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The map label for this gene is moeZ [H]

Identifier: 150398585

GI number: 150398585

Start: 3601840

End: 3602616

Strand: Direct

Name: moeZ [H]

Synonym: Smed_3396

Alternate gene names: 150398585

Gene position: 3601840-3602616 (Clockwise)

Preceding gene: 150398584

Following gene: 150398596

Centisome position: 95.24

GC content: 66.28

Gene sequence:

>777_bases
ATGGAGACGCATATGACGACGGGTGCGACACTCGCTCCTTCGGAGATTGCGCGCTATGCACGCCACATCGTGCTGCCGGA
AATCGGCGGCCCCGGGCAGCAGAAGCTCAAAGCGGCGCGCGTGCTCGTCATCGGCGCGGGCGGTCTAGGCGCGCCGGTGC
TGCAGTATCTTGCGGCCGCCGGCGTGGGTACGCTGGGGATCGTCGACGACGATGTCGTCTCGTTGTCGAACCTTCAGCGG
CAGGTCATCCACGCCACCGAGGATATCGGCCGGGCCAAGGTCGAGAGCGCTGCCGCGGCGATCGACGCTCTAAACCCGCA
TGTGAAGGTAATAACGCACGCGCTGAGGCTCGGTGCCGAAAACGCCAGGGAACTCTTCGATGCATATGATCTCGTCGTCG
ACGGATCGGACAATTTCGACACGCGCTATCTCGCCGCCGATACAGCCGAGGCCGCAGCCGTGGCGCTCGTCACCGGCGCC
GTCGGCCGCTTCGACGGCTCCGTCACGGTGCTGAAGCCCTACGAGACCGACGCGGACGGGCATCCGAACCCCTCCTATCG
CGACCTCTTCCCGGAGCCGCCGCCGCCCGGCGCAGTGCCAAGCTGCGCCGAAGCCGGTGTTCTCGGCGCGCTCACCGGCG
TCATCGGCACATTGCAGGCGATGGAGGCGATCAAGCTTGTCACCGGCATTGGCGAGCCGCTGATCGGCCGGCTGCTGCTT
TACGATGCGCTTGCCGCGCAGTTCAACACGATCCGCTACCGGCGCGGTAAGCGTTGA

Upstream 100 bases:

>100_bases
CGAGGCGCTCGGGGAGCGCGCGCATTATCTGGCCGTTGCAAACGGCCGCGTTTCAGGATGACATGGAGCGAGCGCCGTCC
TCACAGGATAACGAAATGAG

Downstream 100 bases:

>100_bases
GGTTTGATGCGCGTGGCGTCCCGGCCGCATCCCGCAAAGTTATCCTCATCTCCGGTGAGGGGCACTCTCATCGCCGATGG
TTGCGAGGTTTTGTGGTGCC

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
METHMTTGATLAPSEIARYARHIVLPEIGGPGQQKLKAARVLVIGAGGLGAPVLQYLAAAGVGTLGIVDDDVVSLSNLQR
QVIHATEDIGRAKVESAAAAIDALNPHVKVITHALRLGAENARELFDAYDLVVDGSDNFDTRYLAADTAEAAAVALVTGA
VGRFDGSVTVLKPYETDADGHPNPSYRDLFPEPPPPGAVPSCAEAGVLGALTGVIGTLQAMEAIKLVTGIGEPLIGRLLL
YDALAAQFNTIRYRRGKR

Sequences:

>Translated_258_residues
METHMTTGATLAPSEIARYARHIVLPEIGGPGQQKLKAARVLVIGAGGLGAPVLQYLAAAGVGTLGIVDDDVVSLSNLQR
QVIHATEDIGRAKVESAAAAIDALNPHVKVITHALRLGAENARELFDAYDLVVDGSDNFDTRYLAADTAEAAAVALVTGA
VGRFDGSVTVLKPYETDADGHPNPSYRDLFPEPPPPGAVPSCAEAGVLGALTGVIGTLQAMEAIKLVTGIGEPLIGRLLL
YDALAAQFNTIRYRRGKR
>Mature_258_residues
METHMTTGATLAPSEIARYARHIVLPEIGGPGQQKLKAARVLVIGAGGLGAPVLQYLAAAGVGTLGIVDDDVVSLSNLQR
QVIHATEDIGRAKVESAAAAIDALNPHVKVITHALRLGAENARELFDAYDLVVDGSDNFDTRYLAADTAEAAAVALVTGA
VGRFDGSVTVLKPYETDADGHPNPSYRDLFPEPPPPGAVPSCAEAGVLGALTGVIGTLQAMEAIKLVTGIGEPLIGRLLL
YDALAAQFNTIRYRRGKR

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=240, Percent_Identity=48.3333333333333, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI23510338, Length=184, Percent_Identity=29.8913043478261, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI23510340, Length=184, Percent_Identity=29.8913043478261, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4885649, Length=154, Percent_Identity=30.5194805194805, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI38045944, Length=153, Percent_Identity=30.718954248366, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI38045942, Length=153, Percent_Identity=30.718954248366, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI38045948, Length=171, Percent_Identity=35.0877192982456, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1787048, Length=251, Percent_Identity=44.6215139442231, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI87082356, Length=242, Percent_Identity=41.3223140495868, Blast_Score=151, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17540406, Length=247, Percent_Identity=41.7004048582996, Blast_Score=204, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI193203301, Length=140, Percent_Identity=29.2857142857143, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71984476, Length=163, Percent_Identity=28.8343558282209, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI86565433, Length=184, Percent_Identity=32.0652173913043, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI86565431, Length=184, Percent_Identity=32.0652173913043, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321903, Length=240, Percent_Identity=43.75, Blast_Score=202, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6320598, Length=153, Percent_Identity=27.4509803921569, Blast_Score=72, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6325438, Length=123, Percent_Identity=32.520325203252, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322639, Length=198, Percent_Identity=28.7878787878788, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24582879, Length=247, Percent_Identity=46.1538461538462, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI28573937, Length=195, Percent_Identity=30.7692307692308, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24660640, Length=141, Percent_Identity=31.2056737588652, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI20129973, Length=148, Percent_Identity=32.4324324324324, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 26908; Mature: 26908

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METHMTTGATLAPSEIARYARHIVLPEIGGPGQQKLKAARVLVIGAGGLGAPVLQYLAAA
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHEEEEEEECCCCCHHHHHHHHHC
GVGTLGIVDDDVVSLSNLQRQVIHATEDIGRAKVESAAAAIDALNPHVKVITHALRLGAE
CCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCH
NARELFDAYDLVVDGSDNFDTRYLAADTAEAAAVALVTGAVGRFDGSVTVLKPYETDADG
HHHHHHHHHHEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
HPNPSYRDLFPEPPPPGAVPSCAEAGVLGALTGVIGTLQAMEAIKLVTGIGEPLIGRLLL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
YDALAAQFNTIRYRRGKR
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
METHMTTGATLAPSEIARYARHIVLPEIGGPGQQKLKAARVLVIGAGGLGAPVLQYLAAA
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHEEEEEEECCCCCHHHHHHHHHC
GVGTLGIVDDDVVSLSNLQRQVIHATEDIGRAKVESAAAAIDALNPHVKVITHALRLGAE
CCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCH
NARELFDAYDLVVDGSDNFDTRYLAADTAEAAAVALVTGAVGRFDGSVTVLKPYETDADG
HHHHHHHHHHEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
HPNPSYRDLFPEPPPPGAVPSCAEAGVLGALTGVIGTLQAMEAIKLVTGIGEPLIGRLLL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
YDALAAQFNTIRYRRGKR
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]