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The map label for this gene is hemX [C]

Identifier: 148827895

GI number: 148827895

Start: 1277220

End: 1278431

Strand: Reverse

Name: hemX [C]

Synonym: CGSHiGG_06950

Alternate gene names: 148827895

Gene position: 1278431-1277220 (Counterclockwise)

Preceding gene: 148827900

Following gene: 148827894

Centisome position: 67.74

GC content: 33.99

Gene sequence:

>1212_bases
ATGGCAAAAGAGCAACCTAACGACCTCACTGAACAACTTACAGATACGCCAAAAACAGCTGTTGAACAAACTGAAACAAT
GCAGTCTGTTCCGCAAACTATTGTGAAAAAAACGGGTACAGCATTGAGTTTATTAGCAATACTTGTTGCGCTAAGTATTG
GTGGAGCTGGATACTATTTTGGTCAGCAACAAATAGCTGAAATTCAACAGAAATTAACCGCACTTGAAAATCAAACGGGA
GCAAATCTTTCCTCAAATAACACCAACAACAATAAACGACTTACACAATTAGAACAGAGTTTAAAAACTGCACAAGAAAA
TATAGCTCAACTGGAACAATTAATTGTAAGCAAAACAGGGGAAATAACATCCTTACAAACTCAAATGAAACAAGTAAGTC
AGCTTGCCATCGCACAACAACCAAGCGATTGGTTATTTTCCGAAGCTGATTTTTTACTAAATAATGCCCTGCGTAAACTT
GTTTTAGATAACGATGTTGATACAGCGGTTTCTTTATTAAAATTAGCTGATGAAACCCTCGTCAAGGTTAATAATTCACA
AGCAAATGAAATTCGTAGTGCAATCAATCAAGATTTAAAACAACTTCTTTCGCTTTCAAGTGTGGATCAAAATGCGATAA
TGCAAAAACTGTCACAACTTGCAAACACAGTCGATGAATTACAGGCTTTGAATGTAAATTTTGATGAAACATCTAAAAAT
AATGATAAATTATCCAACAACATTACTGACTGGCAACAAAATATTGAAAAAAGTGCAACCTCTTTCCTAAATCATTTTAT
TCGTATTTCGCCAAAACAAAATTCAAATAAAAAAGAATTACTTGCACCAAATCAAGATATTTATCTTCGTGAGAACATTC
GTCTACGTTTACAGCTTGCGATTATGGCAGTTCCTCGTCAGCAAAATGAACTTTATCAGCAATCTCTAGAAGCTGTTTCT
TCTTGGGTTCGTAGCTATTTTGATACAAACGCTGAAGTAACACAAAATTTCTTAAAATTAGTAGATGGATTGACTGATAC
TTCTATTTATGTAGATGTACCAGAGCAATTAAAAAGTTTAACATTACTTGACAAATATCTTAATCGTACAGCTTTAGATC
TACAAAAAGTGGAAATTGAAGCAGACAAGGCGATTGATACAATGCCTAAAGTAGAAGCTGTTAAACCAACACAATCTGAA
TCACAACAATAA

Upstream 100 bases:

>100_bases
AATCTATATTTTCTATTATTAGTGGATAGCTTGATATTTTTCTTATCAACGCAAAGTATTATAAAATACCTTACTCAATA
TCACTTATTAAGGAATTGAT

Downstream 100 bases:

>100_bases
GGATAAGTCTATGTTTAGAGTGCTTTTTTTAATGCTGACATTGCTTGTAGGACTTGTAGCAGGGCCTTATATTTCTGGTC
AGCAAGGTTATGTGCGCATT

Product: cell developmental protein SirA

Products: S-Adenosyl-L-homocysteine; H+; Sirohydrochlorin [C]

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MAKEQPNDLTEQLTDTPKTAVEQTETMQSVPQTIVKKTGTALSLLAILVALSIGGAGYYFGQQQIAEIQQKLTALENQTG
ANLSSNNTNNNKRLTQLEQSLKTAQENIAQLEQLIVSKTGEITSLQTQMKQVSQLAIAQQPSDWLFSEADFLLNNALRKL
VLDNDVDTAVSLLKLADETLVKVNNSQANEIRSAINQDLKQLLSLSSVDQNAIMQKLSQLANTVDELQALNVNFDETSKN
NDKLSNNITDWQQNIEKSATSFLNHFIRISPKQNSNKKELLAPNQDIYLRENIRLRLQLAIMAVPRQQNELYQQSLEAVS
SWVRSYFDTNAEVTQNFLKLVDGLTDTSIYVDVPEQLKSLTLLDKYLNRTALDLQKVEIEADKAIDTMPKVEAVKPTQSE
SQQ

Sequences:

>Translated_403_residues
MAKEQPNDLTEQLTDTPKTAVEQTETMQSVPQTIVKKTGTALSLLAILVALSIGGAGYYFGQQQIAEIQQKLTALENQTG
ANLSSNNTNNNKRLTQLEQSLKTAQENIAQLEQLIVSKTGEITSLQTQMKQVSQLAIAQQPSDWLFSEADFLLNNALRKL
VLDNDVDTAVSLLKLADETLVKVNNSQANEIRSAINQDLKQLLSLSSVDQNAIMQKLSQLANTVDELQALNVNFDETSKN
NDKLSNNITDWQQNIEKSATSFLNHFIRISPKQNSNKKELLAPNQDIYLRENIRLRLQLAIMAVPRQQNELYQQSLEAVS
SWVRSYFDTNAEVTQNFLKLVDGLTDTSIYVDVPEQLKSLTLLDKYLNRTALDLQKVEIEADKAIDTMPKVEAVKPTQSE
SQQ
>Mature_402_residues
AKEQPNDLTEQLTDTPKTAVEQTETMQSVPQTIVKKTGTALSLLAILVALSIGGAGYYFGQQQIAEIQQKLTALENQTGA
NLSSNNTNNNKRLTQLEQSLKTAQENIAQLEQLIVSKTGEITSLQTQMKQVSQLAIAQQPSDWLFSEADFLLNNALRKLV
LDNDVDTAVSLLKLADETLVKVNNSQANEIRSAINQDLKQLLSLSSVDQNAIMQKLSQLANTVDELQALNVNFDETSKNN
DKLSNNITDWQQNIEKSATSFLNHFIRISPKQNSNKKELLAPNQDIYLRENIRLRLQLAIMAVPRQQNELYQQSLEAVSS
WVRSYFDTNAEVTQNFLKLVDGLTDTSIYVDVPEQLKSLTLLDKYLNRTALDLQKVEIEADKAIDTMPKVEAVKPTQSES
QQ

Specific function: Siroheme and cobalamin biosynthesis. [C]

COG id: COG2959

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli hemX N-terminal region [H]

Homologues:

Organism=Escherichia coli, GI1790235, Length=281, Percent_Identity=41.2811387900356, Blast_Score=191, Evalue=6e-50,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007470 [H]

Pfam domain/function: PF04375 HemX [H]

EC number: 2.1.1.107 [C]

Molecular weight: Translated: 45080; Mature: 44949

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKEQPNDLTEQLTDTPKTAVEQTETMQSVPQTIVKKTGTALSLLAILVALSIGGAGYYF
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHH
GQQQIAEIQQKLTALENQTGANLSSNNTNNNKRLTQLEQSLKTAQENIAQLEQLIVSKTG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EITSLQTQMKQVSQLAIAQQPSDWLFSEADFLLNNALRKLVLDNDVDTAVSLLKLADETL
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VKVNNSQANEIRSAINQDLKQLLSLSSVDQNAIMQKLSQLANTVDELQALNVNFDETSKN
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NDKLSNNITDWQQNIEKSATSFLNHFIRISPKQNSNKKELLAPNQDIYLRENIRLRLQLA
CCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCEEEEEEE
IMAVPRQQNELYQQSLEAVSSWVRSYFDTNAEVTQNFLKLVDGLTDTSIYVDVPEQLKSL
EHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHH
TLLDKYLNRTALDLQKVEIEADKAIDTMPKVEAVKPTQSESQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKEQPNDLTEQLTDTPKTAVEQTETMQSVPQTIVKKTGTALSLLAILVALSIGGAGYYF
CCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHH
GQQQIAEIQQKLTALENQTGANLSSNNTNNNKRLTQLEQSLKTAQENIAQLEQLIVSKTG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EITSLQTQMKQVSQLAIAQQPSDWLFSEADFLLNNALRKLVLDNDVDTAVSLLKLADETL
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VKVNNSQANEIRSAINQDLKQLLSLSSVDQNAIMQKLSQLANTVDELQALNVNFDETSKN
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NDKLSNNITDWQQNIEKSATSFLNHFIRISPKQNSNKKELLAPNQDIYLRENIRLRLQLA
CCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCEEEEEEE
IMAVPRQQNELYQQSLEAVSSWVRSYFDTNAEVTQNFLKLVDGLTDTSIYVDVPEQLKSL
EHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHH
TLLDKYLNRTALDLQKVEIEADKAIDTMPKVEAVKPTQSESQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-methionine; Uroporphyrinogen III [C]

Specific reaction: (2) S-Adenosyl-L-methionine + Uroporphyrinogen III --> (2) S-Adenosyl-L-homocysteine + H+ + Sirohydrochlorin [C]

General reaction: Methyl group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]