Click here to switch to the map view.

The map label for this gene is nadC [H]

Identifier: 152976845

GI number: 152976845

Start: 3193052

End: 3193885

Strand: Reverse

Name: nadC [H]

Synonym: Bcer98_3144

Alternate gene names: 152976845

Gene position: 3193885-3193052 (Counterclockwise)

Preceding gene: 152976846

Following gene: 152976844

Centisome position: 78.15

GC content: 38.25

Gene sequence:

>834_bases
ATGAACATATTAAAAGTACAGGAAGCATTAAAACAATTTTTTCTAGAAGATATAGGGGAATGGGATATAACATCTCAGTG
TATCTTTCCAGATTATTTAGAGGCAAAAGGAACATTTCTTATAAAAGAAGCAGGGGTCTTTGCGGGACGTTCAGTAATCG
AAGCAGGATTTCAATTAATTGATGAAAGAATTGCAGTTGAGCTTCATAAAAAAGATGGGGATCTTGTAGAGAAAGGCGAA
ATAATAGCAACTGTGCAAGGGCCAATTGCATCACTATTAACGGCAGAGCGCGTTATATTAAATGTCATCCAGCGTATGAG
CGGAATAGCAACGATGACACGTAAGGCGGTTCTTGCTTTAGATAGTAGTCATACACGCATTTGTGATACGAGAAAGACAA
TGCCTGGACTACGTATGTTTGATAAGTATGCAGTCGTGTGTGGAGGTGGATTTAACCATCGCTTCGGTTTATATGATGGG
GTCATGATTAAAGACAATCATATTGCTTTTGCTGGTTCTATTACAAAAGCTGTTACATCAGTGAAAGAAAAATTAGGGCA
TATGGTGAAAGTAGAAGTGGAAACAGAAACTGAGGAGCAAGTGAGAGAGGCTGTAGCTGCTGGTGTGGATATTATTATGT
TCGATAATCGTACGCCAGATGAGATTCGAGAGTTTTCAAAGATTGTGCCAAGCGCTATTGTTACGGAAGCTTCAGGTGGA
ATTAAAATTGAAGATTTATCGAAATACGGAAAAACAGGGGTGGATTATATTTCACTTGGAGCATTAACGCATTCAGTGAA
AGCACTCGATATTAGTTTCAATATTGAATCGTAA

Upstream 100 bases:

>100_bases
AGGTGGACATTATCGCAGTGATGATCCAAAAAGAAGTGCAGTAGCAAAAGAAATGATGTTAATAAAATGACAAGCACGTT
TGCATGAGGGAGAGAAGATA

Downstream 100 bases:

>100_bases
GAAAAGTGACTTAGAGGGAGAGAGACGTATATGAGTATTTTAGAAAAAGTACAGCCAATTGAAACGATGTTACCAGCGCG
TTATTACACGATGTCAACGG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MNILKVQEALKQFFLEDIGEWDITSQCIFPDYLEAKGTFLIKEAGVFAGRSVIEAGFQLIDERIAVELHKKDGDLVEKGE
IIATVQGPIASLLTAERVILNVIQRMSGIATMTRKAVLALDSSHTRICDTRKTMPGLRMFDKYAVVCGGGFNHRFGLYDG
VMIKDNHIAFAGSITKAVTSVKEKLGHMVKVEVETETEEQVREAVAAGVDIIMFDNRTPDEIREFSKIVPSAIVTEASGG
IKIEDLSKYGKTGVDYISLGALTHSVKALDISFNIES

Sequences:

>Translated_277_residues
MNILKVQEALKQFFLEDIGEWDITSQCIFPDYLEAKGTFLIKEAGVFAGRSVIEAGFQLIDERIAVELHKKDGDLVEKGE
IIATVQGPIASLLTAERVILNVIQRMSGIATMTRKAVLALDSSHTRICDTRKTMPGLRMFDKYAVVCGGGFNHRFGLYDG
VMIKDNHIAFAGSITKAVTSVKEKLGHMVKVEVETETEEQVREAVAAGVDIIMFDNRTPDEIREFSKIVPSAIVTEASGG
IKIEDLSKYGKTGVDYISLGALTHSVKALDISFNIES
>Mature_277_residues
MNILKVQEALKQFFLEDIGEWDITSQCIFPDYLEAKGTFLIKEAGVFAGRSVIEAGFQLIDERIAVELHKKDGDLVEKGE
IIATVQGPIASLLTAERVILNVIQRMSGIATMTRKAVLALDSSHTRICDTRKTMPGLRMFDKYAVVCGGGFNHRFGLYDG
VMIKDNHIAFAGSITKAVTSVKEKLGHMVKVEVETETEEQVREAVAAGVDIIMFDNRTPDEIREFSKIVPSAIVTEASGG
IKIEDLSKYGKTGVDYISLGALTHSVKALDISFNIES

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=248, Percent_Identity=34.2741935483871, Blast_Score=143, Evalue=2e-34,
Organism=Escherichia coli, GI1786299, Length=276, Percent_Identity=40.5797101449275, Blast_Score=184, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6321162, Length=292, Percent_Identity=31.5068493150685, Blast_Score=143, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30417; Mature: 30417

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILKVQEALKQFFLEDIGEWDITSQCIFPDYLEAKGTFLIKEAGVFAGRSVIEAGFQLI
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCEEEEECCCHHHHHHHHHHHHHH
DERIAVELHKKDGDLVEKGEIIATVQGPIASLLTAERVILNVIQRMSGIATMTRKAVLAL
HHHHHEEEECCCCCEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
DSSHTRICDTRKTMPGLRMFDKYAVVCGGGFNHRFGLYDGVMIKDNHIAFAGSITKAVTS
CCCCCEEHHHHHCCCCHHHHHHEEEEECCCCCCCCCCCCCEEEECCCEEEHHHHHHHHHH
VKEKLGHMVKVEVETETEEQVREAVAAGVDIIMFDNRTPDEIREFSKIVPSAIVTEASGG
HHHHCCCEEEEEECCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCHHHEECCCCC
IKIEDLSKYGKTGVDYISLGALTHSVKALDISFNIES
EEEHHHHHCCCCCCCCEEHHHHHHCEEEEEEEEEECC
>Mature Secondary Structure
MNILKVQEALKQFFLEDIGEWDITSQCIFPDYLEAKGTFLIKEAGVFAGRSVIEAGFQLI
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCEEEEECCCHHHHHHHHHHHHHH
DERIAVELHKKDGDLVEKGEIIATVQGPIASLLTAERVILNVIQRMSGIATMTRKAVLAL
HHHHHEEEECCCCCEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
DSSHTRICDTRKTMPGLRMFDKYAVVCGGGFNHRFGLYDGVMIKDNHIAFAGSITKAVTS
CCCCCEEHHHHHCCCCHHHHHHEEEEECCCCCCCCCCCCCEEEECCCEEEHHHHHHHHHH
VKEKLGHMVKVEVETETEEQVREAVAAGVDIIMFDNRTPDEIREFSKIVPSAIVTEASGG
HHHHCCCEEEEEECCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCHHHEECCCCC
IKIEDLSKYGKTGVDYISLGALTHSVKALDISFNIES
EEEHHHHHCCCCCCCCEEHHHHHHCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]