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The map label for this gene is degP1 [H]

Identifier: 150395861

GI number: 150395861

Start: 682614

End: 684167

Strand: Direct

Name: degP1 [H]

Synonym: Smed_0637

Alternate gene names: 150395861

Gene position: 682614-684167 (Clockwise)

Preceding gene: 150395860

Following gene: 150395862

Centisome position: 18.05

GC content: 62.74

Gene sequence:

>1554_bases
ATGTCTATGATCAAAACGTCCCGTCCCTCCTTGAAGACAGTTCTGAAGACCACGACTGTTGCCGGCGTTGCCGCCGTACT
GCTGACCACCGGGCTTCCGGCACAGATCACTCAGTCCTTTGCCGAAGCGGTCAGCGTGCCGGCTCCCGCCGTTCCGAGCT
TTGCCAACGTCGTCGAGGCGGTTTCGCCGGCGGTCGTTTCCGTTCGCGTGCAGGCACGTGAACAAGCCAGTGACGACGAA
AGCAACTTCACCTTTGATTTCGGCGGTCGCGGCTTCGACGATCTGCCGGAAGACCATCCGCTTCGGCGCTTCTTCCGCGA
ATTCGACCCGCGTGACAACGACCGTGCCGACCGGTGGCGCGACCGCCGCGGCCCGCGCGGTGAGGGCCGTCTGCGTCCGC
GGGCGCAAGGCTCCGGCTTCTTCATCACCGAAGACGGCTACCTCGTCACCAACAACCACGTCATTTCTGACGGATCGGCC
TTCACCGTCATTATGGATGACGGTACCGAGCTCGAAGCCAAGCTCGTCGGCAAAGACAGCCGGACAGATCTTGCAGTGCT
CAAGGTGGACGCCAAGCGAAAGTTCACACATGTGAGCTTCGCCGATGACGAAAAGGTGCGTGTCGGCGACTGGGTGGTCG
CTGTCGGTAATCCCTTCGGCCTTGGCGGCACCGTGACAGCGGGGATCATCTCCGCTCGGGGCCGCGATATCGGCTCCGGT
CCTTACGACGATTACCTGCAGGTCGACGCAGCGGTGAACCGTGGGAATTCCGGAGGCCCGACCTTCAACCTCTCCGGAGA
GGTGGTCGGAATCAACACGGCCATATTCTCGCCTTCCGGCGGCAATGTCGGCATCGCCTTCGCAATTCCCGCCTCCGTCG
CGAAGGACGTCGTTGACTCCTTGATCAAGGACGGCACCGTTTCGCGTGGCTGGCTGGGTGTCCAGATCCAGCCGGTGACG
AAGGATATTGCCGAGTCGCTCGGCCTTGCCGAGGCGAAAGGTGCTCTCGTCGTAGAGCCTCAAACGGGCTCGCCGGGCGA
AAAGGCCGGCATCAAGAACGGCGACGTCGTGACGGCCCTTAATGGCGAGCCGGTCAAGGATCCGCGTGATCTTGCCCGGC
GAGTGGCGGCACTGCGCCCCGGCTCCACTGCCGAGGTCACTCTTTGGCGCTCCGGCAAGTCCGAAACGGTCAAGCTCGAG
ATCGGCACGCTGCCGAGCGATGCCAAGGAGACTGCACCGACAACCGGCGAAGCACAGCCGGACGAAGGTCAGGCAAGCGA
CGAGGCACTGGCCGGGCTCGGCCTGACGGTGACCCCGTCGGAAGACGACAGGGGCGTCACGATCACATCCGTCGACCCGG
ACTCCGACGCTAGCGATCGCGGTCTGAAGCAAGGCGAGAAGATCGTCTCCGTCAACAATCAGGAAGTGAAATCGGCGGAC
GACATTCTCAAGGTGATCAACAACGCCAGAAAGGACAATCGGACCAAGGCGCTGTTCCAGATCGAAGCCCAGGAAGGCAG
CCGCTTCGTCGCACTCCCGATCGCTCAGGGCTGA

Upstream 100 bases:

>100_bases
ACGAGCGGGTTTCGGCGGTGCTCGCTGTCCTGCTCGGGAAAAAGTTTCGAAGCAGCCTGCCCCCGCAGGCGAGCTTGATG
AAAGAGAGAAGGCAGAGCCA

Downstream 100 bases:

>100_bases
GACGGCACGATAGAATAATTGCCGTCCATGAGGGGCGCCGCGACATCAAACCATGTCGTGGCGCTCCTTTGTTTCTGGTC
GGACGCCGTATCCGGCAAGT

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MSMIKTSRPSLKTVLKTTTVAGVAAVLLTTGLPAQITQSFAEAVSVPAPAVPSFANVVEAVSPAVVSVRVQAREQASDDE
SNFTFDFGGRGFDDLPEDHPLRRFFREFDPRDNDRADRWRDRRGPRGEGRLRPRAQGSGFFITEDGYLVTNNHVISDGSA
FTVIMDDGTELEAKLVGKDSRTDLAVLKVDAKRKFTHVSFADDEKVRVGDWVVAVGNPFGLGGTVTAGIISARGRDIGSG
PYDDYLQVDAAVNRGNSGGPTFNLSGEVVGINTAIFSPSGGNVGIAFAIPASVAKDVVDSLIKDGTVSRGWLGVQIQPVT
KDIAESLGLAEAKGALVVEPQTGSPGEKAGIKNGDVVTALNGEPVKDPRDLARRVAALRPGSTAEVTLWRSGKSETVKLE
IGTLPSDAKETAPTTGEAQPDEGQASDEALAGLGLTVTPSEDDRGVTITSVDPDSDASDRGLKQGEKIVSVNNQEVKSAD
DILKVINNARKDNRTKALFQIEAQEGSRFVALPIAQG

Sequences:

>Translated_517_residues
MSMIKTSRPSLKTVLKTTTVAGVAAVLLTTGLPAQITQSFAEAVSVPAPAVPSFANVVEAVSPAVVSVRVQAREQASDDE
SNFTFDFGGRGFDDLPEDHPLRRFFREFDPRDNDRADRWRDRRGPRGEGRLRPRAQGSGFFITEDGYLVTNNHVISDGSA
FTVIMDDGTELEAKLVGKDSRTDLAVLKVDAKRKFTHVSFADDEKVRVGDWVVAVGNPFGLGGTVTAGIISARGRDIGSG
PYDDYLQVDAAVNRGNSGGPTFNLSGEVVGINTAIFSPSGGNVGIAFAIPASVAKDVVDSLIKDGTVSRGWLGVQIQPVT
KDIAESLGLAEAKGALVVEPQTGSPGEKAGIKNGDVVTALNGEPVKDPRDLARRVAALRPGSTAEVTLWRSGKSETVKLE
IGTLPSDAKETAPTTGEAQPDEGQASDEALAGLGLTVTPSEDDRGVTITSVDPDSDASDRGLKQGEKIVSVNNQEVKSAD
DILKVINNARKDNRTKALFQIEAQEGSRFVALPIAQG
>Mature_516_residues
SMIKTSRPSLKTVLKTTTVAGVAAVLLTTGLPAQITQSFAEAVSVPAPAVPSFANVVEAVSPAVVSVRVQAREQASDDES
NFTFDFGGRGFDDLPEDHPLRRFFREFDPRDNDRADRWRDRRGPRGEGRLRPRAQGSGFFITEDGYLVTNNHVISDGSAF
TVIMDDGTELEAKLVGKDSRTDLAVLKVDAKRKFTHVSFADDEKVRVGDWVVAVGNPFGLGGTVTAGIISARGRDIGSGP
YDDYLQVDAAVNRGNSGGPTFNLSGEVVGINTAIFSPSGGNVGIAFAIPASVAKDVVDSLIKDGTVSRGWLGVQIQPVTK
DIAESLGLAEAKGALVVEPQTGSPGEKAGIKNGDVVTALNGEPVKDPRDLARRVAALRPGSTAEVTLWRSGKSETVKLEI
GTLPSDAKETAPTTGEAQPDEGQASDEALAGLGLTVTPSEDDRGVTITSVDPDSDASDRGLKQGEKIVSVNNQEVKSADD
ILKVINNARKDNRTKALFQIEAQEGSRFVALPIAQG

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=272, Percent_Identity=34.9264705882353, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI4506141, Length=264, Percent_Identity=35.2272727272727, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI24308541, Length=259, Percent_Identity=32.4324324324324, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI7019477, Length=289, Percent_Identity=33.9100346020761, Blast_Score=133, Evalue=4e-31,
Organism=Escherichia coli, GI1789629, Length=476, Percent_Identity=36.7647058823529, Blast_Score=267, Evalue=2e-72,
Organism=Escherichia coli, GI1786356, Length=445, Percent_Identity=36.4044943820225, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1789630, Length=284, Percent_Identity=38.7323943661972, Blast_Score=187, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24646839, Length=265, Percent_Identity=32.0754716981132, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 54589; Mature: 54458

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMIKTSRPSLKTVLKTTTVAGVAAVLLTTGLPAQITQSFAEAVSVPAPAVPSFANVVEA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHH
VSPAVVSVRVQAREQASDDESNFTFDFGGRGFDDLPEDHPLRRFFREFDPRDNDRADRWR
HCCEEEEEEEEHHHCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHH
DRRGPRGEGRLRPRAQGSGFFITEDGYLVTNNHVISDGSAFTVIMDDGTELEAKLVGKDS
HHCCCCCCCCCCCCCCCCEEEEECCCEEEECCEEEECCCEEEEEECCCCEEEEEEECCCC
RTDLAVLKVDAKRKFTHVSFADDEKVRVGDWVVAVGNPFGLGGTVTAGIISARGRDIGSG
CCCEEEEEEECCCCEEEEEECCCCCEEECCEEEEECCCCCCCCHHHHHHHECCCCCCCCC
PYDDYLQVDAAVNRGNSGGPTFNLSGEVVGINTAIFSPSGGNVGIAFAIPASVAKDVVDS
CCCCCEEEEHHHCCCCCCCCEEECCCEEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHH
LIKDGTVSRGWLGVQIQPVTKDIAESLGLAEAKGALVVEPQTGSPGEKAGIKNGDVVTAL
HHHCCCCCCCEEEEEEEHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHCCCCCCCEEEEE
NGEPVKDPRDLARRVAALRPGSTAEVTLWRSGKSETVKLEIGTLPSDAKETAPTTGEAQP
CCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEECCCCCCHHHCCCCCCCCCC
DEGQASDEALAGLGLTVTPSEDDRGVTITSVDPDSDASDRGLKQGEKIVSVNNQEVKSAD
CCCCCCCHHHHCCCEEECCCCCCCCEEEEECCCCCCCCHHHHHCCCEEEECCCHHHHHHH
DILKVINNARKDNRTKALFQIEAQEGSRFVALPIAQG
HHHHHHHHHCCCCCEEEEEEEEECCCCEEEEEEECCC
>Mature Secondary Structure 
SMIKTSRPSLKTVLKTTTVAGVAAVLLTTGLPAQITQSFAEAVSVPAPAVPSFANVVEA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHH
VSPAVVSVRVQAREQASDDESNFTFDFGGRGFDDLPEDHPLRRFFREFDPRDNDRADRWR
HCCEEEEEEEEHHHCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHH
DRRGPRGEGRLRPRAQGSGFFITEDGYLVTNNHVISDGSAFTVIMDDGTELEAKLVGKDS
HHCCCCCCCCCCCCCCCCEEEEECCCEEEECCEEEECCCEEEEEECCCCEEEEEEECCCC
RTDLAVLKVDAKRKFTHVSFADDEKVRVGDWVVAVGNPFGLGGTVTAGIISARGRDIGSG
CCCEEEEEEECCCCEEEEEECCCCCEEECCEEEEECCCCCCCCHHHHHHHECCCCCCCCC
PYDDYLQVDAAVNRGNSGGPTFNLSGEVVGINTAIFSPSGGNVGIAFAIPASVAKDVVDS
CCCCCEEEEHHHCCCCCCCCEEECCCEEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHH
LIKDGTVSRGWLGVQIQPVTKDIAESLGLAEAKGALVVEPQTGSPGEKAGIKNGDVVTAL
HHHCCCCCCCEEEEEEEHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHCCCCCCCEEEEE
NGEPVKDPRDLARRVAALRPGSTAEVTLWRSGKSETVKLEIGTLPSDAKETAPTTGEAQP
CCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEECCCCCCHHHCCCCCCCCCC
DEGQASDEALAGLGLTVTPSEDDRGVTITSVDPDSDASDRGLKQGEKIVSVNNQEVKSAD
CCCCCCCHHHHCCCEEECCCCCCCCEEEEECCCCCCCCHHHHHCCCEEEECCCHHHHHHH
DILKVINNARKDNRTKALFQIEAQEGSRFVALPIAQG
HHHHHHHHHCCCCCEEEEEEEEECCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550509; 11481430 [H]