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The map label for this gene is aqpZ [H]

Identifier: 154246262

GI number: 154246262

Start: 2592581

End: 2593270

Strand: Direct

Name: aqpZ [H]

Synonym: Xaut_2320

Alternate gene names: 154246262

Gene position: 2592581-2593270 (Clockwise)

Preceding gene: 154246259

Following gene: 154246264

Centisome position: 48.83

GC content: 67.39

Gene sequence:

>690_bases
ATGAACAAGTATGTGGCCGAGTTCATCGGCACTGCGGTGCTGGTGCTGTTCGGGTGTGGGTCTGCGGTGCTGACGGGCTA
CGGCTCGGCGCCCATCGGCATGCTCGCCATCGCGTTCGCCTTCGGCCTTGCGGTCACCTCCATGGCCTATGGCATCGGCC
ACGTGTCGGGCTGCCACATCAATCCGGCGGTCACCATCGGCGTCTGGGCGGCAGGGCGCCTGCCCACCTCTGAGGTGCCC
ATGTACATCGTCGCCCAGGTGCTGGGCGGCATCGCCGGCGCGGCCATCCTCTTCGTCATTGCCTCGGGCAAGCTTGCCGG
CTTCGATGTGGCGACCTCGGGCCTTGGCCAGAACGGCTGGGGCGAGGGCTATATCGGCGGCTACGGGCTCGGCGCGGCCA
TCGTGGCGGAGCTGGTGGGCACCTTCGTGTTCCTGGTGGTGATCCTCGGCTCCACCTCCAAGGCCGGCATCACCCAGGCG
GCGGGCCTCGCCATCGGCCTGTCGCTGGTGATGATCCACATCGTGTTCATCCCGGTCACCGGCGTGTCGGTGAACCCGGC
CCGCTCCATCGGACCGGCCCTGTTCGCCGGCGGCAAGGCCATCAGCCAGCTCTGGCTGTTCATCGTGGTGCCGCTGGTGG
GTGCTTATCTGGCCGGCCTGCTGTTCAAGCTGAAGGTGCTGGAGGACTGA

Upstream 100 bases:

>100_bases
AGCCCGATGGGTGAATCCGGTTCCAAACTTGGGAGAGCGCGCACGCGGGCCATGCCTGGAATTCCGGGCCGGCCGGTGCG
CCGTTCGGGGAGGGGTTGGC

Downstream 100 bases:

>100_bases
GCTTCCCAAGCCCGCGCGGGCGCCTGAGCGAAGGCAACGTCCAGCCCGCGTGGCGCTTGAGCGAAGGCGAGGACTCCGCG
AATCAAAAAGGGGATGGGTC

Product: MIP family channel protein

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MNKYVAEFIGTAVLVLFGCGSAVLTGYGSAPIGMLAIAFAFGLAVTSMAYGIGHVSGCHINPAVTIGVWAAGRLPTSEVP
MYIVAQVLGGIAGAAILFVIASGKLAGFDVATSGLGQNGWGEGYIGGYGLGAAIVAELVGTFVFLVVILGSTSKAGITQA
AGLAIGLSLVMIHIVFIPVTGVSVNPARSIGPALFAGGKAISQLWLFIVVPLVGAYLAGLLFKLKVLED

Sequences:

>Translated_229_residues
MNKYVAEFIGTAVLVLFGCGSAVLTGYGSAPIGMLAIAFAFGLAVTSMAYGIGHVSGCHINPAVTIGVWAAGRLPTSEVP
MYIVAQVLGGIAGAAILFVIASGKLAGFDVATSGLGQNGWGEGYIGGYGLGAAIVAELVGTFVFLVVILGSTSKAGITQA
AGLAIGLSLVMIHIVFIPVTGVSVNPARSIGPALFAGGKAISQLWLFIVVPLVGAYLAGLLFKLKVLED
>Mature_229_residues
MNKYVAEFIGTAVLVLFGCGSAVLTGYGSAPIGMLAIAFAFGLAVTSMAYGIGHVSGCHINPAVTIGVWAAGRLPTSEVP
MYIVAQVLGGIAGAAILFVIASGKLAGFDVATSGLGQNGWGEGYIGGYGLGAAIVAELVGTFVFLVVILGSTSKAGITQA
AGLAIGLSLVMIHIVFIPVTGVSVNPARSIGPALFAGGKAISQLWLFIVVPLVGAYLAGLLFKLKVLED

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI37694062, Length=227, Percent_Identity=35.6828193832599, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI4502179, Length=220, Percent_Identity=35.9090909090909, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI4755125, Length=228, Percent_Identity=35.0877192982456, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI4502181, Length=228, Percent_Identity=35.0877192982456, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI4502183, Length=219, Percent_Identity=37.4429223744292, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI6912506, Length=221, Percent_Identity=31.6742081447964, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI86792455, Length=228, Percent_Identity=32.0175438596491, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI157266307, Length=247, Percent_Identity=32.3886639676113, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI4826645, Length=246, Percent_Identity=32.520325203252, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI4502187, Length=244, Percent_Identity=28.2786885245902, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI22538420, Length=243, Percent_Identity=27.5720164609054, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI45446752, Length=192, Percent_Identity=30.7291666666667, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1787101, Length=208, Percent_Identity=53.8461538461538, Blast_Score=194, Evalue=4e-51,
Organism=Escherichia coli, GI1790362, Length=243, Percent_Identity=28.8065843621399, Blast_Score=76, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71993722, Length=233, Percent_Identity=33.0472103004292, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17558372, Length=239, Percent_Identity=30.1255230125523, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17531429, Length=231, Percent_Identity=31.6017316017316, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17531431, Length=231, Percent_Identity=31.6017316017316, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321054, Length=213, Percent_Identity=31.4553990610329, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24652747, Length=220, Percent_Identity=37.7272727272727, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45551084, Length=220, Percent_Identity=37.7272727272727, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24652751, Length=224, Percent_Identity=34.375, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI19922038, Length=224, Percent_Identity=34.375, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17136672, Length=194, Percent_Identity=32.9896907216495, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24762346, Length=234, Percent_Identity=29.4871794871795, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24762348, Length=234, Percent_Identity=29.4871794871795, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI20130305, Length=234, Percent_Identity=29.4871794871795, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24762344, Length=231, Percent_Identity=29.8701298701299, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 22986; Mature: 22986

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKYVAEFIGTAVLVLFGCGSAVLTGYGSAPIGMLAIAFAFGLAVTSMAYGIGHVSGCHI
CCHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NPAVTIGVWAAGRLPTSEVPMYIVAQVLGGIAGAAILFVIASGKLAGFDVATSGLGQNGW
CCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCC
GEGYIGGYGLGAAIVAELVGTFVFLVVILGSTSKAGITQAAGLAIGLSLVMIHIVFIPVT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GVSVNPARSIGPALFAGGKAISQLWLFIVVPLVGAYLAGLLFKLKVLED
CCCCCCHHHHCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKYVAEFIGTAVLVLFGCGSAVLTGYGSAPIGMLAIAFAFGLAVTSMAYGIGHVSGCHI
CCHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NPAVTIGVWAAGRLPTSEVPMYIVAQVLGGIAGAAILFVIASGKLAGFDVATSGLGQNGW
CCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCC
GEGYIGGYGLGAAIVAELVGTFVFLVVILGSTSKAGITQAAGLAIGLSLVMIHIVFIPVT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GVSVNPARSIGPALFAGGKAISQLWLFIVVPLVGAYLAGLLFKLKVLED
CCCCCCHHHHCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]