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The map label for this gene is sapC

Identifier: 157160802

GI number: 157160802

Start: 1401082

End: 1401972

Strand: Reverse

Name: sapC

Synonym: EcHS_A1406

Alternate gene names: 157160802

Gene position: 1401972-1401082 (Counterclockwise)

Preceding gene: 157160803

Following gene: 157160801

Centisome position: 30.19

GC content: 56.9

Gene sequence:

>891_bases
ATGCCTTACGATAGCGTATACAGCGAAAAGCGCCCGCCGGGCACGCTGCGTACCGCCTGGCGCAAATTTTATAGTGACGC
CTCTGCGATGGTCGGCCTGTACGGCTGCGCGGGGCTGGCTGTACTGTGTATTTTTGGCGGCTGGTTTGCGCCTTACGGCA
TCGACCAGCAATTTCTCGGTTATCAATTATTGCCGCCGTCATGGTCGCGCTATGGCGAAGTTTCTTTCTTCCTGGGGACT
GACGACCTCGGACGCGATGTTTTAAGCCGTTTACTGAGCGGAGCTGCGCCAACCGTGGGTGGCGCATTTGTGGTGACGCT
TGCCGCGACGATCTGTGGCCTGGTACTGGGCACCTTCGCCGGGGCGACACACGGCCTCCGCTCAGCGGTGCTTAACCATA
TTCTGGATACCTTACTGGCGATCCCTTCGCTGCTGTTGGCAATTATCGTTGTAGCGTTTGCCGGACCGAGTTTGTCCCAC
GCTATGTTTGCTGTCTGGCTGGCATTGCTGCCGCGTATGGTACGTTCGATTTACAGCATGGTGCATGACGAACTGGAAAA
AGAGTACGTTATCGCCGCCCGTCTGGATGGCGCATCAACGCTGAATATTCTCTGGTTTGCTGTGATGCCAAACATCACCG
CCGGGCTGGTCACCGAGATCACCCGCGCACTGTCGATGGCAATTCTCGATATCGCCGCGCTGGGCTTTCTCGATCTCGGC
GCACAACTCCCCTCGCCTGAATGGGGAGCGATGCTCGGTGATGCGCTGGAACTGATTTATGTCGCCCCGTGGACTGTCAT
GCTGCCAGGTGCGGCAATTATGATTAGCGTGTTGTTGGTTAACCTCCTTGGCGATGGCGTTCGTCGTGCGATTATTGCGG
GGGTGGAATAA

Upstream 100 bases:

>100_bases
TCCGCCGGAGTGATGGTGTGTGGCTCACTGGTCATTATTGTTAACGTGATTTCTGATATTTTGGGTGCCATGGCTAACCC
TCTGAAACATAAGGAATGGT

Downstream 100 bases:

>100_bases
TGCCATTACTCGATATTCGTAACCTGACCATTGAATTTAAAACCGGTGATGAGTGGGTTAAAGCCGTCGACCGGGTAAGT
ATGACCTTAACCGAAGGTGA

Product: peptide ABC transporter, permease protein SapC

Products: ADP; phosphate; peptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MPYDSVYSEKRPPGTLRTAWRKFYSDASAMVGLYGCAGLAVLCIFGGWFAPYGIDQQFLGYQLLPPSWSRYGEVSFFLGT
DDLGRDVLSRLLSGAAPTVGGAFVVTLAATICGLVLGTFAGATHGLRSAVLNHILDTLLAIPSLLLAIIVVAFAGPSLSH
AMFAVWLALLPRMVRSIYSMVHDELEKEYVIAARLDGASTLNILWFAVMPNITAGLVTEITRALSMAILDIAALGFLDLG
AQLPSPEWGAMLGDALELIYVAPWTVMLPGAAIMISVLLVNLLGDGVRRAIIAGVE

Sequences:

>Translated_296_residues
MPYDSVYSEKRPPGTLRTAWRKFYSDASAMVGLYGCAGLAVLCIFGGWFAPYGIDQQFLGYQLLPPSWSRYGEVSFFLGT
DDLGRDVLSRLLSGAAPTVGGAFVVTLAATICGLVLGTFAGATHGLRSAVLNHILDTLLAIPSLLLAIIVVAFAGPSLSH
AMFAVWLALLPRMVRSIYSMVHDELEKEYVIAARLDGASTLNILWFAVMPNITAGLVTEITRALSMAILDIAALGFLDLG
AQLPSPEWGAMLGDALELIYVAPWTVMLPGAAIMISVLLVNLLGDGVRRAIIAGVE
>Mature_295_residues
PYDSVYSEKRPPGTLRTAWRKFYSDASAMVGLYGCAGLAVLCIFGGWFAPYGIDQQFLGYQLLPPSWSRYGEVSFFLGTD
DLGRDVLSRLLSGAAPTVGGAFVVTLAATICGLVLGTFAGATHGLRSAVLNHILDTLLAIPSLLLAIIVVAFAGPSLSHA
MFAVWLALLPRMVRSIYSMVHDELEKEYVIAARLDGASTLNILWFAVMPNITAGLVTEITRALSMAILDIAALGFLDLGA
QLPSPEWGAMLGDALELIYVAPWTVMLPGAAIMISVLLVNLLGDGVRRAIIAGVE

Specific function: Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides

COG id: COG4171

COG function: function code V; ABC-type antimicrobial peptide transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain

Homologues:

Organism=Escherichia coli, GI1787549, Length=296, Percent_Identity=100, Blast_Score=585, Evalue=1e-169,
Organism=Escherichia coli, GI1789964, Length=288, Percent_Identity=40.9722222222222, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI1787054, Length=284, Percent_Identity=35.2112676056338, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1787760, Length=248, Percent_Identity=35.0806451612903, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1789889, Length=241, Percent_Identity=30.2904564315353, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1787498, Length=275, Percent_Identity=25.8181818181818, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAPC_ECOL6 (P0AGH6)

Other databases:

- EMBL:   AE014075
- RefSeq:   NP_753673.1
- ProteinModelPortal:   P0AGH6
- EnsemblBacteria:   EBESCT00000040593
- GeneID:   1035555
- GenomeReviews:   AE014075_GR
- KEGG:   ecc:c1769
- GeneTree:   EBGT00050000010101
- HOGENOM:   HBG729429
- OMA:   LDGANNF
- ProtClustDB:   PRK15111
- InterPro:   IPR000515

Pfam domain/function: PF00528 BPD_transp_1

EC number: NA

Molecular weight: Translated: 31549; Mature: 31417

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x14690bd0)-; HASH(0x147a2b9c)-; HASH(0x1188cfd0)-; HASH(0x116ed5bc)-; HASH(0x142afa24)-; HASH(0x147006b0)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYDSVYSEKRPPGTLRTAWRKFYSDASAMVGLYGCAGLAVLCIFGGWFAPYGIDQQFLG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCC
YQLLPPSWSRYGEVSFFLGTDDLGRDVLSRLLSGAAPTVGGAFVVTLAATICGLVLGTFA
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GATHGLRSAVLNHILDTLLAIPSLLLAIIVVAFAGPSLSHAMFAVWLALLPRMVRSIYSM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VHDELEKEYVIAARLDGASTLNILWFAVMPNITAGLVTEITRALSMAILDIAALGFLDLG
HHHHHHHHEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AQLPSPEWGAMLGDALELIYVAPWTVMLPGAAIMISVLLVNLLGDGVRRAIIAGVE
CCCCCCHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
PYDSVYSEKRPPGTLRTAWRKFYSDASAMVGLYGCAGLAVLCIFGGWFAPYGIDQQFLG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCC
YQLLPPSWSRYGEVSFFLGTDDLGRDVLSRLLSGAAPTVGGAFVVTLAATICGLVLGTFA
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GATHGLRSAVLNHILDTLLAIPSLLLAIIVVAFAGPSLSHAMFAVWLALLPRMVRSIYSM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VHDELEKEYVIAARLDGASTLNILWFAVMPNITAGLVTEITRALSMAILDIAALGFLDLG
HHHHHHHHEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AQLPSPEWGAMLGDALELIYVAPWTVMLPGAAIMISVLLVNLLGDGVRRAIIAGVE
CCCCCCHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; peptides [Periplasm]; H2O [C]

Specific reaction: ATP + peptides [Periplasm] + H2O = ADP + phosphate + peptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12471157