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The map label for this gene is ybiC [H]

Identifier: 157160277

GI number: 157160277

Start: 862955

End: 864040

Strand: Direct

Name: ybiC [H]

Synonym: EcHS_A0856

Alternate gene names: 157160277

Gene position: 862955-864040 (Clockwise)

Preceding gene: 157160276

Following gene: 157160283

Centisome position: 18.58

GC content: 55.62

Gene sequence:

>1086_bases
ATGGAAAGTGGTCATCGCTTTGATGCTCAGACGCTGCACAGTTTTATTCAGGCTGTATTTCGTCAGATGGGTAGCGAGGA
ACAAGAAGCGAAATTAGTTGCCGATCATTTAATCGCGGCAAACCTGGCAGGGCATGATTCACATGGTATTGGCATGATCC
CAAGCTATGTACGCTCCTGGAGTCAGGGGCACCTGCAAATTAACCATCATGCCAAAACCGTTAAAGAGGCGGGGGCGGCG
GTCACGCTCGATGGCGATCGCGCATTTGGTCAGGTCGCGGCACATGAAGCGATGGCGCTGGGGATTGAGAAAGCGCATCA
GCACGGTATTGCCGCCGTGGCGCTACATAACTCGCATCATATCGGCCGTATCGGTTACTGGGCGGAGCAGTGTGCAGCGG
CGGGGTTTGTCTCTATCCACTTTGTTAGCGTGGTCGGTATTCCAATGGTCGCGCCGTTCCACGGTCGCGACAGCCGCTTT
GGCACCAATCCGTTCTGTGTGGTTTTCCCTCGTAAAGATAATTTCCCGCTGTTGCTTGATTACGCCACCAGCGCCATTGC
ATTTGGCAAAACCCGCGTCGCCTGGCATAAAGGCGTCCCCGTGCCGCCAGGTTGCCTGATTGACGTTAACGGCGTGCCGA
CGACCAATCCGGCGGTAATGCAGGAGTCGCCGTTGGGTTCGCTGTTGACCTTTGCCGAACATAAAGGCTACGCCCTTGCA
GCGATGTGTGAAATTCTTGGCGGGGCGCTTTCCGGCGGTAAAACGACGCATCAGGAAACGTTACAAACCAGTCCCGATGC
CATTCTTAACTGCATGACCACTATCATCATCAACCCGGAACTCTTCGGCGCGCCGGATTGTAACGCGCAGACCGAAGCCT
TTGCCGAGTGGGTGAAAGCCTCGCCGCATGATGATGATAAGCCGATTTTGCTACCGGGCGAGTGGGAAGTGAACACGCGT
CGCGAACGGCAGAAGCAGGGGATTCCACTGGATGCGGGAAGCTGGCAGGCCATTTGTGATGCAGCGCGGCAGATTGGTAT
GCCGGAAGAGACGTTGCAGGCTTTCTGTCAGCAGTTAGCCAGCTAA

Upstream 100 bases:

>100_bases
CCCCACCGCAATATGAAATTCCTGCATCTTTATTGACCTTCCCACGCCCGGCGTGCAGCATAAAAATACAACAAACACAT
AACATAAACAGGAGTTAACC

Downstream 100 bases:

>100_bases
AAAAAAGCCCGTCCAGTGGCGGACGGGCAAACAAGGGTAACATAGGATCAATGAGGGTTAGAGCATATGCGTCTGTCGGC
AAACAGACAGGGAAATACTT

Product: hypothetical protein

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHLQINHHAKTVKEAGAA
VTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRF
GTNPFCVVFPRKDNFPLLLDYATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALA
AMCEILGGALSGGKTTHQETLQTSPDAILNCMTTIIINPELFGAPDCNAQTEAFAEWVKASPHDDDKPILLPGEWEVNTR
RERQKQGIPLDAGSWQAICDAARQIGMPEETLQAFCQQLAS

Sequences:

>Translated_361_residues
MESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHLQINHHAKTVKEAGAA
VTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRF
GTNPFCVVFPRKDNFPLLLDYATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALA
AMCEILGGALSGGKTTHQETLQTSPDAILNCMTTIIINPELFGAPDCNAQTEAFAEWVKASPHDDDKPILLPGEWEVNTR
RERQKQGIPLDAGSWQAICDAARQIGMPEETLQAFCQQLAS
>Mature_361_residues
MESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHLQINHHAKTVKEAGAA
VTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRF
GTNPFCVVFPRKDNFPLLLDYATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALA
AMCEILGGALSGGKTTHQETLQTSPDAILNCMTTIIINPELFGAPDCNAQTEAFAEWVKASPHDDDKPILLPGEWEVNTR
RERQKQGIPLDAGSWQAICDAARQIGMPEETLQAFCQQLAS

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=361, Percent_Identity=100, Blast_Score=748, Evalue=0.0,
Organism=Escherichia coli, GI1786727, Length=357, Percent_Identity=29.9719887955182, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790000, Length=331, Percent_Identity=24.1691842900302, Blast_Score=112, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17507179, Length=315, Percent_Identity=28.8888888888889, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17536633, Length=348, Percent_Identity=26.7241379310345, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24667908, Length=357, Percent_Identity=29.6918767507003, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45553211, Length=355, Percent_Identity=29.8591549295775, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24667912, Length=355, Percent_Identity=29.8591549295775, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24667904, Length=355, Percent_Identity=29.8591549295775, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24658010, Length=306, Percent_Identity=28.1045751633987, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24648360, Length=331, Percent_Identity=27.4924471299094, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 38898; Mature: 38898

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSW
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCC
SQGHLQINHHAKTVKEAGAAVTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHH
CCCCEEECHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
IGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRFGTNPFCVVFPRKDNFPLLLD
CCHHHHHHHHHHHCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCEEEEEECCCCCCEEEE
YATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALA
CHHHHHHHCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHH
AMCEILGGALSGGKTTHQETLQTSPDAILNCMTTIIINPELFGAPDCNAQTEAFAEWVKA
HHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHC
SPHDDDKPILLPGEWEVNTRRERQKQGIPLDAGSWQAICDAARQIGMPEETLQAFCQQLA
CCCCCCCCEEECCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
S
C
>Mature Secondary Structure
MESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSW
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCC
SQGHLQINHHAKTVKEAGAAVTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHH
CCCCEEECHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
IGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRFGTNPFCVVFPRKDNFPLLLD
CCHHHHHHHHHHHCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCEEEEEECCCCCCEEEE
YATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALA
CHHHHHHHCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHH
AMCEILGGALSGGKTTHQETLQTSPDAILNCMTTIIINPELFGAPDCNAQTEAFAEWVKA
HHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHC
SPHDDDKPILLPGEWEVNTRRERQKQGIPLDAGSWQAICDAARQIGMPEETLQAFCQQLA
CCCCCCCCEEECCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]