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The map label for this gene is cusR [H]

Identifier: 150395862

GI number: 150395862

Start: 684311

End: 685012

Strand: Direct

Name: cusR [H]

Synonym: Smed_0638

Alternate gene names: 150395862

Gene position: 684311-685012 (Clockwise)

Preceding gene: 150395861

Following gene: 150395863

Centisome position: 18.09

GC content: 59.83

Gene sequence:

>702_bases
ATGGTCACCCGCATGAAGATTCTGATTGTTGAAGACGACCTTGAGGCCGCCGCCTATCTTGCCAAGGCATTCCGCGAGGC
AGGCATTGTCTGCGATCACGCGAGTGACGGTGAGGCCGGTTTGTTCATGGCGAGCGAGAATGCCTATGACGTTCTCGTCG
TCGATCGCATGCTCCCCCGCCGGGACGGCCTTTCGCTGATTACGGAATTGAGGCGCAAGGACATTCACACACCCGTGCTC
ATCCTCTCTGCGCTCGGCCAGGTGGATGACCGCGTTACCGGTCTTCGCGCCGGCGGCGACGACTACCTGCCGAAACCTTA
CGCCTTCAGCGAGCTTCTGGCGCGCGTCGAGGTGCTTGGCCGGCGAAAAGGCGCACCCGAGCAGGACATGGTCTATCGTG
TCGGCGACCTCGAACTCGACCGCCTGTCGCACTCGGTCCGGCGGCAGGGCAAGGAGATACCCTTGCAGCCGCGCGAATTC
AGGCTGCTGGAATATCTCATGAAGAATGCCGGGCAGGTGGTGACGAGAACCATGTTGCTCGAAAACGTCTGGGACTATCA
TTTCGACCCCCAGACCAATGTGATCGACGTGCATGTTTCGCGCCTGCGTTCGAAGATCGAGAAGGATTTCGATCCACCCT
TGCTGAGGACGATCCGTGGTGCCGGATACATGATCAAGGATGAGCGGGCCGCTGACGCATGA

Upstream 100 bases:

>100_bases
CATCAAACCATGTCGTGGCGCTCCTTTGTTTCTGGTCGGACGCCGTATCCGGCAAGTACAGCGAAGCGAATCCGGTTGAG
ACGAACGGAGGTCCGGGACT

Downstream 100 bases:

>100_bases
GCAGGATCCGCGTGCTGTTCAGGACCACCGCCGTCCGGCTCTCTGCGCTTTATCTGGTCCTCTTCTCCCTCTGCGCGGCT
TTCCTCGTCATTTATGTGAC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MVTRMKILIVEDDLEAAAYLAKAFREAGIVCDHASDGEAGLFMASENAYDVLVVDRMLPRRDGLSLITELRRKDIHTPVL
ILSALGQVDDRVTGLRAGGDDYLPKPYAFSELLARVEVLGRRKGAPEQDMVYRVGDLELDRLSHSVRRQGKEIPLQPREF
RLLEYLMKNAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIEKDFDPPLLRTIRGAGYMIKDERAADA

Sequences:

>Translated_233_residues
MVTRMKILIVEDDLEAAAYLAKAFREAGIVCDHASDGEAGLFMASENAYDVLVVDRMLPRRDGLSLITELRRKDIHTPVL
ILSALGQVDDRVTGLRAGGDDYLPKPYAFSELLARVEVLGRRKGAPEQDMVYRVGDLELDRLSHSVRRQGKEIPLQPREF
RLLEYLMKNAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIEKDFDPPLLRTIRGAGYMIKDERAADA
>Mature_233_residues
MVTRMKILIVEDDLEAAAYLAKAFREAGIVCDHASDGEAGLFMASENAYDVLVVDRMLPRRDGLSLITELRRKDIHTPVL
ILSALGQVDDRVTGLRAGGDDYLPKPYAFSELLARVEVLGRRKGAPEQDMVYRVGDLELDRLSHSVRRQGKEIPLQPREF
RLLEYLMKNAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIEKDFDPPLLRTIRGAGYMIKDERAADA

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=45.4954954954955, Blast_Score=205, Evalue=2e-54,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=41.5525114155251, Blast_Score=175, Evalue=3e-45,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=37.8378378378378, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=35.7142857142857, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=32.2727272727273, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=31.8965517241379, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=32.7354260089686, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=34.5454545454545, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=36.4035087719298, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=34.2342342342342, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1790860, Length=227, Percent_Identity=32.15859030837, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=32.3144104803493, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=30.5309734513274, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=30.6382978723404, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1788550, Length=112, Percent_Identity=32.1428571428571, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=32.4324324324324, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790437, Length=113, Percent_Identity=30.9734513274336, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26435; Mature: 26435

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTRMKILIVEDDLEAAAYLAKAFREAGIVCDHASDGEAGLFMASENAYDVLVVDRMLPR
CCCEEEEEEEECCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEECCCCCEEEEHHHHCCC
RDGLSLITELRRKDIHTPVLILSALGQVDDRVTGLRAGGDDYLPKPYAFSELLARVEVLG
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
RRKGAPEQDMVYRVGDLELDRLSHSVRRQGKEIPLQPREFRLLEYLMKNAGQVVTRTMLL
HCCCCCCHHHEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ENVWDYHFDPQTNVIDVHVSRLRSKIEKDFDPPLLRTIRGAGYMIKDERAADA
HHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEECCCCCCC
>Mature Secondary Structure
MVTRMKILIVEDDLEAAAYLAKAFREAGIVCDHASDGEAGLFMASENAYDVLVVDRMLPR
CCCEEEEEEEECCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEECCCCCEEEEHHHHCCC
RDGLSLITELRRKDIHTPVLILSALGQVDDRVTGLRAGGDDYLPKPYAFSELLARVEVLG
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
RRKGAPEQDMVYRVGDLELDRLSHSVRRQGKEIPLQPREFRLLEYLMKNAGQVVTRTMLL
HCCCCCCHHHEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ENVWDYHFDPQTNVIDVHVSRLRSKIEKDFDPPLLRTIRGAGYMIKDERAADA
HHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]