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The map label for this gene is emrA [H]

Identifier: 150395961

GI number: 150395961

Start: 792065

End: 793132

Strand: Direct

Name: emrA [H]

Synonym: Smed_0737

Alternate gene names: 150395961

Gene position: 792065-793132 (Clockwise)

Preceding gene: 150395960

Following gene: 150395966

Centisome position: 20.94

GC content: 63.76

Gene sequence:

>1068_bases
ATGTTGAAACATTTTCGCTCCCCCAGCACGCTGGTCGTGCTTGTAGCCGGCCTTGCCGGTCTTTCGCTCGTCCTTTACGC
CTGGCGTCTGCCGCCCTTTGCCAGCTCCGTCGAAACCACGGAGAACGCCTATGTCCGCGGCTATGTGACGACTATCAGCC
CGCAGCTTGCCGGCTACGTCGCCGAGGTGCCGGTGCGAGACTACGAGGAGGTTAAGGCGGGCCAGCTCCTCGCCAGGATC
GACGACCGGATCTTCGTCCAGAAGCTTGCGCAGGCGAAAGCCATGCTCGCGACACAGCGGGCGGCCCTCGCGAACTCCTT
CGAACAGGAGCTCTCGGCAAAGGCTGGAATTACCGCGAGCGAGGCCCAGCTCGACGGGGCTAAAGCAGCATTGGCAACCG
CGAGGGCCACTTGGGATCGTATTCGTCCGCTCGCCGACAAGGGCGTTGCAACACGGAGCGACGCCGACCAGGCACGGGCC
GCCTTCCAGCAGGCGGAAGCGGGCGTCAAACAGGCGATCGCCAATCTCGAAGTCTCGCGGCAATCACTCGCCACCACACT
CGGCGCGCGCGCCGGCCTTCAGGGTTCGGTTTCCGGTGCCGAGGCGGCCGTTGAACTCGCCCAGATCGACCTCGACAACA
CCAGGATCGTTGCGCCGCGTGCCGGTAGACTTGGCGAGATTGGCGCCCGTGTCGGACAATATGTCACTGCCGGCACGCAA
TTGGTTTCGGTCGTGCCGCATGACGTCTGGATCGTCGCCAACTTCAAGGAGACGCAGCTTGACGGGATGAGGGTCGGTCA
GCCCGTCACCATCTGGGTGGACGCCCTGAAACGCCAGGAGTTGAAAGGTCACATCGAGCGCTTCTCTCCAGCCGCGGGGT
CGGAATTCAGCATAATACGTCCCGACAACGCCACCGGCAATTTCACGAAGGTGGCGCAACGTCTCGGCGTGCGGATCGCC
GTCGATCCCGAACAGCCGTTGGCCGAGCGCCTTGCTCCCGGGCTTTCGGTCGTGGTCAAGGTCGACAAGGCGGCCGAACC
GCAGGCATCAATCGCATCCGCAGGATAG

Upstream 100 bases:

>100_bases
GCACTCGCGGTGCTGCTCGTACAGGTTGGAGTCAAACGGCTTGCCCGGCCCGGTCTCAACGCCGCGTCGGCGGCCCTACA
CTGATCGATGAAGTAAAGTC

Downstream 100 bases:

>100_bases
ACGAGTTCTGAGATGCTTTGCCCAGACGACGAGTATATCAGGCCTGGCTGGCCTGGTGTCCCGGAAATGAAGAAAGCCCG
GACCGCGAGATCCGGGCTTT

Product: secretion protein HlyD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MLKHFRSPSTLVVLVAGLAGLSLVLYAWRLPPFASSVETTENAYVRGYVTTISPQLAGYVAEVPVRDYEEVKAGQLLARI
DDRIFVQKLAQAKAMLATQRAALANSFEQELSAKAGITASEAQLDGAKAALATARATWDRIRPLADKGVATRSDADQARA
AFQQAEAGVKQAIANLEVSRQSLATTLGARAGLQGSVSGAEAAVELAQIDLDNTRIVAPRAGRLGEIGARVGQYVTAGTQ
LVSVVPHDVWIVANFKETQLDGMRVGQPVTIWVDALKRQELKGHIERFSPAAGSEFSIIRPDNATGNFTKVAQRLGVRIA
VDPEQPLAERLAPGLSVVVKVDKAAEPQASIASAG

Sequences:

>Translated_355_residues
MLKHFRSPSTLVVLVAGLAGLSLVLYAWRLPPFASSVETTENAYVRGYVTTISPQLAGYVAEVPVRDYEEVKAGQLLARI
DDRIFVQKLAQAKAMLATQRAALANSFEQELSAKAGITASEAQLDGAKAALATARATWDRIRPLADKGVATRSDADQARA
AFQQAEAGVKQAIANLEVSRQSLATTLGARAGLQGSVSGAEAAVELAQIDLDNTRIVAPRAGRLGEIGARVGQYVTAGTQ
LVSVVPHDVWIVANFKETQLDGMRVGQPVTIWVDALKRQELKGHIERFSPAAGSEFSIIRPDNATGNFTKVAQRLGVRIA
VDPEQPLAERLAPGLSVVVKVDKAAEPQASIASAG
>Mature_355_residues
MLKHFRSPSTLVVLVAGLAGLSLVLYAWRLPPFASSVETTENAYVRGYVTTISPQLAGYVAEVPVRDYEEVKAGQLLARI
DDRIFVQKLAQAKAMLATQRAALANSFEQELSAKAGITASEAQLDGAKAALATARATWDRIRPLADKGVATRSDADQARA
AFQQAEAGVKQAIANLEVSRQSLATTLGARAGLQGSVSGAEAAVELAQIDLDNTRIVAPRAGRLGEIGARVGQYVTAGTQ
LVSVVPHDVWIVANFKETQLDGMRVGQPVTIWVDALKRQELKGHIERFSPAAGSEFSIIRPDNATGNFTKVAQRLGVRIA
VDPEQPLAERLAPGLSVVVKVDKAAEPQASIASAG

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=307, Percent_Identity=33.8762214983713, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788711, Length=310, Percent_Identity=28.3870967741935, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1790519, Length=342, Percent_Identity=28.6549707602339, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI87081951, Length=330, Percent_Identity=26.969696969697, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37652; Mature: 37652

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKHFRSPSTLVVLVAGLAGLSLVLYAWRLPPFASSVETTENAYVRGYVTTISPQLAGYV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECHHHHHHH
AEVPVRDYEEVKAGQLLARIDDRIFVQKLAQAKAMLATQRAALANSFEQELSAKAGITAS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EAQLDGAKAALATARATWDRIRPLADKGVATRSDADQARAAFQQAEAGVKQAIANLEVSR
HHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QSLATTLGARAGLQGSVSGAEAAVELAQIDLDNTRIVAPRAGRLGEIGARVGQYVTAGTQ
HHHHHHHHHHCCCCCCCCHHHHHHHHHHEECCCCEEECCCCCCHHHHHHHHHHHHHHHHH
LVSVVPHDVWIVANFKETQLDGMRVGQPVTIWVDALKRQELKGHIERFSPAAGSEFSIIR
HHEECCCCEEEEECCCHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEC
PDNATGNFTKVAQRLGVRIAVDPEQPLAERLAPGLSVVVKVDKAAEPQASIASAG
CCCCCCCHHHHHHHCCCEEEECCCHHHHHHHCCCEEEEEEECCCCCCCCHHCCCC
>Mature Secondary Structure
MLKHFRSPSTLVVLVAGLAGLSLVLYAWRLPPFASSVETTENAYVRGYVTTISPQLAGYV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECHHHHHHH
AEVPVRDYEEVKAGQLLARIDDRIFVQKLAQAKAMLATQRAALANSFEQELSAKAGITAS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EAQLDGAKAALATARATWDRIRPLADKGVATRSDADQARAAFQQAEAGVKQAIANLEVSR
HHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QSLATTLGARAGLQGSVSGAEAAVELAQIDLDNTRIVAPRAGRLGEIGARVGQYVTAGTQ
HHHHHHHHHHCCCCCCCCHHHHHHHHHHEECCCCEEECCCCCCHHHHHHHHHHHHHHHHH
LVSVVPHDVWIVANFKETQLDGMRVGQPVTIWVDALKRQELKGHIERFSPAAGSEFSIIR
HHEECCCCEEEEECCCHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEC
PDNATGNFTKVAQRLGVRIAVDPEQPLAERLAPGLSVVVKVDKAAEPQASIASAG
CCCCCCCHHHHHHHCCCEEEECCCHHHHHHHCCCEEEEEEECCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]