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The map label for this gene is cah [H]

Identifier: 154246171

GI number: 154246171

Start: 2488064

End: 2488813

Strand: Direct

Name: cah [H]

Synonym: Xaut_2228

Alternate gene names: 154246171

Gene position: 2488064-2488813 (Clockwise)

Preceding gene: 154246170

Following gene: 154246176

Centisome position: 46.87

GC content: 68.4

Gene sequence:

>750_bases
ATGGCCGTTACACGTCGTACTTTGCTTGCGGGCCTCATCGCGTGCCCGGTCTGTGCCAGCGCCGCGCACGCAGCCGGTGT
GCACTGGACGTATGAGGGCCACGGCGGCCCGCAGGAATGGGGGTCGCTGGAAAGCGGCTTCCAGGCCTGCGCAGTTGGCA
GCCAGCAGTCGCCCATCAACCTGGAAGGGGCCGTGCAGGCCGCTGGAGACGGGCCGACGTTGGCCTGGAAGCCCGACGCC
TTCAAGATCGTCAACAACGGCCACACCATCCAGGCCGACGTGGTGGGGGATGCGGGAACGGCCACCATGGGCGGCAAGAC
CTACACCCTGCGCCAGTTCCACTTCCATGCACCGAGCGAACACGCCCTGAACGGCGAGCGGACCGCCATGGAGGCTCATT
TCGTCCATGACGCGCCCGGAGGCGGCCTGCTGGTGGTGGGGGTGTTCATAAAGCCCGGCGCCACCAACGCCGCCTTCTCC
GAGGTGATGGCGAGCGCCCCCCGCGCGGAAGGCTCGACCGCGCTCAAGGCTCCGCTCGATGCCACCGGGTTGCTGCCGGC
GCAGCGGGCCACCTATCGCTACGAGGGCTCGCTGACCACGCCGCCCTGCTCGGAGGTGGTGGACTGGAACGTGTACGCCA
CGCCCATTTCGGTGGCTGAGGCCGACATCGCCGCCTTCCGCGCCATCTTCCCCATGAATGCGCGGCCGCTGCAGGCGGTG
AACCGGCGCTTCCTGTTGCGGCTCAATTGA

Upstream 100 bases:

>100_bases
ATATGCCGTCGAAATGGCACCAATACCATTTCATCCCTCCTTCTCGTGCTCTAGCTTTCGCACACCGATGGAATTCGGAT
GTCATAAAAGGGGAAACGCC

Downstream 100 bases:

>100_bases
TACCTGCGGGCGGGTGATATCTGGCGGTCGAGTGACCGGTGGGCGAGCCTGGCTCTCCCGCCGGTCAGGCCCGCGCGGCG
TTCGAGCGTATCCCGTTCCG

Product: carbonate dehydratase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MAVTRRTLLAGLIACPVCASAAHAAGVHWTYEGHGGPQEWGSLESGFQACAVGSQQSPINLEGAVQAAGDGPTLAWKPDA
FKIVNNGHTIQADVVGDAGTATMGGKTYTLRQFHFHAPSEHALNGERTAMEAHFVHDAPGGGLLVVGVFIKPGATNAAFS
EVMASAPRAEGSTALKAPLDATGLLPAQRATYRYEGSLTTPPCSEVVDWNVYATPISVAEADIAAFRAIFPMNARPLQAV
NRRFLLRLN

Sequences:

>Translated_249_residues
MAVTRRTLLAGLIACPVCASAAHAAGVHWTYEGHGGPQEWGSLESGFQACAVGSQQSPINLEGAVQAAGDGPTLAWKPDA
FKIVNNGHTIQADVVGDAGTATMGGKTYTLRQFHFHAPSEHALNGERTAMEAHFVHDAPGGGLLVVGVFIKPGATNAAFS
EVMASAPRAEGSTALKAPLDATGLLPAQRATYRYEGSLTTPPCSEVVDWNVYATPISVAEADIAAFRAIFPMNARPLQAV
NRRFLLRLN
>Mature_248_residues
AVTRRTLLAGLIACPVCASAAHAAGVHWTYEGHGGPQEWGSLESGFQACAVGSQQSPINLEGAVQAAGDGPTLAWKPDAF
KIVNNGHTIQADVVGDAGTATMGGKTYTLRQFHFHAPSEHALNGERTAMEAHFVHDAPGGGLLVVGVFIKPGATNAAFSE
VMASAPRAEGSTALKAPLDATGLLPAQRATYRYEGSLTTPPCSEVVDWNVYATPISVAEADIAAFRAIFPMNARPLQAVN
RRFLLRLN

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI4557395, Length=234, Percent_Identity=32.0512820512821, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI4885101, Length=231, Percent_Identity=34.1991341991342, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI4885099, Length=258, Percent_Identity=31.0077519379845, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI258679498, Length=246, Percent_Identity=28.8617886178862, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI192447434, Length=246, Percent_Identity=28.8617886178862, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI192447432, Length=246, Percent_Identity=28.8617886178862, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI192447430, Length=246, Percent_Identity=28.8617886178862, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4502517, Length=246, Percent_Identity=28.8617886178862, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI38348436, Length=230, Percent_Identity=29.5652173913043, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI62240989, Length=176, Percent_Identity=35.2272727272727, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI45935383, Length=257, Percent_Identity=28.4046692607004, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI4502515, Length=257, Percent_Identity=28.4046692607004, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI6912284, Length=266, Percent_Identity=29.3233082706767, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI4502521, Length=235, Percent_Identity=32.3404255319149, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI6005723, Length=230, Percent_Identity=29.1304347826087, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4502519, Length=276, Percent_Identity=28.2608695652174, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI70167127, Length=228, Percent_Identity=30.7017543859649, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI169636420, Length=257, Percent_Identity=29.5719844357977, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI194097398, Length=239, Percent_Identity=27.6150627615063, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17568715, Length=257, Percent_Identity=31.9066147859922, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71995280, Length=272, Percent_Identity=27.5735294117647, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17569163, Length=153, Percent_Identity=33.9869281045752, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17569165, Length=153, Percent_Identity=33.9869281045752, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21358169, Length=289, Percent_Identity=28.719723183391, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17737413, Length=232, Percent_Identity=32.3275862068966, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24645604, Length=268, Percent_Identity=27.6119402985075, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI161079350, Length=272, Percent_Identity=27.2058823529412, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24650523, Length=247, Percent_Identity=28.3400809716599, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116008410, Length=269, Percent_Identity=27.1375464684015, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 26088; Mature: 25956

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTRRTLLAGLIACPVCASAAHAAGVHWTYEGHGGPQEWGSLESGFQACAVGSQQSPIN
CCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHCCHHHHHHHHCCCCCCCCCC
LEGAVQAAGDGPTLAWKPDAFKIVNNGHTIQADVVGDAGTATMGGKTYTLRQFHFHAPSE
CCCEEEECCCCCEEEECCCCEEEECCCCEEEEEECCCCCCCCCCCCEEEEEEEEECCCCC
HALNGERTAMEAHFVHDAPGGGLLVVGVFIKPGATNAAFSEVMASAPRAEGSTALKAPLD
CCCCCCCCEEEEEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCEEECCCC
ATGLLPAQRATYRYEGSLTTPPCSEVVDWNVYATPISVAEADIAAFRAIFPMNARPLQAV
CCCCCCCCCCEEEECCCCCCCCHHHHCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHH
NRRFLLRLN
CCEEEEEEC
>Mature Secondary Structure 
AVTRRTLLAGLIACPVCASAAHAAGVHWTYEGHGGPQEWGSLESGFQACAVGSQQSPIN
CCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHCCHHHHHHHHCCCCCCCCCC
LEGAVQAAGDGPTLAWKPDAFKIVNNGHTIQADVVGDAGTATMGGKTYTLRQFHFHAPSE
CCCEEEECCCCCEEEECCCCEEEECCCCEEEEEECCCCCCCCCCCCEEEEEEEEECCCCC
HALNGERTAMEAHFVHDAPGGGLLVVGVFIKPGATNAAFSEVMASAPRAEGSTALKAPLD
CCCCCCCCEEEEEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCEEECCCC
ATGLLPAQRATYRYEGSLTTPPCSEVVDWNVYATPISVAEADIAAFRAIFPMNARPLQAV
CCCCCCCCCCEEEECCCCCCCCHHHHCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHH
NRRFLLRLN
CCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9108244; 7721686; 9761692 [H]