Click here to switch to the map view.

The map label for this gene is ubiB [H]

Identifier: 154245960

GI number: 154245960

Start: 2275189

End: 2276760

Strand: Direct

Name: ubiB [H]

Synonym: Xaut_2017

Alternate gene names: 154245960

Gene position: 2275189-2276760 (Clockwise)

Preceding gene: 154245959

Following gene: 154245962

Centisome position: 42.86

GC content: 70.17

Gene sequence:

>1572_bases
ATGATCTTCTTTCTCGCCGCCGACGCGGCGCGGCTCGCCCGCGCCGGCTACGTGCTCGCCCGCGAAGGCGTGCTCTCCCT
CATGTCGCCGGCGGCGGCGCCGCCCCTGGCGCGCCCGCTGCTGCGCATCGCCCGGCTGATCGCCCGCAAGGATGCCGGCA
GCCGTCCGGCGCGCTTCTCCGCGGCCCTGTCCCGGCTCGGCCCGTCCTATGTGAAGCTCGGCCAGTTCCTCGCCACCCGG
CCGGACGTGGTGGGCGCCTCGGTGGCCCGCGACCTGGAAGTGCTGCAGGACCGCATGCCCATCATCGGGCAGGAGGTGGC
GGAGGCCACCGTCGCCGAGGCCTTCGAGCGGCCGGTGCACGAGGTCTATGCGCAGTTCGGCCCGGCGGTGGCCGCGGCCT
CCATCGCCGAGGTCCACAAGGCCGAGGTGGCGGACAAGGACGGCACCCGCCACACGGTGGCGGTGAAGATCCTGCGGCCC
GGCGTGGAGCGTCGCTTCTCCTCCGACATGGGCTCGTTCCGCCGCATCGCCCATTTTGCCGAGGCCAATTTTGCCGAGGC
CCGGCGGCTGCGGCTGGAAACCGTGGTGGATACGCTGGCCCGCTCGGTGTCCATGGAAATGGACCTGCGCCTTGAGGCCG
CCGCCTATGCGGAGCTGGCCGAGAACATCGGCGCGGACAAGGAAATCCACGTCCCCCGCGTGGACTGGGACCGCTCCGGC
CGCGAGGTGCTGACCACCGAATGGATCGACGGCATCAAGCTCTCCGACAAGGAGGCGCTGGTCGCGGCCGGGCACGATCT
CAAGGAGATCGCCCGCGTCGTCATGCAGTCGTTCCTGAAGCAGGCCATGCGCGACGGCTTCTTCCACGCCGACATGCATC
CCGGCAATTTGTTCGTGGATGCCCAGGGCCGCCTCGTGATCGTGGATTGCGGCATCATGGGCCGCCTTGGCCTGAAGGAG
CGGCGCTTCCTCGCCGAGATCCTCTACGGTTTCATCACCCGCAACTGGCGGCGCACGGCGGAAGTGCATTTCGAGGCCGG
CTACGTGCCGCTCCATCACTCGGTGGATGATTTCGCCCTGGCCATCCGCGCCATCGGCGAGCCGATCCACTCGCGCACCG
CCGACCAGATCTCCATGGCCCGCCTTCTGGCGCTGCTGCTGGAGGTGACCGCTTTGTTCGACATGCAGACCCGGCCCGAG
CTGCTGCTGCTGCAGAAGACCATGGTGGTGGTGGAAGGCGTCGCCCGCTCCCTCGATCCGCAGCTCGACATGTGGAAGAC
GGCCCGCCCGGTGGTGGAGGACTGGATCGCCGGCAATCTCGGGCCCGTCGGCCAGCTCCAGCGCGCCGGCGGCGGCCTGT
CCGAAATGGCCCATTTCGCCGCCACCTTGCCGGGGCTTCTCACCCGCACCGGGCGGGTGATGGAGCAGCTCGACGTGGCG
ACGCGGGACGGGCTGAGCCTGTCGCCCGCCTCCCTTGAGGGCATCGGCCGCGCCGAGGCCAAGCGCGCCTTCTGGGGCAA
CCTCGCCCTGTGGGTCATCGCCGCCGCCCTGCTGGGCATCTGGCTGGGGTGA

Upstream 100 bases:

>100_bases
CGTGAGGCCGGCTTCTCCCGCGTCGACTTCACGCGCATGACCGGCGGCGTGGTGGCCCTGCACTGGGGCTGGCGCATCTG
ATGGCGCGCGGCCTTTGACC

Downstream 100 bases:

>100_bases
ACGCAAGGCGCGTCGGTATGAAAACCCGCCGCCCGTCCGCTCACTCCGGCATGGATTGCGGGAGGCGCACCCGACCCGCC
GGCGCCGGGCTGCCCACGAG

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MIFFLAADAARLARAGYVLAREGVLSLMSPAAAPPLARPLLRIARLIARKDAGSRPARFSAALSRLGPSYVKLGQFLATR
PDVVGASVARDLEVLQDRMPIIGQEVAEATVAEAFERPVHEVYAQFGPAVAAASIAEVHKAEVADKDGTRHTVAVKILRP
GVERRFSSDMGSFRRIAHFAEANFAEARRLRLETVVDTLARSVSMEMDLRLEAAAYAELAENIGADKEIHVPRVDWDRSG
REVLTTEWIDGIKLSDKEALVAAGHDLKEIARVVMQSFLKQAMRDGFFHADMHPGNLFVDAQGRLVIVDCGIMGRLGLKE
RRFLAEILYGFITRNWRRTAEVHFEAGYVPLHHSVDDFALAIRAIGEPIHSRTADQISMARLLALLLEVTALFDMQTRPE
LLLLQKTMVVVEGVARSLDPQLDMWKTARPVVEDWIAGNLGPVGQLQRAGGGLSEMAHFAATLPGLLTRTGRVMEQLDVA
TRDGLSLSPASLEGIGRAEAKRAFWGNLALWVIAAALLGIWLG

Sequences:

>Translated_523_residues
MIFFLAADAARLARAGYVLAREGVLSLMSPAAAPPLARPLLRIARLIARKDAGSRPARFSAALSRLGPSYVKLGQFLATR
PDVVGASVARDLEVLQDRMPIIGQEVAEATVAEAFERPVHEVYAQFGPAVAAASIAEVHKAEVADKDGTRHTVAVKILRP
GVERRFSSDMGSFRRIAHFAEANFAEARRLRLETVVDTLARSVSMEMDLRLEAAAYAELAENIGADKEIHVPRVDWDRSG
REVLTTEWIDGIKLSDKEALVAAGHDLKEIARVVMQSFLKQAMRDGFFHADMHPGNLFVDAQGRLVIVDCGIMGRLGLKE
RRFLAEILYGFITRNWRRTAEVHFEAGYVPLHHSVDDFALAIRAIGEPIHSRTADQISMARLLALLLEVTALFDMQTRPE
LLLLQKTMVVVEGVARSLDPQLDMWKTARPVVEDWIAGNLGPVGQLQRAGGGLSEMAHFAATLPGLLTRTGRVMEQLDVA
TRDGLSLSPASLEGIGRAEAKRAFWGNLALWVIAAALLGIWLG
>Mature_523_residues
MIFFLAADAARLARAGYVLAREGVLSLMSPAAAPPLARPLLRIARLIARKDAGSRPARFSAALSRLGPSYVKLGQFLATR
PDVVGASVARDLEVLQDRMPIIGQEVAEATVAEAFERPVHEVYAQFGPAVAAASIAEVHKAEVADKDGTRHTVAVKILRP
GVERRFSSDMGSFRRIAHFAEANFAEARRLRLETVVDTLARSVSMEMDLRLEAAAYAELAENIGADKEIHVPRVDWDRSG
REVLTTEWIDGIKLSDKEALVAAGHDLKEIARVVMQSFLKQAMRDGFFHADMHPGNLFVDAQGRLVIVDCGIMGRLGLKE
RRFLAEILYGFITRNWRRTAEVHFEAGYVPLHHSVDDFALAIRAIGEPIHSRTADQISMARLLALLLEVTALFDMQTRPE
LLLLQKTMVVVEGVARSLDPQLDMWKTARPVVEDWIAGNLGPVGQLQRAGGGLSEMAHFAATLPGLLTRTGRVMEQLDVA
TRDGLSLSPASLEGIGRAEAKRAFWGNLALWVIAAALLGIWLG

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=274, Percent_Identity=31.021897810219, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI40254938, Length=279, Percent_Identity=24.7311827956989, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI217035081, Length=229, Percent_Identity=26.2008733624454, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI2367309, Length=390, Percent_Identity=36.1538461538462, Blast_Score=254, Evalue=9e-69,
Organism=Caenorhabditis elegans, GI17559152, Length=266, Percent_Identity=24.4360902255639, Blast_Score=99, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6325148, Length=447, Percent_Identity=22.8187919463087, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6323282, Length=286, Percent_Identity=23.0769230769231, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24662575, Length=278, Percent_Identity=28.7769784172662, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI22024280, Length=257, Percent_Identity=23.3463035019455, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 57273; Mature: 57273

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFFLAADAARLARAGYVLAREGVLSLMSPAAAPPLARPLLRIARLIARKDAGSRPARFS
CEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
AALSRLGPSYVKLGQFLATRPDVVGASVARDLEVLQDRMPIIGQEVAEATVAEAFERPVH
HHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
EVYAQFGPAVAAASIAEVHKAEVADKDGTRHTVAVKILRPGVERRFSSDMGSFRRIAHFA
HHHHHHCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
EANFAEARRLRLETVVDTLARSVSMEMDLRLEAAAYAELAENIGADKEIHVPRVDWDRSG
HCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCC
REVLTTEWIDGIKLSDKEALVAAGHDLKEIARVVMQSFLKQAMRDGFFHADMHPGNLFVD
CEEHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEE
AQGRLVIVDCGIMGRLGLKERRFLAEILYGFITRNWRRTAEVHFEAGYVPLHHSVDDFAL
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHEEEEEECCCEECCCCHHHHHH
AIRAIGEPIHSRTADQISMARLLALLLEVTALFDMQTRPELLLLQKTMVVVEGVARSLDP
HHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCC
QLDMWKTARPVVEDWIAGNLGPVGQLQRAGGGLSEMAHFAATLPGLLTRTGRVMEQLDVA
CHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRDGLSLSPASLEGIGRAEAKRAFWGNLALWVIAAALLGIWLG
HCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIFFLAADAARLARAGYVLAREGVLSLMSPAAAPPLARPLLRIARLIARKDAGSRPARFS
CEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
AALSRLGPSYVKLGQFLATRPDVVGASVARDLEVLQDRMPIIGQEVAEATVAEAFERPVH
HHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
EVYAQFGPAVAAASIAEVHKAEVADKDGTRHTVAVKILRPGVERRFSSDMGSFRRIAHFA
HHHHHHCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
EANFAEARRLRLETVVDTLARSVSMEMDLRLEAAAYAELAENIGADKEIHVPRVDWDRSG
HCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCC
REVLTTEWIDGIKLSDKEALVAAGHDLKEIARVVMQSFLKQAMRDGFFHADMHPGNLFVD
CEEHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEE
AQGRLVIVDCGIMGRLGLKERRFLAEILYGFITRNWRRTAEVHFEAGYVPLHHSVDDFAL
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHEEEEEECCCEECCCCHHHHHH
AIRAIGEPIHSRTADQISMARLLALLLEVTALFDMQTRPELLLLQKTMVVVEGVARSLDP
HHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCC
QLDMWKTARPVVEDWIAGNLGPVGQLQRAGGGLSEMAHFAATLPGLLTRTGRVMEQLDVA
CHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRDGLSLSPASLEGIGRAEAKRAFWGNLALWVIAAALLGIWLG
HCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA