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The map label for this gene is livH [H]

Identifier: 154245806

GI number: 154245806

Start: 2097718

End: 2098611

Strand: Direct

Name: livH [H]

Synonym: Xaut_1862

Alternate gene names: 154245806

Gene position: 2097718-2098611 (Clockwise)

Preceding gene: 154245805

Following gene: 154245807

Centisome position: 39.51

GC content: 62.53

Gene sequence:

>894_bases
ATGCAATCCCAGCTCCTGCTCCAGCTCATCATCAACGGGCTCATCATCGGCACGCTCTATGGCGTGGTCGGCATGTGCTT
CGTGCTCATCTACAAGGCCTCGCAGGTGGTGAACTTCGCCCAGGGCGAGTTCCTGCTCATCGGCGCCTGGACCTGCTGGT
GGCTGCTCACGGCGTGGAACATCCCCTTCTTCTGGGGCTTCCTCATCGCCGTGTGCTTCATGATGGTGTTCGGCATCGTG
GTGCAGATGGTGGTGCTGCGCCCGCTCATCGGCGAGCCGATCATCTCGGTGATCATGGTCACCATCGGCATGTCCATCTT
CTTCCAGGCGCTGATGAAGTGGATGTTCGGCACCTTCGCCCAGCCGTTCCCGCCCATCTTCAGCGTGGACAAGGTGAACA
TCATGGGCCTGCAGGTGCAGACGGCCTATCTCATGTCCACCGGCGTGAGTTTGGCCATCATGGCGGGGTTCGCCTGGTTC
TTTAAGTATTCGCGCCTCGGCCTTGCCATGCGCGCCACCGCCTTCTCCCAGCAGGTGGCGCAGTCGCTCGGCATCTCGGT
GCGCCAGGTGTTCGCTTTGTCCTGGGGCATCTCGGCGGCGGTGTCGGCGGTGGCCGGCGTGGTGGTGGGCATCGTGAACG
GGGTGTCCTCGGCGCTGTCCTACTTCGGCATCAAGGTGTTCCCGGCGGTGATCCTCGGCGGCCTCGACAGCGTGTTCGGG
GCGGTGGTGGGCGGCCTCATCATGGGCCTGCTGGAAAACCTCGCCCAGTTCTTCGACAGCCAGTACCTGAAGTGGGGCAA
CCTCTACGAGATCGTCCCGTTCTACGCGCTCATCATCATCCTGATGATCAAGCCCTACGGGCTGTTCGGCACCCGCGACA
TCGAGAGGGTCTGA

Upstream 100 bases:

>100_bases
CGCCTGCCCGGATCACGGCCGCCGGCATCTGTTTTCACCATCCCTTCCCCCTCCCAACCCTCCCCCGCAAGCGGGAGAGG
GCCTTTGAAGGGAGCCTCTG

Downstream 100 bases:

>100_bases
TCCATGGCCATCGACACCCTTCGCCCGTGCGGCGACTACCGCACCAGCTACAAGGCCGACCAGACCATCTTCGCGACCCG
GCTCACCATGCTGTTCTGCG

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MQSQLLLQLIINGLIIGTLYGVVGMCFVLIYKASQVVNFAQGEFLLIGAWTCWWLLTAWNIPFFWGFLIAVCFMMVFGIV
VQMVVLRPLIGEPIISVIMVTIGMSIFFQALMKWMFGTFAQPFPPIFSVDKVNIMGLQVQTAYLMSTGVSLAIMAGFAWF
FKYSRLGLAMRATAFSQQVAQSLGISVRQVFALSWGISAAVSAVAGVVVGIVNGVSSALSYFGIKVFPAVILGGLDSVFG
AVVGGLIMGLLENLAQFFDSQYLKWGNLYEIVPFYALIIILMIKPYGLFGTRDIERV

Sequences:

>Translated_297_residues
MQSQLLLQLIINGLIIGTLYGVVGMCFVLIYKASQVVNFAQGEFLLIGAWTCWWLLTAWNIPFFWGFLIAVCFMMVFGIV
VQMVVLRPLIGEPIISVIMVTIGMSIFFQALMKWMFGTFAQPFPPIFSVDKVNIMGLQVQTAYLMSTGVSLAIMAGFAWF
FKYSRLGLAMRATAFSQQVAQSLGISVRQVFALSWGISAAVSAVAGVVVGIVNGVSSALSYFGIKVFPAVILGGLDSVFG
AVVGGLIMGLLENLAQFFDSQYLKWGNLYEIVPFYALIIILMIKPYGLFGTRDIERV
>Mature_297_residues
MQSQLLLQLIINGLIIGTLYGVVGMCFVLIYKASQVVNFAQGEFLLIGAWTCWWLLTAWNIPFFWGFLIAVCFMMVFGIV
VQMVVLRPLIGEPIISVIMVTIGMSIFFQALMKWMFGTFAQPFPPIFSVDKVNIMGLQVQTAYLMSTGVSLAIMAGFAWF
FKYSRLGLAMRATAFSQQVAQSLGISVRQVFALSWGISAAVSAVAGVVVGIVNGVSSALSYFGIKVFPAVILGGLDSVFG
AVVGGLIMGLLENLAQFFDSQYLKWGNLYEIVPFYALIIILMIKPYGLFGTRDIERV

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=313, Percent_Identity=31.3099041533546, Blast_Score=118, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 32596; Mature: 32596

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSQLLLQLIINGLIIGTLYGVVGMCFVLIYKASQVVNFAQGEFLLIGAWTCWWLLTAWN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCC
IPFFWGFLIAVCFMMVFGIVVQMVVLRPLIGEPIISVIMVTIGMSIFFQALMKWMFGTFA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QPFPPIFSVDKVNIMGLQVQTAYLMSTGVSLAIMAGFAWFFKYSRLGLAMRATAFSQQVA
CCCCCCCCCCCEEEEEEHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSLGISVRQVFALSWGISAAVSAVAGVVVGIVNGVSSALSYFGIKVFPAVILGGLDSVFG
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVGGLIMGLLENLAQFFDSQYLKWGNLYEIVPFYALIIILMIKPYGLFGTRDIERV
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHCCC
>Mature Secondary Structure
MQSQLLLQLIINGLIIGTLYGVVGMCFVLIYKASQVVNFAQGEFLLIGAWTCWWLLTAWN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCC
IPFFWGFLIAVCFMMVFGIVVQMVVLRPLIGEPIISVIMVTIGMSIFFQALMKWMFGTFA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QPFPPIFSVDKVNIMGLQVQTAYLMSTGVSLAIMAGFAWFFKYSRLGLAMRATAFSQQVA
CCCCCCCCCCCEEEEEEHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSLGISVRQVFALSWGISAAVSAVAGVVVGIVNGVSSALSYFGIKVFPAVILGGLDSVFG
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVGGLIMGLLENLAQFFDSQYLKWGNLYEIVPFYALIIILMIKPYGLFGTRDIERV
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]