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The map label for this gene is nadC [H]

Identifier: 150395925

GI number: 150395925

Start: 757296

End: 758195

Strand: Direct

Name: nadC [H]

Synonym: Smed_0701

Alternate gene names: 150395925

Gene position: 757296-758195 (Clockwise)

Preceding gene: 150395924

Following gene: 150395926

Centisome position: 20.02

GC content: 64.33

Gene sequence:

>900_bases
ATGACCGCCCTTCGCCCCGAACTGCCCGTCCTCATGCTCGAGGAGCAGGTGAAAGCCGCCCTTCTCGAAGATCTCGGCCG
GGCTGGTGACATCACCACGCTCTCGACGATCGGACCGGACCGGAAGGCGAGCGCCGAAATGAGCGTGCGCGAAGCGGGCG
TCGTGGCCGGGCTGGACCTGGCCCGGACCGCCTTCCGCCTGATCGATCCGTCTATCCGCTTCGAAGCGGTCGCCGCGGAT
GGCGATCGCGTGGCGTCAGGTGCGACGATTGCGCGAATTTCCGGCCGTGCCCGGGGGATTCTGTCCGCCGAGCGGGTGGC
ACTCAACTTTCTCATGCATCTTTCGGGAGTCGCGACCTACACGGCCTCTTTCGCCGATGAGATCGCCCATACCGGGGCCA
GGGTCTGCTGCACGCGCAAGACGATCCCCGGGCTTCGCGCGCTCGAAAAATACGCCGTCCGCCTCGGTGGCGGCTCCAAT
CATCGTTACGGTCTCGACGACGCGGTGCTGATCAAGGATAACCATATTGCCGTTTCCGGCGGGGTTGCCGGCGCCATACG
GGCCGCCCGGGCTTACTGCGGCCATCTCGTTAAGGTCGAAGCCGAAGTGGATGGGCTTGCGCAGCTGCGCGAAGCCTTGA
CCGCCGCTCCGGATGTGATCCTGCTCGACAATATGGGACCGGAACTGCTCGGCGAAGCCGTCGCAATCAATGCGGCGCAT
TGGGGGCTTACCTCCGCTTCCTACGCCGGCGACCTGCGCCGCACCAGGCTCGAAGCATCCGGAAATGTGAGGATCGAAAC
CATTCGGGCAATTGCCGAAACGGGCGTGGACTACATCTCGACATCGAAGATCACGATGGCCGCGCCGACGCTCGACATCG
GTCTGGACGTGTCGATTTAG

Upstream 100 bases:

>100_bases
GCCCAGGCGGAGCGCCTGGCCGTCGAAGTGGCCGAGAGCGAGCCGGCATGACGGCGGCAAAGGCGCAAACTGACACCCTT
CCAACCGCAGGAACGACATC

Downstream 100 bases:

>100_bases
CCCGCTTCTCGGGGCTTACCACAACTCCACCGCGTTCTAACGGAACGACCGCGGCAGCCGCGCGTTGTTCCCGATCAACC
CGCGCGTGAGAGGGAGAACT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MTALRPELPVLMLEEQVKAALLEDLGRAGDITTLSTIGPDRKASAEMSVREAGVVAGLDLARTAFRLIDPSIRFEAVAAD
GDRVASGATIARISGRARGILSAERVALNFLMHLSGVATYTASFADEIAHTGARVCCTRKTIPGLRALEKYAVRLGGGSN
HRYGLDDAVLIKDNHIAVSGGVAGAIRAARAYCGHLVKVEAEVDGLAQLREALTAAPDVILLDNMGPELLGEAVAINAAH
WGLTSASYAGDLRRTRLEASGNVRIETIRAIAETGVDYISTSKITMAAPTLDIGLDVSI

Sequences:

>Translated_299_residues
MTALRPELPVLMLEEQVKAALLEDLGRAGDITTLSTIGPDRKASAEMSVREAGVVAGLDLARTAFRLIDPSIRFEAVAAD
GDRVASGATIARISGRARGILSAERVALNFLMHLSGVATYTASFADEIAHTGARVCCTRKTIPGLRALEKYAVRLGGGSN
HRYGLDDAVLIKDNHIAVSGGVAGAIRAARAYCGHLVKVEAEVDGLAQLREALTAAPDVILLDNMGPELLGEAVAINAAH
WGLTSASYAGDLRRTRLEASGNVRIETIRAIAETGVDYISTSKITMAAPTLDIGLDVSI
>Mature_298_residues
TALRPELPVLMLEEQVKAALLEDLGRAGDITTLSTIGPDRKASAEMSVREAGVVAGLDLARTAFRLIDPSIRFEAVAADG
DRVASGATIARISGRARGILSAERVALNFLMHLSGVATYTASFADEIAHTGARVCCTRKTIPGLRALEKYAVRLGGGSNH
RYGLDDAVLIKDNHIAVSGGVAGAIRAARAYCGHLVKVEAEVDGLAQLREALTAAPDVILLDNMGPELLGEAVAINAAHW
GLTSASYAGDLRRTRLEASGNVRIETIRAIAETGVDYISTSKITMAAPTLDIGLDVSI

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=292, Percent_Identity=32.1917808219178, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI1786299, Length=287, Percent_Identity=37.6306620209059, Blast_Score=145, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6321162, Length=268, Percent_Identity=32.8358208955224, Blast_Score=137, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31380; Mature: 31249

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALRPELPVLMLEEQVKAALLEDLGRAGDITTLSTIGPDRKASAEMSVREAGVVAGLDL
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHCCCCCCHHH
ARTAFRLIDPSIRFEAVAADGDRVASGATIARISGRARGILSAERVALNFLMHLSGVATY
HHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
TASFADEIAHTGARVCCTRKTIPGLRALEKYAVRLGGGSNHRYGLDDAVLIKDNHIAVSG
HHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHEECCCCCCCCCCCCEEEEECCEEEEEC
GVAGAIRAARAYCGHLVKVEAEVDGLAQLREALTAAPDVILLDNMGPELLGEAVAINAAH
CHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHCHHHEEECHH
WGLTSASYAGDLRRTRLEASGNVRIETIRAIAETGVDYISTSKITMAAPTLDIGLDVSI
CCCCCHHHHHHHHHHEECCCCCEEHHHHHHHHHCCCCCEECCEEEEECCCEECCEEECC
>Mature Secondary Structure 
TALRPELPVLMLEEQVKAALLEDLGRAGDITTLSTIGPDRKASAEMSVREAGVVAGLDL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHCCCCCCHHH
ARTAFRLIDPSIRFEAVAADGDRVASGATIARISGRARGILSAERVALNFLMHLSGVATY
HHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
TASFADEIAHTGARVCCTRKTIPGLRALEKYAVRLGGGSNHRYGLDDAVLIKDNHIAVSG
HHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHEECCCCCCCCCCCCEEEEECCEEEEEC
GVAGAIRAARAYCGHLVKVEAEVDGLAQLREALTAAPDVILLDNMGPELLGEAVAINAAH
CHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHCHHHEEECHH
WGLTSASYAGDLRRTRLEASGNVRIETIRAIAETGVDYISTSKITMAAPTLDIGLDVSI
CCCCCHHHHHHHHHHEECCCCCEEHHHHHHHHHCCCCCEECCEEEEECCCEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]