Click here to switch to the map view.

The map label for this gene is surE [H]

Identifier: 148827877

GI number: 148827877

Start: 1247652

End: 1248884

Strand: Direct

Name: surE [H]

Synonym: CGSHiGG_06840

Alternate gene names: 148827877

Gene position: 1247652-1248884 (Clockwise)

Preceding gene: 148827876

Following gene: 148827878

Centisome position: 66.11

GC content: 35.36

Gene sequence:

>1233_bases
ATGAAAAAACAACCTTCCATCTTTGGTGGTGCGTGTATTATTGCTAGTGTTTGTGTTGGGGCAGGAATGCTTGGTTTGCC
AACATCTGGCGCGGGTGCTTGGACAATATGGTCAGTATTAGTAATTTGCTTAACAATGATAGTCATGACATTGTCAGGCT
GGTTATTACTTGAGGCCTACTCTACTTATGATTTAAGAGCTTCATTTAGTACTGTAACTAAAGATATGCTCGGTTCAACT
GTCAATTCTATTAATAATCTTGCGGTATATTTTGTCGGGGGTATTTTACTTTATGCTTATACCACTGCATCTGGCAGTAT
ACTAGAAAACCTTATTAAACCGTGGATTGATTTTGGTTCATCTACATTGGCAATTTGTTCCACTGTATTTGTATTAGTCT
TTTCCTTCTTTGTTTGGCACTCCACTCGCATTGTAGATAGAATATCTGTTTTATTGATTGTATGCATGGGTTTTACTTTT
ATTTTTAGTACTTATGGATTAGCAACTAATATTAGTTTAGACACTTTATTAGATATTGGTGGAAAGGAGACAAATTATGC
AAAATATGCGGTAGGAATGTTTCCCGTTGCATTAACATCTTTTGGCTATCATCATTCTGTTTGTACGATGCGAGCTTACT
ATGGGGAAGAAAAAAGAGCAAAATACGCTATTTTAGGTGGAACAGCAATTGCTCTTACGCTTTATTTACTTTGGATTTTC
TCTATTTTTGGCAACTTACCGCGAGATCAATTTGCTCCAGTAATTGCCAGTGATGGTAATTTAGATATTTTACTTAACAC
ATTAGGTGGAGTAATCGAATCTAACACGGTTAAACAAATGATTAATGCCTTTTCTATCGCCGCAATTTTATCATCTTTTA
TTGGCGTAGGATTAGGCGTATTTGATTATTTGGCTGATTTCTTTAAATTTGATAATTGTAAAATTGGAAGAACAAAGTCA
TGGGCTGTGACTTTCCTACCTCCACTAATTATGTCAATTTTATTTCCATTGGGTTTCTTAAAAGCTATTGGGTATGCTGG
TGCGGTAGCTACGATTTGGACAAGTATAATTCCTGCTCTTCTTGCCTATAAATCCCGCAAAATAAATACAGCTGCAACAT
TCCGAGTGTGTGGTGGAAATGGCTTAATAATCTTTATTGCATTATTTGGTGTTTTTGTAGCTATTTTCCATTTTCTTGCA
ATGTTTGGCTACTTACCTTTCTTTAAGTTCTAA

Upstream 100 bases:

>100_bases
TAAAAGAAGTTGAATAATATCACGAAAAATGCAGTTCATTTTGAACTGCATTTTTTTATCAACAGCTAACTCAATAATTT
GTTATTGATAAGGATGTTCT

Downstream 100 bases:

>100_bases
GGGGAAAATATCAATTTTAAGTGCGGTAAAAAATCTCAACAAATTTTTACCGCACTTTTTTATCTGGCTTTTTCCCCTTT
CGGCACCTAAAATAGCCGCC

Product: stationary phase survival protein SurE

Products: Indole [Cytoplasm]; L-tryptophan [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Tryptophan permease [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MKKQPSIFGGACIIASVCVGAGMLGLPTSGAGAWTIWSVLVICLTMIVMTLSGWLLLEAYSTYDLRASFSTVTKDMLGST
VNSINNLAVYFVGGILLYAYTTASGSILENLIKPWIDFGSSTLAICSTVFVLVFSFFVWHSTRIVDRISVLLIVCMGFTF
IFSTYGLATNISLDTLLDIGGKETNYAKYAVGMFPVALTSFGYHHSVCTMRAYYGEEKRAKYAILGGTAIALTLYLLWIF
SIFGNLPRDQFAPVIASDGNLDILLNTLGGVIESNTVKQMINAFSIAAILSSFIGVGLGVFDYLADFFKFDNCKIGRTKS
WAVTFLPPLIMSILFPLGFLKAIGYAGAVATIWTSIIPALLAYKSRKINTAATFRVCGGNGLIIFIALFGVFVAIFHFLA
MFGYLPFFKF

Sequences:

>Translated_410_residues
MKKQPSIFGGACIIASVCVGAGMLGLPTSGAGAWTIWSVLVICLTMIVMTLSGWLLLEAYSTYDLRASFSTVTKDMLGST
VNSINNLAVYFVGGILLYAYTTASGSILENLIKPWIDFGSSTLAICSTVFVLVFSFFVWHSTRIVDRISVLLIVCMGFTF
IFSTYGLATNISLDTLLDIGGKETNYAKYAVGMFPVALTSFGYHHSVCTMRAYYGEEKRAKYAILGGTAIALTLYLLWIF
SIFGNLPRDQFAPVIASDGNLDILLNTLGGVIESNTVKQMINAFSIAAILSSFIGVGLGVFDYLADFFKFDNCKIGRTKS
WAVTFLPPLIMSILFPLGFLKAIGYAGAVATIWTSIIPALLAYKSRKINTAATFRVCGGNGLIIFIALFGVFVAIFHFLA
MFGYLPFFKF
>Mature_410_residues
MKKQPSIFGGACIIASVCVGAGMLGLPTSGAGAWTIWSVLVICLTMIVMTLSGWLLLEAYSTYDLRASFSTVTKDMLGST
VNSINNLAVYFVGGILLYAYTTASGSILENLIKPWIDFGSSTLAICSTVFVLVFSFFVWHSTRIVDRISVLLIVCMGFTF
IFSTYGLATNISLDTLLDIGGKETNYAKYAVGMFPVALTSFGYHHSVCTMRAYYGEEKRAKYAILGGTAIALTLYLLWIF
SIFGNLPRDQFAPVIASDGNLDILLNTLGGVIESNTVKQMINAFSIAAILSSFIGVGLGVFDYLADFFKFDNCKIGRTKS
WAVTFLPPLIMSILFPLGFLKAIGYAGAVATIWTSIIPALLAYKSRKINTAATFRVCGGNGLIIFIALFGVFVAIFHFLA
MFGYLPFFKF

Specific function: Involved in transporting tryptophan across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789552, Length=413, Percent_Identity=40.1937046004843, Blast_Score=278, Evalue=7e-76,
Organism=Escherichia coli, GI1790145, Length=412, Percent_Identity=37.1359223300971, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI1788218, Length=412, Percent_Identity=31.5533980582524, Blast_Score=174, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 44547; Mature: 44547

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQPSIFGGACIIASVCVGAGMLGLPTSGAGAWTIWSVLVICLTMIVMTLSGWLLLEAY
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHEEEHH
STYDLRASFSTVTKDMLGSTVNSINNLAVYFVGGILLYAYTTASGSILENLIKPWIDFGS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
STLAICSTVFVLVFSFFVWHSTRIVDRISVLLIVCMGFTFIFSTYGLATNISLDTLLDIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCC
GKETNYAKYAVGMFPVALTSFGYHHSVCTMRAYYGEEKRAKYAILGGTAIALTLYLLWIF
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHH
SIFGNLPRDQFAPVIASDGNLDILLNTLGGVIESNTVKQMINAFSIAAILSSFIGVGLGV
HHHCCCCHHHCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDYLADFFKFDNCKIGRTKSWAVTFLPPLIMSILFPLGFLKAIGYAGAVATIWTSIIPAL
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAYKSRKINTAATFRVCGGNGLIIFIALFGVFVAIFHFLAMFGYLPFFKF
HHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKKQPSIFGGACIIASVCVGAGMLGLPTSGAGAWTIWSVLVICLTMIVMTLSGWLLLEAY
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHEEEHH
STYDLRASFSTVTKDMLGSTVNSINNLAVYFVGGILLYAYTTASGSILENLIKPWIDFGS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
STLAICSTVFVLVFSFFVWHSTRIVDRISVLLIVCMGFTFIFSTYGLATNISLDTLLDIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCC
GKETNYAKYAVGMFPVALTSFGYHHSVCTMRAYYGEEKRAKYAILGGTAIALTLYLLWIF
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHH
SIFGNLPRDQFAPVIASDGNLDILLNTLGGVIESNTVKQMINAFSIAAILSSFIGVGLGV
HHHCCCCHHHCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDYLADFFKFDNCKIGRTKSWAVTFLPPLIMSILFPLGFLKAIGYAGAVATIWTSIIPAL
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAYKSRKINTAATFRVCGGNGLIIFIALFGVFVAIFHFLAMFGYLPFFKF
HHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Indole [Periplasm]; L-tryptophan [Periplasm]; Proton [Periplasm] [C]

Specific reaction: Proton [Periplasm] + indole [Periplasm] = Proton [Cytoplasm] + indole [Cytoplasm] L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]