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The map label for this gene is pyrC [H]

Identifier: 148267692

GI number: 148267692

Start: 1305337

End: 1306614

Strand: Direct

Name: pyrC [H]

Synonym: SaurJH9_1260

Alternate gene names: 148267692

Gene position: 1305337-1306614 (Clockwise)

Preceding gene: 148267691

Following gene: 148267693

Centisome position: 44.91

GC content: 35.92

Gene sequence:

>1278_bases
ATGATGAAATTAATTAAAAACGGTAAAGTATTACAAAATGGAGAATTACAACAAGCAGATATTTTAATTGATGGTAAGGT
AATTAAACAAATTGCACCTGCAATTGAACCAAGCAATGGTGTTGACATCATAGATGCGAAAGGTCACTTTGTGTCACCTG
GATTTGTCGATGTTCATGTTCATTTACGTGAACCTGGTGGTGAATATAAAGAGACAATTGAAACTGGTACTAAAGCTGCT
GCTAGAGGCGGATTTACAACTGTATGTCCAATGCCTAACACAAGACCGGTACCAGATTCTGTAGAACATTTTGAAGCTTT
ACAAAAATTAATCGATGACAATGCTCAAGTACGTGTATTACCTTATGCTTCAATTACAACACGTCAATTAGGTAAAGAAT
TGGTTGATTTCCCAGCACTAGTAAAAGAAGGTGCCTTTGCGTTTACAGATGACGGTGTAGGAGTACAAACTGCAAGCATG
ATGTATGAAGGCATGATTGAAGCTGCAAAAGTAAACAAAGCCATCGTAGCACACTGTGAAGATAATTCATTAATCTATGG
TGGTGCAATGCATGAAGGGAAACGCAGTAAAGAGTTAGGTATACCAGGTATTCCAAACATTTGTGAATCTGTTCAAATCG
CAAGAGATGTACTATTAGCTGAAGCAGCAGGTTGTCATTATCATGTATGTCATGTTTCTACTAAAGAAAGTGTTAGAGTC
ATTCGTGACGCTAAACGCGCAGGCATTCATGTTACAGCTGAAGTTACACCACACCATTTATTGTTAACAGAAGATGATAT
TCCTGGTAATAATGCCATTTATAAAATGAATCCACCATTGAGAAGTACTGAAGATAGAGAGGCTTTGTTAGAAGGGTTAC
TAGACGGTACAATTGACTGTATCGCAACAGACCATGCACCACATGCACGTGATGAAAAAGCACAACCAATGGAAAAAGCA
CCATTCGGAATTGTTGGTAGTGAAACAGCATTCCCATTATTATATACGCATTTTGTAAAAAATGGTGATTGGACATTACA
ACAATTAGTAGATTACTTAACAATTAAACCATGTGAGACATTTAATTTAGAATACGGCACATTAAAAGAAAATGGTTATG
CAGATTTAACAATCATTGATTTAGATAGTGAACAAGAAATTAAAGGAGAAGATTTCTTATCAAAAGCAGATAATACACCA
TTTATCGGCTATAAAGTTTATGGAAATCCGATCTTAACAATGGTTGAAGGCGAAGTTAAATTTGAGGGGGATAAATAA

Upstream 100 bases:

>100_bases
TAGAAGCTTCAAAATCAAGAATTTTTAAGCAAATGGAAAATGGCGTTTACTTAAGAATGGCAGTCATTGATGAATTATTA
AAATAGGTAAGGGGACGAAA

Downstream 100 bases:

>100_bases
TATGCAAAGCAAACGTTATCTAGTGTTAGAAGACGGTTCTTTTTACGAAGGCTACCGTTTAGGATCTGATAACTTAACTG
TAGGAGAAATTGTATTTAAT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MMKLIKNGKVLQNGELQQADILIDGKVIKQIAPAIEPSNGVDIIDAKGHFVSPGFVDVHVHLREPGGEYKETIETGTKAA
ARGGFTTVCPMPNTRPVPDSVEHFEALQKLIDDNAQVRVLPYASITTRQLGKELVDFPALVKEGAFAFTDDGVGVQTASM
MYEGMIEAAKVNKAIVAHCEDNSLIYGGAMHEGKRSKELGIPGIPNICESVQIARDVLLAEAAGCHYHVCHVSTKESVRV
IRDAKRAGIHVTAEVTPHHLLLTEDDIPGNNAIYKMNPPLRSTEDREALLEGLLDGTIDCIATDHAPHARDEKAQPMEKA
PFGIVGSETAFPLLYTHFVKNGDWTLQQLVDYLTIKPCETFNLEYGTLKENGYADLTIIDLDSEQEIKGEDFLSKADNTP
FIGYKVYGNPILTMVEGEVKFEGDK

Sequences:

>Translated_425_residues
MMKLIKNGKVLQNGELQQADILIDGKVIKQIAPAIEPSNGVDIIDAKGHFVSPGFVDVHVHLREPGGEYKETIETGTKAA
ARGGFTTVCPMPNTRPVPDSVEHFEALQKLIDDNAQVRVLPYASITTRQLGKELVDFPALVKEGAFAFTDDGVGVQTASM
MYEGMIEAAKVNKAIVAHCEDNSLIYGGAMHEGKRSKELGIPGIPNICESVQIARDVLLAEAAGCHYHVCHVSTKESVRV
IRDAKRAGIHVTAEVTPHHLLLTEDDIPGNNAIYKMNPPLRSTEDREALLEGLLDGTIDCIATDHAPHARDEKAQPMEKA
PFGIVGSETAFPLLYTHFVKNGDWTLQQLVDYLTIKPCETFNLEYGTLKENGYADLTIIDLDSEQEIKGEDFLSKADNTP
FIGYKVYGNPILTMVEGEVKFEGDK
>Mature_425_residues
MMKLIKNGKVLQNGELQQADILIDGKVIKQIAPAIEPSNGVDIIDAKGHFVSPGFVDVHVHLREPGGEYKETIETGTKAA
ARGGFTTVCPMPNTRPVPDSVEHFEALQKLIDDNAQVRVLPYASITTRQLGKELVDFPALVKEGAFAFTDDGVGVQTASM
MYEGMIEAAKVNKAIVAHCEDNSLIYGGAMHEGKRSKELGIPGIPNICESVQIARDVLLAEAAGCHYHVCHVSTKESVRV
IRDAKRAGIHVTAEVTPHHLLLTEDDIPGNNAIYKMNPPLRSTEDREALLEGLLDGTIDCIATDHAPHARDEKAQPMEKA
PFGIVGSETAFPLLYTHFVKNGDWTLQQLVDYLTIKPCETFNLEYGTLKENGYADLTIIDLDSEQEIKGEDFLSKADNTP
FIGYKVYGNPILTMVEGEVKFEGDK

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=414, Percent_Identity=32.3671497584541, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI4503375, Length=449, Percent_Identity=25.1670378619154, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI4503051, Length=445, Percent_Identity=24.4943820224719, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI62422571, Length=445, Percent_Identity=24.4943820224719, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI19923821, Length=448, Percent_Identity=25.4464285714286, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4503377, Length=445, Percent_Identity=24.7191011235955, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4503379, Length=443, Percent_Identity=23.4762979683973, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI190194363, Length=456, Percent_Identity=25.4385964912281, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1786722, Length=433, Percent_Identity=29.3302540415704, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI87082175, Length=446, Percent_Identity=27.5784753363229, Blast_Score=133, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI193204318, Length=382, Percent_Identity=32.1989528795811, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17539558, Length=444, Percent_Identity=24.7747747747748, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71989490, Length=448, Percent_Identity=23.8839285714286, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI86575075, Length=442, Percent_Identity=23.3031674208145, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322218, Length=396, Percent_Identity=27.2727272727273, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24642586, Length=372, Percent_Identity=34.6774193548387, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI17137462, Length=443, Percent_Identity=22.7990970654628, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI221377917, Length=457, Percent_Identity=22.5382932166302, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 46503; Mature: 46503

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKLIKNGKVLQNGELQQADILIDGKVIKQIAPAIEPSNGVDIIDAKGHFVSPGFVDVHV
CCCCCCCCCEEECCCCCEEEEEECHHHHHHHHHCCCCCCCCEEEECCCCEECCCEEEEEE
HLREPGGEYKETIETGTKAAARGGFTTVCPMPNTRPVPDSVEHFEALQKLIDDNAQVRVL
EEECCCCHHHHHHHHCCHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEE
PYASITTRQLGKELVDFPALVKEGAFAFTDDGVGVQTASMMYEGMIEAAKVNKAIVAHCE
ECCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEC
DNSLIYGGAMHEGKRSKELGIPGIPNICESVQIARDVLLAEAAGCHYHVCHVSTKESVRV
CCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHH
IRDAKRAGIHVTAEVTPHHLLLTEDDIPGNNAIYKMNPPLRSTEDREALLEGLLDGTIDC
HHHHHHCCEEEEEEECCCEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEE
IATDHAPHARDEKAQPMEKAPFGIVGSETAFPLLYTHFVKNGDWTLQQLVDYLTIKPCET
EEECCCCCCCCCCCCCHHHCCCCEECCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCC
FNLEYGTLKENGYADLTIIDLDSEQEIKGEDFLSKADNTPFIGYKVYGNPILTMVEGEVK
CCCEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHCCCCCEEEEEEECCEEEEEEECEEE
FEGDK
ECCCC
>Mature Secondary Structure
MMKLIKNGKVLQNGELQQADILIDGKVIKQIAPAIEPSNGVDIIDAKGHFVSPGFVDVHV
CCCCCCCCCEEECCCCCEEEEEECHHHHHHHHHCCCCCCCCEEEECCCCEECCCEEEEEE
HLREPGGEYKETIETGTKAAARGGFTTVCPMPNTRPVPDSVEHFEALQKLIDDNAQVRVL
EEECCCCHHHHHHHHCCHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEE
PYASITTRQLGKELVDFPALVKEGAFAFTDDGVGVQTASMMYEGMIEAAKVNKAIVAHCE
ECCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEC
DNSLIYGGAMHEGKRSKELGIPGIPNICESVQIARDVLLAEAAGCHYHVCHVSTKESVRV
CCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHH
IRDAKRAGIHVTAEVTPHHLLLTEDDIPGNNAIYKMNPPLRSTEDREALLEGLLDGTIDC
HHHHHHCCEEEEEEECCCEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEE
IATDHAPHARDEKAQPMEKAPFGIVGSETAFPLLYTHFVKNGDWTLQQLVDYLTIKPCET
EEECCCCCCCCCCCCCHHHCCCCEECCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCC
FNLEYGTLKENGYADLTIIDLDSEQEIKGEDFLSKADNTPFIGYKVYGNPILTMVEGEVK
CCCEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHCCCCCEEEEEEECCEEEEEEECEEE
FEGDK
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA