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The map label for this gene is phoQ [H]

Identifier: 150395855

GI number: 150395855

Start: 676148

End: 677533

Strand: Direct

Name: phoQ [H]

Synonym: Smed_0631

Alternate gene names: 150395855

Gene position: 676148-677533 (Clockwise)

Preceding gene: 150395854

Following gene: 150395856

Centisome position: 17.88

GC content: 62.91

Gene sequence:

>1386_bases
ATGGCCATTAGATCCCTTACTGCCCGTGTTCTGGCGGTTTCGACCGTTTGGGCAGTCGTTGCCCTGGTGGTGATCGGCAT
CGTCATTTCCGCCCTTTACCGGCAGGGATCCGAACGCGGCTTCCAGGACCTGCTGCGAGCGCAGCTCTATAATGTCATCA
ATTCGATCTCTGTCGACGACAAGGCAGCGCTCTCAGGGAGCCCGCAGCTCGGCGACCTGCGCTTTTCCCAGCCGCAGACC
GGGTGGTACTGGATCGTCGAGCCGATCGGCGAGTTCGATACGCCGCCGCTGATTTCGACTTCGCTCGGAACTGCGAAACT
CCCAATCGTCAGCGTTGACGAGGTCCCCTTCGACATCCGCTACGAGCGGTTCTACACCACGACGGATCCGTTCGGGAACG
AGGTCGAAGTCGCCGAAACCGAGGTCGTCCTCGATATCCAGGGTCACGCCGCCCGTTTTCGGATCGCCGGAAATCGCGAG
GTGCTGGAGGCGGACATCGACCGCTTCACGCGTAATCTCACGATCGCCTTGTCGATTTTCGGCCTTGGCGGCCTCGGCAT
GAACGCGCTGACCATCCTCTTCGGCCTGAAGCCGCTCGACCAGGTACGCCGCTCGCTCGAAAAGATCCGCACGGGCGAAA
GCGAGCGGCTGGATGGGGCTTTCCCGCGGGAGATCCAGCCCCTTGCCAACGAAGTGAACGCGCTGATCGACAGCAATCGG
CGCATCGTCGAGCGGGCGCGTATGCAGGTCGGCAATCTGGCCCACTCGCTCAAGACACCCATTGCGGTTCTGCTCAACGA
GGCGAGGGTGCTGGAGGTGCCGCACGGAGAACTGGTCAGGGCGCAGGCCGATGCCATGCAGACCCAGGTACAATCCTATC
TAAGCCGTGCCAGGATCGCGGCCCAGCGCGGGTCGGTGCTTGCGAGGACCGAAGCCCAACCGGCGCTCGAGAGGATCATG
CGGGTGATGCGGCGGCTCAACCCCGACAAGCAATTCAGTCTTTCGATCAATCCGCCTGGACTGGTTCTGGCGATGGAGCA
GCAGGACGTCGAGGAAACAGTCGGCAACCTGCTGGAAAATGCCGCCCGATACGCGCAGGACAGTATCTGGATGACTGTCG
AGCCCGCCCCCGAAGACGCACGCGGGAAGGAGCCTGGCCGCCAGTGGATCGTCCTGCAGATCGACGATGACGGGCCGGGG
CTCGACCCGGATCAGATTGCAGTGGCGATGAAGCGCGGCAAGCGGCTCGACGAGAGCAAGCCCGGAACCGGGCTCGGCCT
TTCCATCGTGAGCGAGATCGTCGGAGAATATCAGGGCAGTGTCGCGCTCAGCCGACGCGATGAGGGAGGATTGCGGGCCA
CGCTCTTTCTCCCGGCTGCGATCTGA

Upstream 100 bases:

>100_bases
AACACGATCGAGGTCTTCATCGGCAGGCTCCGCAAGAAGATCGGCAACGACCTCATCGAAACGGTGCGCGGTCTCGGATA
TCGCATGCAAGCACCCGGCG

Downstream 100 bases:

>100_bases
GGCGCGGCGCCATCAAAAACGGGGCCTCCTCTTAACCTTTCCAGGCAAGGCGGGAAGGCCGATGCGGCGTGATCGTGATC
CGGCGGTCACACCCGGACGG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MAIRSLTARVLAVSTVWAVVALVVIGIVISALYRQGSERGFQDLLRAQLYNVINSISVDDKAALSGSPQLGDLRFSQPQT
GWYWIVEPIGEFDTPPLISTSLGTAKLPIVSVDEVPFDIRYERFYTTTDPFGNEVEVAETEVVLDIQGHAARFRIAGNRE
VLEADIDRFTRNLTIALSIFGLGGLGMNALTILFGLKPLDQVRRSLEKIRTGESERLDGAFPREIQPLANEVNALIDSNR
RIVERARMQVGNLAHSLKTPIAVLLNEARVLEVPHGELVRAQADAMQTQVQSYLSRARIAAQRGSVLARTEAQPALERIM
RVMRRLNPDKQFSLSINPPGLVLAMEQQDVEETVGNLLENAARYAQDSIWMTVEPAPEDARGKEPGRQWIVLQIDDDGPG
LDPDQIAVAMKRGKRLDESKPGTGLGLSIVSEIVGEYQGSVALSRRDEGGLRATLFLPAAI

Sequences:

>Translated_461_residues
MAIRSLTARVLAVSTVWAVVALVVIGIVISALYRQGSERGFQDLLRAQLYNVINSISVDDKAALSGSPQLGDLRFSQPQT
GWYWIVEPIGEFDTPPLISTSLGTAKLPIVSVDEVPFDIRYERFYTTTDPFGNEVEVAETEVVLDIQGHAARFRIAGNRE
VLEADIDRFTRNLTIALSIFGLGGLGMNALTILFGLKPLDQVRRSLEKIRTGESERLDGAFPREIQPLANEVNALIDSNR
RIVERARMQVGNLAHSLKTPIAVLLNEARVLEVPHGELVRAQADAMQTQVQSYLSRARIAAQRGSVLARTEAQPALERIM
RVMRRLNPDKQFSLSINPPGLVLAMEQQDVEETVGNLLENAARYAQDSIWMTVEPAPEDARGKEPGRQWIVLQIDDDGPG
LDPDQIAVAMKRGKRLDESKPGTGLGLSIVSEIVGEYQGSVALSRRDEGGLRATLFLPAAI
>Mature_460_residues
AIRSLTARVLAVSTVWAVVALVVIGIVISALYRQGSERGFQDLLRAQLYNVINSISVDDKAALSGSPQLGDLRFSQPQTG
WYWIVEPIGEFDTPPLISTSLGTAKLPIVSVDEVPFDIRYERFYTTTDPFGNEVEVAETEVVLDIQGHAARFRIAGNREV
LEADIDRFTRNLTIALSIFGLGGLGMNALTILFGLKPLDQVRRSLEKIRTGESERLDGAFPREIQPLANEVNALIDSNRR
IVERARMQVGNLAHSLKTPIAVLLNEARVLEVPHGELVRAQADAMQTQVQSYLSRARIAAQRGSVLARTEAQPALERIMR
VMRRLNPDKQFSLSINPPGLVLAMEQQDVEETVGNLLENAARYAQDSIWMTVEPAPEDARGKEPGRQWIVLQIDDDGPGL
DPDQIAVAMKRGKRLDESKPGTGLGLSIVSEIVGEYQGSVALSRRDEGGLRATLFLPAAI

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=269, Percent_Identity=27.8810408921933, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789808, Length=254, Percent_Identity=24.8031496062992, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790861, Length=215, Percent_Identity=27.4418604651163, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1787894, Length=263, Percent_Identity=25.0950570342205, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786912, Length=247, Percent_Identity=28.7449392712551, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790346, Length=250, Percent_Identity=24.4, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1790551, Length=293, Percent_Identity=24.5733788395904, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50676; Mature: 50544

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRSLTARVLAVSTVWAVVALVVIGIVISALYRQGSERGFQDLLRAQLYNVINSISVDD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC
KAALSGSPQLGDLRFSQPQTGWYWIVEPIGEFDTPPLISTSLGTAKLPIVSVDEVPFDIR
CHHCCCCCCCCCEECCCCCCCEEEEEEECCCCCCCCCEECCCCCCCCCEEEECCCCCCEE
YERFYTTTDPFGNEVEVAETEVVLDIQGHAARFRIAGNREVLEADIDRFTRNLTIALSIF
EEEEEECCCCCCCCEEEEEEEEEEEECCCEEEEEECCCHHHHHHHHHHHHCCEEEEEEEE
GLGGLGMNALTILFGLKPLDQVRRSLEKIRTGESERLDGAFPREIQPLANEVNALIDSNR
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCH
RIVERARMQVGNLAHSLKTPIAVLLNEARVLEVPHGELVRAQADAMQTQVQSYLSRARIA
HHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
AQRGSVLARTEAQPALERIMRVMRRLNPDKQFSLSINPPGLVLAMEQQDVEETVGNLLEN
HHCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHH
AARYAQDSIWMTVEPAPEDARGKEPGRQWIVLQIDDDGPGLDPDQIAVAMKRGKRLDESK
HHHHHCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCC
PGTGLGLSIVSEIVGEYQGSVALSRRDEGGLRATLFLPAAI
CCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCC
>Mature Secondary Structure 
AIRSLTARVLAVSTVWAVVALVVIGIVISALYRQGSERGFQDLLRAQLYNVINSISVDD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC
KAALSGSPQLGDLRFSQPQTGWYWIVEPIGEFDTPPLISTSLGTAKLPIVSVDEVPFDIR
CHHCCCCCCCCCEECCCCCCCEEEEEEECCCCCCCCCEECCCCCCCCCEEEECCCCCCEE
YERFYTTTDPFGNEVEVAETEVVLDIQGHAARFRIAGNREVLEADIDRFTRNLTIALSIF
EEEEEECCCCCCCCEEEEEEEEEEEECCCEEEEEECCCHHHHHHHHHHHHCCEEEEEEEE
GLGGLGMNALTILFGLKPLDQVRRSLEKIRTGESERLDGAFPREIQPLANEVNALIDSNR
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCH
RIVERARMQVGNLAHSLKTPIAVLLNEARVLEVPHGELVRAQADAMQTQVQSYLSRARIA
HHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
AQRGSVLARTEAQPALERIMRVMRRLNPDKQFSLSINPPGLVLAMEQQDVEETVGNLLEN
HHCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHH
AARYAQDSIWMTVEPAPEDARGKEPGRQWIVLQIDDDGPGLDPDQIAVAMKRGKRLDESK
HHHHHCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCC
PGTGLGLSIVSEIVGEYQGSVALSRRDEGGLRATLFLPAAI
CCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]