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The map label for this gene is frlB [H]

Identifier: 157162847

GI number: 157162847

Start: 3545592

End: 3546635

Strand: Direct

Name: frlB [H]

Synonym: EcHS_A3567

Alternate gene names: 157162847

Gene position: 3545592-3546635 (Clockwise)

Preceding gene: 157162846

Following gene: 157162848

Centisome position: 76.36

GC content: 54.21

Gene sequence:

>1044_bases
ATGTTATCTGGAGAAAATAAAATGTTGGATATTGATAAAAGCACCGTGGACTTTCTGGTCACCGAAAATATGGTTCAGGA
AGTGGAAAAAGTTCTCAGCCATGACGTTCCGCTGGTGCACGCCATCGTGGAAGAGATGGTGAAGCGCGACATTGATCGTA
TTTATTTCGTTGCCTGCGGCTCGCCACTCAACGCGGCGCAAACGGCGAAACATCTGGCGGATCGCTTTTCCGATCTTCAG
GTCTACGCCATTTCCGGCTGGGAGTTCTGCGATAACACCCCGTATCGCCTCGACGATCGTTGCGCGGTGATTGGCGTTTC
TGACTACGGTAAAACGGAAGAGGTAATCAAAGCGCTGGAGCTGGGCCGGGCCTGCGGCGCACTCACTGCGGCGTTCACCA
AACGCGCGGACAGCCCGATTACCTCGGCGGCGGAATTTAGCATTGATTATCAGGCCGACTGTATCTGGGAAATTCACCTG
CTGCTCTGCTACAGCGTGGTGCTGGAGATGATCACCCGCCTCGCGCCGAACGCGGAAATCGGCAAGATCAAAAACGATCT
CAAGCAGTTGCCGAATGCGCTCGGTCATCTGGTACGCACCTGGGAAGAAAAAGGCCGCCAGCTTGGTGAACTGGCCAGCC
AGTGGCCGATGATTTATACCGTTGCTGCGGGTCCGCTGCGTCCGCTGGGTTACAAAGAAGGCATTGTAACGCTGATGGAA
TTTACCTGGACGCACGGCTGCGTGATTGAGAGCGGAGAGTTCCGCCATGGCCCGCTGGAGATTGTCGAACCGGGCGTTCC
GTTCCTGTTCCTGCTCGGCAATGATGAAAGTCGCCACACCACCGAACGCGCCATTAACTTTGTTAAACAGCGTACTGACA
ACGTGATCGTCATCGATTACGCCGAAATTTCGCAAGGGCTGCACCCGTGGCTGGCACCGTTCCTGATGTTCGTGCCAATG
GAGTGGCTCTGCTACTACCTGTCTATTTACAAAGATCACAACCCGGATGAACGCCGCTATTACGGTGGTCTGGTGGAATA
TTAA

Upstream 100 bases:

>100_bases
CGATTCCCGGCCTTATCTGCGCCGTCATCGTTATTGCTACTGGTCTGCCTGCTTACGCCTTCTGGGCGAAGCGTAGCCGC
CAGCTCAACGCTTTGTCGTA

Downstream 100 bases:

>100_bases
TCCCTCTCCCGGCCCGGCAACGGGCCGGATTTACGCAAGGAGTTACCCGATGAAAACAGGTATGTTTACCTGCGGCCATC
AGCGGCTGCCTATTGAACAC

Product: fructoselysine-6-P-deglycase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MLSGENKMLDIDKSTVDFLVTENMVQEVEKVLSHDVPLVHAIVEEMVKRDIDRIYFVACGSPLNAAQTAKHLADRFSDLQ
VYAISGWEFCDNTPYRLDDRCAVIGVSDYGKTEEVIKALELGRACGALTAAFTKRADSPITSAAEFSIDYQADCIWEIHL
LLCYSVVLEMITRLAPNAEIGKIKNDLKQLPNALGHLVRTWEEKGRQLGELASQWPMIYTVAAGPLRPLGYKEGIVTLME
FTWTHGCVIESGEFRHGPLEIVEPGVPFLFLLGNDESRHTTERAINFVKQRTDNVIVIDYAEISQGLHPWLAPFLMFVPM
EWLCYYLSIYKDHNPDERRYYGGLVEY

Sequences:

>Translated_347_residues
MLSGENKMLDIDKSTVDFLVTENMVQEVEKVLSHDVPLVHAIVEEMVKRDIDRIYFVACGSPLNAAQTAKHLADRFSDLQ
VYAISGWEFCDNTPYRLDDRCAVIGVSDYGKTEEVIKALELGRACGALTAAFTKRADSPITSAAEFSIDYQADCIWEIHL
LLCYSVVLEMITRLAPNAEIGKIKNDLKQLPNALGHLVRTWEEKGRQLGELASQWPMIYTVAAGPLRPLGYKEGIVTLME
FTWTHGCVIESGEFRHGPLEIVEPGVPFLFLLGNDESRHTTERAINFVKQRTDNVIVIDYAEISQGLHPWLAPFLMFVPM
EWLCYYLSIYKDHNPDERRYYGGLVEY
>Mature_347_residues
MLSGENKMLDIDKSTVDFLVTENMVQEVEKVLSHDVPLVHAIVEEMVKRDIDRIYFVACGSPLNAAQTAKHLADRFSDLQ
VYAISGWEFCDNTPYRLDDRCAVIGVSDYGKTEEVIKALELGRACGALTAAFTKRADSPITSAAEFSIDYQADCIWEIHL
LLCYSVVLEMITRLAPNAEIGKIKNDLKQLPNALGHLVRTWEEKGRQLGELASQWPMIYTVAAGPLRPLGYKEGIVTLME
FTWTHGCVIESGEFRHGPLEIVEPGVPFLFLLGNDESRHTTERAINFVKQRTDNVIVIDYAEISQGLHPWLAPFLMFVPM
EWLCYYLSIYKDHNPDERRYYGGLVEY

Specific function: Catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine [H]

COG id: COG2222

COG function: function code M; Predicted phosphosugar isomerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=311, Percent_Identity=22.508038585209, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI87082251, Length=340, Percent_Identity=100, Blast_Score=708, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532897, Length=311, Percent_Identity=23.7942122186495, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532899, Length=311, Percent_Identity=23.7942122186495, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001347 [H]

Pfam domain/function: PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 39330; Mature: 39330

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSGENKMLDIDKSTVDFLVTENMVQEVEKVLSHDVPLVHAIVEEMVKRDIDRIYFVACG
CCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEEC
SPLNAAQTAKHLADRFSDLQVYAISGWEFCDNTPYRLDDRCAVIGVSDYGKTEEVIKALE
CCCCHHHHHHHHHHHHCCEEEEEEECCHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHH
LGRACGALTAAFTKRADSPITSAAEFSIDYQADCIWEIHLLLCYSVVLEMITRLAPNAEI
HHHHHHHHHHHHHHHCCCCCCCHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
GKIKNDLKQLPNALGHLVRTWEEKGRQLGELASQWPMIYTVAAGPLRPLGYKEGIVTLME
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHH
FTWTHGCVIESGEFRHGPLEIVEPGVPFLFLLGNDESRHTTERAINFVKQRTDNVIVIDY
HHCCCCEEEECCCCCCCCHHEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEH
AEISQGLHPWLAPFLMFVPMEWLCYYLSIYKDHNPDERRYYGGLVEY
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MLSGENKMLDIDKSTVDFLVTENMVQEVEKVLSHDVPLVHAIVEEMVKRDIDRIYFVACG
CCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEEC
SPLNAAQTAKHLADRFSDLQVYAISGWEFCDNTPYRLDDRCAVIGVSDYGKTEEVIKALE
CCCCHHHHHHHHHHHHCCEEEEEEECCHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHH
LGRACGALTAAFTKRADSPITSAAEFSIDYQADCIWEIHLLLCYSVVLEMITRLAPNAEI
HHHHHHHHHHHHHHHCCCCCCCHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
GKIKNDLKQLPNALGHLVRTWEEKGRQLGELASQWPMIYTVAAGPLRPLGYKEGIVTLME
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHH
FTWTHGCVIESGEFRHGPLEIVEPGVPFLFLLGNDESRHTTERAINFVKQRTDNVIVIDY
HHCCCCEEEECCCCCCCCHHEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEH
AEISQGLHPWLAPFLMFVPMEWLCYYLSIYKDHNPDERRYYGGLVEY
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]