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The map label for this gene is hemC [H]

Identifier: 148660279

GI number: 148660279

Start: 603167

End: 604096

Strand: Direct

Name: hemC [H]

Synonym: MRA_0517

Alternate gene names: 148660279

Gene position: 603167-604096 (Clockwise)

Preceding gene: 148660278

Following gene: 148660280

Centisome position: 13.65

GC content: 68.06

Gene sequence:

>930_bases
GTGATCCGGATAGGTACCCGGGGCAGCTTGCTGGCCACCACTCAGGCCGCCACTGTCAGAGACGCCCTCATCGCTGGTGG
CCACTCCGCGGAGTTGGTGACCATCAGCACCGAGGGTGACCGATCCATGGCGCCGATCGCCAGTCTCGGGGTTGGCGTCT
TCACCACGGCGTTGCGCGAGGCGATGGAGGCAGGCCTCGTCGATGCGGCGGTGCATTCGTACAAGGATTTGCCGACTGCC
GCCGATCCAAGGTTCACGGTTGCGGCGATACCGCCGCGCAATGACCCCCGCGACGCGGTGGTAGCCCGTGACGGGCTGAC
GCTGGGGGAATTGCCGGTCGGATCGTTGGTGGGCACATCCTCGCCGCGGCGGGCCGCACAGCTTAGAGCATTGGGTCTCG
GTTTGGAAATCCGCCCCCTACGAGGCAACCTAGATACCAGGTTGAACAAGGTAAGTAGCGGCGATCTTGACGCCATCGTG
GTGGCCCGGGCTGGTCTGGCGCGGCTGGGCCGCCTCGATGACGTGACCGAGACGTTAGAGCCGGTGCAGATGTTGCCCGC
GCCGGCTCAGGGCGCGCTCGCGGTCGAATGCCGCGCCGGCGACAGCCGGTTGGTGGCAGTGCTGGCGGAGTTGGATGACG
CCGACACGCGTGCGGCGGTCACCGCCGAGCGAGCCCTGCTTGCCGACCTGGAGGCAGGTTGCTCCGCACCGGTGGGAGCG
ATCGCAGAAGTGGTCGAGTCCATCGATGAGGACGGCCGTGTCTTCGAGGAGCTGTCGCTGCGCGGGTGCGTGGCGGCGCT
GGACGGATCCGACGTGATCCGCGCGTCCGGCATCGGCAGTTGCGGTCGGGCACGGGAGCTGGGGCTCTCGGTCGCCGCGG
AGCTGTTCGAGCTGGGCGCCCGGGAGCTGATGTGGGGAGTGCGGCATTAG

Upstream 100 bases:

>100_bases
ATTACCGGTGGTGCCAAGCGGATTCGACGCTGAAAGTCGCCGCGGTGGAGGCGACATGCAAAGCAGCCCGAAGCGATCGC
CGAGTAACTGATTGGCGCAC

Downstream 100 bases:

>100_bases
CCCGCATGAAGAAGTGACTGGGAGTGACAATCATGACGCGAGGGCGTAAGCCGAGACCGGGCCGCATCGTTTTCGTGGGC
TCCGGTCCGGGCGACCCCGG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREAMEAGLVDAAVHSYKDLPTA
ADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIV
VARAGLARLGRLDDVTETLEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA
IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGARELMWGVRH

Sequences:

>Translated_309_residues
MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREAMEAGLVDAAVHSYKDLPTA
ADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIV
VARAGLARLGRLDDVTETLEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA
IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGARELMWGVRH
>Mature_309_residues
MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREAMEAGLVDAAVHSYKDLPTA
ADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIV
VARAGLARLGRLDDVTETLEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA
IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGARELMWGVRH

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=284, Percent_Identity=42.6056338028169, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI20149500, Length=284, Percent_Identity=42.6056338028169, Blast_Score=179, Evalue=2e-45,
Organism=Escherichia coli, GI48994974, Length=308, Percent_Identity=43.1818181818182, Blast_Score=199, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6319996, Length=285, Percent_Identity=31.9298245614035, Blast_Score=133, Evalue=4e-32,
Organism=Drosophila melanogaster, GI20130425, Length=284, Percent_Identity=41.5492957746479, Blast_Score=171, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 31939; Mature: 31939

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE
CEEECCCCCEEEECHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS
HHHHCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEEECCCEECCCCCCHHHCCC
SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE
CCHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA
HHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA
HHHHHHHHCCCCHHHHHHHHHHHEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCH
RELMWGVRH
HHHHHHCCC
>Mature Secondary Structure
MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE
CEEECCCCCEEEECHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS
HHHHCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEEECCCEECCCCCCHHHCCC
SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE
CCHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA
HHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA
HHHHHHHHCCCCHHHHHHHHHHHEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCH
RELMWGVRH
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA