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The map label for this gene is caiC [C]

Identifier: 154245805

GI number: 154245805

Start: 2095638

End: 2097590

Strand: Direct

Name: caiC [C]

Synonym: Xaut_1861

Alternate gene names: 154245805

Gene position: 2095638-2097590 (Clockwise)

Preceding gene: 154245804

Following gene: 154245806

Centisome position: 39.47

GC content: 66.31

Gene sequence:

>1953_bases
ATGGCCGAAATCACCGCGACCTATCCGGACATCACCGTCCACGACACCATGCCGAAGCTGCTGGCGCTCAACGCCCGCAC
CCATCCCAACGACACCTGGCTGCGCGAGAAGGACCTCGGCATCTGGATTTCCTACACCTGGGCGCAGGTGGCCGAACGGG
TGCGCAACATCACCCTCGGCTTCACCACGCTGGGCGTCGCCCGCGGCGACGTGGTGGGCCTGCTCGGCGACAACCGCCCC
GAATGGCTGATGGGGGAGATCGCCACCCATGCGCTGGGCGGCATGAGCCTTGGCATCTATCGCGATGCGCTGGCCGACGA
GGTGGCCTATCTCGTCACCTACGCGGACGTGGCGGTGGTGTTCGCCGAGGACGAGGAGCAGGTGGACAAGCTGCTCTCCC
TCGATGAAAAGATCCCCACCGTCCGCCACATCGTCTATGCCGACCCGCGCGGCATCCGCAAATACGACGACCCGCGCCTC
ATCTCCCTGAAGGAGCTGGAAGCGCGCGGCGCGGTGGAGGCGGCGCGCGATTCCGGGGCCTATGACCGGCTGGTGGCCCA
GGGCAAGGCCGAGGACGTGGCCATCCTGTGCACCACCTCGGGCACCACCTCCCACCCCAAGCTCGCCATGCTCACCGGCG
GCGCGCTGCTGCGCCACTGCCGCGCCTATCTGGAGATGGACCCGCGCACCAGCGCCGACGAATATGTCAGCGTGCTGCAG
ATGCCGTGGATCATGGAACAGATCTACGCCTTCGGTCAGGCGCTCATCTCCCGCATGAAGGTGAACTTCGTGGAGGAGCA
GGAAACGCTCATGGCCGACATGCGCGAGATCGGCCCCTCCTTCGTGCTGTTCGCCCCGCGCGTATGGGAGCAGATCGCCG
CCGACGTGCGCTCGCGCATGATGGATTCCTCGGCGCTCAAGCGCGGCATGTTCGAGCTGGGCATGAAGCTCGGGCTTAAG
GCCCTGGAGCAGGGCCGCCGCTCGCCGCTCGCGGACTTCATCCTGTTCCGGGCGCTGCGCGACCGGCTCGGTTTTTCGCA
CCTGAAATCCGCCGCCACCGGCGGGGCGGCGCTGGGGCCGGACACCTTCCGCTTCTTCCTCGCGCTGGGCGTGCCCATGC
GCCAGCTCTATGGCCAGACCGAGCTGCTCGGCGCCTACACGCTGCACAAGGCGCAGGACGTGGATTTCGATACCGTGGGC
GTGCCCTTCGACGGCGTCGAGATCCGCATCGACGATCCCGACCCCAACGGCCTTGGCGAGGTGGTGACGCGTCACGGCAA
TGCCTTCACCGGCTATTTCCGCAATGACGAGGAAACCGCGAAATCCTTCGTGGACGGCGGCTGGATGCGCACCGGCGATG
CCGGCTTCTTCAACGATCGCGGCCACCTTGTGGTCATCGACCGCATCCGCGACATGGCGCGGACCGAGCACGGCGATCGC
TTCTCGCCGCAATACATCGAGAACAAGCTGAAATTCTCGCCCTATGTGGCCGAGGCGGTGGTGCTGGGCGACGGGCGCGA
CAGCCTCGCCGCGCTCATCTGCATCCGCTTCTCCATCGTCTCCAAATGGGCGGAGAAGAACCGCATTTCCTTCACCACCT
ATACGGACCTGTCGGCCCGGCCCGAAGTCATCGCGCTGCTGCGCAAGGAAGTGGAGGCGGTGAACCGCACCCTGCCGGAG
AAGCAGCGCATCGGCCGCTTCCTGCTGCTCTACAAGGAGCTGGATGCCGACGACGGCGAACTGACGCGTACCCGCAAGGT
GCGCAGGGGCGTCATCAACGAGCGCTACGGCACCATCATCGACGCCATGTATGCGGGCGAGAAGGTGATCGACGTGGACA
CCACCATCACCTTCCAGGACGGCACCCGCCAGCGCATCAAGACCACACTGGACGTGATCGACCTCGGCGCACCCCCGCGC
CGGGACGACGATACAAGGCGGAGGGCGGCGTGA

Upstream 100 bases:

>100_bases
CTGCCGAGGTGCTGGCCGATCCCCATGTGCGCAAGGCCTATCTGGGCGAGGACGATCTCGATGAAGCGGCCCCCGCCGCC
ATGACCGCGTGAGGTCCGCC

Downstream 100 bases:

>100_bases
TGGGGCTGAGCGCTCAAACCAAGGCTGCGCCTGCCCGGATCACGGCCGCCGGCATCTGTTTTCACCATCCCTTCCCCCTC
CCAACCCTCCCCCGCAAGCG

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 650; Mature: 649

Protein sequence:

>650_residues
MAEITATYPDITVHDTMPKLLALNARTHPNDTWLREKDLGIWISYTWAQVAERVRNITLGFTTLGVARGDVVGLLGDNRP
EWLMGEIATHALGGMSLGIYRDALADEVAYLVTYADVAVVFAEDEEQVDKLLSLDEKIPTVRHIVYADPRGIRKYDDPRL
ISLKELEARGAVEAARDSGAYDRLVAQGKAEDVAILCTTSGTTSHPKLAMLTGGALLRHCRAYLEMDPRTSADEYVSVLQ
MPWIMEQIYAFGQALISRMKVNFVEEQETLMADMREIGPSFVLFAPRVWEQIAADVRSRMMDSSALKRGMFELGMKLGLK
ALEQGRRSPLADFILFRALRDRLGFSHLKSAATGGAALGPDTFRFFLALGVPMRQLYGQTELLGAYTLHKAQDVDFDTVG
VPFDGVEIRIDDPDPNGLGEVVTRHGNAFTGYFRNDEETAKSFVDGGWMRTGDAGFFNDRGHLVVIDRIRDMARTEHGDR
FSPQYIENKLKFSPYVAEAVVLGDGRDSLAALICIRFSIVSKWAEKNRISFTTYTDLSARPEVIALLRKEVEAVNRTLPE
KQRIGRFLLLYKELDADDGELTRTRKVRRGVINERYGTIIDAMYAGEKVIDVDTTITFQDGTRQRIKTTLDVIDLGAPPR
RDDDTRRRAA

Sequences:

>Translated_650_residues
MAEITATYPDITVHDTMPKLLALNARTHPNDTWLREKDLGIWISYTWAQVAERVRNITLGFTTLGVARGDVVGLLGDNRP
EWLMGEIATHALGGMSLGIYRDALADEVAYLVTYADVAVVFAEDEEQVDKLLSLDEKIPTVRHIVYADPRGIRKYDDPRL
ISLKELEARGAVEAARDSGAYDRLVAQGKAEDVAILCTTSGTTSHPKLAMLTGGALLRHCRAYLEMDPRTSADEYVSVLQ
MPWIMEQIYAFGQALISRMKVNFVEEQETLMADMREIGPSFVLFAPRVWEQIAADVRSRMMDSSALKRGMFELGMKLGLK
ALEQGRRSPLADFILFRALRDRLGFSHLKSAATGGAALGPDTFRFFLALGVPMRQLYGQTELLGAYTLHKAQDVDFDTVG
VPFDGVEIRIDDPDPNGLGEVVTRHGNAFTGYFRNDEETAKSFVDGGWMRTGDAGFFNDRGHLVVIDRIRDMARTEHGDR
FSPQYIENKLKFSPYVAEAVVLGDGRDSLAALICIRFSIVSKWAEKNRISFTTYTDLSARPEVIALLRKEVEAVNRTLPE
KQRIGRFLLLYKELDADDGELTRTRKVRRGVINERYGTIIDAMYAGEKVIDVDTTITFQDGTRQRIKTTLDVIDLGAPPR
RDDDTRRRAA
>Mature_649_residues
AEITATYPDITVHDTMPKLLALNARTHPNDTWLREKDLGIWISYTWAQVAERVRNITLGFTTLGVARGDVVGLLGDNRPE
WLMGEIATHALGGMSLGIYRDALADEVAYLVTYADVAVVFAEDEEQVDKLLSLDEKIPTVRHIVYADPRGIRKYDDPRLI
SLKELEARGAVEAARDSGAYDRLVAQGKAEDVAILCTTSGTTSHPKLAMLTGGALLRHCRAYLEMDPRTSADEYVSVLQM
PWIMEQIYAFGQALISRMKVNFVEEQETLMADMREIGPSFVLFAPRVWEQIAADVRSRMMDSSALKRGMFELGMKLGLKA
LEQGRRSPLADFILFRALRDRLGFSHLKSAATGGAALGPDTFRFFLALGVPMRQLYGQTELLGAYTLHKAQDVDFDTVGV
PFDGVEIRIDDPDPNGLGEVVTRHGNAFTGYFRNDEETAKSFVDGGWMRTGDAGFFNDRGHLVVIDRIRDMARTEHGDRF
SPQYIENKLKFSPYVAEAVVLGDGRDSLAALICIRFSIVSKWAEKNRISFTTYTDLSARPEVIALLRKEVEAVNRTLPEK
QRIGRFLLLYKELDADDGELTRTRKVRRGVINERYGTIIDAMYAGEKVIDVDTTITFQDGTRQRIKTTLDVIDLGAPPRR
DDDTRRRAA

Specific function: Could Catalyze The Transfer Of CoA To Crotonobetaine Or Carnitine. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI27477105, Length=604, Percent_Identity=24.6688741721854, Blast_Score=198, Evalue=2e-50,
Organism=Homo sapiens, GI83745141, Length=603, Percent_Identity=25.7048092868988, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI42794760, Length=596, Percent_Identity=25.8389261744966, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI42794758, Length=596, Percent_Identity=25.8389261744966, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI42794756, Length=596, Percent_Identity=25.8389261744966, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI12669909, Length=619, Percent_Identity=23.5864297253635, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI4758332, Length=616, Percent_Identity=23.7012987012987, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI40807491, Length=601, Percent_Identity=27.1214642262895, Blast_Score=169, Evalue=9e-42,
Organism=Homo sapiens, GI57165410, Length=596, Percent_Identity=24.8322147651007, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI57165412, Length=597, Percent_Identity=24.7906197654941, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI42794754, Length=511, Percent_Identity=23.4833659491194, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI42794752, Length=511, Percent_Identity=23.4833659491194, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17541856, Length=596, Percent_Identity=27.1812080536913, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17510401, Length=586, Percent_Identity=24.7440273037543, Blast_Score=166, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17553312, Length=629, Percent_Identity=24.483306836248, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17564090, Length=631, Percent_Identity=24.8811410459588, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25147511, Length=625, Percent_Identity=24.64, Blast_Score=148, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI193204819, Length=615, Percent_Identity=23.9024390243902, Blast_Score=138, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17556552, Length=572, Percent_Identity=21.5034965034965, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI133901848, Length=232, Percent_Identity=25.4310344827586, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71985884, Length=137, Percent_Identity=27.7372262773723, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17559526, Length=186, Percent_Identity=26.3440860215054, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320852, Length=618, Percent_Identity=22.4919093851133, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324893, Length=362, Percent_Identity=22.6519337016575, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323903, Length=538, Percent_Identity=21.5613382899628, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6322182, Length=357, Percent_Identity=24.3697478991597, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319699, Length=419, Percent_Identity=23.3890214797136, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17933690, Length=627, Percent_Identity=24.2424242424242, Blast_Score=196, Evalue=6e-50,
Organism=Drosophila melanogaster, GI19921316, Length=624, Percent_Identity=23.8782051282051, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24666501, Length=590, Percent_Identity=26.7796610169492, Blast_Score=190, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24666497, Length=590, Percent_Identity=26.7796610169492, Blast_Score=190, Evalue=3e-48,
Organism=Drosophila melanogaster, GI281366413, Length=590, Percent_Identity=26.7796610169492, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI62471681, Length=617, Percent_Identity=22.0421393841167, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI62471687, Length=617, Percent_Identity=22.0421393841167, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24586634, Length=617, Percent_Identity=22.0421393841167, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI22026970, Length=617, Percent_Identity=22.0421393841167, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI62471679, Length=617, Percent_Identity=22.0421393841167, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI62471683, Length=617, Percent_Identity=22.0421393841167, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI62471685, Length=617, Percent_Identity=22.0421393841167, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24586636, Length=617, Percent_Identity=22.0421393841167, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI62471689, Length=617, Percent_Identity=22.0421393841167, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI18859661, Length=485, Percent_Identity=23.9175257731959, Blast_Score=80, Evalue=6e-15,
Organism=Drosophila melanogaster, GI281365686, Length=148, Percent_Identity=31.7567567567568, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21358303, Length=132, Percent_Identity=34.0909090909091, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24648260, Length=129, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24648257, Length=153, Percent_Identity=29.4117647058824, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 72819; Mature: 72688

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEITATYPDITVHDTMPKLLALNARTHPNDTWLREKDLGIWISYTWAQVAERVRNITLG
CCCEEECCCCEEECCCCHHHHEECCCCCCCCCCEEECCCCEEEEEHHHHHHHHHHCEEEE
FTTLGVARGDVVGLLGDNRPEWLMGEIATHALGGMSLGIYRDALADEVAYLVTYADVAVV
HHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEE
FAEDEEQVDKLLSLDEKIPTVRHIVYADPRGIRKYDDPRLISLKELEARGAVEAARDSGA
EECCHHHHHHHHHHHHCCCHHHEEEEECCCCCCCCCCCCEEEHHHHHHCCHHHHHHCCCH
YDRLVAQGKAEDVAILCTTSGTTSHPKLAMLTGGALLRHCRAYLEMDPRTSADEYVSVLQ
HHHHHHCCCCCCEEEEEECCCCCCCCEEEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHH
MPWIMEQIYAFGQALISRMKVNFVEEQETLMADMREIGPSFVLFAPRVWEQIAADVRSRM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHH
MDSSALKRGMFELGMKLGLKALEQGRRSPLADFILFRALRDRLGFSHLKSAATGGAALGP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCH
DTFRFFLALGVPMRQLYGQTELLGAYTLHKAQDVDFDTVGVPFDGVEIRIDDPDPNGLGE
HHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHH
VVTRHGNAFTGYFRNDEETAKSFVDGGWMRTGDAGFFNDRGHLVVIDRIRDMARTEHGDR
HHHHCCCEEEEEECCCHHHHHHHHCCCCEECCCCCCCCCCCCEEEHHHHHHHHHCCCCCC
FSPQYIENKLKFSPYVAEAVVLGDGRDSLAALICIRFSIVSKWAEKNRISFTTYTDLSAR
CCHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
PEVIALLRKEVEAVNRTLPEKQRIGRFLLLYKELDADDGELTRTRKVRRGVINERYGTII
HHHHHHHHHHHHHHHHCCCCHHHHHHHEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
DAMYAGEKVIDVDTTITFQDGTRQRIKTTLDVIDLGAPPRRDDDTRRRAA
HHHHCCCEEEEECEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
AEITATYPDITVHDTMPKLLALNARTHPNDTWLREKDLGIWISYTWAQVAERVRNITLG
CCEEECCCCEEECCCCHHHHEECCCCCCCCCCEEECCCCEEEEEHHHHHHHHHHCEEEE
FTTLGVARGDVVGLLGDNRPEWLMGEIATHALGGMSLGIYRDALADEVAYLVTYADVAVV
HHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEE
FAEDEEQVDKLLSLDEKIPTVRHIVYADPRGIRKYDDPRLISLKELEARGAVEAARDSGA
EECCHHHHHHHHHHHHCCCHHHEEEEECCCCCCCCCCCCEEEHHHHHHCCHHHHHHCCCH
YDRLVAQGKAEDVAILCTTSGTTSHPKLAMLTGGALLRHCRAYLEMDPRTSADEYVSVLQ
HHHHHHCCCCCCEEEEEECCCCCCCCEEEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHH
MPWIMEQIYAFGQALISRMKVNFVEEQETLMADMREIGPSFVLFAPRVWEQIAADVRSRM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHH
MDSSALKRGMFELGMKLGLKALEQGRRSPLADFILFRALRDRLGFSHLKSAATGGAALGP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCH
DTFRFFLALGVPMRQLYGQTELLGAYTLHKAQDVDFDTVGVPFDGVEIRIDDPDPNGLGE
HHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHH
VVTRHGNAFTGYFRNDEETAKSFVDGGWMRTGDAGFFNDRGHLVVIDRIRDMARTEHGDR
HHHHCCCEEEEEECCCHHHHHHHHCCCCEECCCCCCCCCCCCEEEHHHHHHHHHCCCCCC
FSPQYIENKLKFSPYVAEAVVLGDGRDSLAALICIRFSIVSKWAEKNRISFTTYTDLSAR
CCHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
PEVIALLRKEVEAVNRTLPEKQRIGRFLLLYKELDADDGELTRTRKVRRGVINERYGTII
HHHHHHHHHHHHHHHHCCCCHHHHHHHEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
DAMYAGEKVIDVDTTITFQDGTRQRIKTTLDVIDLGAPPRRDDDTRRRAA
HHHHCCCEEEEECEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]