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The map label for this gene is apt [H]

Identifier: 152976826

GI number: 152976826

Start: 3170456

End: 3170968

Strand: Reverse

Name: apt [H]

Synonym: Bcer98_3124

Alternate gene names: 152976826

Gene position: 3170968-3170456 (Counterclockwise)

Preceding gene: 152976827

Following gene: 152976825

Centisome position: 77.59

GC content: 34.11

Gene sequence:

>513_bases
ATGGATTTTAAGCAACATATCGCAATTGTACCAGATTATCCAAAAGAAGGAATTGTATTTAAAGATATTACACCTTTAAT
GAACAATGGGAAAGCATATAAAGCGGCAACAGATGAAATCGTTGCTTATGCAAAAGAAAGAAATATTGATCTTGTAGTAG
GCCCAGAAGCGCGTGGGTTTATTATTGGTTGCCCAGTTTCTTATGCGTTAGAAGTAGGATTTGCGCCTGTTCGTAAATTA
GGGAAATTACCACGAGAAATCATTAAAGTTGATTACGGTAAAGAGTATGGTAAAGATGTTCTAACAATTCATAAAGATGC
TATTAAGCCAGGTCAACGAGTATTAATTACAGATGATTTATTAGCTACAGGCGGAACAATTGAAGCAACGATTCAACTTG
TTGAAGAACTTGGTGGAATTGTAGCTGGTATTGCATTTTTAGTAGAGCTTACTTATTTAGAAGGTCGTGAAAAATTAGAA
GGTTACGATGTATTAGTATTAGAAAAATACTAA

Upstream 100 bases:

>100_bases
CACATGGTTTGAAACGATTCGTAATCATAAAGAAATAGAACAGTTAAGATAAGGGGTTTGCTATTTACAAGCCTTTCATA
TCTGAGGAGGATTCAGAAAT

Downstream 100 bases:

>100_bases
TGATAAGATAGGTGAAGTTACGGCGATAAAAAGTACCCGTGAATCTCTTGGAGAGGAGCGGGTACTTTTGTATAATTGTA
TAAAAAAGTATGGCGAAATA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MDFKQHIAIVPDYPKEGIVFKDITPLMNNGKAYKAATDEIVAYAKERNIDLVVGPEARGFIIGCPVSYALEVGFAPVRKL
GKLPREIIKVDYGKEYGKDVLTIHKDAIKPGQRVLITDDLLATGGTIEATIQLVEELGGIVAGIAFLVELTYLEGREKLE
GYDVLVLEKY

Sequences:

>Translated_170_residues
MDFKQHIAIVPDYPKEGIVFKDITPLMNNGKAYKAATDEIVAYAKERNIDLVVGPEARGFIIGCPVSYALEVGFAPVRKL
GKLPREIIKVDYGKEYGKDVLTIHKDAIKPGQRVLITDDLLATGGTIEATIQLVEELGGIVAGIAFLVELTYLEGREKLE
GYDVLVLEKY
>Mature_170_residues
MDFKQHIAIVPDYPKEGIVFKDITPLMNNGKAYKAATDEIVAYAKERNIDLVVGPEARGFIIGCPVSYALEVGFAPVRKL
GKLPREIIKVDYGKEYGKDVLTIHKDAIKPGQRVLITDDLLATGGTIEATIQLVEELGGIVAGIAFLVELTYLEGREKLE
GYDVLVLEKY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=170, Percent_Identity=41.1764705882353, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI71773201, Length=124, Percent_Identity=41.1290322580645, Blast_Score=102, Evalue=2e-22,
Organism=Escherichia coli, GI1786675, Length=158, Percent_Identity=55.0632911392405, Blast_Score=165, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17509087, Length=169, Percent_Identity=43.7869822485207, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6323619, Length=155, Percent_Identity=43.2258064516129, Blast_Score=117, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=154, Percent_Identity=33.1168831168831, Blast_Score=82, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17136334, Length=160, Percent_Identity=41.25, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 18723; Mature: 18723

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFKQHIAIVPDYPKEGIVFKDITPLMNNGKAYKAATDEIVAYAKERNIDLVVGPEARGF
CCCCCCEEECCCCCCCCEEEECCCHHHCCCCEEEHHHHHHHHHHHHCCEEEEECCCCCEE
IIGCPVSYALEVGFAPVRKLGKLPREIIKVDYGKEYGKDVLTIHKDAIKPGQRVLITDDL
EEECCHHHHHHCCCHHHHHHHHCHHHHHEECCCHHHCCCEEEEEHHHCCCCCEEEEECCH
LATGGTIEATIQLVEELGGIVAGIAFLVELTYLEGREKLEGYDVLVLEKY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MDFKQHIAIVPDYPKEGIVFKDITPLMNNGKAYKAATDEIVAYAKERNIDLVVGPEARGF
CCCCCCEEECCCCCCCCEEEECCCHHHCCCCEEEHHHHHHHHHHHHCCEEEEECCCCCEE
IIGCPVSYALEVGFAPVRKLGKLPREIIKVDYGKEYGKDVLTIHKDAIKPGQRVLITDDL
EEECCHHHHHHCCCHHHHHHHHCHHHHHEECCCHHHCCCEEEEEHHHCCCCCEEEEECCH
LATGGTIEATIQLVEELGGIVAGIAFLVELTYLEGREKLEGYDVLVLEKY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA