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The map label for this gene is frlA [H]

Identifier: 157162846

GI number: 157162846

Start: 3544204

End: 3545592

Strand: Direct

Name: frlA [H]

Synonym: EcHS_A3566

Alternate gene names: 157162846

Gene position: 3544204-3545592 (Clockwise)

Preceding gene: 157162845

Following gene: 157162847

Centisome position: 76.33

GC content: 54.21

Gene sequence:

>1389_bases
ATGACTGCAAACTCTCCCCTACAACGTATTGGACAAGAAAAAGGTATCGCTATGGGAAGCCAGGAACTCCAACGCAAGCT
CGGATTTTGGGCCGTTCTTGCAATCGCCGTCGGGACAACCGTCGGCTCCGGTATTTTTGTATCTGTGGGTGAAGTGGCAA
AAGCAGCGGGCACGCCGTGGCTTACGGTGCTCGCGTTTGTCATTGGCGGGTTAATTGTGATCCCGCAAATGTGCGTCTAT
GCGGAACTATCCACCGCTTATCCGGAAAATGGCGCAGATTATGTTTATCTGAAAAATGCCGGAAGCCGACCGCTGGCTTT
CCTCTCCGGCTGGGCCAGCTTCTGGGCCAACGATGCGCCGTCATTGTCGATTATGGCGCTGGCGATTGTCAGCAATCTTG
GCTTTTTAACGCCTATCGATCCGTTGCTCGGTAAATTTATCGCCGCCGGATTAATTATCGCCTTTATGTTGCTACACCTG
CGCTCCGTTGAAGGCGGCGCAGCGTTTCAGACGCTAATTACCATCGCCAAAATTATCCCGTTCACTATCGTCATTGGCCT
TGGGATCTTCTGGTTTAAAGCGGAGAATTTTGCCGCCCCTACCACCACTGCGATTGGCGCAACGGGCAGCTTTATGGCGC
TGCTGGCGGGGATCTCTGCCACCAGTTGGTCGTATACCGGCATGGCCTCTATCTGTTATATGACCGGCGAAATTAAAAAC
CCCGGAAAAACCATGCCACGAGCGCTGATTGGTTCCTGTCTGCTGGTTCTGGTGCTCTACACCCTGCTGGCGCTGGTGAT
TTCCGGCCTGATGCCCTTCGACAAACTCGCCAATTCTGAAACGCCGATTTCCGACGCCCTGACCTGGATCCCCGCACTCG
GCAGCACCGCTGGGATCTTTGTTGCCATCACGGCGATGATCGTCATTCTTGGTTCGCTTTCCAGCTGCGTGATGTACCAG
CCGCGGCTGGAATACGCGATGGCGAAAGACAACCTGTTCTTTAAATGCTTCGGCCATGTGCATCCGAAATACAACACGCC
GGATGTCTCCATCATCCTGCAAGGGGCGCTGGGGATCTTCTTCATCTTCGTTTCCGATCTCACCAGCCTGCTGGGTTATT
TCACCCTGGTGATGTGTTTCAAAAATACCCTCACCTTCGGCTCCATCATCTGGTGTCGTAAACGCGACGATTACAAACCG
CTGTGGCGTACTCCGGCTTTCGGGCTGATGACCACCCTCGCCATTGCGTCAAGCCTCATTCTGGTCGCCTCAACCTTTGT
CTGGGCACCGATTCCCGGCCTTATCTGCGCCGTCATCGTTATTGCTACTGGTCTGCCTGCTTACGCCTTCTGGGCGAAGC
GTAGCCGCCAGCTCAACGCTTTGTCGTAA

Upstream 100 bases:

>100_bases
AGCCACAGCGCGATCCTGTGCGAAATTTTGTGATCTTCCTCCACATTACATAACATCATATGTTGTTATATTCATCATGC
ATTGTCATGTTACCTTTTAA

Downstream 100 bases:

>100_bases
TGTTATCTGGAGAAAATAAAATGTTGGATATTGATAAAAGCACCGTGGACTTTCTGGTCACCGAAAATATGGTTCAGGAA
GTGGAAAAAGTTCTCAGCCA

Product: putative fructoselysine transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MTANSPLQRIGQEKGIAMGSQELQRKLGFWAVLAIAVGTTVGSGIFVSVGEVAKAAGTPWLTVLAFVIGGLIVIPQMCVY
AELSTAYPENGADYVYLKNAGSRPLAFLSGWASFWANDAPSLSIMALAIVSNLGFLTPIDPLLGKFIAAGLIIAFMLLHL
RSVEGGAAFQTLITIAKIIPFTIVIGLGIFWFKAENFAAPTTTAIGATGSFMALLAGISATSWSYTGMASICYMTGEIKN
PGKTMPRALIGSCLLVLVLYTLLALVISGLMPFDKLANSETPISDALTWIPALGSTAGIFVAITAMIVILGSLSSCVMYQ
PRLEYAMAKDNLFFKCFGHVHPKYNTPDVSIILQGALGIFFIFVSDLTSLLGYFTLVMCFKNTLTFGSIIWCRKRDDYKP
LWRTPAFGLMTTLAIASSLILVASTFVWAPIPGLICAVIVIATGLPAYAFWAKRSRQLNALS

Sequences:

>Translated_462_residues
MTANSPLQRIGQEKGIAMGSQELQRKLGFWAVLAIAVGTTVGSGIFVSVGEVAKAAGTPWLTVLAFVIGGLIVIPQMCVY
AELSTAYPENGADYVYLKNAGSRPLAFLSGWASFWANDAPSLSIMALAIVSNLGFLTPIDPLLGKFIAAGLIIAFMLLHL
RSVEGGAAFQTLITIAKIIPFTIVIGLGIFWFKAENFAAPTTTAIGATGSFMALLAGISATSWSYTGMASICYMTGEIKN
PGKTMPRALIGSCLLVLVLYTLLALVISGLMPFDKLANSETPISDALTWIPALGSTAGIFVAITAMIVILGSLSSCVMYQ
PRLEYAMAKDNLFFKCFGHVHPKYNTPDVSIILQGALGIFFIFVSDLTSLLGYFTLVMCFKNTLTFGSIIWCRKRDDYKP
LWRTPAFGLMTTLAIASSLILVASTFVWAPIPGLICAVIVIATGLPAYAFWAKRSRQLNALS
>Mature_461_residues
TANSPLQRIGQEKGIAMGSQELQRKLGFWAVLAIAVGTTVGSGIFVSVGEVAKAAGTPWLTVLAFVIGGLIVIPQMCVYA
ELSTAYPENGADYVYLKNAGSRPLAFLSGWASFWANDAPSLSIMALAIVSNLGFLTPIDPLLGKFIAAGLIIAFMLLHLR
SVEGGAAFQTLITIAKIIPFTIVIGLGIFWFKAENFAAPTTTAIGATGSFMALLAGISATSWSYTGMASICYMTGEIKNP
GKTMPRALIGSCLLVLVLYTLLALVISGLMPFDKLANSETPISDALTWIPALGSTAGIFVAITAMIVILGSLSSCVMYQP
RLEYAMAKDNLFFKCFGHVHPKYNTPDVSIILQGALGIFFIFVSDLTSLLGYFTLVMCFKNTLTFGSIIWCRKRDDYKPL
WRTPAFGLMTTLAIASSLILVASTFVWAPIPGLICAVIVIATGLPAYAFWAKRSRQLNALS

Specific function: May be involved in fructoselysine transport [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI187423910, Length=454, Percent_Identity=26.6519823788546, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI7657591, Length=454, Percent_Identity=26.6519823788546, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI115648063, Length=407, Percent_Identity=22.6044226044226, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI115648022, Length=407, Percent_Identity=22.6044226044226, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI71979932, Length=479, Percent_Identity=25.8872651356994, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI186910308, Length=441, Percent_Identity=23.5827664399093, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI186910306, Length=441, Percent_Identity=23.5827664399093, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI186910304, Length=441, Percent_Identity=23.5827664399093, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI33286428, Length=466, Percent_Identity=24.2489270386266, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI110347453, Length=368, Percent_Identity=26.9021739130435, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI7657683, Length=476, Percent_Identity=25, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI181337167, Length=354, Percent_Identity=24.2937853107345, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI4507047, Length=166, Percent_Identity=27.710843373494, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI258614003, Length=182, Percent_Identity=27.4725274725275, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI258614005, Length=177, Percent_Identity=28.2485875706215, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI9790235, Length=468, Percent_Identity=22.4358974358974, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI114326544, Length=192, Percent_Identity=23.4375, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI114326550, Length=192, Percent_Identity=23.4375, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87082250, Length=445, Percent_Identity=100, Blast_Score=887, Evalue=0.0,
Organism=Escherichia coli, GI2367353, Length=349, Percent_Identity=29.2263610315186, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87082023, Length=397, Percent_Identity=26.448362720403, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87081869, Length=421, Percent_Identity=23.2779097387173, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788480, Length=272, Percent_Identity=27.2058823529412, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790575, Length=324, Percent_Identity=27.1604938271605, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081708, Length=350, Percent_Identity=24, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI48994972, Length=324, Percent_Identity=28.0864197530864, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71995388, Length=389, Percent_Identity=27.5064267352185, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71995382, Length=389, Percent_Identity=27.5064267352185, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71993915, Length=388, Percent_Identity=24.7422680412371, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI71982612, Length=418, Percent_Identity=24.8803827751196, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71982608, Length=418, Percent_Identity=24.8803827751196, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI32566699, Length=373, Percent_Identity=23.0563002680965, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71990446, Length=426, Percent_Identity=24.6478873239437, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17532491, Length=421, Percent_Identity=22.5653206650831, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17540018, Length=428, Percent_Identity=26.1682242990654, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17531343, Length=415, Percent_Identity=23.1325301204819, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI32566695, Length=392, Percent_Identity=23.7244897959184, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193208714, Length=391, Percent_Identity=23.7851662404092, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71982623, Length=272, Percent_Identity=24.6323529411765, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17533459, Length=399, Percent_Identity=23.0576441102757, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17568033, Length=354, Percent_Identity=24.8587570621469, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321492, Length=356, Percent_Identity=23.5955056179775, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667468, Length=425, Percent_Identity=25.4117647058824, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24641995, Length=383, Percent_Identity=26.1096605744125, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24641993, Length=383, Percent_Identity=26.1096605744125, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21357367, Length=448, Percent_Identity=25.6696428571429, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221331183, Length=404, Percent_Identity=25, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI17647653, Length=404, Percent_Identity=25, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24664379, Length=404, Percent_Identity=25, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24651635, Length=366, Percent_Identity=25.1366120218579, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24651633, Length=366, Percent_Identity=25.1366120218579, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24666159, Length=450, Percent_Identity=23.3333333333333, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221512776, Length=450, Percent_Identity=23.3333333333333, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45550968, Length=465, Percent_Identity=24.5161290322581, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19921172, Length=465, Percent_Identity=24.5161290322581, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281366235, Length=371, Percent_Identity=25.0673854447439, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI116007820, Length=371, Percent_Identity=25.0673854447439, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24668806, Length=411, Percent_Identity=22.6277372262774, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356285, Length=411, Percent_Identity=22.6277372262774, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24668802, Length=411, Percent_Identity=22.6277372262774, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI116007818, Length=373, Percent_Identity=25.7372654155496, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI85725152, Length=373, Percent_Identity=25.7372654155496, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI161077963, Length=364, Percent_Identity=22.8021978021978, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49373; Mature: 49242

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTANSPLQRIGQEKGIAMGSQELQRKLGFWAVLAIAVGTTVGSGIFVSVGEVAKAAGTPW
CCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCHH
LTVLAFVIGGLIVIPQMCVYAELSTAYPENGADYVYLKNAGSRPLAFLSGWASFWANDAP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCC
SLSIMALAIVSNLGFLTPIDPLLGKFIAAGLIIAFMLLHLRSVEGGAAFQTLITIAKIIP
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
FTIVIGLGIFWFKAENFAAPTTTAIGATGSFMALLAGISATSWSYTGMASICYMTGEIKN
HHHHHHHHHHHEECCCCCCCCCHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHEECCCCC
PGKTMPRALIGSCLLVLVLYTLLALVISGLMPFDKLANSETPISDALTWIPALGSTAGIF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHCCCCHHHH
VAITAMIVILGSLSSCVMYQPRLEYAMAKDNLFFKCFGHVHPKYNTPDVSIILQGALGIF
HHHHHHHHHHHHHHHHHEECCHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
FIFVSDLTSLLGYFTLVMCFKNTLTFGSIIWCRKRDDYKPLWRTPAFGLMTTLAIASSLI
HHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
LVASTFVWAPIPGLICAVIVIATGLPAYAFWAKRSRQLNALS
HHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TANSPLQRIGQEKGIAMGSQELQRKLGFWAVLAIAVGTTVGSGIFVSVGEVAKAAGTPW
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCHH
LTVLAFVIGGLIVIPQMCVYAELSTAYPENGADYVYLKNAGSRPLAFLSGWASFWANDAP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCC
SLSIMALAIVSNLGFLTPIDPLLGKFIAAGLIIAFMLLHLRSVEGGAAFQTLITIAKIIP
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
FTIVIGLGIFWFKAENFAAPTTTAIGATGSFMALLAGISATSWSYTGMASICYMTGEIKN
HHHHHHHHHHHEECCCCCCCCCHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHEECCCCC
PGKTMPRALIGSCLLVLVLYTLLALVISGLMPFDKLANSETPISDALTWIPALGSTAGIF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHCCCCHHHH
VAITAMIVILGSLSSCVMYQPRLEYAMAKDNLFFKCFGHVHPKYNTPDVSIILQGALGIF
HHHHHHHHHHHHHHHHHEECCHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
FIFVSDLTSLLGYFTLVMCFKNTLTFGSIIWCRKRDDYKPLWRTPAFGLMTTLAIASSLI
HHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
LVASTFVWAPIPGLICAVIVIATGLPAYAFWAKRSRQLNALS
HHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]