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The map label for this gene is frdB [H]

Identifier: 153949678

GI number: 153949678

Start: 4137434

End: 4138168

Strand: Direct

Name: frdB [H]

Synonym: YpsIP31758_3668

Alternate gene names: 153949678

Gene position: 4137434-4138168 (Clockwise)

Preceding gene: 153950267

Following gene: 153948369

Centisome position: 87.6

GC content: 49.39

Gene sequence:

>735_bases
ATGACTGATATGAAAGTCCTGAAAATGGAAGTCATGCGCTATAACCCGGAACGTGATAGCGAACCTCACTTTGAAACCTT
CGAAGTGCCTTACGATGAACAGACGTCTCTGCTGGATGCACTGGGTTATATCAAAGATAACCTGGCACCGGATCTCTCCT
ATCGCTGGTCTTGTCGAATGGCGATTTGTGGTTCCTGCGGCATGATGGTCAACAAGGTACCAAAACTCGCCTGTAAGACC
TTCCTGCGGGAATATACTGCGGGGATGAAAGTCGAAGCGTTGGGTAACTTCCCGATTGAACGTGATTTAGTGGTTGATAT
GACTCACTTTATCGAGAGTCTGGAAGCCATCAAACCTTATATCATTGGTAACGAACGCCTACCCAAGGATGGCCCGAACA
AGCAGACGCCAGCCCAGATGGCGAAATACCATCAGTTCTCTGGCTGTATCAACTGTGGTTTGTGCTATGCCGCCTGCCCA
CAGTTTGGCTTAAACCCTGAGTTTATTGGCCCCGCAGCAATCACCCTGGCGCATCGTTACAATTTGGACAACCGTGACCA
CGGTAAGAAAGAGCGTATGCCTCAGCTAAACGGTAAAAATGGTGTCTGGAGCTGTACCTTCGTCGGCTACTGTTCTGAAG
TGTGTCCAAAACACGTTGATCCCGCGGCGGCTATCCAGCAGGGCAAGATCGACAGTGCGAAAGACTTCATGATCGCCATG
CTGAAACCACAATAA

Upstream 100 bases:

>100_bases
AAACTGGTACCGGCCAAGCGGGTCTATGGTGGCGAAGCCACCGCCCAAGACGCGAAAGACGCAAAAGATGCACAAGATTT
AAAGGATAAGGAGCAAGCGA

Downstream 100 bases:

>100_bases
GGGAGGGGAGACAGTAATGACAACCAAACGTAAAGCTTATGTTCGTACCATGGCTCCAAACTGGTGGCAACAGCTTGGTT
TCTACCGTTTTTATATGTTG

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MTDMKVLKMEVMRYNPERDSEPHFETFEVPYDEQTSLLDALGYIKDNLAPDLSYRWSCRMAICGSCGMMVNKVPKLACKT
FLREYTAGMKVEALGNFPIERDLVVDMTHFIESLEAIKPYIIGNERLPKDGPNKQTPAQMAKYHQFSGCINCGLCYAACP
QFGLNPEFIGPAAITLAHRYNLDNRDHGKKERMPQLNGKNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKIDSAKDFMIAM
LKPQ

Sequences:

>Translated_244_residues
MTDMKVLKMEVMRYNPERDSEPHFETFEVPYDEQTSLLDALGYIKDNLAPDLSYRWSCRMAICGSCGMMVNKVPKLACKT
FLREYTAGMKVEALGNFPIERDLVVDMTHFIESLEAIKPYIIGNERLPKDGPNKQTPAQMAKYHQFSGCINCGLCYAACP
QFGLNPEFIGPAAITLAHRYNLDNRDHGKKERMPQLNGKNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKIDSAKDFMIAM
LKPQ
>Mature_243_residues
TDMKVLKMEVMRYNPERDSEPHFETFEVPYDEQTSLLDALGYIKDNLAPDLSYRWSCRMAICGSCGMMVNKVPKLACKTF
LREYTAGMKVEALGNFPIERDLVVDMTHFIESLEAIKPYIIGNERLPKDGPNKQTPAQMAKYHQFSGCINCGLCYAACPQ
FGLNPEFIGPAAITLAHRYNLDNRDHGKKERMPQLNGKNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKIDSAKDFMIAML
KPQ

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=231, Percent_Identity=29.8701298701299, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI1790596, Length=244, Percent_Identity=85.2459016393443, Blast_Score=446, Evalue=1e-127,
Organism=Escherichia coli, GI1786943, Length=225, Percent_Identity=37.3333333333333, Blast_Score=143, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17533915, Length=238, Percent_Identity=33.1932773109244, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322987, Length=230, Percent_Identity=33.0434782608696, Blast_Score=129, Evalue=4e-31,
Organism=Drosophila melanogaster, GI17137106, Length=232, Percent_Identity=34.9137931034483, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24643156, Length=231, Percent_Identity=30.7359307359307, Blast_Score=123, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 27489; Mature: 27358

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
9.8 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
9.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDMKVLKMEVMRYNPERDSEPHFETFEVPYDEQTSLLDALGYIKDNLAPDLSYRWSCRM
CCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCEEEHH
AICGSCGMMVNKVPKLACKTFLREYTAGMKVEALGNFPIERDLVVDMTHFIESLEAIKPY
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCE
IIGNERLPKDGPNKQTPAQMAKYHQFSGCINCGLCYAACPQFGLNPEFIGPAAITLAHRY
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHC
NLDNRDHGKKERMPQLNGKNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKIDSAKDFMIAM
CCCCCCCCHHHCCCCCCCCCCEEEEHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEEE
LKPQ
ECCC
>Mature Secondary Structure 
TDMKVLKMEVMRYNPERDSEPHFETFEVPYDEQTSLLDALGYIKDNLAPDLSYRWSCRM
CCHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCEEEHH
AICGSCGMMVNKVPKLACKTFLREYTAGMKVEALGNFPIERDLVVDMTHFIESLEAIKPY
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCE
IIGNERLPKDGPNKQTPAQMAKYHQFSGCINCGLCYAACPQFGLNPEFIGPAAITLAHRY
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHC
NLDNRDHGKKERMPQLNGKNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKIDSAKDFMIAM
CCCCCCCCHHHCCCCCCCCCCEEEEHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEEE
LKPQ
ECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3308458 [H]