFIFNAERRIERVEPTVRNDAHKLIEECMIMANVAAARFVEKNNEP
HHHHCCCEEECCCCEEEECHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ALFRVHDRPSDDHITALRSVLGELGLTLGGGNKPQPKDYATLMDEVSERPDHEMLQTMLL
CEEEECCCCCCHHHHHHHHHHHHHCEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
RSMKQAVYDPENRGHFGLALASYGHFTSPIRRYPDLAMHRAIKYQLAKEHGEPKERWTPT
HHHHHHHCCCCCCCCEEEEEHHCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHCCCC
GGWHSEFEEMLQLGEHCSMAERRADEATRNVADWLKCDFMQDHVGEVFSGIIASVTGFGF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEE
FVRLNDLFIDGLVHVSSLDNDYYRYDNIGQRLIGESSGVVYRLGDTVEIRVEAVHMDERK
EEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCEEEEEEEEEECCCHH
IDFALVSSTRKPRGEGKTERDRAKNGGQRTLRGGAGAGRTSAPRKRRGGKPPANFEPDSA
HHHHHHHCCCCCCCCCCCHHHHHCCCCCCEECCCCCCCCCCCCHHHCCCCCCCCCCCCCH
FRKDEAKPADKVKKDKKAKAKKVSDKTRKIASATKAKRAGKKKGAEQA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 3058695; 1400189; 9603904 [H]