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The map label for this gene is frdA [H]

Identifier: 153950267

GI number: 153950267

Start: 4135618

End: 4137441

Strand: Direct

Name: frdA [H]

Synonym: YpsIP31758_3667

Alternate gene names: 153950267

Gene position: 4135618-4137441 (Clockwise)

Preceding gene: 153949019

Following gene: 153949678

Centisome position: 87.56

GC content: 52.96

Gene sequence:

>1824_bases
GTGCAAACCTTTAACGCCGATCTTGCCATTATCGGGGCCGGAGGTGCTGGCTTACGTGCAGCAATAGCCGCAGCGGAAGC
CAACCCCCAACTGAAGATTGCTTTGATCTCGAAAGTTTACCCAATGCGTAGCCATACCGTGGCCGCCGAGGGAGGATCAG
CTGCCGTCACACAGGACCACGATACGTTTGACTATCATTTCCACGATACCGTTGCGGGCGGTGACTGGTTATGCGAACAA
GATGTTGTTGACCATTTTGTCCACAGTTGCCCCGAAGAAATGGCACAGTTAGAAATTTGGGGCTGCCCATGGAGCCGCAA
AGAGGACGGTTCGGTTAACGTTCGCCGTTTCGGTGGTATGAAGATTGAACGTACATGGTTTGCCGCCGATAAAACCGGTT
TCCACATGCTGCACACCTTGTTCCAAACCTCCCTTAAGTATCCACAAATTCAGCGTTTTGATGAGCATTTCGTCCTGGAT
ATTCTGGTAGACGAGGGTCAGGCACGTGGTGTGGTTGCCATGAATATGATGGAAGGCACCCGCGTACAAATCCGTGCGAA
CGCCGTGATCATGGCCACTGGGGGGGCTGGCCGGGTTTATCGCTATAACACCAACGGCGGTATTGTTACCGGTGATGGTA
TGGGGATGGCATTCCACCATGGCGTTCCACTGCGGGATATGGAATTTGTACAATATCACCCAACGGGCTTGCCGGGGTCT
GGCATCCTGATGACTGAAGGCTGCCGTGGTGAAGGCGGAATTCTGGTGAATAAAGACGGCTATCGTTACTTGCAGGATTA
CGGCATGGGGCCTGAAACGCCACTCGGTGAGCCTAAAAACAAGTACATGGAATTAGGCCCACGGGATAAAGTCTCGCAAG
CATTCTGGCATGAATGGCGCGCTGGCCGCACGGTCGCGACCCCCCGTGGCGATGTGGTTTATCTTGATTTACGCCATCTG
GGTGAGAAGAAGCTGCTTGAGCGCCTGCCGTTTATTTGCGAATTGGCAAAAGCCTATGTCGGCGTTGACCCGGTTAAAGA
GCCCATCCCTGTACGCCCAACCGCGCATTACACCATGGGCGGCATCGAAACCAATCCGCAGTGTGAAACCCGAATCAAAG
GCTTGTTTGCGGTCGGCGAATGCTCTTCTGTAGGCTTGCACGGCGCTAACCGTTTAGGCTCCAATTCATTGGCTGAACTG
GTGGTATTTGGCCGAGTGGCCGGTGAACAAGCCGCTTTACGCGCGATGGAAAGCGGCCCGGCAAATGGTAGCGCACTGGA
TGCCCAGACTCGTGATGTGGAGACCCGTCTGAGCAATCTGATGAAACAGGAAGGAACAGAGAACTGGTCTAAGATTCGCG
ATGAAATGGGTCTGTCGATGGAAGAGGGTTGCGGTATTTACCGTACACCGGAACTGATGCAGAAAACGGTGGATAAACTG
GCCGAGCTGAAAGAACGCTTCAAACGTGTGAAAATCACCGATCACTCCAGTGTATTTAACACTGACCTGCTCTACACCAT
TGAGCTGGGTTATGGTTTGGATGTGGCCGAATGTATGGCGCATTCTGCGCTCAATCGTAAAGAATCTCGTGGTGCCCACC
AGCGTTTGGACGAAGGCTGTACCGAACGTGATGACGTTAACTTCCTCAAACACACCTTAGCCTTCCATACGCCGGGTGGT
GCACCGCGCATTGAATACAGCGATGTGAAAATCACCAAACTGGTACCGGCCAAGCGGGTCTATGGTGGCGAAGCCACCGC
CCAAGACGCGAAAGACGCAAAAGATGCACAAGATTTAAAGGATAAGGAGCAAGCGAATGACTGA

Upstream 100 bases:

>100_bases
TACTCAAAACCCTTGGCGTTACAGCCAGGCAGTTAGCTAACACCCTGTAACGGCAGGGGCGGAGGGTATAAGATTTTCAC
TTGAACAATGGAGAAGCGCA

Downstream 100 bases:

>100_bases
TATGAAAGTCCTGAAAATGGAAGTCATGCGCTATAACCCGGAACGTGATAGCGAACCTCACTTTGAAACCTTCGAAGTGC
CTTACGATGAACAGACGTCT

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MQTFNADLAIIGAGGAGLRAAIAAAEANPQLKIALISKVYPMRSHTVAAEGGSAAVTQDHDTFDYHFHDTVAGGDWLCEQ
DVVDHFVHSCPEEMAQLEIWGCPWSRKEDGSVNVRRFGGMKIERTWFAADKTGFHMLHTLFQTSLKYPQIQRFDEHFVLD
ILVDEGQARGVVAMNMMEGTRVQIRANAVIMATGGAGRVYRYNTNGGIVTGDGMGMAFHHGVPLRDMEFVQYHPTGLPGS
GILMTEGCRGEGGILVNKDGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWRAGRTVATPRGDVVYLDLRHL
GEKKLLERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMGGIETNPQCETRIKGLFAVGECSSVGLHGANRLGSNSLAEL
VVFGRVAGEQAALRAMESGPANGSALDAQTRDVETRLSNLMKQEGTENWSKIRDEMGLSMEEGCGIYRTPELMQKTVDKL
AELKERFKRVKITDHSSVFNTDLLYTIELGYGLDVAECMAHSALNRKESRGAHQRLDEGCTERDDVNFLKHTLAFHTPGG
APRIEYSDVKITKLVPAKRVYGGEATAQDAKDAKDAQDLKDKEQAND

Sequences:

>Translated_607_residues
MQTFNADLAIIGAGGAGLRAAIAAAEANPQLKIALISKVYPMRSHTVAAEGGSAAVTQDHDTFDYHFHDTVAGGDWLCEQ
DVVDHFVHSCPEEMAQLEIWGCPWSRKEDGSVNVRRFGGMKIERTWFAADKTGFHMLHTLFQTSLKYPQIQRFDEHFVLD
ILVDEGQARGVVAMNMMEGTRVQIRANAVIMATGGAGRVYRYNTNGGIVTGDGMGMAFHHGVPLRDMEFVQYHPTGLPGS
GILMTEGCRGEGGILVNKDGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWRAGRTVATPRGDVVYLDLRHL
GEKKLLERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMGGIETNPQCETRIKGLFAVGECSSVGLHGANRLGSNSLAEL
VVFGRVAGEQAALRAMESGPANGSALDAQTRDVETRLSNLMKQEGTENWSKIRDEMGLSMEEGCGIYRTPELMQKTVDKL
AELKERFKRVKITDHSSVFNTDLLYTIELGYGLDVAECMAHSALNRKESRGAHQRLDEGCTERDDVNFLKHTLAFHTPGG
APRIEYSDVKITKLVPAKRVYGGEATAQDAKDAKDAQDLKDKEQAND
>Mature_607_residues
MQTFNADLAIIGAGGAGLRAAIAAAEANPQLKIALISKVYPMRSHTVAAEGGSAAVTQDHDTFDYHFHDTVAGGDWLCEQ
DVVDHFVHSCPEEMAQLEIWGCPWSRKEDGSVNVRRFGGMKIERTWFAADKTGFHMLHTLFQTSLKYPQIQRFDEHFVLD
ILVDEGQARGVVAMNMMEGTRVQIRANAVIMATGGAGRVYRYNTNGGIVTGDGMGMAFHHGVPLRDMEFVQYHPTGLPGS
GILMTEGCRGEGGILVNKDGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWRAGRTVATPRGDVVYLDLRHL
GEKKLLERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMGGIETNPQCETRIKGLFAVGECSSVGLHGANRLGSNSLAEL
VVFGRVAGEQAALRAMESGPANGSALDAQTRDVETRLSNLMKQEGTENWSKIRDEMGLSMEEGCGIYRTPELMQKTVDKL
AELKERFKRVKITDHSSVFNTDLLYTIELGYGLDVAECMAHSALNRKESRGAHQRLDEGCTERDDVNFLKHTLAFHTPGG
APRIEYSDVKITKLVPAKRVYGGEATAQDAKDAKDAQDLKDKEQAND

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=529, Percent_Identity=40.4536862003781, Blast_Score=363, Evalue=1e-100,
Organism=Escherichia coli, GI1790597, Length=583, Percent_Identity=87.1355060034305, Blast_Score=1035, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=543, Percent_Identity=42.7255985267035, Blast_Score=367, Evalue=1e-102,
Organism=Escherichia coli, GI1788928, Length=549, Percent_Identity=32.7868852459016, Blast_Score=238, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI17505833, Length=533, Percent_Identity=39.3996247654784, Blast_Score=350, Evalue=9e-97,
Organism=Caenorhabditis elegans, GI17550100, Length=530, Percent_Identity=38.4905660377359, Blast_Score=344, Evalue=8e-95,
Organism=Saccharomyces cerevisiae, GI6322701, Length=552, Percent_Identity=41.6666666666667, Blast_Score=382, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6322416, Length=560, Percent_Identity=41.0714285714286, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI17137288, Length=540, Percent_Identity=39.8148148148148, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24655642, Length=540, Percent_Identity=39.8148148148148, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24655647, Length=540, Percent_Identity=39.8148148148148, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24663005, Length=600, Percent_Identity=36, Blast_Score=342, Evalue=4e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005884
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66895; Mature: 66895

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTFNADLAIIGAGGAGLRAAIAAAEANPQLKIALISKVYPMRSHTVAAEGGSAAVTQDH
CCCCCCCEEEEECCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEECCCCEEEECCC
DTFDYHFHDTVAGGDWLCEQDVVDHFVHSCPEEMAQLEIWGCPWSRKEDGSVNVRRFGGM
CCEEEEEECCCCCCCCCCHHHHHHHHHHHCHHHHHCEEEECCCCCCCCCCCEEEEEECCE
KIERTWFAADKTGFHMLHTLFQTSLKYPQIQRFDEHFVLDILVDEGQARGVVAMNMMEGT
EEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHCCCEEEEEEEECCCCCCCEEEEEECCCC
RVQIRANAVIMATGGAGRVYRYNTNGGIVTGDGMGMAFHHGVPLRDMEFVQYHPTGLPGS
EEEEEEEEEEEEECCCCEEEEEECCCCEEECCCCCCCEECCCCCCCCCEEEECCCCCCCC
GILMTEGCRGEGGILVNKDGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWR
CEEEECCCCCCCCEEECCCCHHHHHHCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHH
AGRTVATPRGDVVYLDLRHLGEKKLLERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMG
CCCEEECCCCCEEEEEHHHCCHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEC
GIETNPQCETRIKGLFAVGECSSVGLHGANRLGSNSLAELVVFGRVAGEQAALRAMESGP
CCCCCCCHHHHHCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCC
ANGSALDAQTRDVETRLSNLMKQEGTENWSKIRDEMGLSMEEGCGIYRTPELMQKTVDKL
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHH
AELKERFKRVKITDHSSVFNTDLLYTIELGYGLDVAECMAHSALNRKESRGAHQRLDEGC
HHHHHHHHEEEECCCCCEECCCEEEEEEECCCCCHHHHHHHHHHCCHHHCCHHHHHHHCC
TERDDVNFLKHTLAFHTPGGAPRIEYSDVKITKLVPAKRVYGGEATAQDAKDAKDAQDLK
CCCCHHHHHHHHHHEECCCCCCCEEECCEEEEEECCHHHHCCCCCCCHHHHHHHHHHHHH
DKEQAND
HHHHCCC
>Mature Secondary Structure
MQTFNADLAIIGAGGAGLRAAIAAAEANPQLKIALISKVYPMRSHTVAAEGGSAAVTQDH
CCCCCCCEEEEECCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEECCCCEEEECCC
DTFDYHFHDTVAGGDWLCEQDVVDHFVHSCPEEMAQLEIWGCPWSRKEDGSVNVRRFGGM
CCEEEEEECCCCCCCCCCHHHHHHHHHHHCHHHHHCEEEECCCCCCCCCCCEEEEEECCE
KIERTWFAADKTGFHMLHTLFQTSLKYPQIQRFDEHFVLDILVDEGQARGVVAMNMMEGT
EEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHCCCEEEEEEEECCCCCCCEEEEEECCCC
RVQIRANAVIMATGGAGRVYRYNTNGGIVTGDGMGMAFHHGVPLRDMEFVQYHPTGLPGS
EEEEEEEEEEEEECCCCEEEEEECCCCEEECCCCCCCEECCCCCCCCCEEEECCCCCCCC
GILMTEGCRGEGGILVNKDGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWR
CEEEECCCCCCCCEEECCCCHHHHHHCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHH
AGRTVATPRGDVVYLDLRHLGEKKLLERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMG
CCCEEECCCCCEEEEEHHHCCHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEC
GIETNPQCETRIKGLFAVGECSSVGLHGANRLGSNSLAELVVFGRVAGEQAALRAMESGP
CCCCCCCHHHHHCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCC
ANGSALDAQTRDVETRLSNLMKQEGTENWSKIRDEMGLSMEEGCGIYRTPELMQKTVDKL
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHH
AELKERFKRVKITDHSSVFNTDLLYTIELGYGLDVAECMAHSALNRKESRGAHQRLDEGC
HHHHHHHHEEEECCCCCEECCCEEEEEEECCCCCHHHHHHHHHHCCHHHCCHHHHHHHCC
TERDDVNFLKHTLAFHTPGGAPRIEYSDVKITKLVPAKRVYGGEATAQDAKDAKDAQDLK
CCCCHHHHHHHHHHEECCCCCCCEEECCEEEEEECCHHHHCCCCCCCHHHHHHHHHHHHH
DKEQAND
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3308458 [H]