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The map label for this gene is Hgd [H]

Identifier: 148653528

GI number: 148653528

Start: 2140622

End: 2141551

Strand: Direct

Name: Hgd [H]

Synonym: PsycPRwf_1731

Alternate gene names: 148653528

Gene position: 2140622-2141551 (Clockwise)

Preceding gene: 148653523

Following gene: 148653529

Centisome position: 71.86

GC content: 50.97

Gene sequence:

>930_bases
ATGAGCTCTACCCCTGATACGTTTGCGCCTCGCAGTGCTGTCCCTACCTCAGTAAGCTTCATCGGCCTAGGTGCTATGGG
GCACCACATGGCCAAGCACTTAGTCGGTTCGTTTGATACAGTGATGGTCTATAATCGAAATTTTGATAAGGCCACTGCGC
ACGCCGCAGAGTTTGGCACCCAAGCCGTCAGCCTAGAGCAAGCGGTGAGCGCCGATGTCATTTTCTCCTGCCTGCCCACC
AGTCAAGTAGTCGATGACCTTATTGAACAAGCCTTGCCACACCTTAACGATGGCAGTGTGTGGGTAGACTGTACCAGCGG
TGTACCTGAGAACGCCAAGGCCAGTCAGGCTAAGCTTAATGCTGCGGGCTGTGAGTTTTTGGATGCGCCTGTCTCTGGCC
AAACCTCAGGGGCTGACAGCGGTACGTTAACGGTGATGGTCGGCGGCTCAGCCAAAGCGTTGGCTTATGCTAAGAGCGCC
ATCGACTGCTTTGCTGGTCTGATTGTCCATGTCGGTGACTCGGGGGCGGGTTTTGCGGTCAAAGCGGTCAATAATACCTT
ATTTGCCATTAATGCTTGGGCGGCTGTAGAAGGGTTATCGGTGTTAAAGGCGCATGGCGTCAACCCAAGTGATGCCTTAG
CCTGCATCAATAAAGCCAGTGGTCAAAGTTTTGCCACTCTCGTCACTTTGCCAGATCGCATTGTTAATCAAACCTATCCT
AAGACCTTTACCATCGACTTAATGGCCAAAGACTGCGGTATTGCCATTGATTTACAAACCGAAAAACAAGTGCCTACTCC
GGTTATGGCGCAAGTAGCAAGCCTAGTGCGTGCCGCCAGCAATCAATATGAGCCCGGCTCTGCTGACTTTTCAGAGTTTG
CTAAGTTTTATCAGCTGATGAGCGGCATTACTTTAAAAGATAACCATTAA

Upstream 100 bases:

>100_bases
TAAATAAGCTATTCTAGCAATATATGGATGATTTTTTAGTAACTTTAGTGTTCTAATGTAGTGTAACGCTATTCTTATTT
TGGATATAAAGGATTTTGAC

Downstream 100 bases:

>100_bases
AATCTTCTGCAATGCACTAAGCTGCGCTTTGTTGACCGTCACCTCAATAGGATGGATTGGCGTTACATTCGTCCTATTGC
TGTTTTATTCCTGTCTTGTT

Product: NAD-binding 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MSSTPDTFAPRSAVPTSVSFIGLGAMGHHMAKHLVGSFDTVMVYNRNFDKATAHAAEFGTQAVSLEQAVSADVIFSCLPT
SQVVDDLIEQALPHLNDGSVWVDCTSGVPENAKASQAKLNAAGCEFLDAPVSGQTSGADSGTLTVMVGGSAKALAYAKSA
IDCFAGLIVHVGDSGAGFAVKAVNNTLFAINAWAAVEGLSVLKAHGVNPSDALACINKASGQSFATLVTLPDRIVNQTYP
KTFTIDLMAKDCGIAIDLQTEKQVPTPVMAQVASLVRAASNQYEPGSADFSEFAKFYQLMSGITLKDNH

Sequences:

>Translated_309_residues
MSSTPDTFAPRSAVPTSVSFIGLGAMGHHMAKHLVGSFDTVMVYNRNFDKATAHAAEFGTQAVSLEQAVSADVIFSCLPT
SQVVDDLIEQALPHLNDGSVWVDCTSGVPENAKASQAKLNAAGCEFLDAPVSGQTSGADSGTLTVMVGGSAKALAYAKSA
IDCFAGLIVHVGDSGAGFAVKAVNNTLFAINAWAAVEGLSVLKAHGVNPSDALACINKASGQSFATLVTLPDRIVNQTYP
KTFTIDLMAKDCGIAIDLQTEKQVPTPVMAQVASLVRAASNQYEPGSADFSEFAKFYQLMSGITLKDNH
>Mature_308_residues
SSTPDTFAPRSAVPTSVSFIGLGAMGHHMAKHLVGSFDTVMVYNRNFDKATAHAAEFGTQAVSLEQAVSADVIFSCLPTS
QVVDDLIEQALPHLNDGSVWVDCTSGVPENAKASQAKLNAAGCEFLDAPVSGQTSGADSGTLTVMVGGSAKALAYAKSAI
DCFAGLIVHVGDSGAGFAVKAVNNTLFAINAWAAVEGLSVLKAHGVNPSDALACINKASGQSFATLVTLPDRIVNQTYPK
TFTIDLMAKDCGIAIDLQTEKQVPTPVMAQVASLVRAASNQYEPGSADFSEFAKFYQLMSGITLKDNH

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=264, Percent_Identity=32.9545454545455, Blast_Score=108, Evalue=4e-24,
Organism=Escherichia coli, GI145693186, Length=298, Percent_Identity=31.5436241610738, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790315, Length=301, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1786719, Length=248, Percent_Identity=28.6290322580645, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17557316, Length=297, Percent_Identity=27.6094276094276, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24655230, Length=292, Percent_Identity=29.1095890410959, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI19922568, Length=292, Percent_Identity=29.1095890410959, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28574115, Length=232, Percent_Identity=24.5689655172414, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 32166; Mature: 32034

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTPDTFAPRSAVPTSVSFIGLGAMGHHMAKHLVGSFDTVMVYNRNFDKATAHAAEFGT
CCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCH
QAVSLEQAVSADVIFSCLPTSQVVDDLIEQALPHLNDGSVWVDCTSGVPENAKASQAKLN
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHC
AAGCEFLDAPVSGQTSGADSGTLTVMVGGSAKALAYAKSAIDCFAGLIVHVGDSGAGFAV
CCCCCEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHEEECCCCCCEEE
KAVNNTLFAINAWAAVEGLSVLKAHGVNPSDALACINKASGQSFATLVTLPDRIVNQTYP
EEECCEEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCHHHHHCCCC
KTFTIDLMAKDCGIAIDLQTEKQVPTPVMAQVASLVRAASNQYEPGSADFSEFAKFYQLM
CEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
SGITLKDNH
CCCCCCCCC
>Mature Secondary Structure 
SSTPDTFAPRSAVPTSVSFIGLGAMGHHMAKHLVGSFDTVMVYNRNFDKATAHAAEFGT
CCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCH
QAVSLEQAVSADVIFSCLPTSQVVDDLIEQALPHLNDGSVWVDCTSGVPENAKASQAKLN
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHC
AAGCEFLDAPVSGQTSGADSGTLTVMVGGSAKALAYAKSAIDCFAGLIVHVGDSGAGFAV
CCCCCEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHEEECCCCCCEEE
KAVNNTLFAINAWAAVEGLSVLKAHGVNPSDALACINKASGQSFATLVTLPDRIVNQTYP
EEECCEEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCHHHHHCCCC
KTFTIDLMAKDCGIAIDLQTEKQVPTPVMAQVASLVRAASNQYEPGSADFSEFAKFYQLM
CEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
SGITLKDNH
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA