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The map label for this gene is adh [H]

Identifier: 154244620

GI number: 154244620

Start: 752695

End: 753819

Strand: Reverse

Name: adh [H]

Synonym: Xaut_0669

Alternate gene names: 154244620

Gene position: 753819-752695 (Counterclockwise)

Preceding gene: 154244623

Following gene: 154244619

Centisome position: 14.2

GC content: 68.8

Gene sequence:

>1125_bases
ATGACCGACACCATCGAACGCCCCGGCTTCGTCGAGCGCAACCGCCCCGGCAGGGCGAAGATGAAGGCGGCCATCTTCGT
GGAGAAGAACCGCATCGTCCTGGACGAGAAGCCCATTCCGGACGTGGGTCCGCTCGACGCCCTCATCCGCATCACCACCA
CCACCATCTGCGGCACGGATGTCCATATCCTGAAGGGCGAATATCCGGTCGAGAAGGGCCTCACCATCGGCCACGAGCCG
GTGGGCATCATCGAGAAGCTGGGTTCGGCGGTGGAAGGGTTCGCCGAGGGCCAGCGCGTGATCGCCGGCGCCATCACCCC
GTCCGGCTATTCCAACGCCTGCCTGTGCGGCTGCGCCTCGCAGGACGGCCCGCGCATGAAGCACGGCTTCAAGCCCATGG
GCGGCTGGCGCTTCGGCAACACCATCGACGGCGCCCAGGCCGAGTATCTGGTGGTGCCCGACGCCATGACCAACCTTGCC
CCGGTGCCCGAAGCCCTCGGCGACGAGCAGGTCCTCATGTGCCCGGACATCATGTCCACCGGCTTTGCCGGCGCCGAGAG
CGGCAAGGTGCGCATCGGCGACACGGTGGCCGTGTTCGCGCAGGGGCCCATCGGCCTGTGCGCCACCGCCGGAGCCCGGC
TCATGGGCGCCACCCGCATCATCGCCGTGGACCGGGTGGGCGAGCGCCTCAACGTCGCCCGCGCCATGGGGGCGGACGAG
GTGGTGGACTTCTCCAAGGTGGACCCGGTGGAAGAGATCCTGCGCCTCACCGACGGGCGCGGCGTGGACGTGGCCATCGA
GGCCCTCGGCCGGCAGGAGACCTTCGAGGCCGCCCTGCGCGTGCTGCGGCCCGGCGGCACCCTGTCCTCGCTGGGGGTCT
ATTCCAGCGACCTGAAGATCCCGCTGGATGCCTTCGCGGCGGGCCTGGGCGACAACAAGATCGTCACCTCGCTCTGCCCC
GGCGGCAAGGAGCGTATGCGCCGCCTGATGGATGTGGTGGCCTCGGGCCGGGTGGATGCCCGCGCCCTCGTCACCCACCG
CTTCAAGCTGGACGACATCGAAAAGGCCTATGACCTGTTCTCGCACCAGCGCGACGGCGTTCTCAAGGTGGCCATCACGC
CTTAA

Upstream 100 bases:

>100_bases
CCCGCATCAATGCCGCGCCGGCCCCTTCGTCCTAACCAGTTACCGCGGCACCGAAGCGTCCCCACGTTTCCCCACCGGGG
ACGGATCAGGAAGGAACGCC

Downstream 100 bases:

>100_bases
TCTTTTGCCGCCCCGGCTCCGCGCCGGGGCGGCTTCCTCCAAGACTTGCTCCAAGAACTTTCTCCAAGAACTTTCTTCAA
GACGGGACGATCCATGACGG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MTDTIERPGFVERNRPGRAKMKAAIFVEKNRIVLDEKPIPDVGPLDALIRITTTTICGTDVHILKGEYPVEKGLTIGHEP
VGIIEKLGSAVEGFAEGQRVIAGAITPSGYSNACLCGCASQDGPRMKHGFKPMGGWRFGNTIDGAQAEYLVVPDAMTNLA
PVPEALGDEQVLMCPDIMSTGFAGAESGKVRIGDTVAVFAQGPIGLCATAGARLMGATRIIAVDRVGERLNVARAMGADE
VVDFSKVDPVEEILRLTDGRGVDVAIEALGRQETFEAALRVLRPGGTLSSLGVYSSDLKIPLDAFAAGLGDNKIVTSLCP
GGKERMRRLMDVVASGRVDARALVTHRFKLDDIEKAYDLFSHQRDGVLKVAITP

Sequences:

>Translated_374_residues
MTDTIERPGFVERNRPGRAKMKAAIFVEKNRIVLDEKPIPDVGPLDALIRITTTTICGTDVHILKGEYPVEKGLTIGHEP
VGIIEKLGSAVEGFAEGQRVIAGAITPSGYSNACLCGCASQDGPRMKHGFKPMGGWRFGNTIDGAQAEYLVVPDAMTNLA
PVPEALGDEQVLMCPDIMSTGFAGAESGKVRIGDTVAVFAQGPIGLCATAGARLMGATRIIAVDRVGERLNVARAMGADE
VVDFSKVDPVEEILRLTDGRGVDVAIEALGRQETFEAALRVLRPGGTLSSLGVYSSDLKIPLDAFAAGLGDNKIVTSLCP
GGKERMRRLMDVVASGRVDARALVTHRFKLDDIEKAYDLFSHQRDGVLKVAITP
>Mature_373_residues
TDTIERPGFVERNRPGRAKMKAAIFVEKNRIVLDEKPIPDVGPLDALIRITTTTICGTDVHILKGEYPVEKGLTIGHEPV
GIIEKLGSAVEGFAEGQRVIAGAITPSGYSNACLCGCASQDGPRMKHGFKPMGGWRFGNTIDGAQAEYLVVPDAMTNLAP
VPEALGDEQVLMCPDIMSTGFAGAESGKVRIGDTVAVFAQGPIGLCATAGARLMGATRIIAVDRVGERLNVARAMGADEV
VDFSKVDPVEEILRLTDGRGVDVAIEALGRQETFEAALRVLRPGGTLSSLGVYSSDLKIPLDAFAAGLGDNKIVTSLCPG
GKERMRRLMDVVASGRVDARALVTHRFKLDDIEKAYDLFSHQRDGVLKVAITP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=342, Percent_Identity=30.7017543859649, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI4501929, Length=366, Percent_Identity=30.327868852459, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI71565152, Length=376, Percent_Identity=28.7234042553192, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI71743840, Length=375, Percent_Identity=27.4666666666667, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI156523966, Length=335, Percent_Identity=28.6567164179104, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4501939, Length=335, Percent_Identity=28.6567164179104, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI262073058, Length=366, Percent_Identity=27.5956284153005, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI71565154, Length=371, Percent_Identity=29.3800539083558, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI34577061, Length=370, Percent_Identity=28.1081081081081, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI4501933, Length=370, Percent_Identity=28.1081081081081, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=28.8265306122449, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1790045, Length=345, Percent_Identity=29.2753623188406, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1787863, Length=356, Percent_Identity=26.123595505618, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI87082125, Length=368, Percent_Identity=27.445652173913, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1788073, Length=357, Percent_Identity=26.3305322128852, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788075, Length=336, Percent_Identity=27.3809523809524, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1786552, Length=339, Percent_Identity=28.3185840707965, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788407, Length=334, Percent_Identity=25.1497005988024, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI226510992, Length=343, Percent_Identity=26.8221574344023, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790718, Length=289, Percent_Identity=22.8373702422145, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081918, Length=287, Percent_Identity=24.7386759581882, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=363, Percent_Identity=28.099173553719, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI25146526, Length=344, Percent_Identity=30.2325581395349, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71997431, Length=353, Percent_Identity=29.7450424929178, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17562876, Length=358, Percent_Identity=25.6983240223464, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17565904, Length=372, Percent_Identity=29.0322580645161, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=348, Percent_Identity=29.3103448275862, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322619, Length=348, Percent_Identity=28.735632183908, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323099, Length=366, Percent_Identity=26.5027322404372, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320033, Length=336, Percent_Identity=29.7619047619048, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319520, Length=262, Percent_Identity=27.0992366412214, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=388, Percent_Identity=25.5154639175258, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=335, Percent_Identity=25.0746268656716, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=329, Percent_Identity=26.1398176291793, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6323729, Length=352, Percent_Identity=24.7159090909091, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324486, Length=328, Percent_Identity=26.5243902439024, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17137530, Length=361, Percent_Identity=27.9778393351801, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17737897, Length=358, Percent_Identity=27.0949720670391, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17737895, Length=362, Percent_Identity=28.4530386740331, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 39795; Mature: 39664

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTIERPGFVERNRPGRAKMKAAIFVEKNRIVLDEKPIPDVGPLDALIRITTTTICGTD
CCCCCCCCCCCCCCCCCCHHEEEEEEEECCEEEECCCCCCCCCCHHHHEEEEEEEECCCC
VHILKGEYPVEKGLTIGHEPVGIIEKLGSAVEGFAEGQRVIAGAITPSGYSNACLCGCAS
EEEEECCCCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEECCC
QDGPRMKHGFKPMGGWRFGNTIDGAQAEYLVVPDAMTNLAPVPEALGDEQVLMCPDIMST
CCCCCHHCCCCCCCCCCCCCCCCCCCCEEEECCHHHHCCCCCHHHCCCCCEEECCHHHHC
GFAGAESGKVRIGDTVAVFAQGPIGLCATAGARLMGATRIIAVDRVGERLNVARAMGADE
CCCCCCCCCEEECCEEEEEECCCCCHHHHCCHHHHCCEEEEEEHHHCHHHHHHHHCCCHH
VVDFSKVDPVEEILRLTDGRGVDVAIEALGRQETFEAALRVLRPGGTLSSLGVYSSDLKI
HCCCCCCCHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHCCCCCHHHCCEECCCCCC
PLDAFAAGLGDNKIVTSLCPGGKERMRRLMDVVASGRVDARALVTHRFKLDDIEKAYDLF
CHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCEEHHHEECCHHHHHHHHHHH
SHQRDGVLKVAITP
HCCCCCEEEEEECC
>Mature Secondary Structure 
TDTIERPGFVERNRPGRAKMKAAIFVEKNRIVLDEKPIPDVGPLDALIRITTTTICGTD
CCCCCCCCCCCCCCCCCHHEEEEEEEECCEEEECCCCCCCCCCHHHHEEEEEEEECCCC
VHILKGEYPVEKGLTIGHEPVGIIEKLGSAVEGFAEGQRVIAGAITPSGYSNACLCGCAS
EEEEECCCCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEECCC
QDGPRMKHGFKPMGGWRFGNTIDGAQAEYLVVPDAMTNLAPVPEALGDEQVLMCPDIMST
CCCCCHHCCCCCCCCCCCCCCCCCCCCEEEECCHHHHCCCCCHHHCCCCCEEECCHHHHC
GFAGAESGKVRIGDTVAVFAQGPIGLCATAGARLMGATRIIAVDRVGERLNVARAMGADE
CCCCCCCCCEEECCEEEEEECCCCCHHHHCCHHHHCCEEEEEEHHHCHHHHHHHHCCCHH
VVDFSKVDPVEEILRLTDGRGVDVAIEALGRQETFEAALRVLRPGGTLSSLGVYSSDLKI
HCCCCCCCHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHCCCCCHHHCCEECCCCCC
PLDAFAAGLGDNKIVTSLCPGGKERMRRLMDVVASGRVDARALVTHRFKLDDIEKAYDLF
CHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCEEHHHEECCHHHHHHHHHHH
SHQRDGVLKVAITP
HCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]