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The map label for this gene is selB [H]

Identifier: 148827878

GI number: 148827878

Start: 1253284

End: 1255143

Strand: Direct

Name: selB [H]

Synonym: CGSHiGG_06865

Alternate gene names: 148827878

Gene position: 1253284-1255143 (Clockwise)

Preceding gene: 148827877

Following gene: 148827879

Centisome position: 66.41

GC content: 39.25

Gene sequence:

>1860_bases
ATGATTATTGTTACTTCAGGTCACGTTGATCACGGCAAAACAGCATTATTAAAAGCATTAACTGGCACAAGTACCGCCCA
TTTACCAGAAGAAAAAAAACGCGGAATGACCATTGATTTGGGGTATGCCTACCTGCCTTTAGAAAACAAAGTTCTTGGCT
TTATTGATGTGCCGGGGCACGAGAAATTCTTGTCAAATATGCTGGCGGGTTTAGGTGGCGTACATTATGCAATGTTAATT
GTCGCTGCCGATGAAGGCGTTGCAATGCAAACAAAAGAACATTTAGCAATCTTACGCCAACTTCAATTCCACGAAATTAT
TGTTGTCATCACAAAAGCAGATCGTACAAATTCAGAGCAAATAGAATCGTTAATCCAAACAATTAAACAAGATTACAGTT
TTTTACGCAATGCTAACTACTTCGTTACCTCAGCAGAAACGGGACAAGGAATTAATGAATTACGTCATTACTTAGCTAAT
TTGGCAGAATTAGCTGATACTCAGAAACCTTTCCGCTACGCAATAGACCGAGTATTCAGCGTAAAAGGGGCAGGTACCGT
CGTGACAGGCACAGCCTTTTCAGGAACAGTGAAAACGAACGATGAAATTTACCTTTCCACAGGACAGAAAGTTCGTATAA
AAGCGATTTACGCACAAAATACATCAAGCGAACAAGGTATTGCGGGGCAACGTTTAGCGTTAAATTTAAATGCTGATTTA
GACCGCACATCAATGAAACGAGGCGATTGGTTATTGCAGAATGAGCCACTTCCACCAACAGATCGCATCAGTGTACAAAT
TTTGGCTGAAGTACCATTAAATGAAAGCCAACCTGTGCATATTTATCACGGATCGAGTCGTACTACGGGTAAGCTCACCT
TATTACAGGGAAAAAATACCGCTAAAAATGACCGCACTTTAGCTGAAATCATATTAGATTCTCCATTATTCTTGGCTTTT
GGAGACAAACTTATTTTACGCAGTGGCGATACAAAAACCTTAATTGCTGGCGCACGAGTATTGGAAATTAACTCGCCAAA
ACGTCATAAACGTACTGAAGTGCGGTTAAATTTCTTAGCGAATTTAGCATTGGTAGAGAATGCTTCGCAACGTATTGCGC
TTACCCTTCAACATAATGCGAAAACAGCACGCCAATTAATGTGGACGGAACAACTGACTTCCTTGCAATTAGATAAAGCA
CTCGTCGAGCGAGACGCCGTACGTTATCAAGATTGGTGTTTTAATACTAATTACATACAAGAAAAAACGCAGCAAATTTT
AACCGCACTTAATACTTATCACGAGCAACATAATGATCAACTTGGTGTAAGCAAAGCCAGATTATATCGAATGACCGCCT
TAAACCAGCCTGAAAACTTGATCAATCATTTTATTGATGAAATGTTAGAAGAGGGAAGATTACAGCAAACTCGAGGTTGG
CTTCACTTACCCGAATATAAAATCCAATTTAGCCAAGAAGAACAAAAATATTGGTCAAGTGTACTCGATGAATTTGAAAA
AGCCCAAGGTCAAGCCATTTGGGTGCGTGATATGGCGAATGCCTTGGCGATGGATGAAAGTACCATGCGTAATTTTATGT
ATAAAGCTGGGAAATTGGGTTACCTCACACCAATCGTGAAAGATAGATTTTTCTTAACTGAAACCATCTATGTTTATGCA
AGGCTCATCAAGCAAATTGCAGAAGAAAAAGGAAAAGTTTCAGTAAATGAAGTACGTGATAAATTGAATTTCGGACGCAA
ACTTACCGTTCAACTGATGGAATATTTCGACCGAATGGGATTTTTACGTCGCAAAGGCAATGACCATATTCTACGCGATA
AGAATGTTTTTGATTTATGA

Upstream 100 bases:

>100_bases
TTTCTCAACCTATTATTGGGCGAATGGAAAACGGAAAAATTTGGCTAGACTTACGTAGCCTTGCGGATATTGAAACATTA
TTAAATACATTGGATGAACT

Downstream 100 bases:

>100_bases
TTTAAAAAGGAAAAAAGTATGAAAAAAACGCTCGTTGCTGCATTAATTAGTTCTGTCATATTACTCACAGGCTGCCAAGA
TAAAGATACTGAAGCAAAAA

Product: selenocysteine-specific elongation factor

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 619; Mature: 619

Protein sequence:

>619_residues
MIIVTSGHVDHGKTALLKALTGTSTAHLPEEKKRGMTIDLGYAYLPLENKVLGFIDVPGHEKFLSNMLAGLGGVHYAMLI
VAADEGVAMQTKEHLAILRQLQFHEIIVVITKADRTNSEQIESLIQTIKQDYSFLRNANYFVTSAETGQGINELRHYLAN
LAELADTQKPFRYAIDRVFSVKGAGTVVTGTAFSGTVKTNDEIYLSTGQKVRIKAIYAQNTSSEQGIAGQRLALNLNADL
DRTSMKRGDWLLQNEPLPPTDRISVQILAEVPLNESQPVHIYHGSSRTTGKLTLLQGKNTAKNDRTLAEIILDSPLFLAF
GDKLILRSGDTKTLIAGARVLEINSPKRHKRTEVRLNFLANLALVENASQRIALTLQHNAKTARQLMWTEQLTSLQLDKA
LVERDAVRYQDWCFNTNYIQEKTQQILTALNTYHEQHNDQLGVSKARLYRMTALNQPENLINHFIDEMLEEGRLQQTRGW
LHLPEYKIQFSQEEQKYWSSVLDEFEKAQGQAIWVRDMANALAMDESTMRNFMYKAGKLGYLTPIVKDRFFLTETIYVYA
RLIKQIAEEKGKVSVNEVRDKLNFGRKLTVQLMEYFDRMGFLRRKGNDHILRDKNVFDL

Sequences:

>Translated_619_residues
MIIVTSGHVDHGKTALLKALTGTSTAHLPEEKKRGMTIDLGYAYLPLENKVLGFIDVPGHEKFLSNMLAGLGGVHYAMLI
VAADEGVAMQTKEHLAILRQLQFHEIIVVITKADRTNSEQIESLIQTIKQDYSFLRNANYFVTSAETGQGINELRHYLAN
LAELADTQKPFRYAIDRVFSVKGAGTVVTGTAFSGTVKTNDEIYLSTGQKVRIKAIYAQNTSSEQGIAGQRLALNLNADL
DRTSMKRGDWLLQNEPLPPTDRISVQILAEVPLNESQPVHIYHGSSRTTGKLTLLQGKNTAKNDRTLAEIILDSPLFLAF
GDKLILRSGDTKTLIAGARVLEINSPKRHKRTEVRLNFLANLALVENASQRIALTLQHNAKTARQLMWTEQLTSLQLDKA
LVERDAVRYQDWCFNTNYIQEKTQQILTALNTYHEQHNDQLGVSKARLYRMTALNQPENLINHFIDEMLEEGRLQQTRGW
LHLPEYKIQFSQEEQKYWSSVLDEFEKAQGQAIWVRDMANALAMDESTMRNFMYKAGKLGYLTPIVKDRFFLTETIYVYA
RLIKQIAEEKGKVSVNEVRDKLNFGRKLTVQLMEYFDRMGFLRRKGNDHILRDKNVFDL
>Mature_619_residues
MIIVTSGHVDHGKTALLKALTGTSTAHLPEEKKRGMTIDLGYAYLPLENKVLGFIDVPGHEKFLSNMLAGLGGVHYAMLI
VAADEGVAMQTKEHLAILRQLQFHEIIVVITKADRTNSEQIESLIQTIKQDYSFLRNANYFVTSAETGQGINELRHYLAN
LAELADTQKPFRYAIDRVFSVKGAGTVVTGTAFSGTVKTNDEIYLSTGQKVRIKAIYAQNTSSEQGIAGQRLALNLNADL
DRTSMKRGDWLLQNEPLPPTDRISVQILAEVPLNESQPVHIYHGSSRTTGKLTLLQGKNTAKNDRTLAEIILDSPLFLAF
GDKLILRSGDTKTLIAGARVLEINSPKRHKRTEVRLNFLANLALVENASQRIALTLQHNAKTARQLMWTEQLTSLQLDKA
LVERDAVRYQDWCFNTNYIQEKTQQILTALNTYHEQHNDQLGVSKARLYRMTALNQPENLINHFIDEMLEEGRLQQTRGW
LHLPEYKIQFSQEEQKYWSSVLDEFEKAQGQAIWVRDMANALAMDESTMRNFMYKAGKLGYLTPIVKDRFFLTETIYVYA
RLIKQIAEEKGKVSVNEVRDKLNFGRKLTVQLMEYFDRMGFLRRKGNDHILRDKNVFDL

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=296, Percent_Identity=28.0405405405405, Blast_Score=109, Evalue=9e-24,
Organism=Homo sapiens, GI54607086, Length=360, Percent_Identity=25.8333333333333, Blast_Score=100, Evalue=8e-21,
Organism=Homo sapiens, GI223555963, Length=369, Percent_Identity=24.9322493224932, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI5729864, Length=369, Percent_Identity=24.9322493224932, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI82546879, Length=351, Percent_Identity=24.2165242165242, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI46094014, Length=239, Percent_Identity=26.3598326359833, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI53729339, Length=250, Percent_Identity=29.6, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI53729337, Length=250, Percent_Identity=29.6, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI194097354, Length=239, Percent_Identity=25.1046025104602, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI194018520, Length=239, Percent_Identity=25.1046025104602, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI194018522, Length=239, Percent_Identity=25.1046025104602, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI2367247, Length=623, Percent_Identity=42.8571428571429, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI1790412, Length=379, Percent_Identity=27.7044854881267, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1789737, Length=379, Percent_Identity=27.7044854881267, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1789108, Length=327, Percent_Identity=25.6880733944954, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1789559, Length=227, Percent_Identity=28.6343612334802, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25141371, Length=367, Percent_Identity=27.2479564032698, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17556456, Length=389, Percent_Identity=26.2210796915167, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI115532067, Length=329, Percent_Identity=28.2674772036474, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115532065, Length=329, Percent_Identity=28.2674772036474, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17506081, Length=260, Percent_Identity=27.6923076923077, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17565438, Length=325, Percent_Identity=25.8461538461538, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71994658, Length=227, Percent_Identity=25.5506607929515, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6324761, Length=305, Percent_Identity=28.8524590163934, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI19922690, Length=332, Percent_Identity=31.3253012048193, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281363316, Length=297, Percent_Identity=27.6094276094276, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17864358, Length=297, Percent_Identity=27.6094276094276, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19921738, Length=280, Percent_Identity=30, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45550900, Length=396, Percent_Identity=22.4747474747475, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28573213, Length=346, Percent_Identity=24.5664739884393, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221378008, Length=346, Percent_Identity=24.5664739884393, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644462, Length=346, Percent_Identity=24.5664739884393, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644464, Length=346, Percent_Identity=24.5664739884393, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644466, Length=346, Percent_Identity=24.5664739884393, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28572034, Length=118, Percent_Identity=34.7457627118644, Blast_Score=67, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 70319; Mature: 70319

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIVTSGHVDHGKTALLKALTGTSTAHLPEEKKRGMTIDLGYAYLPLENKVLGFIDVPGH
CEEEECCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCEEEECEEEECCCCCEEEEEECCCH
EKFLSNMLAGLGGVHYAMLIVAADEGVAMQTKEHLAILRQLQFHEIIVVITKADRTNSEQ
HHHHHHHHHHCCHHEEEEEEEECCCCCEEHHHHHHHHHHHHCCEEEEEEEEECCCCCHHH
IESLIQTIKQDYSFLRNANYFVTSAETGQGINELRHYLANLAELADTQKPFRYAIDRVFS
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHE
VKGAGTVVTGTAFSGTVKTNDEIYLSTGQKVRIKAIYAQNTSSEQGIAGQRLALNLNADL
ECCCCEEEECCEEECEEECCCEEEEECCCEEEEEEEEECCCCCCCCCCCCEEEEEECCCC
DRTSMKRGDWLLQNEPLPPTDRISVQILAEVPLNESQPVHIYHGSSRTTGKLTLLQGKNT
CHHHHCCCCEEEECCCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCCCCEEEEEECCCC
AKNDRTLAEIILDSPLFLAFGDKLILRSGDTKTLIAGARVLEINSPKRHKRTEVRLNFLA
CCCCHHHHHHHHCCCEEEEECCEEEEECCCCCEEEECEEEEEECCCCHHHHHHHHHHHHH
NLALVENASQRIALTLQHNAKTARQLMWTEQLTSLQLDKALVERDAVRYQDWCFNTNYIQ
HHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
EKTQQILTALNTYHEQHNDQLGVSKARLYRMTALNQPENLINHFIDEMLEEGRLQQTRGW
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHCCC
LHLPEYKIQFSQEEQKYWSSVLDEFEKAQGQAIWVRDMANALAMDESTMRNFMYKAGKLG
EECCCCEEECCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCHHHHHHHHHHCCCCC
YLTPIVKDRFFLTETIYVYARLIKQIAEEKGKVSVNEVRDKLNFGRKLTVQLMEYFDRMG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHH
FLRRKGNDHILRDKNVFDL
HHHCCCCCCEECCCCCCCC
>Mature Secondary Structure
MIIVTSGHVDHGKTALLKALTGTSTAHLPEEKKRGMTIDLGYAYLPLENKVLGFIDVPGH
CEEEECCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCEEEECEEEECCCCCEEEEEECCCH
EKFLSNMLAGLGGVHYAMLIVAADEGVAMQTKEHLAILRQLQFHEIIVVITKADRTNSEQ
HHHHHHHHHHCCHHEEEEEEEECCCCCEEHHHHHHHHHHHHCCEEEEEEEEECCCCCHHH
IESLIQTIKQDYSFLRNANYFVTSAETGQGINELRHYLANLAELADTQKPFRYAIDRVFS
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHE
VKGAGTVVTGTAFSGTVKTNDEIYLSTGQKVRIKAIYAQNTSSEQGIAGQRLALNLNADL
ECCCCEEEECCEEECEEECCCEEEEECCCEEEEEEEEECCCCCCCCCCCCEEEEEECCCC
DRTSMKRGDWLLQNEPLPPTDRISVQILAEVPLNESQPVHIYHGSSRTTGKLTLLQGKNT
CHHHHCCCCEEEECCCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCCCCEEEEEECCCC
AKNDRTLAEIILDSPLFLAFGDKLILRSGDTKTLIAGARVLEINSPKRHKRTEVRLNFLA
CCCCHHHHHHHHCCCEEEEECCEEEEECCCCCEEEECEEEEEECCCCHHHHHHHHHHHHH
NLALVENASQRIALTLQHNAKTARQLMWTEQLTSLQLDKALVERDAVRYQDWCFNTNYIQ
HHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
EKTQQILTALNTYHEQHNDQLGVSKARLYRMTALNQPENLINHFIDEMLEEGRLQQTRGW
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHCCC
LHLPEYKIQFSQEEQKYWSSVLDEFEKAQGQAIWVRDMANALAMDESTMRNFMYKAGKLG
EECCCCEEECCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCHHHHHHHHHHCCCCC
YLTPIVKDRFFLTETIYVYARLIKQIAEEKGKVSVNEVRDKLNFGRKLTVQLMEYFDRMG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHH
FLRRKGNDHILRDKNVFDL
HHHCCCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]