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The map label for this gene is mtbA [H]

Identifier: 148379464

GI number: 148379464

Start: 1625099

End: 1625971

Strand: Direct

Name: mtbA [H]

Synonym: CBO1493

Alternate gene names: 148379464

Gene position: 1625099-1625971 (Clockwise)

Preceding gene: 148379463

Following gene: 148379465

Centisome position: 41.81

GC content: 30.58

Gene sequence:

>873_bases
ATGGATTATGATGTGAACTTTAAATGTGTTTTAGATACAGGAGAAGAGATGCCCAAAGAAGCTGTAGAAAGAGCGGGAAT
AAAATTTCCTGATGTGCACAAAAATGCTAAGGATATGGCGGTACTTTCTAAGAATATAAGAGAATACAATGAGGACTTCT
TTTCTATAGTACCTTTTTGCATGACAGTGGAAGCGGAAGCATTAGGAGGAGAAATAAATTTAGGAGACGAAAAGGCTGGC
CCTAGAGTTTCAAACTATACATTTAAAAGCATTGAGGATATTGAGAGATTAAAGGAAATAGATTTTAAAACTAAAAGAAT
AGGAGAAGTTCTAAAATCCGTTGAGATATTAAAGAAAGAAGGAGAAACTGTAATAATGGATGTACAGGGACCCTTTACTA
TAATAAGTTCTTTAATTGATCCAAGAATTTTTTATAAAGCAGTAAGAAAAAATAAAGATGAAGTAGAAAGACTTATGAAA
ATAGTACAAAAGGGATCAGTGGAATTTATAAAGGAAGGAGTAAAAAGAGGAGTAGATATAATATCCTTTGGAGATTCTGC
TGGAACTTTAGATATATTAGGACCAAAGATGTATAAAGAATTAGGTGGAAAATATACTTACAATGTTTTAAAAGAAGTCA
AAAATTACCTAGGAGATTCTATAATACATCTTTGTGGTATAACTTCATCTTCATTAGATAGAGCAGGATTTATAAAGTCA
AGCCCTATAGAAGTACCAGAAGGAATAACTTATGGACAGGCATTAAATTATATTATAAAAGAAAATAAGGATGTAAAAAT
ATTAGGTCATAATTGTTTAAGAAAGACTATTAAGCCGCTGAAAAAACCTATAGTATGGGAAATAAAATTATAA

Upstream 100 bases:

>100_bases
TGTATAATAGGACAAGACCTACGTAAAAGGAAAATACAATTTTTGTTCAAAGAAAAATATAATATAAAAAAATTATAAAA
AATTTTAAGGAGTAATGATA

Downstream 100 bases:

>100_bases
TAAAAATATCAAGGAGGAAAAGTAAATGAATAATGTATCAGAAGAGCTAATAAAAAAGTTATCAGAATCAGTAGTAGAAA
TGGAAGAAGAAGAAACAGTA

Product: putative methylcobalamin:coenzyme M methyltransferase

Products: NA

Alternate protein names: MT2-A; Methylcobamide:CoM methyltransferase II isozyme A [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MDYDVNFKCVLDTGEEMPKEAVERAGIKFPDVHKNAKDMAVLSKNIREYNEDFFSIVPFCMTVEAEALGGEINLGDEKAG
PRVSNYTFKSIEDIERLKEIDFKTKRIGEVLKSVEILKKEGETVIMDVQGPFTIISSLIDPRIFYKAVRKNKDEVERLMK
IVQKGSVEFIKEGVKRGVDIISFGDSAGTLDILGPKMYKELGGKYTYNVLKEVKNYLGDSIIHLCGITSSSLDRAGFIKS
SPIEVPEGITYGQALNYIIKENKDVKILGHNCLRKTIKPLKKPIVWEIKL

Sequences:

>Translated_290_residues
MDYDVNFKCVLDTGEEMPKEAVERAGIKFPDVHKNAKDMAVLSKNIREYNEDFFSIVPFCMTVEAEALGGEINLGDEKAG
PRVSNYTFKSIEDIERLKEIDFKTKRIGEVLKSVEILKKEGETVIMDVQGPFTIISSLIDPRIFYKAVRKNKDEVERLMK
IVQKGSVEFIKEGVKRGVDIISFGDSAGTLDILGPKMYKELGGKYTYNVLKEVKNYLGDSIIHLCGITSSSLDRAGFIKS
SPIEVPEGITYGQALNYIIKENKDVKILGHNCLRKTIKPLKKPIVWEIKL
>Mature_290_residues
MDYDVNFKCVLDTGEEMPKEAVERAGIKFPDVHKNAKDMAVLSKNIREYNEDFFSIVPFCMTVEAEALGGEINLGDEKAG
PRVSNYTFKSIEDIERLKEIDFKTKRIGEVLKSVEILKKEGETVIMDVQGPFTIISSLIDPRIFYKAVRKNKDEVERLMK
IVQKGSVEFIKEGVKRGVDIISFGDSAGTLDILGPKMYKELGGKYTYNVLKEVKNYLGDSIIHLCGITSSSLDRAGFIKS
SPIEVPEGITYGQALNYIIKENKDVKILGHNCLRKTIKPLKKPIVWEIKL

Specific function: Catalyzes the transfer of the methyl group from the methylated corrinoid cofactor of mtmC, mtbC and mttC to coenzyme M [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family. MtbA/mtaA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006360
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: NA

Molecular weight: Translated: 32692; Mature: 32692

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYDVNFKCVLDTGEEMPKEAVERAGIKFPDVHKNAKDMAVLSKNIREYNEDFFSIVPFC
CCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MTVEAEALGGEINLGDEKAGPRVSNYTFKSIEDIERLKEIDFKTKRIGEVLKSVEILKKE
HHEEHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
GETVIMDVQGPFTIISSLIDPRIFYKAVRKNKDEVERLMKIVQKGSVEFIKEGVKRGVDI
CCEEEEECCCHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEE
ISFGDSAGTLDILGPKMYKELGGKYTYNVLKEVKNYLGDSIIHLCGITSSSLDRAGFIKS
EEECCCCCEEHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCC
SPIEVPEGITYGQALNYIIKENKDVKILGHNCLRKTIKPLKKPIVWEIKL
CCCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure
MDYDVNFKCVLDTGEEMPKEAVERAGIKFPDVHKNAKDMAVLSKNIREYNEDFFSIVPFC
CCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MTVEAEALGGEINLGDEKAGPRVSNYTFKSIEDIERLKEIDFKTKRIGEVLKSVEILKKE
HHEEHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
GETVIMDVQGPFTIISSLIDPRIFYKAVRKNKDEVERLMKIVQKGSVEFIKEGVKRGVDI
CCEEEEECCCHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEE
ISFGDSAGTLDILGPKMYKELGGKYTYNVLKEVKNYLGDSIIHLCGITSSSLDRAGFIKS
EEECCCCCEEHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCC
SPIEVPEGITYGQALNYIIKENKDVKILGHNCLRKTIKPLKKPIVWEIKL
CCCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8702528; 9642198; 7635826; 8617801; 9006042; 9195968; 10852929 [H]