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The map label for this gene is relA [H]

Identifier: 152976825

GI number: 152976825

Start: 3168064

End: 3170247

Strand: Reverse

Name: relA [H]

Synonym: Bcer98_3123

Alternate gene names: 152976825

Gene position: 3170247-3168064 (Counterclockwise)

Preceding gene: 152976826

Following gene: 152976824

Centisome position: 77.57

GC content: 37.59

Gene sequence:

>2184_bases
ATGGCAAATGAGCAAGTACTAACAGCCGAACAGGTACTCGAAAAAGCGGGACAATATTTAGCGGACGATGATATAGAACT
GGTGGCGCGTGCCTATGAATATGCACGTGATGCACATAGCGAACAGTATAGAAAATCGGGCGAACCATATATTATTCATC
CGATTCAAGTTGCAGGTATTTTAGTTGATTTACACATGGATCCCTCTACAGTATCAGCTGGATTTTTACATGATGTAGTA
GAAGATACAGAAGTTACATTAGAGGATATTGAACGGGAATTTAGTAAAGAAATTGCAATGCTTGTTGATGGTGTTACAAA
ACTTGGGAAAATTAAATATAAGTCTCATGAACAGCAACAGGCAGAGAACCATCGCAAAATGTTTATTGCAATGGCGCAAG
ATATTCGTGTCATTTTAATTAAATTAGCTGACCGGCTTCATAATATGCGTACGCTTAAGCATTTGCCTCAAGAAAAGCAG
CGTCGCATTGCAAATGAAACGTTAGAAATTTTTGCACCTTTAGCACATAGGCTCGGAATCAATACGATTAAATGGGAGCT
TGAAGATACATCACTTCGTTATTTAAATCCACAACAATATTATCGTATTGTGAATTTGATGAAGCGAAAACGCGCGGAAC
GTGAAGAATATTTAGATGAGGTTATGACAAGTATTCAAGAGAAATTAAATGAGGTTTCTATTCATCCAGATATTTCAGGA
AGACCGAAACATATTTATAGCATTTATCGTAAAATGGCACTTCAAAATAAACAGTTTAATGAAATTTATGATTTGTTAGC
TGTGCGTGTTGTTGTCAATAGTATTAAGGATTGCTATGCGGTATTAGGAATTATTCATACGTGCTGGAAACCGATGCCAG
GACGTTTTAAAGATTATATCGCAATGCCAAAAGCAAACCTATATCAATCGTTGCATACAACTGTCATCGGTCCAAAGGGC
GATCCACTTGAAGTGCAAATTCGTACGAAGGAAATGCATGAAATTGCTGAATATGGAATTGCGGCACACTGGGCATATAA
AGAAGGAAAAGCAGCAGCGACAGGAACGCTTGAGAAAAAATTAACATGGTTTAGACAAATATTAGAATGGCAAAACGAAG
CTTCTAATGCGGAAGAGTTTATGGAGTCATTAAAGATTGATTTATTTTCCGATATGGTGTTTGTCTTTACACCAAAAGGT
GATGTAATGGAATTGCCAATGGGTTCGGTTCCAATTGATTTTGCATACCGTGTTCATTCAGAAATCGGTAATAAGACCAT
TGGCGCAAAAGTAAATGGTAAAATGGTCACTCTTGATTATAAGTTAAAAACAGGTGACATTATTGAAATTTTAACCTCTA
AACATTCATATGGACCAAGTCAAGATTGGGTAAAACTTGCACAAACTTCTCATGCGAAAAATAAGATTCGTCAATTTTTC
AAAAAGCAACGTCGTGAAGAGAATATTGACAAAGGACGCGAACTTGTTGAAAAAGAAGTGCGTAGCTCAGAGTTTGAAAT
GAAAGAAGTACTCGCACCAGATAATTTAAAACGCGTTGCGGAGAAATTTAATTTTGCTAATGAAGAAGATATGTTTGTAG
CGGTAGGATACAACGGGATTACAGCTGCGCAAATTGTAACGCGATTAACGGACAAGTTCCGCAAACAACGTGAAGAAGAG
CAAGATATTGTTGAGGTTAAAGAAGTTCGTAAACCAATGAAAATTCGAAAATGGGACTCTGGTGTAAAAGTAAGTGGTGC
AGATAATTTATTAATTCGTTTATCAAAATGTTGTAACCCAGTTCCCGGTGACGATATTATCGGATATATTACGAAAGGCC
GCGGTGTCTCTATTCATCGTCGTGACTGCGTGAATGTGCACACGGAAGAAGCGAAAGAGCGTTTATTAGAGGTCGAGTGG
GAAGGTAGCCCTGAAAAAGAAATTGAGTATAATGTTGATATTGAAATTTCTGGTTACGATCGTCGCGGCTTGTTAAATGA
GGTGCTACAAGCTGTTACAGAGACGAAAACTTACATTTCGGCTGTTTCGGGTCGAAGTGACCGCAATAAAATGGCAACCA
TTAACATGTCGATTTCCATTCGTAACTTACAACATTTGAAAAAGGTAGTAGAGCGTATTAAACAAGTTCCAGAAATTTAT
GCAGTACGCCGTATGATGCATTAA

Upstream 100 bases:

>100_bases
ATCTTTTCCTTTTCACAATTCACAATCATTAGGTTATAATGATAGAATAAAATTTATTCTACTGACAAGGGAAAGACAAT
TTTCAATAAAAGGTGATTCG

Downstream 100 bases:

>100_bases
TAGGGAGTGTATAACATATGAGAGTTGTCTTACAGCGATCAAAGGAAGCGTCCGTCACAGTAGATGGTGAGATTGTGGGA
CAAATTCCGTTTGGCTTAAC

Product: (p)ppGpp synthetase I, SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 727; Mature: 726

Protein sequence:

>727_residues
MANEQVLTAEQVLEKAGQYLADDDIELVARAYEYARDAHSEQYRKSGEPYIIHPIQVAGILVDLHMDPSTVSAGFLHDVV
EDTEVTLEDIEREFSKEIAMLVDGVTKLGKIKYKSHEQQQAENHRKMFIAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ
RRIANETLEIFAPLAHRLGINTIKWELEDTSLRYLNPQQYYRIVNLMKRKRAEREEYLDEVMTSIQEKLNEVSIHPDISG
RPKHIYSIYRKMALQNKQFNEIYDLLAVRVVVNSIKDCYAVLGIIHTCWKPMPGRFKDYIAMPKANLYQSLHTTVIGPKG
DPLEVQIRTKEMHEIAEYGIAAHWAYKEGKAAATGTLEKKLTWFRQILEWQNEASNAEEFMESLKIDLFSDMVFVFTPKG
DVMELPMGSVPIDFAYRVHSEIGNKTIGAKVNGKMVTLDYKLKTGDIIEILTSKHSYGPSQDWVKLAQTSHAKNKIRQFF
KKQRREENIDKGRELVEKEVRSSEFEMKEVLAPDNLKRVAEKFNFANEEDMFVAVGYNGITAAQIVTRLTDKFRKQREEE
QDIVEVKEVRKPMKIRKWDSGVKVSGADNLLIRLSKCCNPVPGDDIIGYITKGRGVSIHRRDCVNVHTEEAKERLLEVEW
EGSPEKEIEYNVDIEISGYDRRGLLNEVLQAVTETKTYISAVSGRSDRNKMATINMSISIRNLQHLKKVVERIKQVPEIY
AVRRMMH

Sequences:

>Translated_727_residues
MANEQVLTAEQVLEKAGQYLADDDIELVARAYEYARDAHSEQYRKSGEPYIIHPIQVAGILVDLHMDPSTVSAGFLHDVV
EDTEVTLEDIEREFSKEIAMLVDGVTKLGKIKYKSHEQQQAENHRKMFIAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ
RRIANETLEIFAPLAHRLGINTIKWELEDTSLRYLNPQQYYRIVNLMKRKRAEREEYLDEVMTSIQEKLNEVSIHPDISG
RPKHIYSIYRKMALQNKQFNEIYDLLAVRVVVNSIKDCYAVLGIIHTCWKPMPGRFKDYIAMPKANLYQSLHTTVIGPKG
DPLEVQIRTKEMHEIAEYGIAAHWAYKEGKAAATGTLEKKLTWFRQILEWQNEASNAEEFMESLKIDLFSDMVFVFTPKG
DVMELPMGSVPIDFAYRVHSEIGNKTIGAKVNGKMVTLDYKLKTGDIIEILTSKHSYGPSQDWVKLAQTSHAKNKIRQFF
KKQRREENIDKGRELVEKEVRSSEFEMKEVLAPDNLKRVAEKFNFANEEDMFVAVGYNGITAAQIVTRLTDKFRKQREEE
QDIVEVKEVRKPMKIRKWDSGVKVSGADNLLIRLSKCCNPVPGDDIIGYITKGRGVSIHRRDCVNVHTEEAKERLLEVEW
EGSPEKEIEYNVDIEISGYDRRGLLNEVLQAVTETKTYISAVSGRSDRNKMATINMSISIRNLQHLKKVVERIKQVPEIY
AVRRMMH
>Mature_726_residues
ANEQVLTAEQVLEKAGQYLADDDIELVARAYEYARDAHSEQYRKSGEPYIIHPIQVAGILVDLHMDPSTVSAGFLHDVVE
DTEVTLEDIEREFSKEIAMLVDGVTKLGKIKYKSHEQQQAENHRKMFIAMAQDIRVILIKLADRLHNMRTLKHLPQEKQR
RIANETLEIFAPLAHRLGINTIKWELEDTSLRYLNPQQYYRIVNLMKRKRAEREEYLDEVMTSIQEKLNEVSIHPDISGR
PKHIYSIYRKMALQNKQFNEIYDLLAVRVVVNSIKDCYAVLGIIHTCWKPMPGRFKDYIAMPKANLYQSLHTTVIGPKGD
PLEVQIRTKEMHEIAEYGIAAHWAYKEGKAAATGTLEKKLTWFRQILEWQNEASNAEEFMESLKIDLFSDMVFVFTPKGD
VMELPMGSVPIDFAYRVHSEIGNKTIGAKVNGKMVTLDYKLKTGDIIEILTSKHSYGPSQDWVKLAQTSHAKNKIRQFFK
KQRREENIDKGRELVEKEVRSSEFEMKEVLAPDNLKRVAEKFNFANEEDMFVAVGYNGITAAQIVTRLTDKFRKQREEEQ
DIVEVKEVRKPMKIRKWDSGVKVSGADNLLIRLSKCCNPVPGDDIIGYITKGRGVSIHRRDCVNVHTEEAKERLLEVEWE
GSPEKEIEYNVDIEISGYDRRGLLNEVLQAVTETKTYISAVSGRSDRNKMATINMSISIRNLQHLKKVVERIKQVPEIYA
VRRMMH

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=131, Percent_Identity=37.4045801526718, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1790082, Length=707, Percent_Identity=40.4526166902404, Blast_Score=567, Evalue=1e-163,
Organism=Escherichia coli, GI1789147, Length=691, Percent_Identity=39.2185238784371, Blast_Score=531, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI25143118, Length=132, Percent_Identity=37.8787878787879, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24650996, Length=127, Percent_Identity=36.2204724409449, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83952; Mature: 83820

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANEQVLTAEQVLEKAGQYLADDDIELVARAYEYARDAHSEQYRKSGEPYIIHPIQVAGI
CCCCCCCCHHHHHHHHCHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEE
LVDLHMDPSTVSAGFLHDVVEDTEVTLEDIEREFSKEIAMLVDGVTKLGKIKYKSHEQQQ
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
AENHRKMFIAMAQDIRVILIKLADRLHNMRTLKHLPQEKQRRIANETLEIFAPLAHRLGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
NTIKWELEDTSLRYLNPQQYYRIVNLMKRKRAEREEYLDEVMTSIQEKLNEVSIHPDISG
CEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
RPKHIYSIYRKMALQNKQFNEIYDLLAVRVVVNSIKDCYAVLGIIHTCWKPMPGRFKDYI
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AMPKANLYQSLHTTVIGPKGDPLEVQIRTKEMHEIAEYGIAAHWAYKEGKAAATGTLEKK
CCCHHHHHHHHHHHEECCCCCCEEEEEEHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHH
LTWFRQILEWQNEASNAEEFMESLKIDLFSDMVFVFTPKGDVMELPMGSVPIDFAYRVHS
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEECCCCCEEECCCCCCCHHHHHHHHH
EIGNKTIGAKVNGKMVTLDYKLKTGDIIEILTSKHSYGPSQDWVKLAQTSHAKNKIRQFF
HHCCCEECCEECCEEEEEEEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KKQRREENIDKGRELVEKEVRSSEFEMKEVLAPDNLKRVAEKFNFANEEDMFVAVGYNGI
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEECCCCH
TAAQIVTRLTDKFRKQREEEQDIVEVKEVRKPMKIRKWDSGVKVSGADNLLIRLSKCCNP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEECCCCHHHHHHHHHCCC
VPGDDIIGYITKGRGVSIHRRDCVNVHTEEAKERLLEVEWEGSPEKEIEYNVDIEISGYD
CCCCCCEEEEECCCCCEEECCHHCCCCHHHHHHHHEEEECCCCCCCCEEEEEEEEECCCC
RRGLLNEVLQAVTETKTYISAVSGRSDRNKMATINMSISIRNLQHLKKVVERIKQVPEIY
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHH
AVRRMMH
HHHHHCC
>Mature Secondary Structure 
ANEQVLTAEQVLEKAGQYLADDDIELVARAYEYARDAHSEQYRKSGEPYIIHPIQVAGI
CCCCCCCHHHHHHHHCHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEE
LVDLHMDPSTVSAGFLHDVVEDTEVTLEDIEREFSKEIAMLVDGVTKLGKIKYKSHEQQQ
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
AENHRKMFIAMAQDIRVILIKLADRLHNMRTLKHLPQEKQRRIANETLEIFAPLAHRLGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
NTIKWELEDTSLRYLNPQQYYRIVNLMKRKRAEREEYLDEVMTSIQEKLNEVSIHPDISG
CEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
RPKHIYSIYRKMALQNKQFNEIYDLLAVRVVVNSIKDCYAVLGIIHTCWKPMPGRFKDYI
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AMPKANLYQSLHTTVIGPKGDPLEVQIRTKEMHEIAEYGIAAHWAYKEGKAAATGTLEKK
CCCHHHHHHHHHHHEECCCCCCEEEEEEHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHH
LTWFRQILEWQNEASNAEEFMESLKIDLFSDMVFVFTPKGDVMELPMGSVPIDFAYRVHS
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEECCCCCEEECCCCCCCHHHHHHHHH
EIGNKTIGAKVNGKMVTLDYKLKTGDIIEILTSKHSYGPSQDWVKLAQTSHAKNKIRQFF
HHCCCEECCEECCEEEEEEEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KKQRREENIDKGRELVEKEVRSSEFEMKEVLAPDNLKRVAEKFNFANEEDMFVAVGYNGI
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEECCCCH
TAAQIVTRLTDKFRKQREEEQDIVEVKEVRKPMKIRKWDSGVKVSGADNLLIRLSKCCNP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEECCCCHHHHHHHHHCCC
VPGDDIIGYITKGRGVSIHRRDCVNVHTEEAKERLLEVEWEGSPEKEIEYNVDIEISGYD
CCCCCCEEEEECCCCCEEECCHHCCCCHHHHHHHHEEEECCCCCCCCEEEEEEEEECCCC
RRGLLNEVLQAVTETKTYISAVSGRSDRNKMATINMSISIRNLQHLKKVVERIKQVPEIY
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHH
AVRRMMH
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]