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The map label for this gene is mutT3

Identifier: 148660178

GI number: 148660178

Start: 501023

End: 501676

Strand: Direct

Name: mutT3

Synonym: MRA_0419

Alternate gene names: 148660178

Gene position: 501023-501676 (Clockwise)

Preceding gene: 148660174

Following gene: 148660180

Centisome position: 11.34

GC content: 70.34

Gene sequence:

>654_bases
TTGCCCAGTTGCCCGCCTGCATATTCTGAACAGGTGCGGGGCGACGGTGACGGATGGGTGGTGTCCGACAGCGGCGTTGC
GTACTGGGGCCGCTACGGTGCGGCCGGTCTGTTGCTTCGGGCTCCGCGGCCGGACGGCACCCCCGCGGTGCTGCTGCAGC
ACCGCGCGCTGTGGAGCCATCAGGGCGGCACCTGGGGCTTGCCGGGCGGTGCTCGAGACAGCCACGAGACGCCGGAACAG
ACCGCGGTCCGCGAATCGAGCGAGGAGGCGGGCCTGTCCGCCGAGCGACTCGAGGTGCGGGCCACGGTGGTCACCGCCGA
GGTGTGCGGGGTCGACGACACGCACTGGACCTACACCACCGTTGTCGCCGATGCCGGGGAGTTGCTGGACACCGTGCCCA
ACCGGGAAAGCGCCGAACTGCGCTGGGTGGCCGAGAACGAGGTGGCCGACTTGCCGTTACATCCCGGATTCGCCGCCAGT
TGGCAACGACTGCGGACCGCTCCGGCGACCGTGCCACTGGCCCGGTGCGACGAACGGCGGCAGCGGCTGCCGCGCACCAT
TCAGATCGAGGCCGGGGTTTTCCTCTGGTGTACGCCGGGCGACGCGGATCAGGCGCCCTCGCCGCTGGGTAGGCGGATCA
GTTCGCTGCTGTAA

Upstream 100 bases:

>100_bases
CCGTCACGTCTGTTAGGACCTCATCTTTCGGCTAACGCAACGAAACTCTATAAGCGAATTCTAAGAGAAGGTTCCGACAG
ATGGTGTTAGGCATACGCAA

Downstream 100 bases:

>100_bases
GCGCCGACCGGAGCTGCTCGGCCGCCGCACGTGGGTCGTCAGCCGAGGTGATCGCCCGCACCACCACGATCCGGCGAGCG
CCGGCATCGAGCACGGCCGG

Product: putative mutator protein MutT3

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MPSCPPAYSEQVRGDGDGWVVSDSGVAYWGRYGAAGLLLRAPRPDGTPAVLLQHRALWSHQGGTWGLPGGARDSHETPEQ
TAVRESSEEAGLSAERLEVRATVVTAEVCGVDDTHWTYTTVVADAGELLDTVPNRESAELRWVAENEVADLPLHPGFAAS
WQRLRTAPATVPLARCDERRQRLPRTIQIEAGVFLWCTPGDADQAPSPLGRRISSLL

Sequences:

>Translated_217_residues
MPSCPPAYSEQVRGDGDGWVVSDSGVAYWGRYGAAGLLLRAPRPDGTPAVLLQHRALWSHQGGTWGLPGGARDSHETPEQ
TAVRESSEEAGLSAERLEVRATVVTAEVCGVDDTHWTYTTVVADAGELLDTVPNRESAELRWVAENEVADLPLHPGFAAS
WQRLRTAPATVPLARCDERRQRLPRTIQIEAGVFLWCTPGDADQAPSPLGRRISSLL
>Mature_216_residues
PSCPPAYSEQVRGDGDGWVVSDSGVAYWGRYGAAGLLLRAPRPDGTPAVLLQHRALWSHQGGTWGLPGGARDSHETPEQT
AVRESSEEAGLSAERLEVRATVVTAEVCGVDDTHWTYTTVVADAGELLDTVPNRESAELRWVAENEVADLPLHPGFAASW
QRLRTAPATVPLARCDERRQRLPRTIQIEAGVFLWCTPGDADQAPSPLGRRISSLL

Specific function: May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo- dGTP is inserted opposite dA and dC residues of template DNA with almost equa

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTT3_MYCTU (P96259)

Other databases:

- EMBL:   AE000516
- EMBL:   BX842573
- PIR:   C70629
- RefSeq:   NP_214927.1
- RefSeq:   NP_334836.1
- ProteinModelPortal:   P96259
- SMR:   P96259
- EnsemblBacteria:   EBMYCT00000002796
- EnsemblBacteria:   EBMYCT00000071623
- GeneID:   886405
- GeneID:   923702
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0426
- KEGG:   mtu:Rv0413
- TIGR:   MT0426
- TubercuList:   Rv0413
- GeneTree:   EBGT00050000015831
- HOGENOM:   HBG483699
- OMA:   DGWVISE
- ProtClustDB:   CLSK790505
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: NA

Molecular weight: Translated: 23499; Mature: 23368

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSCPPAYSEQVRGDGDGWVVSDSGVAYWGRYGAAGLLLRAPRPDGTPAVLLQHRALWSH
CCCCCCCHHHHHCCCCCCEEEECCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHC
QGGTWGLPGGARDSHETPEQTAVRESSEEAGLSAERLEVRATVVTAEVCGVDDTHWTYTT
CCCCCCCCCCCCCCCCCCHHHHHHCCHHHHCCCHHHEEEEEEEEEEHHCCCCCCCCEEEE
VVADAGELLDTVPNRESAELRWVAENEVADLPLHPGFAASWQRLRTAPATVPLARCDERR
EEHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHH
QRLPRTIQIEAGVFLWCTPGDADQAPSPLGRRISSLL
HHCCCEEEEECCEEEEECCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
PSCPPAYSEQVRGDGDGWVVSDSGVAYWGRYGAAGLLLRAPRPDGTPAVLLQHRALWSH
CCCCCCHHHHHCCCCCCEEEECCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHC
QGGTWGLPGGARDSHETPEQTAVRESSEEAGLSAERLEVRATVVTAEVCGVDDTHWTYTT
CCCCCCCCCCCCCCCCCCHHHHHHCCHHHHCCCHHHEEEEEEEEEEHHCCCCCCCCEEEE
VVADAGELLDTVPNRESAELRWVAENEVADLPLHPGFAASWQRLRTAPATVPLARCDERR
EEHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHH
QRLPRTIQIEAGVFLWCTPGDADQAPSPLGRRISSLL
HHCCCEEEEECCEEEEECCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036