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The map label for this gene is oxyR [H]

Identifier: 154246264

GI number: 154246264

Start: 2595058

End: 2595954

Strand: Direct

Name: oxyR [H]

Synonym: Xaut_2322

Alternate gene names: 154246264

Gene position: 2595058-2595954 (Clockwise)

Preceding gene: 154246262

Following gene: 154246265

Centisome position: 48.88

GC content: 72.02

Gene sequence:

>897_bases
ATGCTTTCCATCCGTCAGCTGCGCTATTTCGATGCCCTGGCCCGCCATCGGCATTTCGGCCGGGCGGCGGAAGACTGCGC
GGTCACCCAGCCGGCCTTGTCCATGCAGATCCGCGAGATGGAGGAGATGCTGGGCGTGCGCCTTCTGGAGCGCGGGCGCG
GTGGCGTGCGGCTCACCCCGGTGGGGGAGGAGGCGGCCGGCCGGGCCCGGGGCGTGCTCGCGGCGCTGGCCGACATGGAG
CGCACCATCCGCGACAGCGGCCGGCTGCTGGAGGGGCGGCTGCGCCTTGGTGTCATCGCCTCCATCGCGCCCTATCTGTT
GCCGCGACTGCTGCCGGAGATGGCGCGGAGCCATCCGGGGCTGGAAATCGCGCTGCGGGAGAGCCAGACCGAGCATCTGG
TAGCGGACCTCGTCCAGGGGGACCTCGACCTCGTCATCCTGAGCCTGCCGGTCGAGCACCCGGCGCTGGAAGCCATGGCC
CTGTTCGAGGACCGTTTTGTCCTCGCGGTGCCGGAGGCATCGACGGACTTCCCAGGGCCGCAGGCGTCGCCCGACAGCAT
CCTCGCCGCCGACCTGCTGCTGCTGGAGGATGGGCACTGCCTGCGCGACCAGGCGCTCAACGTCTGCCGCAAGGTGGATG
CCCGGCAATTGCGCCGCTTCGGCGCCTCCAGCCTCGCCACCCTGGCGCAACTGGTGGCGAACGGGCAGGGCATCACCCTG
CTGCCGGACCTGTTCGTGCGCGCCGAGGGCGGGCGCCTGGCGGGGGTGCGCCTGCTGCCCTTCCCCGATCCTGTGCCGGC
GCGCACCATCGGCCTGGTCTGGCGCCGCACCCTGCCGTCCCGCAAGGATGTAGCGGCGGTGGCGGACATGGTGAAGGCCT
GCCGGCCGGGGCCGTGA

Upstream 100 bases:

>100_bases
AAAAGGCCCGGAGGGCGAAAATCACGAGCGCAGGATGGGCGTCTCCGGGACTGACTACAAATCAGATTGCGTTCAAGATT
CGATAAGATAATCTGATCGT

Downstream 100 bases:

>100_bases
ACAGGGCGGATAACCCGGGCGCGCATGGCCCGGTTGCGCGCCCTGCCTTGCTTTGCCCCGCATTCAAAGCTAAGCCCCGC
GCCAGATACGAGGACTTCAT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MLSIRQLRYFDALARHRHFGRAAEDCAVTQPALSMQIREMEEMLGVRLLERGRGGVRLTPVGEEAAGRARGVLAALADME
RTIRDSGRLLEGRLRLGVIASIAPYLLPRLLPEMARSHPGLEIALRESQTEHLVADLVQGDLDLVILSLPVEHPALEAMA
LFEDRFVLAVPEASTDFPGPQASPDSILAADLLLLEDGHCLRDQALNVCRKVDARQLRRFGASSLATLAQLVANGQGITL
LPDLFVRAEGGRLAGVRLLPFPDPVPARTIGLVWRRTLPSRKDVAAVADMVKACRPGP

Sequences:

>Translated_298_residues
MLSIRQLRYFDALARHRHFGRAAEDCAVTQPALSMQIREMEEMLGVRLLERGRGGVRLTPVGEEAAGRARGVLAALADME
RTIRDSGRLLEGRLRLGVIASIAPYLLPRLLPEMARSHPGLEIALRESQTEHLVADLVQGDLDLVILSLPVEHPALEAMA
LFEDRFVLAVPEASTDFPGPQASPDSILAADLLLLEDGHCLRDQALNVCRKVDARQLRRFGASSLATLAQLVANGQGITL
LPDLFVRAEGGRLAGVRLLPFPDPVPARTIGLVWRRTLPSRKDVAAVADMVKACRPGP
>Mature_298_residues
MLSIRQLRYFDALARHRHFGRAAEDCAVTQPALSMQIREMEEMLGVRLLERGRGGVRLTPVGEEAAGRARGVLAALADME
RTIRDSGRLLEGRLRLGVIASIAPYLLPRLLPEMARSHPGLEIALRESQTEHLVADLVQGDLDLVILSLPVEHPALEAMA
LFEDRFVLAVPEASTDFPGPQASPDSILAADLLLLEDGHCLRDQALNVCRKVDARQLRRFGASSLATLAQLVANGQGITL
LPDLFVRAEGGRLAGVRLLPFPDPVPARTIGLVWRRTLPSRKDVAAVADMVKACRPGP

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=297, Percent_Identity=43.0976430976431, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI157672245, Length=277, Percent_Identity=31.7689530685921, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1787879, Length=278, Percent_Identity=28.0575539568345, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788748, Length=298, Percent_Identity=29.5302013422819, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788887, Length=298, Percent_Identity=27.1812080536913, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI2367136, Length=268, Percent_Identity=27.6119402985075, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI48994962, Length=292, Percent_Identity=28.4246575342466, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788297, Length=260, Percent_Identity=27.3076923076923, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787601, Length=170, Percent_Identity=31.1764705882353, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1790208, Length=248, Percent_Identity=29.0322580645161, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI145693105, Length=284, Percent_Identity=26.4084507042254, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789173, Length=272, Percent_Identity=26.8382352941176, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789506, Length=290, Percent_Identity=21.3793103448276, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87081904, Length=169, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI145693193, Length=190, Percent_Identity=30.5263157894737, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787806, Length=280, Percent_Identity=22.1428571428571, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786401, Length=276, Percent_Identity=25.7246376811594, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787530, Length=169, Percent_Identity=24.8520710059172, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32464; Mature: 32464

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSIRQLRYFDALARHRHFGRAAEDCAVTQPALSMQIREMEEMLGVRLLERGRGGVRLTP
CCCHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
VGEEAAGRARGVLAALADMERTIRDSGRLLEGRLRLGVIASIAPYLLPRLLPEMARSHPG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LEIALRESQTEHLVADLVQGDLDLVILSLPVEHPALEAMALFEDRFVLAVPEASTDFPGP
EEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCCCCC
QASPDSILAADLLLLEDGHCLRDQALNVCRKVDARQLRRFGASSLATLAQLVANGQGITL
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEE
LPDLFVRAEGGRLAGVRLLPFPDPVPARTIGLVWRRTLPSRKDVAAVADMVKACRPGP
CCHHHEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLSIRQLRYFDALARHRHFGRAAEDCAVTQPALSMQIREMEEMLGVRLLERGRGGVRLTP
CCCHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
VGEEAAGRARGVLAALADMERTIRDSGRLLEGRLRLGVIASIAPYLLPRLLPEMARSHPG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LEIALRESQTEHLVADLVQGDLDLVILSLPVEHPALEAMALFEDRFVLAVPEASTDFPGP
EEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCCCCC
QASPDSILAADLLLLEDGHCLRDQALNVCRKVDARQLRRFGASSLATLAQLVANGQGITL
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEE
LPDLFVRAEGGRLAGVRLLPFPDPVPARTIGLVWRRTLPSRKDVAAVADMVKACRPGP
CCHHHEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]