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The map label for this gene is ubiE [H]

Identifier: 154245959

GI number: 154245959

Start: 2274270

End: 2275169

Strand: Direct

Name: ubiE [H]

Synonym: Xaut_2016

Alternate gene names: 154245959

Gene position: 2274270-2275169 (Clockwise)

Preceding gene: 154245958

Following gene: 154245960

Centisome position: 42.84

GC content: 67.44

Gene sequence:

>900_bases
GTGCGTGCGACGCCGGCTTTATGGCGCCGGCCCGGATCATCCGATAAGGTCCCGGCCCGAAACAACAGCGTGCGGCCAGA
TTCCCCAATGACGGACCTGAATACGGACCTTAATACGGACCCGAATTCCCAGCCCGGCGCCGGCGCGCCCCGGACCGAGA
CCCATTTCGGCTACCGCACGGTTCCGCTCACCGAGAAGCAGTCGCTGGTGGACGACGTGTTCCACAAGGTGGCGCGCCGC
TACGACATCATGAACGACTTCATGTCCGGCGGCCTGCACCGGGTGTGGAAGGATGCGCTGGTCTCCAAAGTGCGCCCGCC
GCAGGGCGCGCGGCCGTTCGAACTGCTGGATCTGGCCGGCGGCACCGGCGACGTGTCGTTTCGGGTGGTGAAGGCGGGCG
GCGCGGGCACCCGCGCCACCGTTGCCGACATCAACGCCGAGATGCTGGCGGTGGGCCGCGAGCGGGCGGAAAAGCGCGGC
CTGGGCGACAAGGTCACCTTCACCGAAGCCAATGCCGAGGCGCTGCCCTTCCCGGACCAGTCCTTCGACGCAGTCACCAT
CGCCTTCGGCATCCGCAACGTGCCGCGCATCCCGCTGGCGCTCACCGAGATGCGGCGGGTGCTGAAGCCGGGCGGCCGCG
CCTTCGTGCTGGAATTCTCCAAGGTGGACGTGCCGCTGCTGGACAAGATCTACGAGGCCTATTCCTTCAACGTCATCCCG
CAGCTCGGCAAGCGGGTGGCCGGCGATGCCGAGCCCTACCAGTATCTGGTGGAATCCATCCGCCGCTTCCCCAATCCGGA
CGTGTTCGCCAACATGATGCGTGAGGCCGGCTTCTCCCGCGTCGACTTCACGCGCATGACCGGCGGCGTGGTGGCCCTGC
ACTGGGGCTGGCGCATCTGA

Upstream 100 bases:

>100_bases
TCGTGACGGCGGATCGGGAGCTGTTCTGGGGCAACGACCGGCTGGAGATGGCCCTCGACCACGCCCGCAGCCTCGCCAGG
GTGGGGTGAGGATCACGCCG

Downstream 100 bases:

>100_bases
TGGCGCGCGGCCTTTGACCATGATCTTCTTTCTCGCCGCCGACGCGGCGCGGCTCGCCCGCGCCGGCTACGTGCTCGCCC
GCGAAGGCGTGCTCTCCCTC

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MRATPALWRRPGSSDKVPARNNSVRPDSPMTDLNTDLNTDPNSQPGAGAPRTETHFGYRTVPLTEKQSLVDDVFHKVARR
YDIMNDFMSGGLHRVWKDALVSKVRPPQGARPFELLDLAGGTGDVSFRVVKAGGAGTRATVADINAEMLAVGRERAEKRG
LGDKVTFTEANAEALPFPDQSFDAVTIAFGIRNVPRIPLALTEMRRVLKPGGRAFVLEFSKVDVPLLDKIYEAYSFNVIP
QLGKRVAGDAEPYQYLVESIRRFPNPDVFANMMREAGFSRVDFTRMTGGVVALHWGWRI

Sequences:

>Translated_299_residues
MRATPALWRRPGSSDKVPARNNSVRPDSPMTDLNTDLNTDPNSQPGAGAPRTETHFGYRTVPLTEKQSLVDDVFHKVARR
YDIMNDFMSGGLHRVWKDALVSKVRPPQGARPFELLDLAGGTGDVSFRVVKAGGAGTRATVADINAEMLAVGRERAEKRG
LGDKVTFTEANAEALPFPDQSFDAVTIAFGIRNVPRIPLALTEMRRVLKPGGRAFVLEFSKVDVPLLDKIYEAYSFNVIP
QLGKRVAGDAEPYQYLVESIRRFPNPDVFANMMREAGFSRVDFTRMTGGVVALHWGWRI
>Mature_299_residues
MRATPALWRRPGSSDKVPARNNSVRPDSPMTDLNTDLNTDPNSQPGAGAPRTETHFGYRTVPLTEKQSLVDDVFHKVARR
YDIMNDFMSGGLHRVWKDALVSKVRPPQGARPFELLDLAGGTGDVSFRVVKAGGAGTRATVADINAEMLAVGRERAEKRG
LGDKVTFTEANAEALPFPDQSFDAVTIAFGIRNVPRIPLALTEMRRVLKPGGRAFVLEFSKVDVPLLDKIYEAYSFNVIP
QLGKRVAGDAEPYQYLVESIRRFPNPDVFANMMREAGFSRVDFTRMTGGVVALHWGWRI

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=281, Percent_Identity=45.5516014234875, Blast_Score=249, Evalue=3e-66,
Organism=Escherichia coli, GI48994983, Length=247, Percent_Identity=50.2024291497976, Blast_Score=246, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17557039, Length=259, Percent_Identity=47.1042471042471, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI25143945, Length=188, Percent_Identity=26.063829787234, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323526, Length=271, Percent_Identity=41.3284132841328, Blast_Score=211, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24641702, Length=266, Percent_Identity=46.9924812030075, Blast_Score=245, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 33102; Mature: 33102

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRATPALWRRPGSSDKVPARNNSVRPDSPMTDLNTDLNTDPNSQPGAGAPRTETHFGYRT
CCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
VPLTEKQSLVDDVFHKVARRYDIMNDFMSGGLHRVWKDALVSKVRPPQGARPFELLDLAG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEEECC
GTGDVSFRVVKAGGAGTRATVADINAEMLAVGRERAEKRGLGDKVTFTEANAEALPFPDQ
CCCCEEEEEEEECCCCCCEEHHHCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCC
SFDAVTIAFGIRNVPRIPLALTEMRRVLKPGGRAFVLEFSKVDVPLLDKIYEAYSFNVIP
CCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCHHH
QLGKRVAGDAEPYQYLVESIRRFPNPDVFANMMREAGFSRVDFTRMTGGVVALHWGWRI
HHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHCCCEEEEECCCCC
>Mature Secondary Structure
MRATPALWRRPGSSDKVPARNNSVRPDSPMTDLNTDLNTDPNSQPGAGAPRTETHFGYRT
CCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
VPLTEKQSLVDDVFHKVARRYDIMNDFMSGGLHRVWKDALVSKVRPPQGARPFELLDLAG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEEECC
GTGDVSFRVVKAGGAGTRATVADINAEMLAVGRERAEKRGLGDKVTFTEANAEALPFPDQ
CCCCEEEEEEEECCCCCCEEHHHCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCC
SFDAVTIAFGIRNVPRIPLALTEMRRVLKPGGRAFVLEFSKVDVPLLDKIYEAYSFNVIP
CCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCHHH
QLGKRVAGDAEPYQYLVESIRRFPNPDVFANMMREAGFSRVDFTRMTGGVVALHWGWRI
HHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA