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The map label for this gene is emrB [C]

Identifier: 150395960

GI number: 150395960

Start: 790438

End: 792048

Strand: Direct

Name: emrB [C]

Synonym: Smed_0736

Alternate gene names: 150395960

Gene position: 790438-792048 (Clockwise)

Preceding gene: 150395959

Following gene: 150395961

Centisome position: 20.9

GC content: 61.14

Gene sequence:

>1611_bases
ATGACATCCAATGCGGCCCCGCAGCCGAGCCTTCCTGCTCAGATGGCGCCCGGTAAATCGGCCCTTTACATTGCCGGCTC
CGCGTTCCTTTTCCTGACGCAGGGACTCGGCCTGAATCTGGCGTCGGCCAACCTTGCGCAGGTCCAGGGCTCCCTTTCGG
CCACATCAGTCGAGGCTGCATGGCTTGCGGCTGCCTATATGGCTCCGAATGTCAGCCTTTCAGCCGCTCTCGTGAAGATC
CGCGCCCAGTACGGCCTGCGCCGCTTTGCTGAACTGGGCATCGCCGGCTTCGTCATCGCTTCGTTGATGAACGTCTTCGT
CTCGGATCTTCACTCGGCAATCGTCGTCCGCTTCATCAGCGGAATTGCGGCCGCGCCTTTGTCGTCGCTCGGCTTCCTCT
ATATGCTGGAAGCCTTCTCGCCGGAGAGAAAGCTGACGATAGGCCTCGCACTTGCCCTGACATGCACGACCCTGGCCGCT
CCGGTCACGCGTCTGATCTCGCCGCAGCTTATCGAAATCGGACAATGGCACGGACTGTACACCCTCGAAATGGCGCTCTC
GCTGCTCGCATTGCCGATCATCTATTTGCTGCCGCTGACGCCGGTGCCCCATGGCAAGGTCATTCAGCGTACCGATATTT
CCAGCTATCTGCTGCTCGCCGTCGGCTTTGGCTGCCTTGCCGTCGTCCTCGCCATGGGGAGGCTCTATTGGTGGTTCGAG
GCTCCCTGGCTCGGCGTCCTGCTCGCGCTCTCGGTCGTGACTCTCACGACGGTGATACTGATCGAGCTCAACCGTGAGCA
GCCCCTAATCGACGTGCGCTGGCTGGCCTCGCGCGAGATCGTGCATTTCGCTGTGGTCCTGTTGATCTTCCGCCTCGTCG
CCTCGGAGCAGTCGGCGATCGCCACCAGTTTCTACCAATTGCTCGGCCTGCAATATGATCAGCTCGCCACGCTTTACTGG
ATTATTCTGGCCGCGTCGGTCGGCGGAGGGCTGCTCTGCGCGGCGCTGATGGACCCGGCGCGCGCGGACGTCGTCCATGT
ACTTGCCTTAAGCATGATCACGGTCGGAGCTTACATGGACAGTCATGCGACGAGCCTCACGCGACCCGAGCAGATGTATG
TGAGCCAGGCTTTGGTCAGCGCTGGCTCGGCTCTTTTCCTGCCGCCGGCGATGGCGCGAGGTTTCAGGTCGGCGCTCGCA
AAAGGCCCGAACTACATCTTGAGCTTCATCGTGGTTTTTCTGTTCACGCAAAGCATTGGCGGCCTGATGGGCTCGGCCGC
CTTTGGGACTTTCGTGACATTACGCGAAAAATTCCACGCCAATGTTCTGGCCGAGCAGATCGTTCTCACCAATCCCTTCG
TCGCCCAGCGCATCGGCCAGCTGTCGGGCGGTTACGCCAGCGCAATTGGCGACAAGGCGTTGCTGCACGGGGAAGGTGTG
GCCCTGCTTGGACGGTCGATTACCCGCGAGTCCAACATCCTCGCCTACAACGATGCCTTCCTGCTGATTGCTATCATCGC
GGTTTTCGCACTCGCGGTGCTGCTCGTACAGGTTGGAGTCAAACGGCTTGCCCGGCCCGGTCTCAACGCCGCGTCGGCGG
CCCTACACTGA

Upstream 100 bases:

>100_bases
AGGTTCTGGGCGGGCTGCGGCCGGAGGAGATCGCCGGTGCGCTGAAGGTCGTCAACACGATCGCAACGAACATCCAGTCG
ATCGGGCGGAGTGGCGGCCG

Downstream 100 bases:

>100_bases
TCGATGAAGTAAAGTCATGTTGAAACATTTTCGCTCCCCCAGCACGCTGGTCGTGCTTGTAGCCGGCCTTGCCGGTCTTT
CGCTCGTCCTTTACGCCTGG

Product: major facilitator transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: EmrB/QacA Family Drug Resistance Transporter; Facilitator Superfamily Protein; Transport Protein Transmembrane; Facilitator Superfamily Transporter; MFS Drug Efflux Transporter RmrB; EmrB/QacA Subfamily Drug Resistance Transporter; Transporter Facilitator Family; Multidrug Efflux Transporter Protein; Multidrug Resistance Protein B; Transmembrane Efflux Pump Protein; Tat Pathway Signal Sequence Domain Protein; MFS Drug Efflux Transporter; MFS Permease; LOW QUALITY PROTEIN MFS Drug Efflux Transporter; Efflux Protein; Facilitator Superfamily Transporter Protein; MFS Family Transporter; HlyD Family Protein; Facilitator Family Transporter; Facilitator Superfamily Permease

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MTSNAAPQPSLPAQMAPGKSALYIAGSAFLFLTQGLGLNLASANLAQVQGSLSATSVEAAWLAAAYMAPNVSLSAALVKI
RAQYGLRRFAELGIAGFVIASLMNVFVSDLHSAIVVRFISGIAAAPLSSLGFLYMLEAFSPERKLTIGLALALTCTTLAA
PVTRLISPQLIEIGQWHGLYTLEMALSLLALPIIYLLPLTPVPHGKVIQRTDISSYLLLAVGFGCLAVVLAMGRLYWWFE
APWLGVLLALSVVTLTTVILIELNREQPLIDVRWLASREIVHFAVVLLIFRLVASEQSAIATSFYQLLGLQYDQLATLYW
IILAASVGGGLLCAALMDPARADVVHVLALSMITVGAYMDSHATSLTRPEQMYVSQALVSAGSALFLPPAMARGFRSALA
KGPNYILSFIVVFLFTQSIGGLMGSAAFGTFVTLREKFHANVLAEQIVLTNPFVAQRIGQLSGGYASAIGDKALLHGEGV
ALLGRSITRESNILAYNDAFLLIAIIAVFALAVLLVQVGVKRLARPGLNAASAALH

Sequences:

>Translated_536_residues
MTSNAAPQPSLPAQMAPGKSALYIAGSAFLFLTQGLGLNLASANLAQVQGSLSATSVEAAWLAAAYMAPNVSLSAALVKI
RAQYGLRRFAELGIAGFVIASLMNVFVSDLHSAIVVRFISGIAAAPLSSLGFLYMLEAFSPERKLTIGLALALTCTTLAA
PVTRLISPQLIEIGQWHGLYTLEMALSLLALPIIYLLPLTPVPHGKVIQRTDISSYLLLAVGFGCLAVVLAMGRLYWWFE
APWLGVLLALSVVTLTTVILIELNREQPLIDVRWLASREIVHFAVVLLIFRLVASEQSAIATSFYQLLGLQYDQLATLYW
IILAASVGGGLLCAALMDPARADVVHVLALSMITVGAYMDSHATSLTRPEQMYVSQALVSAGSALFLPPAMARGFRSALA
KGPNYILSFIVVFLFTQSIGGLMGSAAFGTFVTLREKFHANVLAEQIVLTNPFVAQRIGQLSGGYASAIGDKALLHGEGV
ALLGRSITRESNILAYNDAFLLIAIIAVFALAVLLVQVGVKRLARPGLNAASAALH
>Mature_535_residues
TSNAAPQPSLPAQMAPGKSALYIAGSAFLFLTQGLGLNLASANLAQVQGSLSATSVEAAWLAAAYMAPNVSLSAALVKIR
AQYGLRRFAELGIAGFVIASLMNVFVSDLHSAIVVRFISGIAAAPLSSLGFLYMLEAFSPERKLTIGLALALTCTTLAAP
VTRLISPQLIEIGQWHGLYTLEMALSLLALPIIYLLPLTPVPHGKVIQRTDISSYLLLAVGFGCLAVVLAMGRLYWWFEA
PWLGVLLALSVVTLTTVILIELNREQPLIDVRWLASREIVHFAVVLLIFRLVASEQSAIATSFYQLLGLQYDQLATLYWI
ILAASVGGGLLCAALMDPARADVVHVLALSMITVGAYMDSHATSLTRPEQMYVSQALVSAGSALFLPPAMARGFRSALAK
GPNYILSFIVVFLFTQSIGGLMGSAAFGTFVTLREKFHANVLAEQIVLTNPFVAQRIGQLSGGYASAIGDKALLHGEGVA
LLGRSITRESNILAYNDAFLLIAIIAVFALAVLLVQVGVKRLARPGLNAASAALH

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789042, Length=508, Percent_Identity=22.244094488189, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 56948; Mature: 56817

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSNAAPQPSLPAQMAPGKSALYIAGSAFLFLTQGLGLNLASANLAQVQGSLSATSVEAA
CCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHCCCCCEECCCHHHHHHCCCCHHHHHHH
WLAAAYMAPNVSLSAALVKIRAQYGLRRFAELGIAGFVIASLMNVFVSDLHSAIVVRFIS
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIAAAPLSSLGFLYMLEAFSPERKLTIGLALALTCTTLAAPVTRLISPQLIEIGQWHGLY
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHH
TLEMALSLLALPIIYLLPLTPVPHGKVIQRTDISSYLLLAVGFGCLAVVLAMGRLYWWFE
HHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
APWLGVLLALSVVTLTTVILIELNREQPLIDVRWLASREIVHFAVVLLIFRLVASEQSAI
CCHHHHHHHHHHHHHHHHHHEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHH
ATSFYQLLGLQYDQLATLYWIILAASVGGGLLCAALMDPARADVVHVLALSMITVGAYMD
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
SHATSLTRPEQMYVSQALVSAGSALFLPPAMARGFRSALAKGPNYILSFIVVFLFTQSIG
HHHHHCCCHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GLMGSAAFGTFVTLREKFHANVLAEQIVLTNPFVAQRIGQLSGGYASAIGDKALLHGEGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHCCCCEECCCCH
ALLGRSITRESNILAYNDAFLLIAIIAVFALAVLLVQVGVKRLARPGLNAASAALH
HHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC
>Mature Secondary Structure 
TSNAAPQPSLPAQMAPGKSALYIAGSAFLFLTQGLGLNLASANLAQVQGSLSATSVEAA
CCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHCCCCCEECCCHHHHHHCCCCHHHHHHH
WLAAAYMAPNVSLSAALVKIRAQYGLRRFAELGIAGFVIASLMNVFVSDLHSAIVVRFIS
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIAAAPLSSLGFLYMLEAFSPERKLTIGLALALTCTTLAAPVTRLISPQLIEIGQWHGLY
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHH
TLEMALSLLALPIIYLLPLTPVPHGKVIQRTDISSYLLLAVGFGCLAVVLAMGRLYWWFE
HHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
APWLGVLLALSVVTLTTVILIELNREQPLIDVRWLASREIVHFAVVLLIFRLVASEQSAI
CCHHHHHHHHHHHHHHHHHHEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHH
ATSFYQLLGLQYDQLATLYWIILAASVGGGLLCAALMDPARADVVHVLALSMITVGAYMD
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
SHATSLTRPEQMYVSQALVSAGSALFLPPAMARGFRSALAKGPNYILSFIVVFLFTQSIG
HHHHHCCCHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GLMGSAAFGTFVTLREKFHANVLAEQIVLTNPFVAQRIGQLSGGYASAIGDKALLHGEGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHCCCCEECCCCH
ALLGRSITRESNILAYNDAFLLIAIIAVFALAVLLVQVGVKRLARPGLNAASAALH
HHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA